JPH04198131A - Wound treatment promoter and composition for external use containing the same promoter - Google Patents
Wound treatment promoter and composition for external use containing the same promoterInfo
- Publication number
- JPH04198131A JPH04198131A JP2331862A JP33186290A JPH04198131A JP H04198131 A JPH04198131 A JP H04198131A JP 2331862 A JP2331862 A JP 2331862A JP 33186290 A JP33186290 A JP 33186290A JP H04198131 A JPH04198131 A JP H04198131A
- Authority
- JP
- Japan
- Prior art keywords
- promoter
- wound treatment
- oil
- composition
- melaleuca
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 17
- 206010052428 Wound Diseases 0.000 title abstract description 13
- 208000027418 Wounds and injury Diseases 0.000 title abstract description 13
- 230000001737 promoting effect Effects 0.000 claims abstract description 10
- 241000366182 Melaleuca alternifolia Species 0.000 claims abstract description 7
- 241001264681 Melaleuca linariifolia Species 0.000 claims abstract description 5
- 239000000341 volatile oil Substances 0.000 claims description 20
- 230000029663 wound healing Effects 0.000 claims description 11
- 239000003995 emulsifying agent Substances 0.000 claims description 2
- 239000002199 base oil Substances 0.000 claims 1
- 230000007794 irritation Effects 0.000 abstract description 3
- 241000196324 Embryophyta Species 0.000 abstract description 2
- 238000001256 steam distillation Methods 0.000 abstract description 2
- 208000010201 Exanthema Diseases 0.000 abstract 1
- 201000005884 exanthem Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 210000004877 mucosa Anatomy 0.000 abstract 1
- 206010037844 rash Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- 238000007796 conventional method Methods 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 239000002674 ointment Substances 0.000 description 3
- 239000003871 white petrolatum Substances 0.000 description 3
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- 239000004166 Lanolin Substances 0.000 description 2
- 241000378467 Melaleuca Species 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 235000019388 lanolin Nutrition 0.000 description 2
- 229940039717 lanolin Drugs 0.000 description 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 235000019271 petrolatum Nutrition 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000010677 tea tree oil Substances 0.000 description 2
- 229940111630 tea tree oil Drugs 0.000 description 2
- 230000000699 topical effect Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- YHQGMYUVUMAZJR-UHFFFAOYSA-N α-terpinene Chemical compound CC(C)C1=CC=C(C)CC1 YHQGMYUVUMAZJR-UHFFFAOYSA-N 0.000 description 2
- YKFLAYDHMOASIY-UHFFFAOYSA-N γ-terpinene Chemical compound CC(C)C1=CCC(C)=CC1 YKFLAYDHMOASIY-UHFFFAOYSA-N 0.000 description 2
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- WSTYNZDAOAEEKG-UHFFFAOYSA-N Mayol Natural products CC1=C(O)C(=O)C=C2C(CCC3(C4CC(C(CC4(CCC33C)C)=O)C)C)(C)C3=CC=C21 WSTYNZDAOAEEKG-UHFFFAOYSA-N 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 241000700157 Rattus norvegicus Species 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 235000013871 bee wax Nutrition 0.000 description 1
- 239000012166 beeswax Substances 0.000 description 1
- UDEWPOVQBGFNGE-UHFFFAOYSA-N benzoic acid n-propyl ester Natural products CCCOC(=O)C1=CC=CC=C1 UDEWPOVQBGFNGE-UHFFFAOYSA-N 0.000 description 1
- 229910021538 borax Inorganic materials 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 239000008341 cosmetic lotion Substances 0.000 description 1
- 239000010639 cypress oil Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 229940124600 folk medicine Drugs 0.000 description 1
- 229940075507 glyceryl monostearate Drugs 0.000 description 1
- 208000014617 hemorrhoid Diseases 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- OLXYLDUSSBULGU-UHFFFAOYSA-N methyl pyridine-4-carboxylate Chemical compound COC(=O)C1=CC=NC=C1 OLXYLDUSSBULGU-UHFFFAOYSA-N 0.000 description 1
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
- 229940105631 nembutal Drugs 0.000 description 1
- 231100000344 non-irritating Toxicity 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- WEXRUCMBJFQVBZ-UHFFFAOYSA-N pentobarbital Chemical compound CCCC(C)C1(CC)C(=O)NC(=O)NC1=O WEXRUCMBJFQVBZ-UHFFFAOYSA-N 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 239000004328 sodium tetraborate Substances 0.000 description 1
- 235000010339 sodium tetraborate Nutrition 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 239000003357 wound healing promoting agent Substances 0.000 description 1
Abstract
Description
【発明の詳細な説明】
［産業上の利用分野：
本発明はある種の植物の精油よりなる良好な創傷治癒促
進作用を有する物質およびそれを含有する化粧料、医薬
等に用いることのできる外用組成物に関する。[Detailed Description of the Invention] [Industrial Field of Application] The present invention relates to a substance that is made of essential oils of certain plants and has a good wound healing promoting effect, and to external use that can be used in cosmetics, medicines, etc. containing the same. Regarding the composition.
