BR102020010538A2 - PRODUCT AND PROCESS FOR THE PREPARATION OF WATER-BASED SANITIZING GEL - Google Patents
PRODUCT AND PROCESS FOR THE PREPARATION OF WATER-BASED SANITIZING GEL Download PDFInfo
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- 238000011012 sanitization Methods 0.000 title claims abstract description 23
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 238000000034 method Methods 0.000 title claims description 13
- 239000000203 mixture Substances 0.000 claims abstract description 36
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 17
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 13
- 239000002562 thickening agent Substances 0.000 claims abstract description 10
- 150000001875 compounds Chemical class 0.000 claims abstract description 5
- 239000002904 solvent Substances 0.000 claims abstract description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 23
- KFZMGEQAYNKOFK-UHFFFAOYSA-N iso-propanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- 239000004480 active ingredient Substances 0.000 claims description 14
- 238000004519 manufacturing process Methods 0.000 claims description 9
- 239000004094 surface-active agent Substances 0.000 claims description 8
- 230000003750 conditioning Effects 0.000 claims description 6
- 239000003974 emollient agent Substances 0.000 claims description 6
- LRHPLDYGYMQRHN-UHFFFAOYSA-N n-butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 6
- 239000002736 nonionic surfactant Substances 0.000 claims description 5
- JYVLIDXNZAXMDK-UHFFFAOYSA-N 2-Pentanol Chemical compound CCCC(C)O JYVLIDXNZAXMDK-UHFFFAOYSA-N 0.000 claims description 4
- 229960003260 Chlorhexidine Drugs 0.000 claims description 4
- MTHSVFCYNBDYFN-UHFFFAOYSA-N Diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 claims description 4
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Exidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 claims description 4
- 230000000845 anti-microbial Effects 0.000 claims description 4
- AMQJEAYHLZJPGS-UHFFFAOYSA-N n-pentanol Chemical compound CCCCCO AMQJEAYHLZJPGS-UHFFFAOYSA-N 0.000 claims description 4
- -1 polymines Substances 0.000 claims description 4
- 239000003755 preservative agent Substances 0.000 claims description 4
- BDERNNFJNOPAEC-UHFFFAOYSA-N propanol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 4
- YSJGOMATDFSEED-UHFFFAOYSA-M Behentrimonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCCCCCC[N+](C)(C)C YSJGOMATDFSEED-UHFFFAOYSA-M 0.000 claims description 3
- 229940075506 Behentrimonium chloride Drugs 0.000 claims description 3
- 229960000686 Benzalkonium Chloride Drugs 0.000 claims description 3
- 229960002788 CETRIMONIUM CHLORIDE Drugs 0.000 claims description 3
- WOWHHFRSBJGXCM-UHFFFAOYSA-M Cetrimonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+](C)(C)C WOWHHFRSBJGXCM-UHFFFAOYSA-M 0.000 claims description 3
- 239000002202 Polyethylene glycol Substances 0.000 claims description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-M chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 3
- 235000011187 glycerol Nutrition 0.000 claims description 3
- 229920001223 polyethylene glycol Polymers 0.000 claims description 3
- 239000003352 sequestering agent Substances 0.000 claims description 3
- CWSZBVAUYPTXTG-UHFFFAOYSA-N 5-[6-[[3,4-dihydroxy-6-(hydroxymethyl)-5-methoxyoxan-2-yl]oxymethyl]-3,4-dihydroxy-5-[4-hydroxy-3-(2-hydroxyethoxy)-6-(hydroxymethyl)-5-methoxyoxan-2-yl]oxyoxan-2-yl]oxy-6-(hydroxymethyl)-2-methyloxane-3,4-diol Chemical compound O1C(CO)C(OC)C(O)C(O)C1OCC1C(OC2C(C(O)C(OC)C(CO)O2)OCCO)C(O)C(O)C(OC2C(OC(C)C(O)C2O)CO)O1 CWSZBVAUYPTXTG-UHFFFAOYSA-N 0.000 claims description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 2
- 240000005497 Cyamopsis tetragonoloba Species 0.000 claims description 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 2
- ZXEKIIBDNHEJCQ-UHFFFAOYSA-N Isobutanol Chemical compound CC(C)CO ZXEKIIBDNHEJCQ-UHFFFAOYSA-N 0.000 claims description 2
- 229920000161 Locust bean gum Polymers 0.000 claims description 2
