JPH04128235A - Mental fatigue preventing and removing agent - Google Patents

Abstract

PURPOSE:To obtain a mental fatigue preventing and removing agent containing fennel oil, prepared in a form absorbed from nosal mucosa, oral cavity mucosa or lung and effective for prevention and removal of fatigue caused by mental stress or ulcer induced by mental stress. CONSTITUTION:A mental fatigue preventing a removing agent which is an essential oil obtained by subjecting the fruits of Foeniculum vulgare Miller to steam distillation, containing fennel oil which contains anethole as a main ingredient, alpha-pinene, camphene, limonene, cineole, p-cymene, fenchone and anise aldehyde as other ingredients, and prepared in a form of spraying agent or volatile aromatic inhaled by diffusing into air, confectioneries such as gum and candy, troche, mouth-washing liquid, jelly, soft drink, sublingual tablet, etc., and absorbed by diffusing in mouth. In the form for diffusing into air, the concentration in air is to be kept to >=0.45ng/l and in the form for diffusing in mouth, concentration of fennel oil is to be kept to 4.5X10<-7>%.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to a mental fatigue prevention and recovery agent containing fennel oil as an active ingredient.

[Problems to be solved by conventional techniques and inventions] In recent years,
There have been many reports that scents have various effects on menstruation and psychological conditions, and the psychophysiological effects of scents have been attracting attention. Traditionally, aromatherapy has been known in Europe for a long time as a method for preventing or recovering from mental fatigue using scents (The Theory and Practice of Aromatherapy): Robert Tisland, Fragrance Journal, 1987. ).

In addition, fennel is included in two Chinese herbal medicine prescriptions, Anchuhe and Chokogakiteito, and is used as an anti-cold medicine, warming the entire body or local areas by dilating blood vessels, promoting blood circulation, central stimulation, and local stimulation. It is said to be effective (Illustrated composition and application of Chinese herbal prescriptions, written by Yuzai Mori, Ishiyaku Publishing, 1977)
. Fennel oil (fennel oil), which is an essential oil obtained from fennel, has stomachic, carminative, and phlegm effects (Newly revised Japanese and Chinese Medicine, written by Kinyoshi Akamatsu, Ishiyaku Publishing, 1970), and its main component. Anethole has been shown to have an intestinal constriction effect in isolated guinea pigs (Izumi Reimon, Yoshiko Kitabatake: Pharmaceutical Journal, 82.
1326-1328, 1962) is known,
Furthermore, for fennel powder, 600 mg/kg
It has been reported that oral administration of 35-39% ulcer suppressive effect was observed (Joji Yamahara, Tokunosuke Sawada, Fujimura-
24th Natural Drug Development and Application Symposium, 68-7
0 page, 19B2). There is also a detailed report by Ito et al. regarding other pharmacological effects of fennel [Ito et al., Modern Oriental Medicine, 9. Nα3゜pages 57-63,
(1988), there are no reports on the psychophysiological effects of the scent of fennel oil.

[Means to solve the problem]

Under these circumstances, the present inventors tested the effects of many aromatic substances on their physiological effects, and found that when fennel oil was absorbed and administered through the nasal mucosa, oral mucosa, or lungs, it had a rapid effect. The present invention has been completed based on the discovery that, at low concentrations, fatigue caused by mental stress and stress ulcers that occur accompanying this can be prevented or cured.

Therefore, the present invention provides a mental fatigue prevention and recovery agent, which contains fennel oil as an active ingredient and is formulated in a form that allows the active ingredient to be absorbed through the nasal mucosa, oral mucosa, or lungs. This is what we provide.

Fennel oil comes from fennel, Poen icu lum
Vulgare Miller (Umbelifer)
ae) or Illicium verum Hooker
fil, (Illiciaceae) is an essential oil obtained by steam distillation of the fruit, and contains anethole as the main component (50
% or more) and also contains α-pinene, camphene, limonene, cineole, p-cymene, fenchon, and anisaldehyde. This product is also listed in Part 2 of the 11th edition of the Japanese Pharmacopoeia, for example.