［従来の技術と本発明が解決しようとする課題］メラレ
ウカ・アルテルニフォリア（Ｍｅｌａｌｅｕｃａａｌｔ
ｅｒｎｉｆｏｌ ｉａ）およびメラレウカ・リナリフォ
リア（Ｍｅｌａｌｅｕｃａ １ｉｎａｒｉｆｏｌｉａ
）はオーストラリアの低湿地帯に成育する低木で、それ
らの葉から水蒸気蒸留で精油を採取することができ、特
に、前者から得た精油はティー・ツリー・オイル（ＴＥ
ＡＴＲＥＥ ０ＩＬ）と呼ばれている。これらの精油は
成分としてα−テルピネン、γ−テルピネン等を含み、
弱い殺菌作用があり、無毒性、無刺激性であることが知
られており、従来、オーストラリアの民間薬として抗菌
作用を期待して用いられている。[Prior art and problems to be solved by the present invention] Melaleuca alternifolia (Melaleuca alternifolia)
ernifolia) and Melaleuca linarifolia
) is a shrub that grows in the low humid areas of Australia, and essential oil can be extracted from its leaves by steam distillation.In particular, the essential oil obtained from the former is called tea tree oil (TE
ATREE 0IL). These essential oils contain α-terpinene, γ-terpinene, etc. as components,
It is known to have a weak bactericidal effect, and is non-toxic and non-irritating, and has traditionally been used as a folk medicine in Australia for its antibacterial properties.
しかし、外用面での研究は少なく、その創傷面修復効果
の機能などについては全く未知である。However, there has been little research on external use, and its function, such as its effect on wound surface repair, is completely unknown.
［課題を解決するための手段］
本発明者らは、こわらの精油の外用面での研究を重ねる
間に、意外にも、これらの精油が創傷治癒促進効果を示
すことを見出し、本発明を完成するに至った。[Means for Solving the Problems] The present inventors, while conducting repeated research on the external use of essential oils of Kowara, unexpectedly discovered that these essential oils exhibit the effect of promoting wound healing, and have developed the present invention. I was able to complete it.
すなわち、本発明は、メラレウカ・アルテルニフォリア
またはメラレウカ・リナリフォリアの葉の精油よりなる
創傷治を促進剤およびこれを基剤と合してなる創傷治癒
促進用外用組成物を提供するものである。メラレウカ・
アルテルニフォリアまたはメラレウカ・リナリフォリア
の葉の精油（以下、単に精油という場合もある）は優れ
た創傷治癒促進効果を発揮し、それを配合した組成物を
外用することにより、迅速に創傷を冶唸させることがで
きる。That is, the present invention provides a wound healing promoting agent comprising the essential oil of Melaleuca alternifolia or Melaleuca linarifolia leaves, and a topical composition for promoting wound healing comprising this in combination with a base. . melaleuca
The essential oil of the leaves of Alternifolia or Melaleuca linarifolia (hereinafter sometimes simply referred to as essential oil) exhibits an excellent wound healing promoting effect, and by externally applying a composition containing it, wounds can be healed quickly. It can make you groan.
本発明においては、メラレウカ・アルテルニフォリア、
メラレウカ・リナリフォリアいずれもの葉も使用でき、
これらの葉を常法ｊこより水蒸気蒸留することにより精
油が得られる。得られｒ二精油は、そのまま、本発明の
創傷治癒促進剤として使用できる。In the present invention, Melaleuca alternifolia,
You can also use the leaves of both Melaleuca and Linarifolia.
