JPH04331752A - Antibacterial and antifungal basic material for building - Google Patents

Abstract

PURPOSE:To improve antibacterial and antifungal properties by adding a compound of formula I to a basic material for a building, showing alkaline by reaction with water. CONSTITUTION:With 100 pts. wt. basic material (e.g. cement material or gypsum) for a building, showing alkaline (e.g. >=pH10) by reaction with water, 0.01-30 pts.wt. compound (e.g. 2,2,3-triiodoallyl alcohol) of formula I (X<1>, X<2> and X<3> show Cl, Br or I. R<1> and R<2> show H or lower alkyl group. R shows hydroxyl group, lower alkoxy group, lower alkanoyloxy or imidazolyl group. n is 1-4) is blended in a condition where the basic material for a building is powdery or not molded or cured yet. Or, the compound is applied to the surface of the basic material by the coating method or the spraying method.

Description

BACKGROUND OF THE INVENTION [0001] [Industrial Field of Application] The present invention relates to a construction base material having antibacterial and antifungal properties, and more particularly, to a base material for construction having antibacterial and antifungal properties. It relates to building materials such as cement and plaster that react with water and become alkaline. [0002] In general houses, apartment complexes, general office buildings, hotels, etc., condensation is likely to occur due to improved structural airtightness and the spread of heating equipment, and moisture contained in building materials can cause mold and mildew. There are often environments where it is easy to grow. In such an environment, mold grows using organic compounds contained in wallpaper, paint, adhesives, etc. used for interior decoration as a source of nutrients. [0003] As a hitherto known antibacterial and antifungal measure, an antibacterial and antifungal agent has been mixed into paints, adhesives, and the like when performing interior construction work on buildings. The antibacterial and antifungal agents used include 2-(4-thiazolyl)-benzimidazole (Japanese Unexamined Patent Publication No. 127960/1983), 2,3,5,6-tetrachloro-4-methylsulfonylpyridine (Japanese Patent Application Laid-Open No. 1983-127960), Publication No. 51-106158)
, triorganotin (Japanese Unexamined Patent Application Publication No. 57-133150, Japanese Unexamined Patent Publication No. 57-96044) are known. [0004] However, because there is a limit to the absolute amount of the antibacterial and antifungal agent that can be mixed into these materials, it has not been possible to impart sufficient antibacterial and antifungal activity. Furthermore, these antibacterial and antifungal agents can be used in joints in the bathroom, where mold damage is most common in ordinary homes, interior wallpaper on the inside of walls that face the outside, and carpets on the floor. could hardly exhibit any antibacterial or antifungal effects. On the other hand, to date, there have been no reports of adding antibacterial and antifungal properties to architectural base materials such as cement, plaster, and joint materials by mixing them with antibacterial and antifungal agents. do not have. In order to impart antibacterial and antifungal properties to these building materials themselves, it is generally necessary to mix in a larger amount of antibacterial and antifungal agent than in the interior construction materials mentioned above. This is because the addition of antibacterial and antifungal agents has the potential to adversely affect the physical properties of the building materials themselves. Furthermore, many of these building materials react with water during the molding process, curing process, or storage state and become alkaline, and this alkalinity decomposes the antibacterial and antifungal agent. This is because it was thought that the activity would disappear. In fact, the present inventors have confirmed that many of the currently widely used antibacterial and antifungal agents show almost no antibacterial and antifungal activity when mixed into these architectural base materials. [Summary of the Invention] [Problems to be Solved by the Invention] Accordingly, the present invention aims to provide a construction base material that reacts with water to become alkaline and has antibacterial and antifungal properties. The purpose is [Means for Solving the Problems] A building material according to the present invention is a building material that reacts with water to become alkaline, and is a building material made of a compound represented by the following general formula (I). It is characterized in that it is made by adding. [Formula 2] (wherein, X1, X2 and X3 may be the same or different and each represents a chlorine, bromine or iodine atom, and R1 and R2 may be the same or different and each represents a hydrogen atom or Represents a lower alkyl group, R3
represents a hydroxyl group, a lower alkoxy group, a lower alkanoyloxy or an imidazolyl group, and n represents an integer of 1 to 4. ) Conventionally, it has been necessary to mix a large amount of a fungicide, and the effect of adding the fungicide has not been expected.In construction base materials that react with water and become alkaline, compounds of the general formula (I) have been used. It was unexpected that the compound represented by the following exhibited strong antifungal activity and a broad antifungal spectrum. [Detailed Description of the Invention] The architectural base material having antifungal properties according to the present invention contains a compound represented by the general formula (I). The compound represented by the general formula (I) is a known compound (Japanese Patent Publication No. 53-20
006, JP 53-20484, JP 56-33373, JP 63-7170, JP 63-41375, JP 1-3222
Publication No. 0, Japanese Patent Publication No. 2-20636, Japanese Unexamined Patent Publication No. 1987-
112341), can be easily obtained commercially or by a known manufacturing method or a manufacturing method similar thereto. In the general formula (I), the alkyl group moiety in the lower alkyl group, lower alkoxy group and lower alkanoyloxy group is preferably a linear or branched C1-6 alkyl group, more preferably a C1-6 alkyl group. 3 represents an alkyl group. Preferred compound groups in the present invention include:
X1, X2 and X3 are iodine or bromine, and R1