This fennel oil may be of any purity as long as it can provide the effective concentration described below, and it may contain other ingredients such as bergamot, lemon, rose, ginger, etc. to the extent that its action is not impaired. It can also be used in combination with aromatic substances such as grapefruit, neroli, palmarosa, tarari sage, rosemary, nutmeg, chamomile, marjoram, lavender, geranium, sandalwood, vetiver, and ziconiper.

The effects of the agent for preventing and recovering from mental fatigue of the present invention are achieved when fennel oil is absorbed through the nasal mucosa, oral mucosa, or lungs. It is necessary that the drug be formulated in a form that can be easily absorbed. The formulation method is not particularly limited, and it is sufficient that the aromatic components of fennel oil are absorbed through the nasal mucosa, oral mucosa, or lungs to form an ink-like formulation. Examples of such forms include sprays that are diffused into the air and inhaled, volatile fragrances, and confectionery such as gums and candies that are diffused into the mouth and absorbed, alcoholic products such as troches, mouth washes, and jelly liqueurs. , soft drinks, sublingual tablets, or additives added to coffee, tea, etc. Furthermore, fennel oil may be encapsulated in microcapsules.

In the case of a type of fennel oil that can be diffused into the air and inhaled, the concentration of fennel oil in the air should be at least 0.45 ng/1 in order to achieve the effects of the present invention. Even if the concentration is increased further beyond this, no appreciable increase in effect will be observed, so it is usually 0.45 to 9. On
It is preferable to adjust the ratio to 1 g/1. For this purpose, when using a spray agent, it is necessary to use a solvent such as alcohol.
．． For volatile fragrances, it is dissolved to a concentration of 1 to 10% and filled into a container with a propellant, or by a conventional method.
It is preferable to dissolve or disperse it in a solution or gel such as isoparaffin.

Furthermore, in the case of □ type that diffuses during the day,
may be contained in an amount of 4.5 x lO-'% or more of fennel oil.

The effects of the mental fatigue prevention and recovery agent and the ulcer prevention and treatment agent of the present invention were evaluated by the following methods.

Measurement of mental fatigue: Objective physiological evaluation by humans (a) Work that causes mental stress on humans, e.g.
Evaluation is based on the degree of variation in the heartbeat interval or the degree of change in the respiratory component of the heartbeat interval when a computer-based calculation task load is applied. Regarding the relationship between autonomic nervous function and heart rate interval variation during stress work, 5ay
This has been proven in experiments by Ers et al. [8,ilc^,5
ayars, Brgonomics, 16°p1
7-32.1973゜Nakagaki, Iwata, Hirose, Ishii0 Journal of the Japan Society of Mechanical Engineers, 53. p2699-2702 (1988), Terashita, Osuga, Kaibe, Proceedings of the 53rd Japanese Psychological Association.

p878.1989, Nagai, Nakagawa, Miyake, Breakfast, No. 23
Proceedings of Symposium on Taste and Smell, p55-58.19
89].

During simple calculation tasks, a decrease in heart rate variability occurs due to excitation of the sympathetic nervous system and inhibition of the parasympathetic nervous system, and an increase in heart rate interval variability occurs due to excitation of the parasympathetic nervous system immediately before and after a stressful workload. However, evaluation can be made based on whether these reactions are suppressed by providing a scent.

(b) Evaluate by the decrease in pupil constriction response when tasks that cause mental stress to humans are performed, such as computer calculation tasks. It has been proven in experiments by Louise Profy et al. that the constriction reaction of the pupils due to light during stress is suppressed. (Louise Plo
uffe and Robert M.

Stelmack, Perceptual an
d Motor 5kill, ↓l.

p635-642.1979, Nakagawa, Nagai, Miyake, Breakfast, Proceedings of the 23rd Taste and Smell Symposium, p30
5-308°1989). In addition, the correlation between the constriction reaction of the pupil due to light and the autonomic nervous function was clarified through experiments by Utsumi (Takashi Utsumi, Daily Journal, 83. p1524)
~1528°1972). If the pupillary response to light is measured immediately before and after the stress workload, a decline in the miotic function of the pupil due to the excitement of the parasympathetic nervous system is observed;
Evaluation can be made based on whether these reactions are suppressed by providing a scent.