Essential oils can be obtained by steam distilling these leaves using conventional methods. The obtained r2 essential oil can be used as it is as a wound healing promoter of the present invention.
また、該精油は常法に従って公知の基剤と合してペース
ト、軟膏、ロー７ョン等の皮膚外用の化粧料や医薬の列
形とすることができる。基剤としてはラノリンや白色ワ
セリン、ミツロウ等を用いた油溶性の基剤や、グリセリ
ン、アルコール等を用いた水溶性の基剤が挙げられる。Further, the essential oil can be combined with a known base in a conventional manner to form cosmetics and medicines for external use on the skin, such as pastes, ointments, and lotions. Examples of the base include oil-soluble bases using lanolin, white petrolatum, beeswax, etc., and water-soluble bases using glycerin, alcohol, etc.
一般に、該組成物には０５〜２０重量％、好ましくは、
１〜１５重量％の割合で該精油か配合される。所望によ
り、適当量の乳化剤、防腐剤、香料、着色料等を配合し
てもよい。Generally, the composition contains 05 to 20% by weight, preferably
The essential oil is blended in a proportion of 1 to 15% by weight. If desired, appropriate amounts of emulsifiers, preservatives, fragrances, colorants, etc. may be added.
かくして本発明に係わる精油および組成物は傷、ひび、
あかぎれ、火傷なとに対する皮膚外用剤、痔疾薬、アフ
ターンエービングなどの皮膚外用剤、局所用剤などに使
用され、使用量は特に限定するものではなく、必要に応
じて適当量を定期的または不定期的に適用すればよい。Thus, essential oils and compositions according to the present invention can be used to treat scratches, cracks,
It is used in external skin preparations for chapped and burns, hemorrhoid medicine, after-aging and other skin preparations, and topical preparations.The amount used is not particularly limited. It can be applied irregularly.
なお、該精油は皮膚粘膜に対する刺激性もなく、かつ適
用面にかぶれやたたれ等を生じることもなく、使用上の
安全性は高いものである。The essential oil has no irritation to the skin and mucous membranes, and does not cause irritation or dripping on the surface to which it is applied, so it is highly safe to use.
寒巖五
つぎに、実験例および処方例を挙げて本発明をさらに詳
しく説明する。Next, the present invention will be explained in more detail by giving experimental examples and prescription examples.
実験例！
体重１５０〜１７ｏ９のウィスター系ラットをネンブタ
ール麻酔下背部を除毛し、７０％エタノール綿で消毒後
カミソリを用いて２５〜３０＋ｒｐの切創を１ケ所作成
した。Experimental example! The backs of Wistar rats weighing 150-17o9 were removed under Nembutal anesthesia, disinfected with 70% ethanol cotton, and one incision of 25-30+rp was made using a razor.
作成した切創はただちに１０ｚｘ間隔に３ケ所ミツヘル
縫合した。The created incisions were immediately sutured at three locations at 10zx intervals.
縫合した切創部およびその周囲に各薬剤を１日２回（９
：００．１５・００）４日間塗布した。Apply each drug to the sutured incision and its surroundings twice a day (9
:00.15.00) It was applied for 4 days.
切創作成３日目にミツヘルを除去し、切創作成４日目に
ラットの創傷部皮膚を切り取り（創面２０ｘｘ）創の開
口に要するカ（９）を測定し、創耐張力とした。On the 3rd day of making the incision, Mitsuhel was removed, and on the 4th day of making the incision, the wound skin of the rat was cut (wound surface 20xx) and the force (9) required to open the wound was measured and used as the wound tension resistance.
なお、対照として生理食塩水を塗布し、同様にして張力
を測定した。Note that as a control, physiological saline was applied and the tension was measured in the same manner.
試験結果を表１に示す。The test results are shown in Table 1.
創傷治癒促進作用ありとされるインスリン溶液塗布群は
、１回の塗布量０．０２〜２単位でほぼ同等の治癒促進
傾向がみられたか、コントロール群に対して有意差（ｐ
＜０．０５）はなかった。The insulin solution application group, which is said to have a wound healing promoting effect, showed almost the same tendency to promote healing with a single application amount of 0.02 to 2 units, or a significant difference (p
<0.05).