- 239000004952 Polyamide Substances 0.000 claims description 2
- 241001558929 Sclerotium <basidiomycota> Species 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims description 2
- 150000007513 acids Chemical class 0.000 claims description 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 2
- 229920003086 cellulose ether Polymers 0.000 claims description 2
- LCXAARCEIWRIMU-UHFFFAOYSA-M dibenzyl(dimethyl)azanium;chloride Chemical group [Cl-].C=1C=CC=CC=1C[N+](C)(C)CC1=CC=CC=C1 LCXAARCEIWRIMU-UHFFFAOYSA-M 0.000 claims description 2
- 235000013312 flour Nutrition 0.000 claims description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 2
- 229920000591 gum Polymers 0.000 claims description 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 2
- 229940035429 isobutyl alcohol Drugs 0.000 claims description 2
- 239000000711 locust bean gum Substances 0.000 claims description 2
- 235000010420 locust bean gum Nutrition 0.000 claims description 2
- 229920002647 polyamide Polymers 0.000 claims description 2
- 229920000570 polyether Polymers 0.000 claims description 2
- 230000002335 preservative Effects 0.000 claims description 2
- 229920001285 xanthan gum Polymers 0.000 claims description 2
- 229910052799 carbon Inorganic materials 0.000 claims 3
- KPSSIOMAKSHJJG-UHFFFAOYSA-N Neopentyl alcohol Chemical compound CC(C)(C)CO KPSSIOMAKSHJJG-UHFFFAOYSA-N 0.000 claims 2
- AQIXEPGDORPWBJ-UHFFFAOYSA-N 3-Pentanol Chemical compound CCC(O)CC AQIXEPGDORPWBJ-UHFFFAOYSA-N 0.000 claims 1
- 229920002126 Acrylic acid copolymer Polymers 0.000 claims 1
- CBTVGIZVANVGBH-UHFFFAOYSA-N Aminomethyl propanol Chemical compound CC(C)(N)CO CBTVGIZVANVGBH-UHFFFAOYSA-N 0.000 claims 1
- JJWLVOIRVHMVIS-UHFFFAOYSA-N Isopropylamine Chemical compound CC(C)N JJWLVOIRVHMVIS-UHFFFAOYSA-N 0.000 claims 1
- 239000003443 antiviral agent Substances 0.000 claims 1
- 150000002334 glycols Chemical class 0.000 claims 1
- 229920003145 methacrylic acid copolymer Polymers 0.000 claims 1
- 230000003472 neutralizing Effects 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- DKGAVHZHDRPRBM-UHFFFAOYSA-N t-BuOH Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 claims 1
- 229920002554 vinyl polymer Polymers 0.000 claims 1
- 230000000249 desinfective Effects 0.000 abstract description 13
- 210000004247 Hand Anatomy 0.000 abstract description 12
- 210000003491 Skin Anatomy 0.000 abstract description 11
- 230000000844 anti-bacterial Effects 0.000 abstract description 5
- 230000003253 viricidal Effects 0.000 abstract description 5
- 210000000707 Wrist Anatomy 0.000 abstract description 4
- 230000002421 anti-septic Effects 0.000 abstract description 3
- 238000004140 cleaning Methods 0.000 abstract description 2
- 238000009472 formulation Methods 0.000 abstract description 2
- 125000004432 carbon atoms Chemical group C* 0.000 abstract 1
- 239000012153 distilled water Substances 0.000 abstract 1
- 230000000887 hydrating Effects 0.000 abstract 1
- 230000001050 lubricating Effects 0.000 abstract 1
- 239000008213 purified water Substances 0.000 abstract 1
- 238000009736 wetting Methods 0.000 abstract 1
- 239000000499 gel Substances 0.000 description 17
- 241000736262 Microbiota Species 0.000 description 6
- 238000005187 foaming Methods 0.000 description 5
- 239000000344 soap Substances 0.000 description 5
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 4
- 238000004090 dissolution Methods 0.000 description 4
- 201000009910 diseases by infectious agent Diseases 0.000 description 3
- 229920001888 polyacrylic acid Polymers 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 206010022998 Irritability Diseases 0.000 description 2
- HOVAGTYPODGVJG-WLDMJGECSA-N Methylglucoside Chemical class COC1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HOVAGTYPODGVJG-WLDMJGECSA-N 0.000 description 2
- 206010029803 Nosocomial infection Diseases 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 230000003260 anti-sepsis Effects 0.000 description 2
- 230000001580 bacterial Effects 0.000 description 2
