JPH04134036A - Finger disinfectant - Google Patents
Finger disinfectantInfo
- Publication number
- JPH04134036A JPH04134036A JP2250232A JP25023290A JPH04134036A JP H04134036 A JPH04134036 A JP H04134036A JP 2250232 A JP2250232 A JP 2250232A JP 25023290 A JP25023290 A JP 25023290A JP H04134036 A JPH04134036 A JP H04134036A
- Authority
- JP
- Japan
- Prior art keywords
- iodine
- disinfectant
- hand
- alcohol
- hands
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000645 desinfectant Substances 0.000 title abstract description 20
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 18
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 6
- 150000002497 iodine compounds Chemical class 0.000 claims abstract description 4
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims description 13
- 229910052740 iodine Inorganic materials 0.000 claims description 13
- 239000011630 iodine Substances 0.000 claims description 13
- 238000004659 sterilization and disinfection Methods 0.000 claims description 11
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- 238000001035 drying Methods 0.000 abstract description 7
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract description 6
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 abstract description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract description 5
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract description 5
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract description 4
- 235000012000 cholesterol Nutrition 0.000 abstract description 3
- 230000000249 desinfective effect Effects 0.000 abstract description 3
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 abstract description 2
- 239000004202 carbamide Substances 0.000 abstract description 2
- 229920002674 hyaluronan Polymers 0.000 abstract description 2
- 229960003160 hyaluronic acid Drugs 0.000 abstract description 2
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 abstract 2
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 abstract 1
- 238000013329 compounding Methods 0.000 abstract 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 abstract 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 abstract 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract 1
- 229940069328 povidone Drugs 0.000 abstract 1
- 238000000034 method Methods 0.000 description 9
- 238000002360 preparation method Methods 0.000 description 9
- CPKVUHPKYQGHMW-UHFFFAOYSA-N 1-ethenylpyrrolidin-2-one;molecular iodine Chemical compound II.C=CN1CCCC1=O CPKVUHPKYQGHMW-UHFFFAOYSA-N 0.000 description 7
- 229920000153 Povidone-iodine Polymers 0.000 description 7
- 229960001621 povidone-iodine Drugs 0.000 description 7
- 230000000844 anti-bacterial effect Effects 0.000 description 6
- 230000001954 sterilising effect Effects 0.000 description 6
- 241000894006 Bacteria Species 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 206010029803 Nosocomial infection Diseases 0.000 description 3
- 241000283973 Oryctolagus cuniculus Species 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 241000282994 Cervidae Species 0.000 description 2
- 206010011409 Cross infection Diseases 0.000 description 2
- 206010015150 Erythema Diseases 0.000 description 2
- 206010030113 Oedema Diseases 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 2
- 229960000686 benzalkonium chloride Drugs 0.000 description 2
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 2
- 238000011109 contamination Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 231100000321 erythema Toxicity 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000002791 soaking Methods 0.000 description 2
- 239000000344 soap Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- MLIWQXBKMZNZNF-KUHOPJCQSA-N (2e)-2,6-bis[(4-azidophenyl)methylidene]-4-methylcyclohexan-1-one Chemical compound O=C1\C(=C\C=2C=CC(=CC=2)N=[N+]=[N-])CC(C)CC1=CC1=CC=C(N=[N+]=[N-])C=C1 MLIWQXBKMZNZNF-KUHOPJCQSA-N 0.000 description 1
- FAAHNQAYWKTLFD-UHFFFAOYSA-N 1-butan-2-ylpyrrolidin-2-one Chemical compound CCC(C)N1CCCC1=O FAAHNQAYWKTLFD-UHFFFAOYSA-N 0.000 description 1
- UYKWDAPDQOLFRV-UHFFFAOYSA-N 2-methyloxirane;molecular iodine;oxirane Chemical compound II.C1CO1.CC1CO1 UYKWDAPDQOLFRV-UHFFFAOYSA-N 0.000 description 1