ＴＥＡ ＴＲＥＥ ＯＩＬ塗布群は、：］：／）ロール
群に対して創耐張力を有意に増加さけた。The TEA TREE OIL application group significantly increased the wound tension strength compared to the :]:/) roll group.
表１に示すごとく、本発明に係わるＭ油は、これを線状
切削を作成し１ニラツトに適用乙だ場合、創傷治癒促進
作用を有する物質の標準とされているイノスリノに比較
して顕著な治癒促進効果を発揮し、貯記線状切削の創面
を短期間で強固に接着し、速やかに創傷を治癒に至らし
めるなと、特異的で優れた創傷冶府作用を存する。As shown in Table 1, when the M oil according to the present invention is applied to one day after making a linear cut, it has a remarkable effect compared to Inosulino, which is considered to be the standard substance that has a wound healing promoting effect. It has a unique and excellent wound-healing effect, exhibiting a healing promoting effect, firmly adhering the wound surface of the linear cut in a short period of time, and causing the wound to heal quickly.
処方例１
常法により下記組成の皮膚外用剤（乳剤性軟膏）を調製
した。Formulation Example 1 A skin preparation for external use (emulsion ointment) having the following composition was prepared by a conventional method.
精 油 １
０ Ｗ／Ｖシバラオキ７安ｅ、香酸メチル
０．１ ＝パラオキン安息香酸プロピル
０１ 〃白色ワセリン
２５ ／／ステアリルアルコール
２０ 〃プロピレングリコール
Ｉ２ 〃ポリオキシエチレン硬化ヒマノ油６０ ４
〃モノステアリン酸グリセリン １
〃精製水 適量
全 量 Ｉ
００ ／／処方例２
常法により下記組成の皮膚外用剤（油脂性軟膏）を調製
した。essential oil 1
0 W/V Shibaraoki 7am e, methyl fragrant
0.1 = paraoquine propyl benzoate
01 White petrolatum
25 //stearyl alcohol
20 Propylene glycol
I2 〃Polyoxyethylene hydrogenated cypress oil 60 4
〃Glyceryl monostearate 1
〃Purified water (appropriate amount) I
00 // Formulation Example 2 A skin external preparation (oil-based ointment) having the following composition was prepared by a conventional method.
精 ７［Ｉ］２Ｗ／ｖ♂
ラノリン ５ “サ
ラシミッロウ ５ ″白色
ワセリン 適量全 ！
ｌ ００ ７′処
方例３
常法により下記組成の化粧料ローションを調製し１こ。Sei 7 [I] 2W/v♂ Lanolin 5 “Sarashimirou 5” White Vaseline Appropriate amount!
l 00 7' Formulation Example 3 A cosmetic lotion having the following composition was prepared by a conventional method.
精 油
０．１Ｗ／Ｉ／：グリセリン
６ ／／アルコール
３３７７ホウ砂 ０５
〃香 料
適量精製水 適量
全 量 １００
”［発明の効果］
本発明によれば、優れた創傷治癒促進効果を有する皮膚
外用組成物が提供される。essential oil
0.1W/I/: Glycerin
6 // Alcohol
3377 Borax 05
〃Fragrance
Appropriate amount of purified water Appropriate amount of total amount 100
[Effects of the Invention] According to the present invention, a skin external composition having an excellent wound healing promoting effect is provided.
Claims (4)
たはメラレウカ・リナリフォリア（Ｍ．ｌｉｎａｒｉｆ
ｏｌｉａ）の葉の精油よりなる創傷治癒促進剤。(1) Melaleuca alternifolia or M.linarif
A wound healing promoter consisting of the essential oil of the leaves of A. olia.
はメラレウカ・リナリフォリアの葉の精油を配合してな
ることを特徴とする創傷治癒促進用外用組成物。(2) An external composition for promoting wound healing, comprising a base and essential oil of Melaleuca alternifolia or Melaleuca linarifolia leaves.
、所望により、乳化剤を含有する請求項（２）記載の外
用組成物。(3) The external composition according to claim (2), wherein the base is an oil-soluble and/or water-soluble base, and optionally contains an emulsifier.