- 244000052616 bacterial pathogens Species 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- 230000003641 microbiacidal Effects 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 230000001717 pathogenic Effects 0.000 description 2
- 244000052769 pathogens Species 0.000 description 2
- 230000003389 potentiating Effects 0.000 description 2
- 244000005714 skin microbiome Species 0.000 description 2
- 239000003381 stabilizer Substances 0.000 description 2
- QRAXLHLYZJCAKB-XZBKPIIZSA-N (2R,3S,4R,5R)-3,4,5,6-tetrahydroxy-2-methoxyhexanal Chemical class CO[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO QRAXLHLYZJCAKB-XZBKPIIZSA-N 0.000 description 1
- 229960003093 ANTISEPTICS AND DISINFECTANTS Drugs 0.000 description 1
- 206010009866 Cold sweat Diseases 0.000 description 1
- 210000004207 Dermis Anatomy 0.000 description 1
- QZKRHPLGUJDVAR-UHFFFAOYSA-K EDTA trisodium salt Chemical compound [Na+].[Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O QZKRHPLGUJDVAR-UHFFFAOYSA-K 0.000 description 1
- 210000002615 Epidermis Anatomy 0.000 description 1
- 210000003608 Feces Anatomy 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 210000001035 Gastrointestinal Tract Anatomy 0.000 description 1
- 208000006641 Skin Disease Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000006172 buffering agent Substances 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 239000011928 denatured alcohol Substances 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- LCGLNKUTAGEVQW-UHFFFAOYSA-N dimethyl ether Chemical group COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N edta Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000002070 germicidal Effects 0.000 description 1
- 150000002303 glucose derivatives Chemical class 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 239000002973 irritant agent Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 210000000056 organs Anatomy 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 230000021317 sensory perception Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001052 transient Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/08—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
- A01N25/10—Macromolecular compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/12—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
- A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
- A01N47/44—Guanidine; Derivatives thereof
Abstract
A presente invenção refere-se à formulação e preparação de um gel sanitizante/ antisséptico de base aquosa para a desinfecção da pele, mãos e pulsos. Em uma modalidade, onde o sanitizante para as mãos e pulsos compreende na sua composição, um monoálcool de alquila utilizado na faixa de 10 a 40 % em peso, com base no peso total do desinfetante para as mãos, onde o monoálcool possui de 1 a 5 átomos de carbono. O desinfetante para as mãos e pulsos também compreende a associação de agentes ativos adicionais com ação bactericida de cerca de 1 a 5 % com base no peso total do sanitizante; pelo menos um solubilizante com ação hidratante e lubrificante de 0,05 a cerca de 5 por cento em peso; de 0,1 a 15% em peso de pelo menos um espessante; e de 0,1% a 10% em peso de pelo menos um composto ativo de ação virucida; pelo menos um componente do composto ativo selecionado do grupo que consiste em componentes não iônico umectante e auxiliar de limpeza, sendo o saldo de 100% em peso; água purificada ou destilada.
Description
[0001] A presente invenção refere-se ao processo de fabricação e formulação de gel sanitizante/antisséptico para a desinfecção da pele, mãos e pulsos. A finalidade desse processo está na confecção de um produto com matérias-primas genuinamente nacionais com caraterísticas similares ao álcool em gel.[0001] The present invention relates to the process of manufacturing and formulating a sanitizing/antiseptic gel for disinfecting the skin, hands and wrists. The purpose of this process is to make a product with genuinely national raw materials with characteristics similar to gel alcohol.
