JPH0412759A - Hollow yarn type blood processor - Google Patents
Hollow yarn type blood processorInfo
- Publication number
- JPH0412759A JPH0412759A JP11646190A JP11646190A JPH0412759A JP H0412759 A JPH0412759 A JP H0412759A JP 11646190 A JP11646190 A JP 11646190A JP 11646190 A JP11646190 A JP 11646190A JP H0412759 A JPH0412759 A JP H0412759A
- Authority
- JP
- Japan
- Prior art keywords
- blood
- header
- hollow fiber
- port
- processing device
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008280 blood Substances 0.000 title claims abstract description 113
- 210000004369 blood Anatomy 0.000 title claims abstract description 113
- 210000003734 kidney Anatomy 0.000 claims abstract description 15
- 239000012510 hollow fiber Substances 0.000 claims description 43
- 238000005192 partition Methods 0.000 claims description 8
- 239000012530 fluid Substances 0.000 claims description 6
- 238000005406 washing Methods 0.000 abstract 1
- 230000017531 blood circulation Effects 0.000 description 5
- 230000004087 circulation Effects 0.000 description 3
- 241000283690 Bos taurus Species 0.000 description 2
- 208000007536 Thrombosis Diseases 0.000 description 2
- 230000023555 blood coagulation Effects 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical group OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 230000002785 anti-thrombosis Effects 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 239000012503 blood component Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 238000001631 haemodialysis Methods 0.000 description 1
- 230000000322 hemodialysis Effects 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 238000004382 potting Methods 0.000 description 1
- 239000004627 regenerated cellulose Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
Landscapes
- External Artificial Organs (AREA)
Abstract
Description
【発明の詳細な説明】 （発明の利用分野） 本発明は、中空糸型血液処理装置に関するものである。[Detailed description of the invention] (Field of application of the invention) The present invention relates to a hollow fiber type blood processing device.
詳しく述べると、血液ポート部において血液のよどみが
なく、かつ各中空糸へ血液を均等に分配することのでき
る中空糸型血液処理装置に関するものである。More specifically, the present invention relates to a hollow fiber type blood processing device that does not stagnate blood in a blood port portion and can evenly distribute blood to each hollow fiber.
（従来の技術）
従来より中空糸型血液処理装置は、人工腎臓、人工肝臓
、血漿分離装置、人工肺等として広く使用されてきてい
る。このような中空糸型血液処理装置は、例えば人工腎
臓を例にとって説明すると、両端にそれぞれ血液流入口
ポートおよび血液流出口ポートを、また側壁部にそれぞ
れ透析液流入口および透析液流出口を備え円筒状本体内
に多数の中空糸を収納し、該中空糸の両端に設けられた
隔壁により該中空糸を前記円筒状本体に固定するととも
に、前記中空糸を前記各ポートと連通させてなるもので
ある。しかして、前記のごとき中空糸型血液処理装置に
おいては、血液流入口ポートおよび血液流出口ポートと
は色分は等による近いはあったが、内部形状については
同一のものが使用されている。(Prior Art) Hollow fiber blood processing devices have been widely used as artificial kidneys, artificial livers, plasma separation devices, artificial lungs, and the like. Taking an artificial kidney as an example, such a hollow fiber blood processing device is equipped with a blood inlet port and a blood outlet port at both ends, and a dialysate inlet and a dialysate outlet at the side wall. A device in which a large number of hollow fibers are housed in a cylindrical body, the hollow fibers are fixed to the cylindrical body by partition walls provided at both ends of the hollow fibers, and the hollow fibers are communicated with each of the ports. It is. Therefore, in the hollow fiber type blood processing apparatus as described above, the blood inlet port and the blood outlet port are similar in color, etc., but have the same internal shape.
しかしながら、このような従来の中空糸型血液処理装置
においては、血液が体外循環回路を経て中空糸型人工腎
臓に流入する際に、血液流通管より広い血液流入口ポー
トの空間に流入して、その空間体積の増加によって血液
成分の損傷が考えられ、それに起因する血液凝固の問題
があった。また、中空糸内を通過した血液が血液流出口
ポート内を流通する際に、該ポート内において血液の滞
留に起因する血液凝固の問題があった。However, in such conventional hollow fiber type blood processing devices, when blood flows into the hollow fiber type artificial kidney via the extracorporeal circulation circuit, it flows into the space of the blood inlet port which is wider than the blood distribution tube. It is thought that the increase in spatial volume may damage blood components, and there is a problem with blood coagulation caused by this. Furthermore, when the blood that has passed through the hollow fibers flows through the blood outlet port, there is a problem of blood coagulation due to blood retention within the port.
