JPH0417860A - Dissolving therapy apparatus - Google Patents

Abstract

PURPOSE:To make a drug liquid recycle through a part to be treated through while allowing the suction of a body liquor sufficiently by arranging an opening of a pipeline for injection invivo at a tip side position from the opening of a pipeline for suction and providing a switching means to switch the pipeline for injection so as to be used as pipeline for suction and a control means to operate the switching means. CONSTITUTION:In an injection pump head 16 of an injection pump 22, a motor rotates being controlled by a control means 24, a roller 16b pivoted with a power shaft 16a of the motor rotates and a roller 16c provided at both ends of the roller 16b rotates while an injection tube 11 is pressed to inject a drug liquid 17a within the injection tube 11 being extruded to a gall bladder 4 from a liquid tank 17 through a solenoid changeover valve 25, a cock 10, a collection connector 9 and a catheter 7. Or a fluid 19a' in the injection tube 11 is sucked being extruded to a waste liquor tank 19' through the catheter 7, the collection connector 9, the cock 10 and the solenoid changeover valve 25.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to a dissolution treatment in which a drug solution that dissolves coagulates in a living body is introduced into the living body, and a fluid containing the drug solution is discharged from the living body. Concerning improvements to equipment.

[Prior Art] In recent years, agglomerates such as stones formed in the gallbladder (gallstones) in the living body have been treated with monooctenoin, octodiol, or methyl butyl ether (MTBE).
A stone dissolution treatment device for dissolving and treating the coagulum with the medicinal solution has been proposed.

The above-mentioned stone dissolution treatment device is disclosed in, for example, Japanese Patent Application Laid-open No. 63-10
This is proposed in Publication No. 541. This stone dissolution treatment device, for example, as shown in Fig. 7 (A> and Fig. 7 (B)),
The distal end of a catheter 97 consisting of an injection conduit 98 and a suction conduit 99 is positioned within the body cavity, for example, in the bile 1194, and the medicinal solution 95 is introduced into the bile 1194 through the injection conduit 98. The drug solution 95 dissolves clots, such as gallstones 96, and the fluid containing the drug solution 95 is sucked from inside the gallbladder 94 through the suction conduit 99.

[Problem M to be Solved by the Invention] However, if the opening of the injection conduit 98 is disposed at a position closer to the distal end than the openings of the nine suction conduits, as shown in FIG. 7(A), for example, When aspirating bile, which is a process before injecting the medicinal solution 95, the bile cannot be suctioned sufficiently, and the bile has a higher specific gravity than the medicinal solution 95, so the medicinal solution 95 does not come into contact with the gallstones 96. However, there is a problem in that it is not possible to provide sufficient dissolution treatment.

In addition, for example, as shown in FIG. 7(B), the suction pipe 9
9 is disposed at a position on the distal side of the opening of the injection conduit 98, when the medical solution 95 is circulated within the gallbladder 94, the medical solution 95 introduced from the injection conduit 98 is There is a problem in that the medicinal solution 95 does not come into contact with the gallstones 96 because they are immediately sucked from the suction conduit 99, making it impossible to perform proper dissolution treatment.

The present invention has been made in view of the above-mentioned points, and it is possible to sufficiently aspirate body fluids such as bile, which is a process before injecting a medical solution, and to make it possible to sufficiently aspirate body fluids such as bile, which is a process before injecting a medical solution. It is an object of the present invention to provide a dissolution treatment device that can circulate the drug solution evenly within a treatment site.

[Means for Solving the Problems] An injection conduit for injecting into the living body a medicinal solution for dissolving coagulum, and an aspiration conduit for aspirating the fluid containing the medicinal solution from the living body. In the dissolution treatment apparatus, the opening of the injection conduit in the living body is provided at a position closer to the distal end than the opening of the suction conduit, and a switching means is configured to switch the injection conduit to be used as the suction conduit. and a control means for operating the switching means.

[Function] With the above-described configuration, the injection channel is used as the suction channel at least when the device is started up.

[Example 1 Hereinafter, the present invention will be described in detail with reference to the drawings.

1 to 3 relate to the first embodiment of the present invention, FIG. 1 is an explanatory diagram showing the configuration of the dissolution treatment device, and FIGS. 2 and 3 are block diagrams showing the configuration of the control means. .