[0002] A pele é o maior órgão do corpo humano e apresenta diversas funções: proteção contra agentes externos, excretas de eletrólitos e água, armazenamento de gordura e percepção sensorial tátil. As camadas da pele epiderme e a derme são colonizadas por bactérias que se encontram dispersas em várias partes do corpo, nas mãos, já foram classificados dois tipos de microbiotas a temporária e a permanente (SCHOMMER N. N.; GALLO, R. L. Structure and function of the human skin microbiome, Trends in Microbiology, v. 21:12:660-668, 2013). A microbiota permanente está sempre aderida às camadas mais profundas da pele e é menos associada às infecções hospitalares, mas podem causar infecções após procedimentos invasivos. A microbiota temporária é formada por fontes externas que colonizam a superfície cutânea por um curto período de tempo e são de logo removidas com a higienização das mãos. A microbiota temporariamente residente compõe a microbiota transitória não detectada na pele por períodos prolongados e conseguem multiplicar-se sem causar qualquer infecção ao hospedeiro (FINDLEY K.; GRICE E. A; The Skin microbiome: a focus on pathogens amd their association with skin disease. Plos Pathogen, v. 10(11): 1-3, 2014). O processo de lavagem de mãos está associada à redução do risco de infecção e o efeito de lavar as mãos com água e sabão antimicrobiano diminuem o índice de infecção hospitalar. Existem várias preparações para higienização das mãos dentre elas: sabões e detergentes comuns, álcool, clorexidina e polivinilpirrolidona iodo (LOZUPONE C. A et al., Diversity, stability and resilience of the human gut microbiota, NATURE, v. 489(7415): 220–230, 2012). Os álcoois são germicidas quando aplicados à pele, entretanto a recolonização bacteriana na pele ocorre lentamente após o uso de antisséptico à base de álcool nas mãos. O álcool presente em concentrações adequadas na solução de higiene de mãos também tem ação contra vários vírus envelopados, microbactérias e fungos. Produtos a base de álcool são usados visando reduzir o risco de exposição e disseminação de germes bacterianos encontrados nas atividades diárias (TIYO etal., Determinação do Álcool 70% utilizado para antissepsia em drogarias e farmácias de Maringá-Paraná. Rev. Bras. Farm.,v. 90(3): 231-235, 2009).[0002] The skin is the largest organ of the human body and has several functions: protection against external agents, electrolyte and water excreta, fat storage and tactile sensory perception. The layers of the skin, epidermis and dermis are colonized by bacteria that are dispersed in various parts of the body, on the hands, two types of microbiota have been classified, temporary and permanent (SCHOMMER NN; GALLO, RL Structure and function of the human skin microbiome, Trends in Microbiology, v. 21:12:660-668, 2013). The permanent microbiota is always adhered to the deeper layers of the skin and is less associated with nosocomial infections, but they can cause infections after invasive procedures. The temporary microbiota is formed by external sources that colonize the skin surface for a short period of time and are then removed with hand hygiene. The temporarily resident microbiota makes up the transient microbiota not detected in the skin for prolonged periods and can multiply without causing any infection to the host (FINDLEY K.; GRICE E. A; The Skin microbiome: a focus on pathogens amd their association with skin disease). Plos Pathogen, v. 10(11): 1-3, 2014 ). The handwashing process is associated with a reduced risk of infection and the effect of washing hands with antimicrobial soap and water decreases the rate of nosocomial infection. There are several preparations for hand hygiene, among them: common soaps and detergents, alcohol, chlorhexidine and polyvinylpyrrolidone iodine (LOZUPONE C. A et al., Diversity, stability and resilience of the human gut microbiota, NATURE, v. 489(7415): 220–230, 2012). Alcohols are germicidal when applied to the skin, however bacterial recolonization on the skin occurs slowly after using an alcohol-based hand sanitizer. The alcohol present in adequate concentrations in the hand hygiene solution also has action against several enveloped viruses, microbacteria and fungi. Alcohol-based products are used to reduce the risk of exposure and dissemination of bacterial germs found in daily activities (TIYO et al., Determination of 70% Alcohol used for antisepsis in drugstores and pharmacies in Maringá-Paraná. Rev. Bras. Farm. , v. 90(3): 231-235, 2009 ).
[0003] O FDA classificou etanol 60-95% como seguro e eficaz como agente de higiene e antissepsia de mãos embora na Europa o álcool isopropílico 70% tornou-se referência na higiene de mãos (WORLD HEALTH ORGANIZATION, Global Patient Safety Challenge 2005-2006 - Clean Care is Safer Care, 2007). Entretanto devido a escassez do uso das matérias primas (carbopol) na produção do álcool torna-se necessário a produção de outros tipos de formulações na produção de gel sanitizante.[0003] The FDA has classified ethanol 60-95% as safe and effective as a hand hygiene and antisepsis agent although in Europe 70% isopropyl alcohol has become a reference in hand hygiene (WORLD HEALTH ORGANIZATION, Global Patient Safety Challenge 2005- 2006 - Clean Care is Safer Care, 2007). However, due to the scarcity of use of raw materials (carbopol) in the production of alcohol, it becomes necessary to produce other types of formulations in the production of sanitizing gel.