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 1
- 241000233788 Arecaceae Species 0.000 description 1
- 208000019300 CLIPPERS Diseases 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- RDOFJDLLWVCMRU-UHFFFAOYSA-N Diisobutyl adipate Chemical compound CC(C)COC(=O)CCCCC(=O)OCC(C)C RDOFJDLLWVCMRU-UHFFFAOYSA-N 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 229960000458 allantoin Drugs 0.000 description 1
- 229960001950 benzethonium chloride Drugs 0.000 description 1
- UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000001680 brushing effect Effects 0.000 description 1
- 235000013877 carbamide Nutrition 0.000 description 1
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 description 1
- 229960003333 chlorhexidine gluconate Drugs 0.000 description 1
- 208000021930 chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids Diseases 0.000 description 1
- 230000003749 cleanliness Effects 0.000 description 1
- 235000019864 coconut oil Nutrition 0.000 description 1
- 239000003240 coconut oil Substances 0.000 description 1
- 239000013065 commercial product Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 229940031769 diisobutyl adipate Drugs 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 210000000245 forearm Anatomy 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 description 1
- 230000036074 healthy skin Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 239000005416 organic matter Substances 0.000 description 1
- -1 polyoxyethylene Polymers 0.000 description 1
- JLKDVMWYMMLWTI-UHFFFAOYSA-M potassium iodate Chemical compound [K+].[O-]I(=O)=O JLKDVMWYMMLWTI-UHFFFAOYSA-M 0.000 description 1
- 239000001230 potassium iodate Substances 0.000 description 1
- 229940093930 potassium iodate Drugs 0.000 description 1
- 235000006666 potassium iodate Nutrition 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
Landscapes
- Apparatus For Disinfection Or Sterilisation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
【発明の詳細な説明】
(産業上の利用分野)
本発明は医療機関等の医療従事者等が、簡便に場所を選
ばず確実に手指の消毒ができるブロードスペクトルなヨ
ウ素を含有する速乾性擦弐手指消毒剤に関する。Detailed Description of the Invention (Field of Industrial Application) The present invention is a quick-drying hand rub containing broad-spectrum iodine that can be easily and reliably disinfected by medical personnel at medical institutions and other locations. Regarding hand sanitizer.
(従来の技術及び発明が解決しようとする課題)通常殺
菌消毒剤による手指消毒は、洗面器とタオルを使うベー
スン法、手でこすりその後消毒剤を除去するため、水洗
しタオルを使うスクラブ法、手でこする代わりにブラシ
でこするブラッシング法といずれも乾燥にはタオル又は
熱風を使用していた。これらは比較的簡便ではあるが、
消毒剤自体の汚染、手を希釈消毒剤に浸すだけという効
果の問題、またタオルを共同で使用するため疾患によっ
ては交叉感染、院内感染の危険もあり、消毒液の頻繁な
交換、ペーパータオルの使用が望まれるが経済的な問題
もあった。(Prior Art and Problems to be Solved by the Invention) Hand disinfection using a sterilizing disinfectant is usually carried out by the basin method, which uses a washbasin and a towel, and the scrub method, which uses a towel washed with water to remove the disinfectant after rubbing by hand. The brushing method uses a brush instead of rubbing by hand, and both methods use a towel or hot air for drying. Although these are relatively simple,
Contamination of the disinfectant itself, problems with the effectiveness of simply soaking hands in diluted disinfectant, and the risk of cross-infection and hospital-acquired infections depending on the disease because towels are shared, frequent replacement of disinfectant, and use of paper towels. Although this was desirable, there were also economic problems.
古くからアルコールの綿による清拭は、一般的に行われ
ていた。しかしアルコールに浸すという方法では実際に
は、短時間では殺菌できない。Wiping with alcohol and cotton has been commonly practiced since ancient times. However, soaking in alcohol cannot actually sterilize it in a short period of time.
そこで、消毒用エタノール等に殺菌消毒剤を低濃度添加
し、その薬液約3m(2を手掌に取り、強くこすり合わ
せることにより摩擦により熱を出し、アルコール及び殺
菌消毒剤が、手指の角質の中にまで浸透し、細菌をほぼ
完全に死滅させ、同時に薬液を蒸発させ、手指を乾燥さ
せるという速乾性擦式消毒法が考案された。Therefore, we added a low concentration of a sterilizing disinfectant to disinfectant ethanol, etc., put about 3 m of the solution on the palms of our hands, and rubbed them together to generate heat due to friction. A quick-drying hand rub disinfection method was devised that penetrates deep into the skin, almost completely killing bacteria, and at the same time evaporates the chemical solution and dries hands and fingers.