Subjective psychological evaluation by humans> Evaluation is based on changes in subjective psychological scales when humans are subjected to tasks that cause mental stress, such as computational work on a computer. Psychological scales include McNi1r
Profile of MoodSta developed by e etc.
te (POMS, Mood State Scale) (Mc Ni
1ireet al, An Analysis of
Mood in Neurotics, J.

^bnormal and 5ocial Psy
chology, 69. 620°1964). By comparing the changes in psychological state before and after stress workload with and without the administration of essential oil scents, it is possible to evaluate whether subjective symptoms during stress have improved.

Evaluation using mice (a) Evaluate the increase or decrease in spontaneous locomotor activity of mice using an ambulometer. The correlation between changes in locomotor activity measured by an ambulometer and central effects was clarified by Hirabayashi et al. (Hirabayashi, Iizuka, Tadokoro, Japanese Pharmacological Journal, 74, p.
9-639 (1978)). If a clear decrease in locomotor activity is observed when the aroma of essential oils is given, it can be concluded that a central depression, or sedative effect, is observed.

(b) Evaluate based on the degree of stress-induced gastric ulcers that occur when mice are subjected to water immersion restraint stress. Mice were restrained by immersing them in water from the neck down, and the incidence of ulcers was determined based on autopsy findings when the scent of essential oil was applied and when it was not.

(c) Evaluate whether or not the sleeping time induced by hexobarbital in mice is prolonged by providing the scent of essential oil. Central depression, or sedation, prolongs the duration of induced sleep.

〔Example〕

Next, an example will be given and explained.

Example 1 Four subjects were placed in an electromagnetic shield room with constant temperature (24° C.) and constant temperature (60%), and their electrocardiograms were measured in a resting state for 10 minutes. After the measurement was completed, the pupillary reaction to light was measured immediately before the computational workload, and the subjects were asked to describe their psychological state at that time in a self-report questionnaire.

Next, a 10-minute written calculation task (Kraepelin calculation work)
This was performed three times for a total of 30 minutes to induce mental fatigue, and electrocardiograms were recorded during this period, and the task was interrupted every 10 minutes to measure light pupillary reactions. Afterwards, the participants were asked to describe their psychological state after completing the calculation load using a self-report questionnaire. Thereafter, the subjects were allowed to rest for an additional 30 minutes, and their state of recovery from fatigue was measured. This trial was conducted twice for each subject, once with and without fennel oil. Administration of fennel oil: Fennel oil (Fragrance for Hase, S^5057) 3
atl! Dissolve fennel oil in 30 ml of liquid paraffin, place it in a gas cleaning bottle, and blow in air from the outside at 61 ng/min to dissipate the fennel oil in the air in the shield room to a concentration of 13.5 ng/min before the start of the test. It was done by

(i) Changes in heartbeat interval The electrocardiogram derived from the chest and left ankle was measured using a time constant of 0.1 seconds, a high-cut filter 10) 1z width (manufactured by NEC Sanei Co., Ltd., multipurpose polygraph model 363) L, and the obtained electrocardiogram The R wave was automatically detected from the waveform and the R-R interval was calculated (Signal Processor 77, manufactured by NEC Sanei Co., Ltd.
18).

From this R-R interval data, 1 is calculated by the following formula.
The fennel oil administration group and the non-administration group were compared using the 0 minute heart rate interval variation coefficient ([''Vi-i) as an index.

The heartbeat interval variation coefficient for 10 minutes at rest (B, L mouth) is set as 100, and during calculation work 0 to 10 minutes (0°LOAD
IO), 10-20 minutes (0,Lro^ro20),
20-30 minutes (D, LOAD30) and 0-10 minutes at rest after calculation (A.