[0004] O documento de patente 5,942,478 (MICROBICIDAL AND SANITIZING SOAP), publicado em 1999, descreve a produção de um sabão microbicida e desinfetante usadas para aplicação de uso pessoal e desinfetante de mãos e pele. Contudo produtos a base de álcool são mais eficazes para a lavagem de mãos do que sabões antimicrobianos incluindo aqueles que usam PVPI e clorexidina e não deixam resíduos na mão.[0004] Patent document 5,942,478 (MICROBICIDAL AND SANITIZING SOAP), published in 1999, describes the production of a microbicidal soap and disinfectant used for personal use and disinfectant of hands and skin. However, alcohol-based products are more effective for handwashing than antimicrobial soaps including those that use PVPI and chlorhexidine and leave no residue on the hand.
[0005] O documento de patente US 2009/0082472 A1,356,168 (Hand Sanitizer and Method of Preparation), publicado em 2009, descreve a composição de um desinfetante ou composição de gel para as mãos baseado na mistura de álcool desnaturado e isopropílico para matar germes e bactérias, um espessante, como um polímero acrílico, um estabilizador ou um neutralizador de ácido acrílico polimérico e utilizam o carbopol em sua formulação além de emoliente, glicerina. A patente utiliza o carbopol assim como a maioria dos álcoois produzidos e não apresenta uma alternativa caso haja uma carência desta matéria prima.[0005] US patent document 2009/0082472 A1,356,168 (Hand Sanitizer and Method of Preparation), published in 2009, describes the composition of a disinfectant or hand gel composition based on the mixture of denatured and isopropyl alcohol to kill germs and bacteria, a thickener, such as an acrylic polymer, a stabilizer or a polymeric acrylic acid neutralizer and use carbopol in their formulation in addition to an emollient, glycerin. The patent uses carbopol as well as most of the alcohols produced and does not present an alternative if there is a shortage of this raw material.
[0006] A presente invenção descreve produto e processo para a preparação de um gel sanitizante de base aquosa para higienização pessoal e de aplicações industriais. A composição do gel sanitizante/desinfetante não formador de espuma, consiste essencialmente em:[0006] The present invention describes a product and process for the preparation of a water-based sanitizing gel for personal hygiene and industrial applications. The composition of the non-foaming sanitizing/disinfectant gel essentially consists of:
[0007] - Um componente A, constituído pela dissolução em água, de um agente espessante, essencialmente utilizado para a obtenção de géis aquosos, utilizando-se substâncias sintéticas como ácidos policarboxílicos, poliminas, poliamidas, poliéteres, e/ou espessantes selecionados, de origem natural, como a goma sclerotium, carboximetilceluloses, hidroxietilcelulose, éteres de celulose, xantanos, farinha de guar, goma de alfarroba e suas combinações; adiciona-se o EDTA tetrassódico ou composto de ação similar para atuar como agente sequestrante, estabilizante e tamponante;[0007] - A component A, consisting of the dissolution in water of a thickening agent, essentially used to obtain aqueous gels, using synthetic substances such as polycarboxylic acids, polymines, polyamides, polyethers, and/or selected thickeners, natural origin, such as sclerotium gum, carboxymethylcelluloses, hydroxyethylcellulose, cellulose ethers, xanthans, guar flour, locust bean gum and combinations thereof; tetrasodium EDTA or similarly acting compound is added to act as a sequestering, stabilizing and buffering agent;
[0008] - Um componentes B, formado pela dissolução em alquil monoálcool de 2 a 5 carbonos, um agente solubilizante e lubrificante selecionado a partir de: glicerina, monoetilenoglicol, díetilenoglicol, propilenoglicol, polietilenoglicol; um composto ativo com ação bactericida/virucida constituídos por: Hexametileno Biguanida, Clorexidina, Cloreto de Benzalcônio e cloreto de Dimetil Dibenzil Amônio e Cloreto de benzalcônio suficiente para sanitizar as mãos durante o uso; um tensoativo não iônico como surfactante/emoliente selecionado entre o éter metílico de glicose etoxilada, éster do metil glucosídeo dioleato etoxilado ou similares; e agentes condicionadores, como o Cloreto de estearilcônio, Cloreto de behentrimônio e Cloreto de cetrimônio e similares[0008] - A component B, formed by dissolving in an alkyl monoalcohol of 2 to 5 carbons, a solubilizing and lubricating agent selected from: glycerin, monoethylene glycol, diethylene glycol, propylene glycol, polyethylene glycol; an active compound with bactericidal/virucidal action consisting of: Hexamethylene Biguanide, Chlorhexidine, Benzalkonium Chloride and Dimethyl Dibenzyl Ammonium Chloride and Benzalkonium Chloride sufficient to sanitize hands during use; a non-ionic surfactant as a surfactant/emollient selected from ethoxylated glucose methyl ether, ethoxylated methyl glucoside dioleate ester or the like; and conditioning agents such as Stearylconium Chloride, Behentrimonium Chloride and Cetrimonium Chloride and the like
[0009] - Um componente C, formado pela utilização de soluções aquosas dos agentes conservantes do grupo dos parabenos ou similares.[0009] - A component C, formed by the use of aqueous solutions of preservative agents from the group of parabens or similar.