この消毒法は、常に新しい消毒液を1回ずつ使い切るこ
とにより、従来のベースン法の問題点の1つである殺菌
消毒液自体の汚染や、タオルを使用しないことにより、
交叉感染の可能性もなく、しかも簡便で、いつでもどこ
でも手軽に手指の消毒が可能な方法として注目を集めて
いる。This disinfection method avoids contamination of the disinfectant itself, which is one of the problems with the conventional basin method, by always using up a new disinfectant once, and by not using towels.
It is attracting attention as a simple method that eliminates the possibility of cross-infection and allows you to easily disinfect your hands anytime, anywhere.
しかしこの方法に使用できる薬剤は無色でしかも手指に
べたつき感の残らないものだけであった。However, the only chemicals that could be used in this method were those that were colorless and did not leave a sticky feeling on the hands and fingers.
それらは塩化ベンザルコニウム、塩化ベンゼトニウム、
グルコン酸クロルヘキシジン、塩酸アルキルジアミノエ
チルグリシン等の殺菌消毒剤で、商品として販売又は院
内製剤として実用に供されている。しかしこれらの殺菌
消毒剤は、一部の細菌や真菌、結核菌、ウィルス等に無
効なことや、殺菌消毒剤自体の皮膚刺激性により長期連
用による手荒れ等が問題となっている。They are benzalkonium chloride, benzethonium chloride,
It is a bactericidal disinfectant such as chlorhexidine gluconate and alkyldiaminoethylglycine hydrochloride, and is sold as a commercial product or used as an in-hospital preparation. However, these sterilizing disinfectants are ineffective against some bacteria, fungi, tuberculosis bacteria, viruses, etc., and the sterilizing disinfectants themselves are irritating to the skin, causing problems such as rough hands due to long-term use.
ポビドンヨードに代表されるヨウ素製剤は、手指にすり
込んだ場合のべたつき感並びに残色感があり、速乾性す
り込み式手指消毒剤には不向と考えられていた。またポ
ビドンヨードを比較的低濃度アルコール類に溶解した場
合、医薬品として実用に耐えうる2年間の安定性を保ち
難く、製剤的な問題もあった。Iodine preparations, such as povidone-iodine, have a sticky feel and a residual color when rubbed into the hands, and were considered unsuitable as quick-drying hand sanitizers. Furthermore, when povidone-iodine is dissolved in relatively low-concentration alcohol, it is difficult to maintain stability for two years, which is sufficient for practical use as a pharmaceutical, and there are also formulation problems.
(課題を解決するための手段)
本発明者らは、殺菌力の強いヨウ素製剤をいかに速乾性
擦弐手指消毒剤とするかについて、鋭意検討した。その
結果、有効ヨウ素として0.O1〜0.2%含むヨウ素
製剤と消毒用アルコール50重量%以上並びに1重量%
以下の手荒れ防止剤を含む医薬品組成物がその目的に適
合することをみつけた。(Means for Solving the Problems) The present inventors have conducted extensive studies on how to use an iodine preparation with strong bactericidal activity as a quick-drying hand rub. As a result, the effective iodine was 0. Iodine preparation containing 1 to 0.2% O and 50% or more of rubbing alcohol and 1% by weight
It has been found that a pharmaceutical composition containing the following agent for preventing rough hands is suitable for this purpose.
ヨウ素製剤及び手荒れ防止剤は水又はアルコール類に不
溶であって、単に分散するだけでもよいが、好ましくは
水溶性であり、かつアルコール可溶であることが望まし
い。The iodine preparation and the agent for preventing rough hands are insoluble in water or alcohols, and may be simply dispersed, but preferably they are water-soluble and alcohol-soluble.
