JPH04134036A - Finger disinfectant - Google Patents

Abstract

PURPOSE:To provide a quick-drying rubbing type finger disinfectant capable of simply and surely disinfecting fingers at any place by compounding an iodine compound, an alcohol and a hand roughness-preventing agent in a specific ratio. CONSTITUTION:A finger disinfectant contains an iodine compound such as iodine, potassium iodide or povidone iodide in an amount of 0.01-0.2wt.% as active iodine, <=50wt.% of an alcohol (e.g. 70% ethanol or 50% isopropanol), and <1wt.% of a hand roughness-preventing agent such as glycerol, urea, cholesterol or hyaluronic acid. The application of the disinfectant to the palm in an amount of 3ml and subsequent rubbing until dried permit to surely disinfect the hand.

Description

Detailed Description of the Invention (Field of Industrial Application) The present invention is a quick-drying hand rub containing broad-spectrum iodine that can be easily and reliably disinfected by medical personnel at medical institutions and other locations. Regarding hand sanitizer.

(Prior Art and Problems to be Solved by the Invention) Hand disinfection using a sterilizing disinfectant is usually carried out by the basin method, which uses a washbasin and a towel, and the scrub method, which uses a towel washed with water to remove the disinfectant after rubbing by hand. The brushing method uses a brush instead of rubbing by hand, and both methods use a towel or hot air for drying. Although these are relatively simple,
Contamination of the disinfectant itself, problems with the effectiveness of simply soaking hands in diluted disinfectant, and the risk of cross-infection and hospital-acquired infections depending on the disease because towels are shared, frequent replacement of disinfectant, and use of paper towels. Although this was desirable, there were also economic problems.

Wiping with alcohol and cotton has been commonly practiced since ancient times. However, soaking in alcohol cannot actually sterilize it in a short period of time.

Therefore, we added a low concentration of a sterilizing disinfectant to disinfectant ethanol, etc., put about 3 m of the solution on the palms of our hands, and rubbed them together to generate heat due to friction. A quick-drying hand rub disinfection method was devised that penetrates deep into the skin, almost completely killing bacteria, and at the same time evaporates the chemical solution and dries hands and fingers.

This disinfection method avoids contamination of the disinfectant itself, which is one of the problems with the conventional basin method, by always using up a new disinfectant once, and by not using towels.
It is attracting attention as a simple method that eliminates the possibility of cross-infection and allows you to easily disinfect your hands anytime, anywhere.

However, the only chemicals that could be used in this method were those that were colorless and did not leave a sticky feeling on the hands and fingers.

They are benzalkonium chloride, benzethonium chloride,
It is a bactericidal disinfectant such as chlorhexidine gluconate and alkyldiaminoethylglycine hydrochloride, and is sold as a commercial product or used as an in-hospital preparation. However, these sterilizing disinfectants are ineffective against some bacteria, fungi, tuberculosis bacteria, viruses, etc., and the sterilizing disinfectants themselves are irritating to the skin, causing problems such as rough hands due to long-term use.

Iodine preparations, such as povidone-iodine, have a sticky feel and a residual color when rubbed into the hands, and were considered unsuitable as quick-drying hand sanitizers. Furthermore, when povidone-iodine is dissolved in relatively low-concentration alcohol, it is difficult to maintain stability for two years, which is sufficient for practical use as a pharmaceutical, and there are also formulation problems.

(Means for Solving the Problems) The present inventors have conducted extensive studies on how to use an iodine preparation with strong bactericidal activity as a quick-drying hand rub. As a result, the effective iodine was 0. Iodine preparation containing 1 to 0.2% O and 50% or more of rubbing alcohol and 1% by weight
It has been found that a pharmaceutical composition containing the following agent for preventing rough hands is suitable for this purpose.

The iodine preparation and the agent for preventing rough hands are insoluble in water or alcohols, and may be simply dispersed, but preferably they are water-soluble and alcohol-soluble.