LOADIO), 10-20 minutes (^, to LO 802)
The results of comparing the heartbeat interval variation coefficients are shown in FIG. As shown in Figure 1, in the fennel oil non-administered group, the heart rate interval variation coefficient decreases due to stress during simple descriptive calculation work, but in the fennel oil administered group, this effect is suppressed and the heart rate interval variation decreases. The coefficient increased with a significant difference within 20% of the risk rate compared to the non-administered group, confirming that mental fatigue during calculation work was reduced.

(ii) Optical pupillary response Using an open-loop infrared binocular iris coder (C2515 manufactured by Hamamatsu Photonics), a light stimulus was applied to the right eye at a stimulus intensity of 1/2 and a light stimulus lighting time of 0.25 seconds, and the pupillary response of the right eye at that time was measured. Measurement was performed for 4.25 seconds after light stimulation. From the obtained time series data of the pupil area, the miosis rate (Cll) was calculated as shown in the following formula.

The pupillary reaction to light was measured three times in succession, and the average value of the three times of the obtained miosis rate was taken as the miosis rate at that point.

The miosis rate at rest (0 minutes) is assumed to be 100, and the calculation is performed at 10 minutes, 20 minutes, 30 minutes after the start of calculation work, and at rest 1 after the end of calculation.
The results of comparing the miosis rates at 0 minutes and 20 minutes are shown in FIG. As is clear from Figure 2, in the control group to which fennel oil was not administered, the miosis rate decreased due to the accumulation of mental fatigue due to calculation work, and did not recover immediately after the work was completed, but in the control group to which fennel oil was not administered. There was almost no decrease in the miosis rate due to calculation work, and it is clear that fennel oil has a preventive effect on eye strain.

(ii) Psychological state McNi1re explains the psychological states that occur before and after calculation work, including tension, depression, anger, vitality, fatigue, and confusion.
et al: ^n Analysis of Mood 1nN
eurotics, J, ^bnora+al and
Social Physics, 69.620
．． The method described in 1964 was used. The results are shown in Figure 3. From Figure 3, tension, repression, anger,
It was observed that there was a tendency to suppress the factors of fatigue and confusion.

Example 2 Using 12 subjects, constant temperature (24°C), constant temperature (60%)
The subjects were placed in an electromagnetically shielded room, and their electrocardiograms were measured during a 10-minute period of rest. After the measurements were completed, the resting state pupillary response was measured, and the subjects were asked to describe their psychological state at that time in a self-report questionnaire. Subsequently, an electrocardiogram was measured for 10 minutes immediately before the start of the calculation task, and subsequently, the light emitting pupillary response immediately before the start of the calculation task was measured.

Next, a keyboard-input calculation task using a personal Combi coater was performed four times in a row for a total of 40 minutes. This calculation work task was created so that the questions became more difficult every 10 minutes in order to prevent the subjects from getting used to the calculation work.

In addition, the task task is designed to be answered in 40 seconds for 20 periods, and if the answer is not entered in time, the next 20 periods will be presented, and the subject will work at the computer's pace while feeling a sense of failure. It is designed to help you learn things. Electrocardiograms were measured during the 40-minute calculation task, and immediately after the calculation was completed, the pupillary reaction to light was measured and the subjects were asked to describe their psychological state in a self-report questionnaire. Afterwards, the subjects were asked to perform the same calculation task as previously, and their electrocardiograms were measured during this period, and their pupillary responses to light were measured immediately after the calculation task was completed. After completing this task, the resting state was measured for another 20 minutes, the state of recovery from fatigue was measured, and the psychological state was described in a self-report questionnaire. This trial was conducted twice for each subject, once with and without fennel oil.

The administration of fennel oil is fennel oil (Fragrance for Hase, S
^-5057) Dissolve 1 if in liquid paraffin 30- and put it in a gas cleaning bottle, blow in air from the outside at 61/min, and let it diffuse into the shield room from a resting state 10 minutes before starting calculation work. This was done by dispersing fennel oil so that the concentration in the air was 4.5 times g/1.