[0010] Para a finalização do processo de preparação do gel sanitizante/desinfetante para as mãos e outras superfícies, o Componente “B” e o Componente “C” deverão ser adicionados sobre o Componente “A” e homogeneizados.[0010] To complete the process of preparing the sanitizing/disinfectant gel for hands and other surfaces, Component “B” and Component “C” must be added to Component “A” and homogenized.
[0011] A composição de gel sanitizante/desinfetante de base aquosa, para as mãos e outras superfícies não formadora de espuma, consiste essencialmente de um gel a base de água que pode incluir um ou mais componentes selecionados do grupo de condicionadores de superfície, por exemplo: Cloreto de esterealcônio, Cloreto de behentrimônio e Cloreto de cetrimônio, a partir de uma quantidade suficiente para potencializar a ação desinfetante, antimicrobiana dos agentes ativos de superfície com ação bactericida/virucida e reduzir o índice de desidratação e irritabilidade da pele;[0011] The water-based sanitizing/disinfectant gel composition for hands and other non-foaming surfaces essentially consists of a water-based gel which may include one or more components selected from the group of surface conditioners, for example example: Sterealkonium Chloride, Behentrimonium Chloride and Cetrimonium Chloride, from an amount sufficient to potentiate the disinfectant, antimicrobial action of surface active agents with bactericidal/virucidal action and reduce the rate of dehydration and skin irritability;
[0012] A composição de gel sanitizante/desinfetante para as mãos e outras superfícies não formadora de espuma, consistindo essencialmente em um gel a base de água pode incluir ainda pelo menos um ingrediente ativo do grupo de alquil monoálcool contendo de 2 a 5 carbonos ou suas misturas na proporção de 10 a 40 %, constituído por: etanol, 1-propanol, 2-propanol (álcool isopropílico), 1-butanol, isobutil álcool, 1-pentanol, 2-pentanol suficiente para funcionar como um dos agentes ativo Para garantir o combate a presença de micro-organismos resistentes a antissépticos e desinfetantes desempenhando um papel importante de forma a minimizar a disseminação de microrganismos seja com ação antisséptica para monoálcoois contendo até 3 carbonos, ou como retardador de evaporação para os monoálcoois de 4 e 5 carbonos, mantendo as superfícies úmidas por maior período potencializando a ação dos agentes ativos de ação bactericida/virucida;[0012] The sanitizing/sanitizing gel composition for hands and other non-foaming surfaces, consisting essentially of a water-based gel, may further include at least one active ingredient from the alkyl monoalcohol group containing 2 to 5 carbons or their mixtures in a proportion of 10 to 40 %, consisting of: ethanol, 1-propanol, 2-propanol (isopropyl alcohol), 1-butanol, isobutyl alcohol, 1-pentanol, 2-pentanol sufficient to function as one of the active agents for guarantee the fight against the presence of microorganisms resistant to antiseptics and disinfectants, playing an important role in minimizing the spread of microorganisms, either with antiseptic action for monoalcohols containing up to 3 carbons, or as an evaporation retardant for monoalcohols of 4 and 5 carbons , keeping the surfaces moist for a longer period, potentiating the action of active agents with bactericidal/virucidal action;
[0013] A composição de gel sanitizante/desinfetante para as mãos e outras superfícies não formadora de espuma, Consistindo essencialmente em um gel a base de água pode incluir ainda pelo menos um tensoativo não iônico como surfactante/emoliente contido no grupo do éter metílico de glicose etoxilado, éster do metil glucosídeo dioleato etoxilado ou similares em uma quantidade na faixa de 0,2 a 7% do peso da composição, como agente umectante da pele e anti-irritante, capaz de reduzir significativamente a irritabilidade de outros tensoativos;[0013] The sanitizing/disinfectant gel composition for hands and other non-foaming surfaces, consisting essentially of a water-based gel, may further include at least one non-ionic surfactant as a surfactant/emollient contained in the methyl ether group of ethoxylated glucose, ethoxylated methyl glucoside dioleate ester or the like in an amount ranging from 0.2 to 7% by weight of the composition, as a skin wetting and anti-irritant agent, capable of significantly reducing the irritability of other surfactants;