and those in which R2 is a hydrogen atom or a methyl group, R3 is a hydroxyl group, methoxy group, ethoxy group, or imidazolyl group, and n is 1 or 2. especially,
Specific examples of preferred compounds include 2,2,3-triiodoallylic alcohol, 3-bromo-2,3-diiodoallylic alcohol, 3-chloro-2,3-diiodoallylic alcohol, 3-bromo-2 , 3-diiodoallyl methyl ether, 2,2,3-triiodoallyl methyl ether, 2,2,3-triiodoallyl ethyl ether, 1-(2',3',3'-triiodoallyl)imidazole Examples include. [0011] In the present invention, the architectural base material to which antifungal activity is imparted is one that exhibits alkalinity by reacting with water during, for example, the molding process, curing process, or storage state. Specific examples include calcium compounds (e.g., calcium carbonate, calcium sulfate, calcium silicate, etc.)
It is a material that hardens by reacting with water, and is used as a joint material such as tile joint material, marble joint material, terrazzo joint material, portland cement, concrete panel, cement mortar, cement filler, and cement. Examples include sprayed materials, slate boards, cement materials such as ready-mixed concrete, and plaster. When these architectural substrates react with water (e.g. during the molding process, curing process or storage condition), they exhibit alkalinity, and the alkalinity usually ranges from pH 8.0 to 13.0, and in some cases from pH 12.0 to 13.0. 5. In the above-mentioned high alkaline region, many antibacterial and antifungal agents are decomposed by hydrolysis and lose their activity. On the other hand, the compound represented by the general formula (I) stably exhibits its activity even in the above-mentioned highly alkaline region, particularly at pH 10 or higher. [0012] The compound represented by the general formula (I) is added to the architectural base material before the molding or curing process. That is, the compound represented by the general formula (I) is added to a powdered building material or to a building material mixed with water and not yet shaped or hardened. After thorough mixing, the mixture is subjected to a molding or curing process. In addition, the general formula (
It is also possible to contain the compound represented by I) only near the surface. The amount of the compound represented by general formula (I) can be determined as appropriate depending on the type of architectural base material and the manner in which it is used, but it is 0.01 parts by weight per 100 parts by weight of the dry architectural base material. ~30.0 parts by weight, preferably about 0.1 to 5.0 parts by weight. The architectural base material according to the present invention can be used in the same manner and in the manner in which the architectural base material has been used in the past. In other words, joint materials for tiles, concrete that constitutes the main structural parts of buildings, concrete panels used in panel construction methods or two-by-four construction methods, slate boards, gypsum boards, fireproof boards, ready-mixed concrete,
It can be used in the form of mortar, plaster, etc. Since these architectural base materials themselves have antibacterial and antifungal activity, they can prevent mold from adhering to and growing on interior materials placed in contact with these base materials. . Furthermore, it is possible to prevent the attachment and growth of mold not only on interior decorations but also on external walls, and in areas that come into contact with soil, corrosion by microorganisms in the soil can be suppressed. Further, although the general formula (I) has been originally used as a fungicidal agent, it has sometimes been colored by ultraviolet rays, etc., probably because it contains a halogen atom. As a result, there were restrictions on where it could be used and how it could be used. However, the present invention is advantageous because in most cases, the material is a building material located in a location that is not easily exposed to ultraviolet rays, so coloring poses little practical problem. EXAMPLES The present invention will be further explained by the following examples, but the present invention is not limited to these examples. In addition, the compound represented by the general formula (I) is a known compound as described above, and is a microbial control agent, acaricide,
It is known to be used as an underwater antifouling paint, a slime control agent for paper manufacturing, an insect repellent, an anticide, a fungicide, and a fungicide (Japanese Patent Publication No. 50-2731, Japanese Patent Application Laid-Open No. 57-116)
002, JP 57-64602, JP 57-193401, JP 58-22082, JP 59-227960, JP 59-
227959, JP 61-254502, JP 62-238203, JP 63-44
504, JP-A-1-125303, JP-A-2-3761, and JP-A-2-49217). Although the mechanism of these antimicrobial effects is not clear, the similarities in behavior of these known compounds are clear. Therefore, among these compounds represented by general formula (I), 2,3,3-triiodoallylic alcohol, which is easily available, was used in the following examples. Example 1 Joint Material Triiodoallyl alcohol was added to a joint material, and its antifungal effect against standard strains of bacteria that are most often isolated in ordinary households was confirmed. To 100 parts by weight of a commercially available joint material (NS Medicement, manufactured by Hitachi Chemical Co., Ltd.), add 0.1 part by weight, 0.5 part by weight, or 1.0 part by weight of triiodoallyl alcohol, and water. After kneading and kneading to the same hardness as an earlobe, the mixture was molded into a 2.5 cm square and 2 mm thick test piece. P of joint material during test piece preparation
H was 12.3. When this test piece was stored in a carbon dioxide gas incubator until it was used in the following experiment, the pH
was 8.8. Place this test piece in the center of a 90 mm diameter petri dish, and add 25 ml of potato dextrose agar medium.
was added and solidified. 0.1 ml of a spore suspension (1.0 x 106 cells/ml) of each test bacterium was applied onto the solidified agar and incubated at 28°C for 7 days. After 7 days, the ratio of the area of the growth inhibition zone formed on the petri dish to the area of the entire petri dish was determined, and this was taken as the growth inhibition rate. The values are shown in Table 1 below. [0016]
Table 1
Growth inhibition rate of triiodoallyl alcohol