ヨウ素製剤としては、ヨウ素(I2)、ヨウ化カリウム
(Kl)、ヨウ素酸カリウム(KIO)、過ヨウ素酸カ
リウム(KIO3)、ポビドンヨード(PVP−I )
、ポロキサマーヨウ素等が単独又は混合物として使用さ
れる。Iodine preparations include iodine (I2), potassium iodide (Kl), potassium iodate (KIO), potassium periodate (KIO3), and povidone-iodine (PVP-I).
, poloxamer iodine, etc. are used alone or as a mixture.
消毒用アルコールとしては70%エタノール、50%イ
ソプロパツール等又はそれらの変性アルコールが、単独
又は混合物として使用される。As the disinfecting alcohol, 70% ethanol, 50% isopropanol, etc., or denatured alcohols thereof are used alone or as a mixture.
=3
一4=
手荒れ防止剤としてはグリセリン、尿素、コレステロー
ル、アラントイン、ヤシ油脂肪酸ポリオキシエチレング
リセリル、アジピン酸ジイソブチル、ヒアルロン酸が単
独又は混合物として使用される。=3 -4= As the agent for preventing rough hands, glycerin, urea, cholesterol, allantoin, coconut oil fatty acid polyoxyethylene glyceryl, diisobutyl adipate, and hyaluronic acid are used singly or as a mixture.
ヨウ素製剤としてポビドンヨードは特に本発明に適する
。ポビドンヨードの殺菌力は1□(遊離ヨウ素)に深く
関与することが知られているが、氷晶を消毒用エタノー
ルに溶解したときの1□濃度はポビドンヨードとして1
%(有効ヨウ素0.1%)濃度で最大となることから、
殺菌力の面からこの付近の濃度が好ましいと考えられる
。Povidone-iodine is particularly suitable as an iodine preparation for the present invention. It is known that the bactericidal power of povidone-iodine is deeply related to 1□ (free iodine), but the concentration of 1□ when ice crystals are dissolved in disinfectant ethanol is 1□ as povidone-iodine.
% (available iodine 0.1%) concentration is maximum, so
From the viewpoint of bactericidal activity, a concentration around this range is considered preferable.
しかし、手荒れ、べたつき感、残色感、製剤の安定性と
殺菌力を総合的に判断すると、ポビドンヨード0.1〜
2%(有効ヨウ素として0.O1〜0.2%)の範囲が
好ましい。However, when comprehensively judging the roughness of hands, stickiness, residual color, stability of the preparation, and bactericidal power, povidone-iodine
A range of 2% (0.01 to 0.2% as effective iodine) is preferred.
本発明に係る医薬組成物は、速乾性すり込み式手指消毒
剤として以下のような使用で有効である。The pharmaceutical composition according to the present invention is effective in the following uses as a quick-drying hand disinfectant.
1、医療従事者の通常の手指消毒の場合本則約3mQを
1回手掌にとり、乾燥するまで摩擦する。ただし、血清
、膿汁等の有機物が付着している場合は、十分に洗い落
とした後、本則による消毒を行う。1. For regular hand disinfection for medical workers, apply approximately 3 mQ of disinfectant once in the palm of your hand and rub until dry. However, if organic matter such as serum or pus is attached, thoroughly wash it off and then disinfect according to the standard rules.
2、術前・術後の術者の手指消毒の場合手指及び前腕部
を石けんでよく洗浄し、水で石けん分を十分洗い落とし
た後、本則約3m12を手掌にとり、乾燥するまで摩擦
し、更にこの本則による消毒を2回繰り返す。2. When disinfecting the hands of the operator before and after surgery: Wash the hands and forearms thoroughly with soap, thoroughly wash off the soap with water, then apply approximately 3m12 of the disinfectant on the palm of your hand, rub it until dry, and then Repeat disinfection according to this basic rule twice.