[0014] A invenção prevê um processo para preparar do gel sanitizante/desinfetante para as mãos e outras superfícies não formadora de espuma, de acordo com a Figura 1, compreendendo três etapas de preparação, para posterior mistura dos componentes A, B e C:[0014] The invention provides a process for preparing the sanitizing/disinfectant gel for hands and other non-foaming surfaces, according to Figure 1, comprising three preparation steps, for subsequent mixing of components A, B and C:
[0015] - O Componente “A” prevê a dissolução, em misturador de palheta de baixa velocidade contendo 90 % do peso da água como a ser utilizada como veículo e solvente prevista na Reivindicação 1, da quantidade de um ou mais agentes espessantes na proporção em peso da composição; com adição e dissolução da quantidade prevista de EDTA trissódico como agente sequestrante; com adição e dissolução da quantidade prevista de pelo menos um tensoativo não iônico como surfactante/emoliente, mantida a agitação até a formação de um gel transparente isento de material não dissolvido aparente;[0015] - Component "A" provides for the dissolution, in a low speed vane mixer containing 90% of the weight of water as to be used as a vehicle and solvent provided for in Claim 1, of the amount of one or more thickening agents in the proportion by weight of the composition; with addition and dissolution of the predicted amount of trisodium EDTA as a sequestering agent; with addition and dissolution of the predicted amount of at least one non-ionic surfactant as a surfactant/emollient, with stirring until a clear gel free of apparent undissolved material is formed;
[0016] - Para a preparação do Componente “B”: homogeinizar, em outro misturador de palheta de baixa velocidade, as proporções previstas na Reivindicação 1 de pelo menos um ingrediente ativo do grupo de alquil monoálcool contendo de 2 a 5 carbonos ou suas misturas; pelo menos um dos agente solubilizante e lubrificante; pelo menos um dos agente condicionador de superfície; pelo menos um dos agentes ativos de superfície com ação bactericida/virucida;[0016] - For the preparation of Component "B": homogenize, in another low speed vane mixer, the proportions provided for in Claim 1 of at least one active ingredient from the alkyl monoalcohol group containing 2 to 5 carbons or mixtures thereof ; at least one of solubilizing and lubricating agent; at least one of the surface conditioning agents; at least one of the surface active agents with bactericidal/virucidal action;
[0017] - Para a preparação do Componente “C”: dissolver, em outro misturador de palheta de baixa velocidade contendo os 10% restante da quantidade de água da proporção previstas na Reivindicação 1 de pelo menos um dos agentes conservantes;[0017] - For the preparation of Component “C”: dissolve, in another low speed vane mixer containing the remaining 10% of the amount of water in the proportion provided for in Claim 1 of at least one of the preservatives;
[0018] Para a finalização do processo de preparação do gel sanitizante/desinfetante para as mãos e outras superfícies de acordo com a Figura 1, adicionar o Componente “B” e o Componente “C” sobre o Componente “A”, homogeneizar e envasar.[0018] To finish the process of preparing the sanitizing/disinfectant gel for hands and other surfaces according to Figure 1, add Component “B” and Component “C” over Component “A”, homogenize and fill .
Claims (9)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR102020010538A2 true BR102020010538A2 (en) | 2021-11-30 |
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