Treatment using the stone dissolution treatment device is as shown in Figure 1. This is performed on a living body 2, such as a human body, in which a coagulum, such as a stone 5, has formed in the bile a4, which is the p site. The living body 2 is positioned on a treatment table 3, and an outer cylindrical sheath 6 of the dissolution treatment device 1, which will be described later, is percutaneously implanted toward the gallbladder 4. One open end of the outer sheath 6 is located at the bulge 114 as described above, and the other open end is provided with a connector 8, which will be described later. A catheter 7, which will be described later, can be inserted into the outer sheath 6.

The dissolution treatment device 1 includes the outer cylinder sheath 6, one end of which is formed so as to be insertable into the outer cylinder sheath 6 as described above, and the other end of which is provided with a collective connector 9, which will be described later. a catheter 7 with a main duct installed therein, the connector 8, the collection connector 9 that branches the catheter 7 into an injection tube 11, a suction tube 13, and a pressure conduit 15, and the collection of the injection tube 1. A cock 10 provided near the connector 9 and the suction tube 13
A cock 12 provided near the collective connector 9 of the pressure conduit 15, and a cock J4 provided near the collective connector 9 of the pressure conduit 15. Stone-dissolving chemical solution such as methyl butyl ether (MTBE)],
The liquid WJ 17 containing 7 a and the fluid 7, which is the fluid sucked from the living body 2, and the waste liquid tank 1≦) containing the fluid 19a holding the living body 2 The injection tube 11 is connected to a waste liquid tank 19 into which a body fluid a', for example bile, is put, and the K m L 7 :I is injected into the living body 2, and the fluid 19a' is injected into the living body 2. An infusion pump 22 that suctions the living body 2 and an infusion tube 11 into the liquid tank 17.
Alternatively, an electromagnetic switching valve 25 which is a switching means for switching and connecting to the waste if tank 19', a suction bong 123 connected to the suction tube 13 and sucking the fluid 19a from the living body 2, and a pressure guide gl5 a connector 20 provided at the end of the gallbladder 4; and a pressure detection means 21 to which the connector 20 is connected, which detects the pressure within the gallbladder 4 from the pressure conduit 15 and converts it into an electrical signal (hereinafter referred to as a pressure signal). , the injection pump 22 and the suction pump 23 are activated by the pressure signal from the pressure detection means 21 and the start input means described later.
and a control means 24 for controlling the electromagnetic switching valve 25.

At the end of the catheter 7 inserted into the gallbladder 4, the opening of the suction tube 13 is located above the opening of the injection tube 11.

The infusion pump 22 is provided with an infusion pump head 16, a rotor 16b is pivotally supported by an output shaft 16a which is a drive shaft of a motor (not shown), and rollers 16c are provided at both ends of the rotor 16b. It is provided.

The suction pump 23 is provided with a suction pump head 18, in which a rotor 18b is pivotally supported by an output shaft 18a which is a drive shaft of a motor (not shown), and rollers 18c are provided at both ends of the rotor 18b. It is provided.

In the injection pump head 16 of the injection pump 22, a motor (not shown) rotates under the control of the control means 24, and a rotor 16b pivotally supported by the output shirt 1-16a of this motor rotates, and both ends of the rotor 16b rotate. As the roller 16c provided in the injection tube 1 rotates, the injection tube 1
1 to transfer the chemical solution 17a in the injection tube 11 from the liquid tank 17 to the electromagnetic switching valve 25 and the cock 1.
0. Inject the fluid 19a'' in the injection tube 11 into the gallbladder 4 through the collection tube lid 9 and the catheter 7, or inject the fluid 19a'' in the injection tube 11 into the gallbladder
1, the catheter 7.11 is designed to be sucked into the waste liquid tank 19'' through the collection connector 9, the cock 10, and the electromagnetic switching valve 25.

Further, the suction pump head 18 of the suction pump 23 is
A motor (not shown) rotates under the control of the control means 24, and a rotor 18b, which is pivotally supported by an output shaft 18a of this motor, rotates. Press the suction tube 13 to remove the fluid 19a inside the suction tube 13.
is sucked out from the gallbladder 4 through the catheter 7, the collection connector 9, and the cock 12 into the waste liquid tank 19.

Further, the pressure caused by the medical solution 17a and the like in the bile 1I4 is transmitted to the pressure detection means 21 via the catheter 7, the collection connector 9, the cock 14, the pressure conduit 15, and the connector 20.