ス凰習
in vitroでの殺菌効果をみる目的で被験者11
名について、本則(ポビドンヨード帆5重量%、エタノ
ール70重量%、コレステロール0.025重量%)3
mffを手掌に取り、乾燥するまで手指にすり込んだ後
、手掌に残存する生菌数を測定した。すり込み消毒は1
回及び連続3回の2種類行った。その結果、1回使用し
た場合の平均滅菌率は92.3%であったが、連続3回
では98.5%であり、いずれの場合にも本則の強い殺
菌作用が認められた。本結果より、通常病棟等の手指消
毒においては1回の使用で十分と考えられるが、手術室
、無菌室等の特に清浄を求められる場合には連続3回使
用が考えられる。Subject 11 was tested to see the bactericidal effect in vitro.
Regarding the name, the main rules (5% by weight of povidone-iodine, 70% by weight of ethanol, 0.025% by weight of cholesterol) 3
After taking mff into the palm of the hand and rubbing it into the fingers until dry, the number of viable bacteria remaining on the palm was measured. Rub disinfection is 1
Two types of tests were performed: twice and three times in a row. As a result, the average sterilization rate was 92.3% when used once, but it was 98.5% when used three times in a row, and the strong sterilization effect was observed in each case. From this result, it is considered that one use is sufficient for hand disinfection in normal hospital wards, etc., but three consecutive uses may be considered in cases where special cleanliness is required, such as in operating rooms and sterile rooms.
また、皮膚刺激性をみる目的で雌ウサギ6羽の背部皮膚
を電気バリカンにより除毛した健常皮膚に末剤を1日5
回7日間塗布し、対照薬として、市販の0.2%塩化ベ
ンザルコニウムエタノール溶液製剤を同様の方法で塗布
し、その刺激性を比較検討した。その結果、末剤の刺激
性は対照薬に比べきわめて弱く、末剤では塗布開始後2
日目以降に紅斑の発現するウサギが現われ、9日日以降
1〜2例浮腫もみられたが、いずれも軟度であった。In addition, for the purpose of examining skin irritation, the powder was applied 5 times a day to the healthy skin of six female rabbits whose hair had been removed using electric clippers.
As a control drug, a commercially available 0.2% benzalkonium chloride ethanol solution preparation was applied in the same manner, and its irritation properties were compared and examined. As a result, the irritation of the powder was extremely weak compared to the control drug;
Some rabbits developed erythema after the 9th day, and edema was observed in 1 to 2 cases after the 9th day, but it was soft in all cases.
対照薬では1日目から全例に紅斑が現われ、2日目から
8書I1%5日目からは全例に浮腫、9日目からは鹿皮
を形成するウサギも現われ、144日目以降は全例で鹿
皮が形成された。以上の結果より、連続長期使用に対し
て、刺激はきわめて弱いものと考えられた。With the control drug, erythema appeared in all cases from the 1st day, edema appeared in all cases from the 5th day onwards from the 2nd day, deer skin formation appeared in some rabbits from the 9th day, and after the 144th day. Deer skin was formed in all cases. From the above results, it was considered that the stimulation was extremely weak for continuous long-term use.
(発明の効果)
本発明は、簡便で実用的なヨウ素化合物系手指消毒用医
薬品組成物を特徴する(Effects of the Invention) The present invention is characterized by a simple and practical iodine compound-based pharmaceutical composition for hand disinfection.
