JPH04361733A - Ophthalmologic cell photographing device - Google Patents

Abstract

PURPOSE:To accomplish an ophthalmologic cell photographing device of a cheap and simple construction, with which an approximate number of cells of a cornea endodermis can be grasped instantly and judgement whether it may undergo operation with no problem can be obtained easily. CONSTITUTION:A beam of light from an illuminative optical system A is led to the cornea of an eye to be inspected R, which is photographed by a photographing optical system B. On a pattern member 9 a plurality of stitches are arranged for judging the number of endodermis cells per unit area, and a screen 12a displays the endodermis cellular image of the cornea and the stitches of this pattern member 9. Thereby the number of endodermis cells per unit area can be calculated from the density of the stitches.

Description

[Detailed description of the invention]

0001

[Industrial Application Field] The present invention relates to ophthalmological cell imaging in which an image of endothelial cells in the cornea is displayed on a screen by guiding illumination light from an illumination optical system to the cornea of the eye to be examined and photographing it through a photographing optical system. It is related to the device.

0002

2. Description of the Related Art Generally, as shown in FIG.
has an outer skin b, a corneal stroma c, and an endothelium d.

[0003] The endothelial d cells normally have 4,000 to 5,000 cells in early childhood. When one of these many cells dies, the dead cell is absorbed by an adjacent cell, and the number of cells gradually decreases while the size of a single cell increases.

On the other hand, when cells die and decrease to less than 500 cells, for example, some of the cells are cut off with a scalpel during eye surgery and die, which prevents nutrients from being supplied to the cornea. Surgery is not performed because it may lead to corneal disease such as infection.

Therefore, before ophthalmic surgery, it is necessary to measure the shape and number of corneal endothelial cells to confirm their deterioration, and to ensure that cells within the range that will not have any adverse effects even if subjected to artificial cell death during corneal surgery. It was necessary to confirm in advance whether the number of cells was present using an ophthalmic cell imaging device. Further, even after corneal surgery, it is necessary to check the progress of damage to endothelial cells using an ophthalmic cell imaging device.

[0006] This ophthalmic cell imaging device displays an image of the endothelial cells of the cornea on the screen by guiding illumination light from the illumination optical system to the cornea of the eye to be examined and photographing it through the imaging optical system. An image processing device or the like is installed inside the imaging device or separately to measure and calculate various data such as the number of cells per unit area, and display the measurement and calculation results on the screen.

[0007]

[Problems to be Solved by the Invention] However, the ophthalmic cell imaging device configured as described above requires a circuit for measuring and calculating the number of cells, making the ophthalmic cell imaging device expensive. Not only that, but the calculation process and the like require time.

The present invention was developed in view of the above circumstances, and although it is inexpensive and has a simple structure, it is possible to instantly determine the approximate number of cells in the corneal endothelium, and there is no problem even if surgery is performed. It is an object of the present invention to provide an ophthalmic cell imaging device that can easily determine whether or not .

[0009]

[Means for Solving the Problem] In order to achieve the object, the invention according to claim 1 introduces illumination light from an illumination optical system to the cornea of the eye to be examined, and passes it through the imaging optical system to the endothelium of the cornea. The gist of the present invention is that an ophthalmic cell imaging device for observing cell images is provided with a pattern for determining the number of endothelial cells per unit area.

0010

[Operation] In the structure according to claim 1,
The number of endothelial cells in the cornea can be calculated based on a pattern corresponding to the size of the cells.

[0011]

[Embodiment] Next, an embodiment of the ophthalmic cell imaging apparatus of the present invention will be described based on FIGS. 1 to 5.

FIG. 1 is a diagram showing an optical system of an ophthalmic cell imaging device according to the present invention, and FIGS. 2(A) to 2(D) are front views showing examples of pattern members, and FIGS. 3(A) to 2(D), respectively. 3(D)
4(A) and 4(B) are enlarged front views showing an example of the screen display state on which a corneal endothelial cell image and a scale image of the stitches are formed, respectively. 5A and 5B are enlarged front views showing examples of display screens, respectively.