Growth inhibition rate (%)
Bacterial name Strain 0.1 parts by weight 0.5 parts by weight 1.0 parts by weight Cladosporium
IFO-31677 57.8 10
0.0 100.0 Alternaria
IFO-31805 50.0 1
00.0 100.0 Urocladium
IFO-9210 51.1 100
．． 0 100.0 Aureobasidium IFO-
6353 70.0 100.0
100.0 Trichoderma IFO-
31137 0.0 100.0
100.0 Forma I
FO-5287 26.7 100.
Example 2 Cement Triiodoallyl alcohol was added to cement, and its antifungal effect against the same bacterial strain as in Example 1 was confirmed. 0.1 part by weight, 0.5 part by weight or 1.0 part by weight of triiodoallyl alcohol per 100 parts by weight of commercially available cement (manufactured by Keikagaku Kogyo Co., Ltd., waterproof cement),
Then, water was added and kneaded to make it as hard as an earlobe, and then molded into a 2.5 cm square and 2 mm thick test piece. The pH of the cement at the time of test piece preparation was 12.8. When this test piece was stored in a carbon dioxide gas incubator until it was used in the following experiment, the pH was 8.9. The growth inhibition rate of this test piece was determined in the same manner as in Example 1. The values are shown in Table 2 below. [0018]
Table 2
Growth inhibition rate of triiodoallyl alcohol