Claims (1)
0.2重量%、 b)アルコール類として50重量%以上、 c)手荒れ防止剤として1重量%未満を含有する製剤で
、 a)、b)及びc)と適合し、化学的及び製剤的に安定
な手指消毒用医薬品組成物。(1)a) 0.01 to 0.01 as effective iodine of iodine compound
0.2% by weight, b) 50% by weight or more as alcohol, and c) less than 1% by weight as an agent for preventing rough hands, which is compatible with a), b) and c), and is chemically and pharmaceutically compliant. Stable pharmaceutical composition for hand disinfection.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2250232A JP2661783B2 (en) | 1990-09-21 | 1990-09-21 | Pharmaceutical composition for hand rubbing |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2250232A JP2661783B2 (en) | 1990-09-21 | 1990-09-21 | Pharmaceutical composition for hand rubbing |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH04134036A true JPH04134036A (en) | 1992-05-07 |
JP2661783B2 JP2661783B2 (en) | 1997-10-08 |
Family
ID=17204801
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2250232A Expired - Lifetime JP2661783B2 (en) | 1990-09-21 | 1990-09-21 | Pharmaceutical composition for hand rubbing |
Country Status (1)
Country | Link |
---|---|
JP (1) | JP2661783B2 (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995005737A1 (en) * | 1993-08-27 | 1995-03-02 | Bode Chemie Gmbh & Co. | Alcohol-based hand disinfectant with a skin care component |
US5529987A (en) * | 1993-08-04 | 1996-06-25 | Patent Biopharmaceutics, Inc. | Hyaluronic acid-urea pharmaceutical compositions and uses |
US5550112A (en) * | 1992-12-30 | 1996-08-27 | Patent Biopharmaceutics, Inc. | Hyaluronic acid-urea pharmaceutical compositions and uses |
KR20030003954A (en) * | 2001-07-04 | 2003-01-14 | 밝은미래산업 주식회사 | Povidone iodine-based antiseptic solutions and method of making the same |
WO2007017176A1 (en) * | 2005-08-11 | 2007-02-15 | Biokosmes S.R.L. | Wound-healing composition |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS63264528A (en) * | 1987-04-02 | 1988-11-01 | ユーロ−セルティーク・ソシエテ・アノニム | Medicinal composition |
JPH01156904A (en) * | 1987-09-21 | 1989-06-20 | Sunstar Inc | Iodine-based bactericide composition and wet tissue-type bactericidal material using said composition |
-
1990
- 1990-09-21 JP JP2250232A patent/JP2661783B2/en not_active Expired - Lifetime
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS63264528A (en) * | 1987-04-02 | 1988-11-01 | ユーロ−セルティーク・ソシエテ・アノニム | Medicinal composition |
JPH01156904A (en) * | 1987-09-21 | 1989-06-20 | Sunstar Inc | Iodine-based bactericide composition and wet tissue-type bactericidal material using said composition |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5550112A (en) * | 1992-12-30 | 1996-08-27 | Patent Biopharmaceutics, Inc. | Hyaluronic acid-urea pharmaceutical compositions and uses |
US5529987A (en) * | 1993-08-04 | 1996-06-25 | Patent Biopharmaceutics, Inc. | Hyaluronic acid-urea pharmaceutical compositions and uses |
US5583120A (en) * | 1993-08-04 | 1996-12-10 | Patent Biopharmaceutics, Inc. | Hyaluronic acid-urea pharmaceutical compositions and uses |
US5583118A (en) * | 1993-08-04 | 1996-12-10 | Patent Biopharmaceutics, Inc. | Method of treating an anorectal disease using hyaluronic acid-urea pharmaceutical compositions |
US5583119A (en) * | 1993-08-04 | 1996-12-10 | Patent Biopharmaceutics, Inc. | Hyaluronic acid-urea pharmaceutical compositions and uses |
US5624915A (en) * | 1993-08-04 | 1997-04-29 | Patent Biopharmaceutics, Inc. | Hyaluronic acid-urea pharmaceutical compositions and uses |
US5631242A (en) * | 1993-08-04 | 1997-05-20 | Patent Biopharmaceutics, Inc. | Hyaluronic acid-urea pharmaceutical compositions utilized for treatment of diseases of cutis |
US5679655A (en) * | 1993-08-04 | 1997-10-21 | Patent Biopharmaceutics, Inc. | Method of treating lesions resulting from genital herpes with hyaluronic acid-urea pharmaceutical compositions |
WO1995005737A1 (en) * | 1993-08-27 | 1995-03-02 | Bode Chemie Gmbh & Co. | Alcohol-based hand disinfectant with a skin care component |
KR20030003954A (en) * | 2001-07-04 | 2003-01-14 | 밝은미래산업 주식회사 | Povidone iodine-based antiseptic solutions and method of making the same |
WO2007017176A1 (en) * | 2005-08-11 | 2007-02-15 | Biokosmes S.R.L. | Wound-healing composition |
EP2489355A1 (en) * | 2005-08-11 | 2012-08-22 | BMG PHARMA s.r.l. | Wound-healing composition |
Also Published As
Publication number | Publication date |
---|---|
JP2661783B2 (en) | 1997-10-08 |
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