JPH04290822A - Allergy preventing medicine and food - Google Patents

Abstract

PURPOSE:To obtain a fat and oil composition by blending an perilla oil as alpha-linolenic acid-containing fats and oils with a sesame oil as fats and oils containing a sesamin. CONSTITUTION:Treatment of allergic patient has been conventionally depended upon a drug having side effects but in this invention, alpha-linolenic acid and a sesamin can be taken in a common food life from an perilla oil and a sesame oil and both alpha-linolenic acid and the sesamin show extremely high effects on allergic diseases. Further both alpha-linolenic acid and the sesame consist of natural substances, are safe as foods and simply produced.

Description

[Detailed description of the invention]

0001

TECHNICAL FIELD The present invention relates to allergy preventive drugs and foods.

0002

BACKGROUND OF THE INVENTION At present, the rapid increase in the number of allergic patients is said to be partly due to an increase in biological reactions to allergens (mold, mites, pollen, etc.) due to changes in the living environment. but,
In recent years, it has been pointed out that the main cause of this is an imbalance of essential fatty acids due to excessive intake of linoleic acid due to the Westernization of dietary habits.

[0003] Okuyama et al. (Faculty of Pharmaceutical Sciences, Nagoya City University) have reported that the production of leukotrienes, which are the causative agents of allergic reactions in living organisms, can be suppressed by ingesting fats and oils containing α-linolenic acid. (Front Strategy, 36, 3 (1988)).

[0004] Similar effects have also been recognized for other omega-3 fatty acids, eicosapentaenoic acid and docosahexaenoic acid.

[0005] Allergic symptoms occur when an antigen-antibody reaction occurs in the body and immunoglobulin E (IgE antibody) is produced, which eventually stimulates the cell membrane of mast cells and releases histamine and leukotrienes. These released substances have the effect of promoting vascular permeability and contracting smooth muscle, causing white blood cells and proteins to leak from blood vessels, and inflammation that constricts the bronchi, causing asthma.

[0006] Conventionally, in order to alleviate such symptoms, the basic approach has been to remove or avoid ingesting substances that act as antigens, and antihistamines and adrenocortical hormones have been orally administered or used as ointments.

[0007] However, the above-mentioned drug methods have side effects such as drowsiness, gastrointestinal disorders, liver disorders, diabetes, and high blood pressure, and are only temporary treatments, with problems such as symptoms reappearing if not used. .

[0008]

[Problems to be Solved by the Invention] The purpose of the present invention is to provide a safe and easy-to-take allergy-preventing drug made of a natural oil and fat composition, in order to solve the above-mentioned problems in treatment with drugs. It provides food.

[0009]

[Means for Solving the Problems] The allergy-preventing oil and fat food of the present invention uses perilla oil (perilla oil) or linseed oil as the α-linolenic acid-containing oil and fat food, and sesame oil is selected as the oil and fat containing lignan compounds such as sesamin. This is an oil and fat composition characterized by using these in combination. Additionally, licorice extract or tea extract may be added.

[0010] The α-linolenic acid used in the present invention is ω3
It belongs to the ω6 fatty acids and competes with ω6 fatty acids such as linoleic acid and arachidonic acid in vivo.

[0011] By ingesting ω3 fatty acids such as α-linolenic acid, ω6 fatty acids in living tissues are reduced, resulting in a decrease in the amount of arachidonic acid and suppression of leukotriene production.

[0012] Among the omega-3 fatty acids, eicosapentaenoic acid can also be a substrate for leukotrienes, but the activity of leukotrienes is much weaker than that derived from arachidonic acid, and the amount produced is low.

[0013] As described above, it is clear that the production of leukotrienes from arachidonic acid is suppressed by ingesting omega-3 fatty acids, and it has been confirmed that it is effective in preventing and treating allergic symptoms.

Furthermore, several lignan compounds such as sesamin, sesaminol, and episesamin contained in sesame oil
Shimizu (Kyoto University) et al. reported that 5-desaturation reaction was specifically inhibited (Bioscience and Industry., vol. 48 No. 12 (1990)
).

[0015] That is, the sesamin compounds in sesame oil have no effect on the desaturases of fatty acids with 18 carbon atoms (△9△12, △6), but on the △5 desaturases with fatty acids with 20 carbon atoms. The production of arachidonic acid from dihomogammalinolenic acid is suppressed. This means that
As a result, it suppresses the production of leukotrienes, which are the cause of allergic symptoms.

[0016] Sesame oil has been known to have a unique aroma and high oxidation stability, and has been used in edible fats and oils and health foods with anti-aging effects.

The present discovery by Shimizu et al. is the first desaturase inhibitor made from a natural product, and is also interesting from the point of view of a new use of sesame oil.

[0018] Furthermore, tea extract and licorice extract have been attracting attention for their antioxidant properties against fats and oils, and the addition of these will improve the oxidative stability of the fat and oil composition of the present invention containing a large amount of α-linolenic acid. I will let you do it. Generally, antioxidants such as tocopherols are added to the above oils and fats to suppress oxidation, but the allergy preventive properties are further enhanced by adding tea extract or licorice extract.