記載の外用組成物。(4) Claim (2) containing 0.5 to 20% by weight of essential oil
External composition as described.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2331862A JPH04198131A (en) | 1990-11-28 | 1990-11-28 | Wound treatment promoter and composition for external use containing the same promoter |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2331862A JPH04198131A (en) | 1990-11-28 | 1990-11-28 | Wound treatment promoter and composition for external use containing the same promoter |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH04198131A true JPH04198131A (en) | 1992-07-17 |
Family
ID=18248482
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2331862A Pending JPH04198131A (en) | 1990-11-28 | 1990-11-28 | Wound treatment promoter and composition for external use containing the same promoter |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH04198131A (en) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06247866A (en) * | 1993-02-22 | 1994-09-06 | Kazuyuki Sugawara | Agent for preventing skin damage |
| EP0613680A1 (en) * | 1993-03-03 | 1994-09-07 | Robertet S.A. | Use of derivatives of 6,6 dimethyl 2-acylcyclohex 4 en 1,3 dione in sunscreening compositions |
| FR2702146A1 (en) * | 1993-03-03 | 1994-09-09 | Robertet Sa | Use of 6,6-dimethyl-2-acylcyclohex-4-ene-1,3-diones in the cosmetic field of sun protection and compositions containing them |
| WO1995001808A1 (en) * | 1993-07-09 | 1995-01-19 | Karl Werner An Haack | Wound sealing chitosane foil and process for producing the same |
| EP1126861A2 (en) * | 1998-11-03 | 2001-08-29 | Safe 'n Sound Solutions, Inc. | Compositions comprising oleum melaleuca |
| WO2004073674A1 (en) * | 2003-02-19 | 2004-09-02 | Bonapharm Gmbh | Tea-tree oil-based preparation, methods for the production and use thereof |
| JP2005512992A (en) * | 2001-11-06 | 2005-05-12 | ペルフェッティ ヴァン メッレ ソシエタ ペル アチオニ | Anti-calculus and anti-plaque solid oral composition |
| US8128968B2 (en) * | 2007-08-29 | 2012-03-06 | Tissuetech, Inc. | Compositions and methods for treating Demodex infestations |
| US8865232B2 (en) | 2005-04-30 | 2014-10-21 | Tissuetech, Inc. | Method for treating ocular Demodex |
-
1990
- 1990-11-28 JP JP2331862A patent/JPH04198131A/en active Pending
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06247866A (en) * | 1993-02-22 | 1994-09-06 | Kazuyuki Sugawara | Agent for preventing skin damage |
| EP0613680A1 (en) * | 1993-03-03 | 1994-09-07 | Robertet S.A. | Use of derivatives of 6,6 dimethyl 2-acylcyclohex 4 en 1,3 dione in sunscreening compositions |
| FR2702146A1 (en) * | 1993-03-03 | 1994-09-09 | Robertet Sa | Use of 6,6-dimethyl-2-acylcyclohex-4-ene-1,3-diones in the cosmetic field of sun protection and compositions containing them |
| WO1995001808A1 (en) * | 1993-07-09 | 1995-01-19 | Karl Werner An Haack | Wound sealing chitosane foil and process for producing the same |
| EP1126861A2 (en) * | 1998-11-03 | 2001-08-29 | Safe 'n Sound Solutions, Inc. | Compositions comprising oleum melaleuca |
| EP1126861A4 (en) * | 1998-11-03 | 2003-05-02 | Safe N Sound Solutions Inc | Compositions comprising oleum melaleuca |
| JP2005512992A (en) * | 2001-11-06 | 2005-05-12 | ペルフェッティ ヴァン メッレ ソシエタ ペル アチオニ | Anti-calculus and anti-plaque solid oral composition |
| WO2004073674A1 (en) * | 2003-02-19 | 2004-09-02 | Bonapharm Gmbh | Tea-tree oil-based preparation, methods for the production and use thereof |
| US8865232B2 (en) | 2005-04-30 | 2014-10-21 | Tissuetech, Inc. | Method for treating ocular Demodex |
| US8128968B2 (en) * | 2007-08-29 | 2012-03-06 | Tissuetech, Inc. | Compositions and methods for treating Demodex infestations |
| US8455015B2 (en) | 2007-08-29 | 2013-06-04 | Tissuetech, Inc. | Compositions and methods for treating Demodex infestations |
| US8865233B2 (en) | 2007-08-29 | 2014-10-21 | Tissuetech, Inc. | Compositions and methods for treating Demodex infestations |
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