(i) Respiratory variation in heartbeat interval The electrocardiogram derived from the chest and left ankle was amplified with a time constant of 0.1 seconds and a high-cut filter of 10 Hz (manufactured by NEC Sanei Co., Ltd., multipurpose polygraph model 363) L, the obtained electrocardiogram waveform The R-wave was automatically detected from the
B).

This RR interval time series data was resampled at equal M intervals using the third-order Lagrange interpolation method, and frequency analysis was performed at 512 points every 100 seconds using the fast Fourier transform method (FPT). 0.15 including the respiratory fluctuation component from the power spectrum data of the obtained frequency distribution.
The total power values at ~0 and 50 Hz were determined, and the fennel oil administration group and non-administration group were compared using this heart rate interval respiratory variation component (R3^ component) as an index.

Note that the heartbeat interval respiratory variation component for every 100 seconds was added and averaged for 500 seconds, that is, for 5 consecutive data, and the average value was taken as the heartbeat interval respiratory variation component at that point.

Based on the resting state (RBSTI) heart rate interval respiratory variation component, immediately before calculation work (RIllST2), during calculation work 0
~10 minutes (LD^Di), 10-20 minutes (LOAD2
), 20-30 minutes (LOAD3), 30-40 minutes (LOAD3),
AD4), 40-50 minutes (LOAD5), 50-60 minutes (L mouth ^ mouth 6) and 0-10 minutes at rest after calculation (RBS
The results of comparing the increases and decreases in the heartbeat interval and respiratory fluctuation components between T3) and 10 to 20 minutes (RBST4) are shown in FIG. As shown in Figure 4, in the fennel oil non-administered group,
Immediately before and after calculation work, the feeling of depression associated with mental stress increases, which activates the activity of the parasympathetic nervous system and increases the respiratory variable component, but in the fennel oil administration group, the respiratory variable component increases. There was a significant decrease compared to the group, and it was confirmed that anxiety immediately before calculation work and mental fatigue after completing the work were reduced.

(ii) Light pupillary response It was measured in the same manner as in Example 1 (i).

Based on the miosis rate at rest (-10 minutes), immediately before the start of calculation work (0 minutes), after 40 minutes of calculation work (40 MIN),
LOAD), after 60 minutes of calculation work (60MIN
LOAD), 10 minutes after resting after completing the calculation task (IOM
IN RBST>, 20 minutes later (20MIN REST)
The results of comparing the increases and decreases in the miosis rate are shown in FIG. As is clear from Figure 5, in the control group to which fennel oil was not administered, the miosis rate decreased due to the accumulation of mental fatigue due to calculation work, but in the fennel oil-administered group, the miosis rate decreased by 40.
It was confirmed that the decrease in the miosis rate was significantly suppressed after the minute calculation task was completed. In addition, for the maximum velocity of miosis (Vc) obtained from time-series data of pupil area, the average value of the three measurements is taken as the maximum velocity of miosis at that time, and the calculation is based on the resting state. Figure 6 shows the results of comparing the increases and decreases in the maximum velocity of miosis immediately before the start of the work, immediately after the end of the calculation work, and at rest after the end of the calculation work. As with the miosis rate, it was confirmed that in the 7-channel oil administration group, the decrease in the maximum velocity of miosis was suppressed with a significant difference after 40 minutes of calculation work.

(ii) Mental state Measurement was performed in the same manner as in Example 1 (iii).

The results are shown in Figure 7. From Figure 7, tension,
It was observed that there was a tendency to suppress each factor of suppression and fatigue. In particular, it was confirmed that depression and fatigue, which are indicators of mental stress, were significantly suppressed in the fennel oil administration group.

Example 3 Fennel oil (same as Example 1) toId! diameter 5
A 501 m filter paper (TOY mouth ADVANTBC5^) was impregnated with the solution and placed in a measurement container (Gundai type ambulometer, Ohara Medical Sangyo). A ddy male mouse (8 weeks old) was placed in this and left to stand, and the amount of movement for 30 minutes was counted using an ambulometer, and compared with a case in which no fennel oil-impregnated filter paper was placed. The results are shown in FIG. 8, and a significant decrease in locomotor activity was observed by administration of fennel oil.

Example 4 Diameter 55III + filter paper (↑RoYRoADVANT [
! [' 5^) and fennel oil (same as Example 1) 50
It was impregnated with I or 300 I and placed in an infusion box filled with water. Among them, ddy male mice (6 weeks old) were subjected to water immersion restraint stress, and after being left for 5 hours, the stomach was removed and incised to observe the gastric wall and evaluated by ulcer index.

Ulcer coefficient 1: Condition similar to normal stomach 2: There is almost no bleeding and the mucosal epithelium is necrotic and white. 3: Bleeding is partially observed and both surfaces are red in places. 4: Bleeding is severe and both surfaces are The result was as shown in FIG. 9, and the administration of fennel oil significantly inhibited the formation of ulcers.

Example 5 Diameter 5511+11177) Filter paper (TOYOADVAN
TBC5A) Nia, tunnel oil (same as Example 1)
30111 or 300111 was impregnated and placed in an inhalation box.

A DDY male mouse (5 weeks old) was placed in the solution and left for 30 minutes, after which 0 kg/kg of hexoparbital was administered intraperitoneally, and the sleeping time was measured using the mouse's righting reflex as an index.

The results are shown in Figure 1O, and a significant extension of sleep time was observed with the administration of fue and tunnel oil.

Example 6 (Gum) Gum base Calcium carbonate Stevioside Fennel oil Lactose (parts by weight) 0.1 76.895 Total amount Example 7 (Candy) Powdered sorbitol Fennel oil flavoring 99.93 (Parts by weight) 0, Ol 0.01 Total amount carried out Example 8 (lozenge) Gum arabic glucose fennel oil dibasic potassium phosphate dibasic potassium phosphate lactose flavoring magnesium stearate total amount Example 9 (mouth rinse) sodium lauryl sulfate glycerin ethyl alcohol fennel oil sorbitol flavor saccharin sodium water total amount 0 , 0G5 0.2 0.1 0.005 Remaining amount 0.8 0, Low 0, Old 0, Old remaining amount (parts by weight) (parts by weight) Example 10 (Liquor) Neutral Spirits Stevioside Orange Juice Fennel Oil Flavor 0 .1 0.01 0.01 (parts by weight) Total amount Example 11 (soft drink) Orange juice Sodium citrate L-Ascorbic acid Fennel oil Flavor Citric acid 0.2 0.02 0.01 0, Rho 0.2 ( (parts by weight) Total amount Example 12 (Juice) Frozen orange concentrated fruit juice Sugar 5.0 11.0 (parts by weight) Citric acid 0.2 Shi = Ascorbic! 0.02 Fennel oil 0.l Total amount 100 Example 1
3 (Black tea) Put 1.2 parts by weight of tea confectionery into an appropriate amount of hot water (80°C) and infuse it thoroughly, then filter the used tea leaves and add 3.0 parts by weight of sugar and hydrogen carbonate to the infusion solution. 0.08 parts by weight, 0.1 parts by weight of L-ascorbic acid, and 1.0 parts by weight of fennel oil, and the remaining water (20° C.) was added to make 100 parts by weight.

Example 14 (Oolong tea) 1.2 parts by weight of tea confectionery was placed in an appropriate amount of hot water (80°C), and after sufficient infusion, the used tea leaves were filtered and 0.03 parts by weight of sodium bicarbonate and L-ascorbic acid were added to the infusion liquid. 0.1 part by weight,
Add 1.0 parts by weight of fennel oil to the remaining water (20℃)
was added to make 100 parts by weight.

Example 15 (Jelly) Fennel oil 0.3 (parts by weight) Sugar Nato citrate Gelatin Water Orange juice Liumium 15.0 0.3 1.1 73, O Total amount Example 16 (Emulsion) Setanol stearate Vaseline Lanolin Alcohol Liquid paraffin Squalane S Power Roll 507 Fennel oil 20 mouths (10) Monooleate Triethanolamine Propylene Glycol Preservative 2.0 1.0 3.0 2.0 8.0 3.0 2.0 5.0 2.5 1 .0 5.0 Appropriate amount (parts by weight) Total amount of distilled water Example 17 (Nutritional cream) Stearic acid stearyl alcohol reduced lanolin squalane octyl dodecanol POB (25) Seventhyl ether glyceryl monostearate preservative fennel oil propylene glycol remaining amount 0G 2.0 7.0 2.0 5.0 6.0 3.0 2.0 Appropriate amount 2.0 5.0 (Parts by weight) Total amount Example 18 (Ointment) Stearyl alcohol Oak fennel oil 18.0 20 .0 0.5 0.25 (Parts by weight) Polyoxyethylene thousand-year-old oleic acid ester petrolatum 40.0 Total amount Example 19 (Lotion) Fennel oil Propylene glycol Citric acid 95% Ethanol PUB (20) Lauryl ether 1.0 1.0 0.2 1000 0.5 (parts by weight) Total amount Example 20 (Ripped candelilla wax solid paraffin beeswax carnauba lanolin castor oil fennel oil treatment) 9.0 8.0 5.0 5.0 11. 0 Remaining amount 1.0 (parts by weight) Isopropyl myristate 10.0 Antioxidant Appropriate amount Total amount 100 Example 2
1 (Spray agent) Ethanol 50 (parts by weight) Dichlorodifluoromethane 49.5 Fennel oil 0.5 Total amount 100 Example 22 (Fragrance agent) Isoparaffin 80 (Parts by weight) Fennel oil 20 Total amount 100 Example 23 (Fragrance agent) K - Carrageenan powder 1.1 (parts by weight) Locust bean gum 1.0 Fennel oil 5.0 Water Total remaining amount 100 [Effects of the invention] As described above, fennel oil, which is the active ingredient of the preparation of the present invention, was applied to the nasal mucosa, When absorbed through the oral mucosa or lungs, especially as a scent, fatigue caused by mental stress and ulcers that occur accompanying this can be significantly prevented or cured.

[Brief explanation of the drawing]

Figure 1 shows a comparison of the heartbeat interval variation coefficients with and without administration of fennel oil when subjects were asked to perform continuous calculation tasks, the second WJ shows a comparison of the pupil miosis rate, and the third
T! l indicates a comparison of same psychological states. Figure 4 shows a comparison of VDT heart rate and respiratory fluctuation components with and without administration of 7-ennel oil when subjects were made to perform continuous calculation tasks, and the 51st! l indicates a comparison of the same pupil miosis rate,
FIG. 6 shows a comparison of the maximum speed of miosis, and FIG. 7 shows a comparison of the same psychological states. FIG. 8 shows a comparison of locomotor activity of mice with and without administration of fennel oil. FIG. 9 shows the effect of suppressing stress ulcers by administration of fennel oil. FIG. 1O shows hexobarbital-induced sleep duration by administration of fennel oil. The above - one ae reward (Me) - one and one Fennel, Yu administration group - → Fennel oil non-effective E + group end p<o, os P<0.1 Fig. Tension suppression E 5 vitality fatigue l disorder 2. Fennel oil administration group 2. Fennel oil non-administration group αφ Kuzetun C ! 1tllll [FI! Bonito C drive ε l drive Koo e Ken Ning figure N=9-10 Group 9 figure! IS 暉=嘗: Huge procedural amendment (spontaneous) December 17, 1990

Claims (1)

[Claims] 1. Prevention and recovery from mental fatigue, characterized in that it contains fennel oil as an active ingredient, and the active ingredient is formulated in a form that is absorbed through the nasal mucosa, oral mucosa, or lungs. agent. 2. The agent for preventing and recovering from mental fatigue according to claim 1, which is a preventive and therapeutic agent for stress ulcers.