[0019] Based on the above findings, the present inventors have discovered that a higher allergy prevention effect can be achieved by combining two types of ingredients that have different properties and, as a result, suppress the production of leukotrienes, which are the causative substances of allergies. I found that there is. Furthermore, tea extract or licorice extract may be added.

That is, the present inventors used perilla oil (perilla oil) or linseed oil containing 40 to 60% α-linolenic acid as the oil containing ω3 fatty acids, and sesame oil as the oil containing sesamin. By blending the two, an oil and fat composition with a high allergy prevention effect was obtained.

[0021] Excellent allergy prevention effects can be obtained when the blending ratio is in the range of 90 to 50% by weight of perilla oil and 10 to 50% by weight of sesame oil. Moreover, even higher allergy prevention effects can be obtained by adding 0.1 to 2% by weight of tea extract or licorice extract.

The allergy-preventing oil and fat food of the present invention is obtained by blending perilla oil and sesame oil, but other ingredients may be blended and added.

In particular, since it contains a large amount of α-linolenic acid, an antioxidant such as tocopherol may be added to maintain oxidative stability.

The allergy-preventing oil and fat food of the present invention may be administered orally or by injection in the form of capsules, tablets, emulsions, etc., or may be administered in the form of food by mixing it with salad oil, margarine, dressing, etc.

[0025] Although there are no particular restrictions on the dosage, sufficient effects can be obtained with approximately 2.0 to 3.0 g per day for adults.

[0026]

[Examples and Comparative Examples] The present invention will be explained in more detail with reference to Examples and Comparative Examples.

[Example 1] A total of 20 hay fever patients (15 males, 5 females, aged 22 to 43) were divided into 4 groups and a clinical trial was conducted for 3 months. The results are shown in Table 1. Ta.

[Table 1]

[0028] Regarding the test method, each year the subjects were given 10 ml of pollen every day, starting approximately one month before the patient's symptoms of pollen appeared.
The oil capsules of Groups A to D are administered orally in tablets.

On the other hand, there were no particular restrictions on daily activities including meals.

[0030] Diagnosis was carried out four times in total, one month, two months, and three months after the test start date. The evaluation was based on the subjects' subjective symptoms in four stages: marked effect, effective, ineffective, and worsening. The results are shown in Table 2.

[Table 2]

[0031] From this result, although some effects were observed even when the perilla oil of group A and sesame oil of group B were used alone, a higher effect was observed when perilla oil and sesame oil were used in combination.

[Example 2] A clinical trial was conducted for 3 months with 24 atopic dermatitis patients (18 males, 6 females, aged 5-32) divided into 4 groups. The fourth group is the same as in Example 1.

[0033] There were no particular restrictions on bathing or eating during the test.

[0034] As in Example 1, the diagnosis was evaluated on a four-level scale based on the opinions of the subjects and the examiner. The results are shown in Table 3.

[Table 3]

[0035] From this result, a result almost identical to that of Example 1 was obtained.

[Example 3] Thirty boys (23 to 48) who had already begun to show pollen symptoms were divided into 5 groups: A, C, E, F, and G for 2 months. A clinical trial was conducted.

[0037] Regarding the test method, the test was started sequentially from the subjects who started to show pollen symptoms. The administration method and diagnosis were performed in the same manner as in Examples 1 and 2. This result is shown in Table 4.
Shown below.

[Table 4]

[0038] From this result, it can be said that a sufficient anti-allergy effect is achieved when the blending ratio of perilla oil and sesame oil is between about 50% and 10%. However, 50% sesame oil
If more than 100% is added, the allergy prevention effect will be reduced.

[Example 4] Twelve patients (3 to 14 years old) with atopic dermatitis were divided into Groups C, H, and I, and a clinical trial was conducted for 3 months.

The test method was the same as in Examples 1-3. The results are shown in Table 5.

[Table 5]

[0041] From these results, it was found that the allergy preventive effect tended to be somewhat strengthened by adding tea extract and licorice extract.

[0042]

[Effects of the Invention] Currently, although hay fever is increasing in adults and atopic dermatitis is increasing in children, no methods for preventing or treating these diseases have been established.

[0043] Unlike conventional treatment methods that rely on drugs, the present invention supplements α-linolenic acid, which is deficient in the normal diet, with perilla oil, and also has a synergistic effect with α-linolenic acid. This is an allergy-preventing oil and fat composition that is safe for use in medicine and food, and aims to extract sesamin from sesame oil.

Claims (3)

[Claims] 1. Allergy preventive medicine and food, characterized by containing oil and fat having α-linolenic acid as a main component and a lignan compound such as sesamin as active ingredients. 2. The allergy preventive medicine and food according to claim 1, wherein the α-linolenic acid-containing fat or oil is perilla oil (perilla oil) or linseed oil, and the active ingredient such as sesamin is obtained from sesame oil. 3. The allergy preventive drug and food according to claim 1, which are obtained by adding a tea extract or a licorice extract to an oil and fat composition containing active ingredients such as α-linolenic acid and sesamin.