Growth inhibition rate (%)
Bacterial name Strain 0.1 parts by weight 0.5 parts by weight 1.0 parts by weight Cladosporium
IFO-31677 56.5 10
0.0 100.0 Alternaria
IFO-31805 59.8 1
00.0 100.0 Urocladium
IFO-9210 52.3 100
．． 0 100.0 Aureobasidium IFO-
6353 68.3 100.0
100.0 Trichoderma IFO-
31137 20.1 100.0
100.0 Forma IF
O-5287 32.8 100.0
100.0 Example 3 Triiodoallyl alcohol was added to gypsum plaster, and its antifungal effect against the same bacterial strains as in Example 1 was confirmed. 0.1 part by weight of triiodoallyl alcohol per 100 parts by weight of commercially available gypsum (Wake Sangyo Sales, gypsum)
．． Add 5 parts by weight or 1.0 parts by weight and water and knead to make it as hard as an earlobe.
It was molded into a test piece with a thickness of mm. The pH of the gypsum at the time of test piece preparation was 7.8. The growth inhibition rate of this test piece was determined in the same manner as in Example 1. Its value is the third
As shown in the table. [0020]
Table 3
Growth inhibition rate of triiodoallyl alcohol


Growth inhibition rate (%)
Bacterial name Strain 0.1 parts by weight 0.5 parts by weight 1.0 parts by weight Cladosporium
IFO-31677 68.3 10
0.0 100.0 Alternaria
IFO-31805 75.3 1
00.0 100.0 Urocladium
IFO-9210 72.6 100
．． 0 100.0 Aureobasidium IFO-
6353 89.1 100.0
100.0 Trichoderma IFO-
31137 52.8 100.0
100.0 Forma IF
O-5287 60.4 100.0
Comparative Example 1 Triiodo alcohol (TIAA), 2-(4-thiazolyl)-benzimidazole (TBZ) or 2,3,5 was added to 100 parts by weight of the same joint material as in Example 1. , 6-tetrachloroisophthalonitrile (TCIN) was added in an amount of 0.5 parts by weight to prepare a test piece similar to that in Example 1. The pH of the joint material at the time of preparing the test piece was 12.5 regardless of the antifungal material added. When this test piece was stored in a carbon dioxide gas incubator, the pH was 8.4. This test piece was placed in the center of a 90 mm diameter petri dish in the same manner as in Example 1, and 25 ml of potato dextrose agar medium was added to solidify it. Apply 0.1 ml of a spore suspension (1.0 x 106/ml) of each test bacterium on the solidified agar,
It was incubated at 28°C for 7 days. After 7 days, the degree to which the growth of the bacterial strain was suppressed was evaluated. The result is the following 4th
As shown in the table. [0022]
Table 4
Antifungal activity of various antifungal agents in joint materials
Bacteria name
Stock T
IAA TCIN TBZ Cladosporium IFO-31677
− ++ ++
Alternaria IFO-
31805-
+++ +++ Urocladium I
FO-9210-
+++ +++ Aureobasidium
IFO-6353-
++ +++ Trichoderma
IFO-31137 -
++ +++ Forma IFO-5287
- +++
+++ Comparative Example 2 The antifungal activity of 100 parts by weight of the same cement as in Example 2 was compared in the same manner as in Comparative Example 1. The results are shown in Table 5 below.

Claims (4)

[Claims] 1. An architectural base material that reacts with water to become alkaline, characterized in that it contains a compound represented by the following general formula (I). [Formula 1] (wherein, X1, X2 and X3 may be the same or different and each represents a chlorine, bromine or iodine atom; R1 and R2 may be the same or different and each represents a hydrogen atom or Represents a lower alkyl group, R3
represents a hydroxyl group, a lower alkoxy group, a lower alkanoyloxy or an imidazolyl group, and n represents an integer of 1 to 4. ) Claim 2: The compound represented by general formula (I) is 0.01
The architectural base material according to claim 1, wherein 30 parts by weight is added. Claim 3: The alkaline pH exhibited by reaction with water is 1.
The architectural base material according to claim 1 or 2, which is 0 or more. Claim 4: The compound represented by the general formula (I) is 2,2,
Claims 1 to 3, wherein the alcohol is 3-triiodoallylic alcohol.
Architectural base material according to any one of the items.