In FIG. 1, A is an illumination optical system, and B is a photographic optical system.

The illumination optical system A includes a halogen lamp 1, a condenser lens 2, a flash lamp 3, a collimator lens 4, and a slit 5.

The halogen lamp 1 and the flash lamp 3 are conjugate with respect to the condenser lens 2. Further, the halogen lamp 1 is used for observation illumination, and the flash lamp 3 is used for photography illumination.
The corneal endothelium is illuminated.

The photographing optical system B includes objective lenses 6a and 6b and a relay lens 7, and the illumination light projected from the illumination optical system A onto the eye R is reflected by the corneal endothelial cells of the eye R (for example, at an angle of 45°). ), the light is then received by the CCD 8 via the objective lenses 6a, 6b and the relay lens 7.

Further, a rotatably set disk-shaped pattern member 9 is disposed at a position Q located between the objective lens 6b and the relay lens 7 and conjugate with the cornea and the central portion P of the CCD 8. It is set up.

As shown in FIG. 2(A), this pattern member 9 is a transparent printed member 9b, in which a plurality of regular hexagonal stitches (patterns) 9a, 9a, . . . of the same size are regularly arranged. 9b... are provided at multiple locations. Also,
Stitches 9a, 9a... of each transparent print member 9b, 9b...
The densities of the transparent members 9b, 9b, . . . are set to be different from each other, and each of the transparent members 9b, 9b, .

The shape of the pattern member 9 used here and the outer shape of the transparent print member 9b are, for example, as follows.
As shown in FIG. 2(B), a plurality of regular hexagonal stitches 19a, 19a of the same size are formed on the disk-shaped pattern member 19.
Transparent print member 19b, 1 in which... are regularly arranged
9b... are provided at a plurality of locations and configured to rotate around a shaft 19c, as shown in FIG. , 29a... are arranged regularly in a plurality of locations and are movable in the vertical (or horizontal) direction, or as shown in FIG. 2(D).
As shown in the figure, a plate-like pattern member 39 is provided with transparent printed members 39b, 39b in which a plurality of regular hexagonal stitches 39a, 39a... of the same size are regularly arranged. , is not limited to what is shown in FIG. 2(A).

Furthermore, the shapes of the stitches 9a, 9a... are also as shown in FIG.
One in which regular hexagons are regularly arranged as shown in A), one in which squares are regularly arranged as shown in Fig. 3(B),
As shown in Figure 3(C), perfect circles are regularly arranged,
The present invention is not limited to the above embodiments, such as the one in which rhombuses are regularly arranged as shown in FIG. 3(D).

The reflected light reflected by the endothelial cells of the cornea and the stitches 9a of the pattern member 9 are simultaneously imaged at the center P of the CCD 8, and this imaged image is sent to the frame memory 10 and the processing circuit 11. The screen 12a of the display unit 12
The image will be displayed.

At this time, on the screen 12a, as shown in FIG. 4(A), a cell image 13 of corneal endothelial cells per unit area and a scale image 14 of the stitches 9a, 9a, . . . are superimposed, Alternatively, as shown in FIG. 4(B), the scale image 14 is displayed on the screen 12a so as to be positioned around the cell image 13 of corneal endothelial cells.

Further, as shown in FIG. 5(A), this screen 12a is divided into a cell image display section 12b and a pattern display section 12c, and the cell image display section 12b has a CC
A reflected image of the endothelial cells from D8 is displayed, and a plurality of patterns 12d, 12d... having stitches of different densities are displayed on the screen in the pattern display section 12c. 5(B), the size of the endothelial cells can be compared by selecting and focusing the image on the cell image display section 12b, or as shown in FIG. 5(B), The cell image display section 12b displays a reflected image of endothelial cells from the CCD 8, and the pattern display section 12c displays a reflected image of endothelial cells from the CCD 8.
By using a pattern selection switch (not shown), two types of patterns 12d and 12d having stitches of different densities are displayed, and the size of the meshes of these two types of patterns is compared with the size of the cells in the cell image. It is also possible to set