Iodine preparations include iodine (I2), potassium iodide (Kl), potassium iodate (KIO), potassium periodate (KIO3), and povidone-iodine (PVP-I).
, poloxamer iodine, etc. are used alone or as a mixture.

As the disinfecting alcohol, 70% ethanol, 50% isopropanol, etc., or denatured alcohols thereof are used alone or as a mixture.

=3 -4= As the agent for preventing rough hands, glycerin, urea, cholesterol, allantoin, coconut oil fatty acid polyoxyethylene glyceryl, diisobutyl adipate, and hyaluronic acid are used singly or as a mixture.

Povidone-iodine is particularly suitable as an iodine preparation for the present invention. It is known that the bactericidal power of povidone-iodine is deeply related to 1□ (free iodine), but the concentration of 1□ when ice crystals are dissolved in disinfectant ethanol is 1□ as povidone-iodine.
% (available iodine 0.1%) concentration is maximum, so
From the viewpoint of bactericidal activity, a concentration around this range is considered preferable.

However, when comprehensively judging the roughness of hands, stickiness, residual color, stability of the preparation, and bactericidal power, povidone-iodine
A range of 2% (0.01 to 0.2% as effective iodine) is preferred.

The pharmaceutical composition according to the present invention is effective in the following uses as a quick-drying hand disinfectant.

1. For regular hand disinfection for medical workers, apply approximately 3 mQ of disinfectant once in the palm of your hand and rub until dry. However, if organic matter such as serum or pus is attached, thoroughly wash it off and then disinfect according to the standard rules.

2. When disinfecting the hands of the operator before and after surgery: Wash the hands and forearms thoroughly with soap, thoroughly wash off the soap with water, then apply approximately 3m12 of the disinfectant on the palm of your hand, rub it until dry, and then Repeat disinfection according to this basic rule twice.

Subject 11 was tested to see the bactericidal effect in vitro.
Regarding the name, the main rules (5% by weight of povidone-iodine, 70% by weight of ethanol, 0.025% by weight of cholesterol) 3
After taking mff into the palm of the hand and rubbing it into the fingers until dry, the number of viable bacteria remaining on the palm was measured. Rub disinfection is 1
Two types of tests were performed: twice and three times in a row. As a result, the average sterilization rate was 92.3% when used once, but it was 98.5% when used three times in a row, and the strong sterilization effect was observed in each case. From this result, it is considered that one use is sufficient for hand disinfection in normal hospital wards, etc., but three consecutive uses may be considered in cases where special cleanliness is required, such as in operating rooms and sterile rooms.

In addition, for the purpose of examining skin irritation, the powder was applied 5 times a day to the healthy skin of six female rabbits whose hair had been removed using electric clippers.
As a control drug, a commercially available 0.2% benzalkonium chloride ethanol solution preparation was applied in the same manner, and its irritation properties were compared and examined. As a result, the irritation of the powder was extremely weak compared to the control drug;
Some rabbits developed erythema after the 9th day, and edema was observed in 1 to 2 cases after the 9th day, but it was soft in all cases.

With the control drug, erythema appeared in all cases from the 1st day, edema appeared in all cases from the 5th day onwards from the 2nd day, deer skin formation appeared in some rabbits from the 9th day, and after the 144th day. Deer skin was formed in all cases. From the above results, it was considered that the stimulation was extremely weak for continuous long-term use.

(Effects of the Invention) The present invention is characterized by a simple and practical iodine compound-based pharmaceutical composition for hand disinfection.

Claims (1)

[Claims] (1)a) 0.01 to 0.01 as effective iodine of iodine compound
0.2% by weight, b) 50% by weight or more as alcohol, and c) less than 1% by weight as an agent for preventing rough hands, which is compatible with a), b) and c), and is chemically and pharmaceutically compliant. Stable pharmaceutical composition for hand disinfection.