The pressure detection means 21 converts the pressure within the gallbladder 4 transmitted as described above into an electrical signal, and outputs the electrical signal to the control means 24 as a pressure signal.

The control means 24, as shown in FIGS. 2 and 3,
A differential amplifier 30 that differentially amplifies the pressure signal from the pressure detection means 21, a gain adjustment means 31 that adjusts the amplification factor of the differential amplifier 30, and a pressure offset value of the pressure detection means 21 based on the difference. an offset adjusting means 32 set in the dynamic amplifier 30; an integrator 33 for preventing influence on subsequent stages even if the output signal of the dynamic amplifier 30 fluctuates for a predetermined short time (instantaneous); , time constant adjusting means 3 and 4 for setting a predetermined time of this integrator 33;
A reference voltage source 35 that generates a voltage that is the upper limit reference value of the detected pressure of the pressure detection means 21, and a second voltage source 35 (quasi voltage source 35).
a reference voltage source 37 that generates a voltage that is a reference value for the suction start pressure;
8, the output signal of the integrator 33 and the reference voltage source 3
Differential amplifier 3 differentially amplifies the output signal (reference voltage) of 5.
and a gain adjustment means 410 for adjusting the amplification factor of the second differential amplifier 39;
offset adjusting means 41 for determining the ifcent value of;
A limiter circuit 42 limits the output signal of the differential amplifier 39 so that it does not exceed a predetermined voltage value, and controls whether or not the output signal of the limiter circuit 42 is output to a starting/normal switching means 57 to be described later. a switch means 43; a differential amplifier 44 that differentially amplifies the signal of the reference voltage source 3537 and outputs a control signal for controlling the rotation speed of the suction pump 23; and a differential amplifier 44 that adjusts the amplification factor of the differential amplifier 44. gain adjustment means 45; a limiter circuit 46 that limits the output signal of the integrator 33 so that it does not exceed a predetermined voltage value; A hysteresis comparator 47 that compares output signals according to predetermined hysteresis characteristics and controls a switch control means 48 described later, and the above-mentioned switch means 4 that controls the operation and stop of the suction pump 23.
8, a logic circuit 49 that controls the switch means 4348 by signals from the limiter circuit 46 and the end input means 50, which will be described later, and the above-mentioned end circuit, such as a switch, which performs control to end the treatment. Input means 5
0, a pressure display means 51 that displays the detected pressure of the pressure detection means 21, an offset display means 52 that is a display means for adjusting the offset adjustment means 32, and a rotational speed of the injection pump 22 at startup. a reference voltage source 55 that outputs a control signal to control the reference voltage source 55; an output adjustment means 56 that sets the voltage value of the reference voltage source 55; and a starting input, for example a switch, that controls the start of the treatment. means 54, a starting control circuit 53 for controlling a starting/normal switching means 57, which will be described later, based on signals from the pressure detecting means 21 and the starting input means 54, and controlling the electromagnetic switching valve 25; and a start/normal switching means 57 for switching the output signal of the limiter circuit 42 or the control of the reference voltage source 55 (, ;) to the infusion pump 22 via the switch means 43. There is.

The input terminal of the differential amplifier 30 is connected to the pressure regulator 1.
It is connected to the output end of the fourth stage 21, an offset adjustment end is connected to the offset adjustment means 32, and an amplification factor adjustment end is connected to the gain adjustment means 31.

The integrator 33 has an input end connected to the output end of the differential amplifier 30, and a time constant adjustment end connected to the time constant adjustment means 34.
It is connected to the.

The output adjusting means 36 is connected to the input terminal of the reference voltage source 35.
is connected to the input terminal of the reference voltage source 37, and the output adjustment means 38 is connected to the input terminal of the reference voltage source 37.

The three differential amplifiers have a first input terminal connected to the output terminal of the integrator 33, a second input terminal connected to the output terminal of the reference voltage source 35, and an amplification factor adjustment terminal connected to the gain adjustment means. 40, and an offset adjusting end thereof is connected to the offset adjusting means 41.

The input end of the limiter circuit 42 is connected to the output ends of the three differential amplifiers.

The switch means 43 has an input terminal connected to the limiter circuit 4.
2, a control end is connected to the first output end of the logic circuit 49, and an output end is connected to the second input end of the start/normal switching means 57.

The differential amplifier 44 has a first input terminal connected to the reference voltage source 3.
5, and the second input terminal is connected to the reference voltage source 3.
7, and the output end is connected to the rotation speed control end of the suction pump 23.

The input end of the limiter circuit 46 is connected to the output end of the integrator 33.

The hysteresis comparator 47 has a first input terminal or I
i? It is connected to the output terminal of the reference voltage source 37, and its second input terminal is connected to the input terminal of the limiter circuit 46.

The switch means 48 is connected to an input end of the hysteresis comparator 47, a control end to the second output end of the four logic circuits, and an output end of the suction pump 23. Operation Connected to the stop control end.

The +iii logic circuit 19 is connected to either the first input terminal or the output terminal of the limiter [Tjl/46], and the second input terminal is connected to the termination input means 50.

1)? 1 pressure display means 51 and offset 1 display means 5
The input terminal of No. 2 is connected to the output terminal of the limiter circuit 46.

The output adjusting means 56 is connected to the input terminal of the reference voltage source 55.
is connected.

The starting control circuit 53 has a first input terminal connected to the pressure detecting means 21 and a second input terminal connected to the starting input means 54.
The first output terminal is connected to the starting/normal switching means 57.
The second output end is connected to the control end of the electromagnetic switching valve 25.
connected to the control end of the

The start/normal switching means 57 has a first input terminal connected to the output terminal of the reference voltage source 55, a second input terminal connected to the switch means 43 as described above, and a control terminal connected to the output terminal of the reference voltage source 55 as described above. It is connected to the starting control circuit 53, and its output end is connected to the rotation speed control end of the injection pump 22.

The differential amplifier 30 converts the pressure signal from the pressure detection means 21 into an error contained in the pressure signal of the pressure detection means 21 due to the positional relationship between the pressure detection means 21 and the gallbladder 4, atmospheric pressure, etc. The offset signal from the offset adjustment means 32 is used to adjust the offset of the pressure signal so as to remove the noise component, and the gain adjustment means 3 is used to remove the noise component included in the pressure signal, for example.
Differential amplification is performed using the set amplification factor. Further, this offset adjustment is performed by the offset adjusting means 32 while the operator monitors the display on the offset display means 52, for example.

The integrator 33 integrates the output signal of the differential amplifier 30 using a time constant set by the time constant adjusting means 34, thereby detecting a signal level between the eyelids that is generated due to slight movement of the living body 2, for example. fluctuations are not transmitted to subsequent stages.

The three differential amplifiers adjust the offset of zero potential deviation due to differential amplification using signals from the offset adjusting means 41, and the integrator 33 at an amplification factor set by the gain adjusting means 40. The output signal of the reference voltage source 35 and the output voltage of the reference voltage source 35 are differentially amplified. Further, the output voltage of the base voltage source 35 is controlled by the output adjusting means 36, and becomes a signal indicating the upper limit pressure.

The limiter circuit 42 limits the output signals of the three differential amplifiers so that they do not exceed a predetermined upper limit.

The switch means 43 is adapted to control whether or not the output signal of the limiter circuit 42 is outputted as a rotation speed control signal to the infusion pump 22 in accordance with the control signal of the logic circuit 49.

The differential amplifier 44 differentially amplifies the output voltage of the reference voltage source 35 and the output voltage of the reference voltage source 37 using an amplification factor set by the Kane adjustment means 45. Further, the output voltage of the reference voltage source 37 is controlled by the output adjusting means 38, and becomes a signal indicating the suction start pressure. The output signal of the differential amplifier 44 is outputted as a rotational speed control signal for the suction pump 23.

The limiter circuit 46 limits the output signal of the integrator 33 so that the signal falls within a range that does not cause malfunctions of subsequent circuits (means).

I) The 11th hysteresis comparator 47 compares the output voltage of the reference voltage source 37 and the limiter circuit 46 output 11ξ, and outputs the comparison result with a predetermined hysteresis characteristic.

ii) The switching means 48 controls whether or not the output signal of the hysteresis comparator 47 is outputted as an operation stop control signal to the suction pump 23 based on the control signals of the four logic circuits. It has become.

The four logic circuits are the output of the limiter circuit 46 (
According to No. 5, when the pressure inside the gallbladder 1 reaches the suction start pressure (target pressure), the switch means 18 or 1i
The switch means 48 is controlled so that the output 1 m of the hysteresis comparator 47 is output as an operation signal to the suction pump 23, and the pressure inside the gallbladder 4 reaches the suction stop pressure. If the threshold is reached, the switch means 48 controls the switch means 48 so as not to output the output signal of the hysteresis comparator 47 as an operation signal to the suction pump 23, and the pressure inside the gallbladder 4 becomes abnormal. If the rotation speed has increased, the switch means 43 controls the switch means 43 so as not to output the output signal of the limiter circuit 42 as a rotation speed control signal to the infusion pump 22, and the output signal is input from the end input means 50. The end signal controls the switch means 43 so that the switch means 43 does not output the output signal of the limiter circuit 42 as a rotational speed control signal to the infusion pump 22.

The termination input means 50 is, for example, a switch, and when the operator operates this switch, it outputs a termination signal for operating each part of the dissolution treatment device 1 so as to terminate this treatment (treatment). It looks like this.

The pressure display means 51 is adapted to display the pressure within the gallbladder 4 detected by the pressure detection means 21 from the output signal of the limiter circuit 46.

The offset display means 52 includes the limiter circuit 46
Based on the output signal, the pressure within the 1fflW4 detected by the pressure detection means 21 is displayed by the offset adjustment means 32 so that the operator can easily adjust the offset throat.

The starting control circuit 53 outputs, for example, a switching signal to the electromagnetic switching valve 25 and the starting/normal switching means 57 in response to the starting signal from the starting input means 54; The starting signal from the starting input means 54 causes the electromagnetic switching well 25 and the starting/normal switching means 57 to stop, for example, a switching signal.
For example, a switching signal from IYf reference voltage #55
or the control signal from the switch means 13 is switched and outputted to the injection pump 22 as a rotation speed control signal. Further, the output voltage of the reference pressure source 55 is controlled by the output adjusting means 56, and becomes a rotation speed control signal indicating the suction rotation speed of the injection pump 22.

The start input means 54 is, for example, a switch, and when the operator operates this switch, it outputs a start signal for operating each part of the dissolution treatment device 1 to start this treatment (treatment). It is supposed to be done.

The electromagnetic switching valve 25 connects the end of the injection tube 11 to the liquid tank 17 in response to a control signal from the start control circuit 53.
Alternatively, it is connected to the waste liquid tank 19'.

The operation of the dissolution treatment device configured as described above will be explained.

When a signal to start treatment (treatment) is input from the start input means 54 to the start control circuit 53, the start control circuit 53 outputs a start signal for each part of the dissolution treatment device 1 to operate. .

In response to the start signal from the start control circuit 53, the start control means 53 detects that the pressure signal from the pressure detection means 21 indicates that the pressure inside the gallbladder 4 is zero, that is, the liquid such as bile is removed from the inside of the gallbladder Q4. A control signal is output to the extraction pressure solenoid switching valve 25 and the starting/normal switching element 57 until the suction of the fluid 19a' is completed.

The electromagnetic switching valve 25 is connected to the start control means 53,
The suction tube 11 is moved to the d/d tank 1 by the control signal of
7 to lYifg[l! The waste liquid tank 19'I\ is connected, and the starting normal switching means 57 is connected to the reference voltage source 55
outputting a rotation speed control signal from to the injection pump 22;
The infusion pump 22 is configured to control the infusion tube 1 by controlling the rotation speed (i'+ii reference voltage reference voltage source 55).
, I': )'r'-te city record moon! ] The fluid 191' in the tank 1 is sucked into the waste liquid tank 19'/\\.

As described above, the start control circuit 53 controls the completion of suction of the fluid 1 in the gallbladder 1 by the pressure detection stage 21. ! If possible, the electromagnetic switching valve 25 and the starting
The control signal to the normal switching means 57 is stopped.

The electromagnetic switching valve 25 switches the suction tube 11 when the first control of the start control means 53 is stopped.
from the waste liquid tank 19' to the liquid tank 17, 1i
IR start The normal switching means 57 is the switch means 4.
3 to the infusion pump 22, and the infusion pump 22 injects the fluid into the gallbladder 4 through the infusion tube 11 in accordance with the rotation speed control signal via the switch means 43. The chemical solution 17a of No. 17 is injected.

Note that the switch means 48 may be operated simultaneously by a control signal from the start control circuit 53, so that suction by the suction pump 23 and suction by the above-mentioned injection pump 22 are performed simultaneously.

That is, by aspirating one fluid ao, which is a body fluid such as bile, using the infusion tube 11 and the infusion pump 22, for example, one fluid ao at the bottom of the gallbladder 4 can be aspirated, and the medicinal solution 17a can be aspirated. and the stone 5 which is a coagulum.
This has the effect of making it possible to bring the stones into sufficient contact with each other and promoting the dissolution of the stones 5.

4 to 6 relate to the second embodiment of the present invention, FIG. 4 is an explanatory diagram showing the configuration of the dissolution treatment device, FIG. 5 is a block diagram showing the configuration of the dissolution treatment device, and FIG. 6 is an explanatory diagram showing the configuration of the dissolution treatment device. It is an explanatory diagram regarding control of a dissolution treatment device. Note that the same reference numerals are used for the same components as those in the above-described embodiment, and the description thereof will be omitted.

The dissolution treatment device of this embodiment is the dissolution treatment device 1 of the first embodiment, and further includes an ultrasonic generator 60 that emits ultrasonic waves to the gallbladder 4, and an ultrasonic vibration that drives the ultrasonic generator 60. A child drive circuit 65, an ultrasound probe 4 for observing the condition of the gallbladder 4 using ultrasound, an ultrasound observation device 67 for driving and controlling the ultrasound probe 64, a collective connector 9 of the injection tube 10, and a cock. 10, and the electromagnetic switching valve 25 inserted between the collective connector 9 of the suction tube 13 and the cock 12.
b, and a communication pipe line 26 connecting the electromagnetic switching valves 25a and 25b.

The ultrasonic generator 60 includes an ultrasonic transducer 61 that generates ultrasonic waves, a water bag 62 for stably transmitting the ultrasonic waves generated by the ultrasonic transducer 61 to the living body 2, and the ultrasonic probe. 64 and an ultrasonic probe holder 63 for holding the probe.

A monitor 68 is installed inside the ultrasonic observation device 67.

The ultrasonic transducer drive circuit 65 has a control end connected to the control means 2.
4, and its output end is connected to the ultrasonic transducer 61.

The water bag 62 has one end surface in contact with the ultrasonic transducer 61 and the other end surface in contact with the living body 2, and is filled with an acoustic transmission medium such as water.

The ultrasonic probe 64 is attached to the ultrasonic probe holding f
4.63, and is connected to the ultrasonic observation device 67.

The ultrasonic transducer drive circuit 65 is controlled by the control means 24 to drive the ultrasonic transducer 61.

The ultrasonic wave 10-bu 64 is driven by the ultrasonic observation device 67 and emits ultrasonic waves to a substantially fan-shaped observation range 66 of the living body 2, and this ultrasonic wave is reflected by each part of the living body 2. It is designed to receive reflected signals.

The ultrasonic observation device 67 drives the ultrasonic wave 10-b01 and displays the reflected signal received by the ultrasonic probe 64 as an image on the screen of a monitor 68, for example.

The ultrasonic transducer drive circuit 65 drives the ultrasonic transducer 0.
The ultrasonic wave emitted from the ultra-11 wave transducer 61 is transmitted so as to enter the living body 2 by the ultra-11 wave transducer 62. The super RI waves that entered the living body 2 are caused by the pressure on the gallbladder 4.
The gallstones 5 are vibrated to further promote the dissolution of the gallstones 5.

Further, the situation inside the gallbladder 4 can be determined by the ultrasonic observation device 67.
The ultrasound probe 64, which is driven and controlled, images the gallbladder 1" and gallstones 5" on the monitor 68 of the ultrasound observation device 67.

The electromagnetic switching valves 25a and 25b are controlled by the control port 824 to control the injection tube 1 installed inside the catheter 7.
1 and the suction tube 13 on the side of the suction pump 23 are communicated through the communication conduit 26.

The configuration related to the control means 24 will be explained using FIG. 5.

The control ends of the electromagnetic switching valves 25a, 25b are connected to the output end of the T10 interface 84.

The pressure sensor 21 is connected via a signal amplifier 70 and a low-pass filter 72 to one input terminal of a comparator circuit 76, 78 and a pressure display circuit 73 that displays the offset-adjusted pressure at the treatment site, etc. .

A pressure signal of the pressure detected by the pressure sensor 21 is amplified in the signal amplifier 70, and is sent to one input terminal of the comparator circuit 76, 78 via the low-pass filter 72;
The pressure is input to the pressure display circuit 73.

The comparator circuit 76 has one input terminal connected to the low-pass filter 72 as described above, the other input terminal connected to the reference voltage source 75, and the output terminal I'rl [I, .
10 interface 84.

The comparison circuit 78 has one input terminal connected to the low-pass filter 72 as described above, the other input terminal connected to the reference voltage source 77, and the output terminal connected to the input terminal of the T10 interface 84. ing.

The T,10 interface 84 is connected to the input control device 90 via a pass line 85.

1rI comparison circuit 76 compares the amplified pressure signal as described above with the reference voltage of the reference voltage source 75, and sends a signal resulting from this comparison via the T10 interface 8.1 and the pass line 85. It is configured to output to the input control device 90.

The comparison circuit 78 compares the amplified pressure signal as described above with the reference voltage of the reference voltage source 77, and sends the comparison result signal to the input terminal via the T10 interface 84 and the pass line 85. It is configured to output to the control device 90.

Further, the pressure signal amplified as described above is input to the pressure display circuit 73. Therefore,
The pressure display circuit 73 is configured to display a pressure value that takes into account the attenuation characteristics of the low-pass filter 72.

The input ends of the infusion pump 22 and the suction pump 23 are each connected to the output end of the operation R adjustment circuit 879.81, and the input end of the operation adjustment circuit 7981 is connected to the output end of the r/○ interface 84. It is connected.

Further, rotation speed display times #I80 and #I82 are connected to the operation adjustment circuits 79 and 81, respectively.

The output terminal of the oscillator 88 is connected to the input terminal of the output adjustment circuit 83.

As described above, the output adjustment circuit 83 has an input terminal connected to the oscillator 88, a control terminal connected to the output terminal of the T10 interface 84, and an output terminal connected to the input terminal of the power amplifier 87. There is.

The output end of the FF main power amplifier 87 is connected to the ultrasonic applicator 86 .

Before, the ultrasonic allocator 86 and the power amplifier 8
7 is, for example, the ultrasonic generator 60. The ultrasonic vibration γ
61, the above-mentioned overback 62 and the ultrasonic transducer drive circuit 65.

The signal from the oscillator 88 is sent to the output adjustment circuit 83, to the output control circuit 83, to the I/O interface 8.1 and to the hash line 85.
Input f'r'. '90 control signal, for example, the frequency, amplitude, number of pulses, pulse interval, and drive time are adjusted, and then amplified in the power amplifier 87,
The ultrasonic transducer 61 is driven by the ultrasonic transducer 61.

Ff 1. -'O interface 84 has an input end connected to the output end of the comparison circuit 76, 78 as described above, and an output end connected to the electromagnetic switching valve 25a, 25 as described above.
b. It is connected to the input terminals of the operation adjustment circuit 8183 and the output adjustment circuit 83, and an input/output terminal using a parallel signal, for example, is connected to the input/control device 90 via the pass line 85.
It is connected to the.

The signal amplifier 70, the low-pass filter 72, the pressure display circuit 73, the reference voltage source 7577, the comparison circuit 76.78, the operation adjustment circuit 79, 81, iif
The rotation speed display circuit 802 and the output adjustment circuit 83
etc., the eight control units are configured.

The input/control device 90 connects to the control unit 8 via the Hassline 85 and I10 interface 84.
In addition to inputting from and controlling each part of 9, the electromagnetic switching valves 25a and 25b are also controlled.

The sixth section describes the operation of the dissolution treatment device constructed in this way.
This will be explained using figures.

FIG. 6(A) shows the hair of the drug solution 1-7a in the bile Q4, FIG. 6(B) shows the operation of the infusion pump 22, and FIG. 6(C) shows the operation of the suction pump 23. 6(I) shows the driving of the ultrasonic applicator 86,
FIG. 6(E) shows the driving of the electromagnetic switching valves 2Eia and 25b.

A period S1 shown in FIG. 6 is the time when the treatment using the ultrasound generator 1 is started, and the heavy pressure suction pump 23 is operated and the electromagnetic switching valves 25a and 25b are driven.

As a result, the injection tip installed inside the catheter 7! , the suction tube 13 on the side of the suction pump 23, the electromagnetic switching valve 25a, and the communication pipe 26.
The catheter 7
Liquid such as body fluid, for example bile, is sucked into the waste liquid tank 19 by the suction pump 23 from the side injection tube 11 from the I1.04.

When the pressure sensor 21 detects that the pressure within the gallbladder 4 has become zero, and that the suction of the liquid has ended, the process shifts to period S2, and the electromagnetic switching valves 25a, 2
5b is restored, and the injection tube 11 on the catheter 7 side
and the infusion tube 11 on the infusion pump 22 side, and the suction tube 13 on the catheter 7 side and the suction tube 13 on the suction pump 23 side are connected, and further,
The infusion pump 22 operates to inject the medical solution 17 into the gallbladder 4.
a is injected.

When the pressure sensor 21 detects that the pressure inside the gallbladder 4 has reached a predetermined pressure and that the injection of the drug solutions 1 and 7a has been completed, the process shifts to period S3, and the operation of the infusion pump 22 is started. At the same time as stopping, the ultrasonic applicator 86 is also driven.

Further, when the predetermined period S3 ends, a period S4 begins, in which the driving of the ultrasonic applicator 86 is stopped and the suction pump 23 is also operated, and the fluid 19a containing the medicinal solution is pumped from the bile duct 4 to the suction pump. Waste liquid tank 19 by 23
is attracted to.

When the pressure sensor 21 detects that the pressure within the gallbladder 4 has become zero, for example, and that suction of the fluid 19a has ended, the process from the period S2 is repeated until the treatment is completed.

In addition, after the above-mentioned period S4, l/JL from the period S1! : Even if repeated, the above S
4, it is better to repeat the process from the period S1 at an appropriate interval, such as once every two times. In this case, treatment (
During treatment), body fluids such as decoction accumulated in the gallbladder 4 can be aspirated.

In addition, the ultrasonic generator 60 and the ultrasonic transducer drive circuit 05
and the ultrasonic observation device 67 may be used separately.

That is, in this embodiment, only one waste liquid tank is required, and treatment (animal ii
'+: ) It has the effect of making it easier to clean ropes such as 17IL fTII.

Other configurations, operations, and effects are the same as those of the embodiments described above.

Incidentally, the injection and suction may be performed at the same time, and the medicinal solution 17.1 may be refluxed within the gallbladder 4. Furthermore, at appropriate intervals during this reflux period, the injection tube 11 is
Alternatively, suction may be performed from. In this case, treatment (
During the procedure), body fluids such as bile accumulated in the bile 114 can be aspirated.

Further, the control means may be a control means using a microprocessor or the like, a control means using a logic circuit, or a combination of the two, and one or both of them may be combined with an analog control means such as a differential amplifier. A combination may also be used.

Furthermore, the control means may be a control means using fuzzy inference.

[Effects of the Invention] As explained above, according to the present invention, body fluids etc. accumulated at the bottom of the treatment area can be reliably sucked, and the medicinal solution comes into sufficient contact with the clot, resulting in efficient treatment. It has the effect of being able to

[Brief explanation of the drawing]

1 to 3 relate to the first embodiment of the present invention, in which FIG. 1 is an explanatory diagram showing the configuration of the dissolution treatment device, FIGS. 2 and 3 are block diagrams showing the configuration of the control means, and FIG. 4 to 6 relate to the second embodiment of the present invention, FIG. 4 is an explanatory diagram showing the configuration of the dissolution treatment device, FIG. 5 is a block diagram showing the configuration of the dissolution treatment device, and FIG. 6 is the dissolution treatment device. FIG. 7 is an explanatory diagram regarding the control of the treatment device, and is an explanatory diagram showing the state of the drug solution within the treatment site according to the conventional technique. 24. Control means 25. Solenoid switching valve injection pump rotation calibration Figure 7 (A)

Claims (1)

[Scope of Claims] A dissolution device comprising an injection conduit for injecting into the living body a medicinal solution for dissolving a coagulated substance in the living body, and a suction conduit for aspirating a fluid containing the medicinal solution from the living body. In the treatment device, the opening of the injection conduit in the living body is provided at a position closer to the distal end than the opening of the suction conduit, and a switching means for switching the injection conduit to be used as the suction conduit; A dissolution treatment device comprising: control means for operating the switching means at least when the device is started.