In the above configuration, the illumination light projected from the illumination optical system A onto the eye R is reflected by the corneal endothelial cells of the eye R, and then passes through the objective lenses 6a, 6b and the relay lens 7 to the CCD 8. The light is received by the

At this time, the CCD 8 simultaneously receives the light reflected by the endothelial cells of the cornea and the stitches 9a of the pattern member 9, and the received light is displayed via the frame memory 10 and the processing circuit 11. Screen 12a of section 12
are displayed as a cell image 13 and a scale image 14.

Furthermore, if the cell size of the cell image 13 per unit area of the corneal endothelial cells displayed on the screen 12a does not match the size of the scale image 14, the pattern member 9 is rotated to The print member 9b is displaced to display on the screen 12a a transparent print member 9b having meshes 9a, 9a, . . . having meshes 9a, 9a, .

When the cell image 13 and the scale image 14 substantially match, when an end switch (not shown) is operated, the density of the stitches 9a, 9a, . . . of the transparent print member 9b projected as the scale image 14 is changed. The number of endothelial cells is displayed on the screen 12a, and data on the number of cells is accumulated by operating an output switch (not shown). At this time, it is also possible to display the endothelial cell information of the left and right eyes of the subject on the screen 12a by providing a switch for detecting the left and right eyes of the subject.

[0028] Furthermore, it is also possible to calculate the accumulated cell number data by individually detecting the number of cells in substantially the entire cornea of the eye R to be examined, and then calculating the cell density per unit area of the corneal endothelium as an average value. It is.

On the other hand, as shown in FIG. 6, a pattern generating circuit 15 is provided as a pattern member in which the scale of the stitches is electrically changed. It is also possible to form an image on the display screen 18 via the.

[0030]

As explained above, in the ophthalmic cell imaging device of the present invention, a pattern member in which a plurality of meshes are arranged for determining the number of endothelial cells per unit area is provided on the screen. By installing this system, it is possible to instantly determine the rough estimate of the number of cells in the corneal endothelium, even though it is an inexpensive and simple configuration, and it is easy to determine whether or not there will be any problems even if surgery is performed. be able to.

[Brief explanation of drawings]

FIG. 1 is a diagram showing an optical system of an ophthalmic cell imaging device of the present invention.

FIGS. 2A to 2D are front views showing examples of pattern members, respectively.

FIGS. 3A to 3D are enlarged front views showing examples of stitch shapes, respectively.

FIGS. 4(A) and 4(B) are enlarged front views showing examples of display states of a screen on which images of corneal endothelial cells and stitches are formed, respectively.

FIGS. 5A and 5B are enlarged front views showing examples of display screens, respectively.

FIG. 6 is a block diagram showing a second embodiment of the screen.

FIG. 7 is an enlarged cross-sectional view of a portion of the cornea.

[Explanation of symbols]

A...Illumination optical system B...Photography optical system R... Eye to be examined 9...Pattern member 9a...mesh (pattern)

Claims (3)

[Claims] 1. An ophthalmic cell imaging device that guides illumination light from an illumination optical system to the cornea of an eye to be examined and observes an image of endothelial cells in the cornea through an imaging optical system, wherein the number of endothelial cells per unit area is An ophthalmic cell imaging device characterized by being provided with a pattern for determining. 2. A pattern for determining the number of corneal endothelial cells per unit area is provided in an observation measurement optical system, and the pattern is superimposed on the cell image of the endothelial cells and displayed on the screen. Ophthalmic cell imaging device. 3. A pattern for determining the number of corneal endothelial cells per unit area is provided in an observation measurement optical system, and the pattern is displayed along the screen so as to be located on the outer periphery of the cell image of the endothelial cells. An ophthalmic cell imaging device characterized by: