JPH04128214A - Trichogenous promoting and gray hair blackening agent - Google Patents
Trichogenous promoting and gray hair blackening agentInfo
- Publication number
- JPH04128214A JPH04128214A JP2247825A JP24782590A JPH04128214A JP H04128214 A JPH04128214 A JP H04128214A JP 2247825 A JP2247825 A JP 2247825A JP 24782590 A JP24782590 A JP 24782590A JP H04128214 A JPH04128214 A JP H04128214A
- Authority
- JP
- Japan
- Prior art keywords
- hair
- agent
- solution
- trichogenous
- organic solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000001737 promoting effect Effects 0.000 title claims description 10
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 11
- 239000000284 extract Substances 0.000 claims abstract description 9
- 239000003960 organic solvent Substances 0.000 claims abstract description 8
- 239000000341 volatile oil Substances 0.000 claims abstract description 7
- 238000001256 steam distillation Methods 0.000 claims abstract description 5
- 230000003779 hair growth Effects 0.000 claims description 13
- 241000219793 Trifolium Species 0.000 claims description 3
- 241000208195 Buxaceae Species 0.000 claims 1
- 239000012752 auxiliary agent Substances 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract description 11
- 235000016639 Syzygium aromaticum Nutrition 0.000 abstract description 6
- 235000019441 ethanol Nutrition 0.000 abstract description 6
- 210000004761 scalp Anatomy 0.000 abstract description 4
- 239000005556 hormone Substances 0.000 abstract description 2
- 229940088597 hormone Drugs 0.000 abstract description 2
- 239000000126 substance Substances 0.000 abstract description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 abstract 2
- 244000266945 Decaspermum fruticosum Species 0.000 abstract 2
- 244000061408 Eugenia caryophyllata Species 0.000 abstract 2
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 abstract 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 abstract 1
- 229930003427 Vitamin E Natural products 0.000 abstract 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 abstract 1
- 230000003450 growing effect Effects 0.000 abstract 1
- 239000002304 perfume Substances 0.000 abstract 1
- 229940046009 vitamin E Drugs 0.000 abstract 1
- 235000019165 vitamin E Nutrition 0.000 abstract 1
- 239000011709 vitamin E Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 14
- 201000004384 Alopecia Diseases 0.000 description 8
- 230000003676 hair loss Effects 0.000 description 8
- 208000024963 hair loss Diseases 0.000 description 8
- 230000003247 decreasing effect Effects 0.000 description 6
- 239000002904 solvent Substances 0.000 description 5
- 244000223014 Syzygium aromaticum Species 0.000 description 4
- 238000000605 extraction Methods 0.000 description 3
- 230000002087 whitening effect Effects 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 230000000202 analgesic effect Effects 0.000 description 2
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 2
- NPNUFJAVOOONJE-ZIAGYGMSSA-N β-(E)-Caryophyllene Chemical compound C1CC(C)=CCCC(=C)[C@H]2CC(C)(C)[C@@H]21 NPNUFJAVOOONJE-ZIAGYGMSSA-N 0.000 description 2
- NVEQFIOZRFFVFW-UHFFFAOYSA-N 9-epi-beta-caryophyllene oxide Natural products C=C1CCC2OC2(C)CCC2C(C)(C)CC21 NVEQFIOZRFFVFW-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 244000144730 Amygdalus persica Species 0.000 description 1
- NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 description 1
- PLQDLOBGKJCDSZ-UHFFFAOYSA-N Cypromid Chemical compound C1=C(Cl)C(Cl)=CC=C1NC(=O)C1CC1 PLQDLOBGKJCDSZ-UHFFFAOYSA-N 0.000 description 1
- 239000005770 Eugenol Substances 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 241001166994 Kummerowia striata Species 0.000 description 1
- 241000594592 Lanugo Species 0.000 description 1
- 241000219926 Myrtaceae Species 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 235000006040 Prunus persica var persica Nutrition 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- UVMRYBDEERADNV-UHFFFAOYSA-N Pseudoeugenol Natural products COC1=CC(C(C)=C)=CC=C1O UVMRYBDEERADNV-UHFFFAOYSA-N 0.000 description 1
- 244000184734 Pyrus japonica Species 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- FAMPSKZZVDUYOS-UHFFFAOYSA-N alpha-Caryophyllene Natural products CC1=CCC(C)(C)C=CCC(C)=CCC1 FAMPSKZZVDUYOS-UHFFFAOYSA-N 0.000 description 1
- NPNUFJAVOOONJE-UHFFFAOYSA-N beta-cariophyllene Natural products C1CC(C)=CCCC(=C)C2CC(C)(C)C21 NPNUFJAVOOONJE-UHFFFAOYSA-N 0.000 description 1
- 229940117948 caryophyllene Drugs 0.000 description 1
- NPNUFJAVOOONJE-UONOGXRCSA-N caryophyllene Natural products C1CC(C)=CCCC(=C)[C@@H]2CC(C)(C)[C@@H]21 NPNUFJAVOOONJE-UONOGXRCSA-N 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 239000001353 eugenia caryophyllata l. Substances 0.000 description 1
- 229960002217 eugenol Drugs 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 125000001232 pantothenyl group Chemical group C(CCNC([C@H](O)C(C)(C)CO)=O)(=O)* 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 230000003658 preventing hair loss Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000008326 skin blood flow Effects 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
- 235000012141 vanillin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Landscapes
- Cosmetics (AREA)
Abstract
Description
【発明の詳細な説明】 （産業上の利用分野） 本発明は発毛促進・白髪黒化剤に間する。[Detailed description of the invention] (Industrial application field) The present invention is directed to an agent for promoting hair growth and graying hair.
（従来の技術）
丁香の花蕾又はフンシュンツブの若葉、花穂はオイゲノ
ール、その酢酸エステル、カリオフィレン、バニリン等
の精油を含有し、古くからスパイス、香料として用いら
れ、その精油は皮膚刺激作用、殺１１消毒作用、鎮痛作
用等があって、医薬品原料として使用されてきた。(Prior art) The flower buds of the clove or the young leaves and flower spikes of the Chinese clove contain essential oils such as eugenol, its acetate, caryophyllene, and vanillin, and have been used as spices and fragrances since ancient times. It has analgesic and analgesic effects, and has been used as a raw material for pharmaceuticals.
本発明者はこれら植物抽圧液の生理作用を研究の結果、
皮膚に障害を及ぼすことなく、皮膚血流を増進し、発毛
促進・脱毛予防・刺毛硬化・白髪黒化等の作用を有する
ことを見出した。As a result of research on the physiological effects of these plant extracts, the present inventor found that
It has been found that it increases skin blood flow without causing any damage to the skin, and has effects such as promoting hair growth, preventing hair loss, hardening stinging hair, and graying hair.
（発明が解決しようとする課題）
本発明の目的は何ら皮膚に悪影響を及ぼさず優れた発毛
、育毛作用を有する発毛促進・白髪黒化剤を提供するこ
とにある。(Problems to be Solved by the Invention) An object of the present invention is to provide a hair growth promoting/whitening agent that does not have any adverse effects on the skin and has excellent hair growth and hair growth effects.
（ｍ１題を解決するための手段）
本発明は丁香の花蕾又はコンシュンツゲの若葉、花穂を
有機溶媒により抽出した抽出液、或いはこれらを水蒸気
蒸留して得られる精油を有機溶媒に溶解して得られる溶
液からなることを特徴とする発毛促進・白髪黒化剤に係
る。(Means for Solving Problem M1) The present invention is an extract obtained by extracting the flower buds of clover or the young leaves and flower spikes of Konshutsuge with an organic solvent, or an essential oil obtained by steam distillation of these, which is obtained by dissolving in an organic solvent. This invention relates to a hair growth promoting and graying hair darkening agent, which is comprised of a solution.
本発明においては丁香（丁子、丁字）の花蕾又はフンシ
ュンツブの若葉、花！（以下、本植物部分ということが
ある）を有機溶媒で抽出する。上記丁香は学名がＥ ｕ
ｇｅｎｉａ ａｒｏｍａｔｉｃａ ＫＬＩＮＴＺＥ
＝Ｅ、 ｅａｒｙｏｐｌ＋ｙｌｌａｔａ Ｔ）ＩＵＮ
ＢＥＲ（ａ （Ｍｙｒｔａｃｅａｅ７トモモ科）であ
り、フンシュンツブは学名がＤｅｃａｓｐｅｒａ＋ｕｍ
ｆｒｕＬｉｅｏｓｕｍ ＦＯＲＳＴ （
Ｍｙｒｔａｃｅａｅ７Ｆモモ科）である植物である。In the present invention, the flower buds of clove (clobber, clove) or the young leaves and flowers of Japanese clover! (hereinafter sometimes referred to as this plant part) is extracted with an organic solvent. The scientific name of the above clover is E u
genia aromatica KLINTZE
=E, earlyopl+yllata T)IUN
BER (a (Myrtaceae7 Aleaceae)), and the scientific name of the fungus is Decaspera + um.
fruLieosum FORST (
Myrtaceae 7F (family Peach family).
抽出溶媒としては、例えばアルコール、エーテル、ケト
ン、エステル等を使用できるが、中でも肴エチルアルコ
ールが最も好ましい。具体的には本植物部分を５〜１０
倍量の３０〜９９％の範囲の抽出溶媒で冷浸し濾過する
。冷浸及び−過は１回〜数回行うのが好ましい。水蒸気
蒸留は通常の化学的方法に基づいて行い、得られる精油
を０．２〜１．５％の濃度になるように有機溶媒に溶解
するのが好ましい。有１１ｉ媒としては上記で用いた抽
出溶媒と同様の溶媒を用いることができる。As the extraction solvent, for example, alcohol, ether, ketone, ester, etc. can be used, but among them, ethyl alcohol is the most preferred. Specifically, 5 to 10 parts of this plant
Cold soak with extraction solvent ranging from 30 to 99% of double volume and filter. It is preferable to carry out cooling and filtration once to several times. It is preferable that the steam distillation is carried out based on a conventional chemical method, and the obtained essential oil is dissolved in an organic solvent to a concentration of 0.2 to 1.5%. As the 11i medium, the same solvent as the extraction solvent used above can be used.
かくして得られる抽出液或いは溶液に、例えば適量の女
性ホルモン類、エデト酢酸塩、パントテニールアルフー
ル、ビタミンＥ１香料等を配合しても差し支えない。本
発明の発毛促進・白髪黒化剤は例えば１日１〜２回、１
回１〜３ｖｌｌを頭皮に振り掛け１〜２分開、指頭で軽
くマッサーノして浸透させるのが好ましい。For example, an appropriate amount of female hormones, edetacetate, pantothenyl alfur, vitamin E1 fragrance, etc. may be added to the extract or solution thus obtained. The hair growth promoting/whitening agent of the present invention may be administered once or twice a day, for example.
It is preferable to sprinkle 1 to 3 ml onto the scalp, leave it open for 1 to 2 minutes, and gently massage it with your fingertips to allow it to penetrate.
（実 施 例）
以下に実施例を季げて説明する。これらの実施例は何ら
本発明の範囲を限定するものではない。(Example) Examples will be explained below. These examples do not limit the scope of the invention in any way.
実施例１
丁１の花蕾（丁字）５０ｇに７０％−エチルアルコール
２００＠ｌを加えて１〜３日室温に族Ｎ後、枦遇する。Example 1 200@l of 70% ethyl alcohol was added to 50 g of clove buds (Cho), and the mixture was kept at room temperature for 1 to 3 days.
同様の操作を２００ｍｆずつの同じ溶媒を用いて３回繰
り返す。このようにして５０．の丁字から約５００Ｉｌ
ｌｌの赤褐色透明の抽出液からなる本発明の発毛促進・
白髪黒化剤を得る。本抽出液は空気中において次第に着
色の度を増すので、不透明容器に満杯とし、冷暗所に置
くことが望ましい。The same operation is repeated three times using 200 mf of the same solvent. In this way, 50. Approximately 500 Il from the T character of
The hair growth promoting product of the present invention consists of a reddish-brown transparent extract of
Obtain a gray hair blackening agent. Since the color of this extract gradually increases in the air, it is desirable to fill an opaque container and store it in a cool, dark place.
実施例２
フンシュンツブの若葉、花穂の陰干し乾燥したもの１ｋ
ｇを３０分水蒸気蒸留して、約８０６の精油を得る。こ
の精油 １Ｅに７０％エチルアルコール１００ｍ１を加
えて溶解して本発明の発毛促進・白髪黒化剤を得る。保
存については実施例１と同様である。Example 2 1k of dried young leaves and flower spikes of Rhizophrenia japonica dried in the shade
g is steam distilled for 30 minutes to obtain approximately 806 essential oils. 100 ml of 70% ethyl alcohol is added to this essential oil 1E and dissolved to obtain the hair growth promoting/whitening agent of the present invention. Storage is the same as in Example 1.
試験例１
対象ニ一般ボランティア
１日１〜２回、特に洗髪乾燥後、０．５〜３ｍｌを頭皮
に振り掛け、軽くマッサーノした。Test Example 1 Subject - General volunteers Once or twice a day, especially after washing and drying the hair, 0.5 to 3 ml was sprinkled on the scalp and lightly massaged.
症例■ ３７オ、男子 −ケ月使用
効果：脱毛減少
症例■ ２６オ、男子 −ケ月使用
効果：脱毛減少
症例０３７オ、男子 二ケ月使用
効果：脱毛減少
症例■ ４１才、男子 三ケ月使用
効果二二ケ月目で産毛発生、三ケ月目で毛が太くなって
きた。Case ■ 37 years old, male - Months usage effect: Reduced hair loss Case ■ 26 years old, boy - Months usage effect: Reduced hair loss case 037 Boys, 2 months Use effect: Reduced hair loss case ■ 41 years old, male 3 months usage effect: 22 months Lanugo hair has developed in the eyes, and the hair has become thicker by the third month.
症例■ ３９才、男子 三ケ月使用
効果二−ケＨ目で産毛発生、二ケ月後には毛が太くなっ
てきた。Case ■ 39-year-old male. Effect of using the product for 3 months. Hair started to develop after 2 months. After 2 months, the hair became thicker.
症例０４５才、女性 三ケ月使用
効果＝１ケ月で脱毛減少、二ケ月目で毛が太くなってき
た。Case 0: 45-year-old female. Effects after 3 months of use: Hair loss decreased after 1 month, and hair became thicker after 2 months.
症例■ ６０才、男子 四ケ月使用
効果：三ケ月位から毛が少し生え始めて次第に濃くなっ
てきた。Case ■ 60-year-old male Effects after using for 4 months: After about 3 months, hair started to grow a little and gradually became thicker.
症例■ ４２才、男子 九ケ月使用
効果：脱毛が減少すると共に、−ケ月目位から毛が少し
ずつ濃くなって外た。Case ■ 42-year-old male After 9 months of use Effect: Hair loss decreased, and the hair gradually became thicker and fell off from around month 2.
試験例２
症例■ ４５才、女子 二ケ月使用
効果：７ケ、カユミが減り、脱毛が減った一ケ月目位か
ら髪が濃くなって産毛が生えて軽だ。Test Example 2 Case■ 45-year-old female 2 months of use Effects: 7 cases After about the first month, the itching decreased and hair loss decreased, and the hair became thicker and grew finer hair.
症例■ ４３才、女子 二週間使用 効果：脱毛が減り、髪が太くなって腰が呂できた。Case: 43 years old, female, used for 2 weeks Effects: Hair loss decreased, hair became thicker, and my waist felt better.
症例■ ４３才、男子 −ケ月使用 効果：脱毛が減少した。Case: 43 years old, male - Monthly use Effect: Hair loss decreased.
（以 上） 代(that's all) teenager
Claims (2)
機溶媒により抽出した抽出液、或いはこれらを水蒸気蒸
留して得られる精油を有機溶媒に溶解して得られる溶液
からなることを特徴とする発毛促進・白髪黒化剤。(1) Hair growth characterized by consisting of an extract obtained by extracting the flower buds of clover or the young leaves and flower spikes of Japanese boxwood using an organic solvent, or a solution obtained by dissolving essential oil obtained by steam distillation of these in an organic solvent. Accelerator and gray hair blackening agent.
の発毛促進・白髪黒化剤。(2) The agent for promoting hair growth and graying hair according to claim 1, further comprising an auxiliary agent for promoting hair growth and hair growth.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2247825A JPH04128214A (en) | 1990-09-17 | 1990-09-17 | Trichogenous promoting and gray hair blackening agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2247825A JPH04128214A (en) | 1990-09-17 | 1990-09-17 | Trichogenous promoting and gray hair blackening agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH04128214A true JPH04128214A (en) | 1992-04-28 |
Family
ID=17169228
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2247825A Pending JPH04128214A (en) | 1990-09-17 | 1990-09-17 | Trichogenous promoting and gray hair blackening agent |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH04128214A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2735026A1 (en) * | 1995-06-07 | 1996-12-13 | Fabre Pierre Dermo Cosmetique | HAIR COMPOSITION COMPRISING MYRTLE EXTRACT, ITS PREPARATION METHOD AND ITS USE IN PARTICULAR FOR ANTI-DANDRUFF TREATMENT. |
| JP2002212040A (en) * | 2001-01-19 | 2002-07-31 | Kanebo Ltd | Gray hair preventing cosmetic |
| JP2013203730A (en) * | 2012-03-29 | 2013-10-07 | Kobayashi Pharmaceutical Co Ltd | Trichogenous agent |
| US20130323331A1 (en) * | 2011-02-16 | 2013-12-05 | Korea Institute Of Oriental Medicine | Pharmaceutical composition for preventing and treating inflamatory disease or asthma containing an extract of decaspermum fruticosum |
-
1990
- 1990-09-17 JP JP2247825A patent/JPH04128214A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2735026A1 (en) * | 1995-06-07 | 1996-12-13 | Fabre Pierre Dermo Cosmetique | HAIR COMPOSITION COMPRISING MYRTLE EXTRACT, ITS PREPARATION METHOD AND ITS USE IN PARTICULAR FOR ANTI-DANDRUFF TREATMENT. |
| WO1996040180A1 (en) * | 1995-06-07 | 1996-12-19 | Pierre Fabre Dermo-Cosmetique | Hair composition comprising a myrtle extract, preparation process and utilization particularly for an anti-dandruff treatment |
| JP2002212040A (en) * | 2001-01-19 | 2002-07-31 | Kanebo Ltd | Gray hair preventing cosmetic |
| US20130323331A1 (en) * | 2011-02-16 | 2013-12-05 | Korea Institute Of Oriental Medicine | Pharmaceutical composition for preventing and treating inflamatory disease or asthma containing an extract of decaspermum fruticosum |
| CN103501797A (en) * | 2011-02-16 | 2014-01-08 | 韩国生命工学研究院 | Pharmaceutical composition for preventing and treating inflammatory disease or asthma containing an extract of decaspermum fruticosum |
| US8883226B2 (en) * | 2011-02-16 | 2014-11-11 | Korea Institute Of Oriental Medicine | Pharmaceutical composition for the prevention and treatment of inflammatory disease or asthma containing an extract of Decaspermum fruticosum |
| JP2013203730A (en) * | 2012-03-29 | 2013-10-07 | Kobayashi Pharmaceutical Co Ltd | Trichogenous agent |
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