一方、血液流入口ポートまたは血液流出口ポートを形成
する各ヘッダーが共に中空糸束の端面を底とする山形の
内部空間を有してなる中空糸型血液処理装置は知られて
いる（４）開閉５７−８６゜３５９号、特開昭５９−１
３９，２７４号および特公昭５９−４０，４８１号）。On the other hand, a hollow fiber type blood processing device is known in which each header forming a blood inlet port or a blood outlet port has a chevron-shaped internal space whose bottom is the end face of a hollow fiber bundle (4). Opening/closing No. 57-86゜359, JP-A-59-1
39,274 and Special Publication No. 59-40,481).
しかしながら、これらの血液処理装置は、いずれも両端
のヘッダーの形状が同一であるため、前記のごとき理由
により種々の問題点があった。However, since all of these blood processing apparatuses have headers at both ends that have the same shape, they have had various problems for the reasons mentioned above.
（発明が解決しようとする課題）
したがって、本発明の目的は、新規な中空糸型血液処理
装置を提供することにある。本発明の他の目的は、血液
ポート部においてよどみがなく、かつ各中空糸へ血液を
均等に分配することのできる中空糸型血液処理装置を提
供することにある。(Problems to be Solved by the Invention) Therefore, an object of the present invention is to provide a novel hollow fiber type blood processing device. Another object of the present invention is to provide a hollow fiber type blood processing device that is free from stagnation at the blood port and can evenly distribute blood to each hollow fiber.
（課題を解決するための手段）
これらの諸口的は、両端にそれぞれ血液流入口ポートお
よび血液流出口ポートを備えかつ側壁部に物質移動流体
流入口および物質移動流体流出口を備えた円筒状本体と
、該円筒状本体内に収容されるとともに、その両端を隔
壁により該円筒状本体に固定されかつその両端部が前記
両ポートに連通してなる多数の中空糸とよりなる中空糸
型血液処理装置において、前記血液流入口ポートと血液
流出口ポートの内部形状が互いに異なる形状であること
を特徴とする中空糸型血液処理装置により達成される。(Means for Solving the Problems) These ports include a cylindrical body having a blood inlet port and a blood outlet port at both ends, respectively, and a mass transfer fluid inlet and a mass transfer fluid outlet on the side wall. and a hollow fiber type blood treatment comprising a large number of hollow fibers housed in the cylindrical body, both ends of which are fixed to the cylindrical body by partition walls, and both ends of which are communicated with the two ports. This is achieved by a hollow fiber type blood processing device characterized in that the internal shapes of the blood inlet port and the blood outlet port are different from each other.
本発明はまた、血液流入口ポートの内面傾斜角θ１と、
血液流出口ポートの内面傾斜角θ２との比θ１／θ２が
１．１〜３．０である中空糸型血液処理装置である。本
発明はさらに、血液流入口ポートの内面傾斜角θｌが１
０’〜３０″の範囲である中空糸型血液処理装置である
。本発明はまた、血液処理装置が人工腎臓である中空糸
型血液処理装置である。The present invention also provides an inner surface inclination angle θ1 of the blood inlet port;
This is a hollow fiber type blood processing device in which the ratio θ1/θ2 to the inner surface inclination angle θ2 of the blood outlet port is 1.1 to 3.0. The present invention further provides that the inner surface inclination angle θl of the blood inlet port is 1.
The present invention is also a hollow fiber blood processing device in which the blood processing device is an artificial kidney.
（作用）
本発明における中空糸型血液処理装置とは、人工腎臓、
人工肝臓、血漿分離装置、人・１肺等をいう。したがっ
て、つぎに図面を参照しながら人工腎臓を例にとって、
本発明による中空糸血液処理装置について説明する。(Function) The hollow fiber blood processing device in the present invention includes an artificial kidney,
Refers to artificial livers, plasma separators, human lungs, etc. Therefore, next, referring to the drawings and taking an artificial kidney as an example,
A hollow fiber blood processing device according to the present invention will be explained.
第１図は、本発明による中空糸型人工腎臓を示すもので
ある。すなわち、人工腎臓１は、相対する端部付近に透
析液流入口２ｉよび透析液流出口３を備えた筒状本体４
よりなり、該筒状本体４内には中空糸束５が内蔵され、
その両端は、例えばポリウレタン等のポツティング剤で
形成される隔壁６，７で該筒状本体４に固定されてシー
ルされている。該筒状本体４の両開口端には、血液流入
口８および血液流出口９をそれぞれ備えたヘッダー１０
．１１がそれぞれねじリング１２．１３により固定され
ている。FIG. 1 shows a hollow fiber artificial kidney according to the present invention. That is, the artificial kidney 1 includes a cylindrical body 4 having a dialysate inlet 2i and a dialysate outlet 3 near opposing ends.
A hollow fiber bundle 5 is built in the cylindrical main body 4,
Both ends thereof are fixed and sealed to the cylindrical body 4 by partition walls 6 and 7 formed of a potting agent such as polyurethane. At both open ends of the cylindrical body 4, there is a header 10 provided with a blood inlet 8 and a blood outlet 9, respectively.
．． 11 are each fixed by a screw ring 12, 13.
前記のように、人工腎臓において、血液流入口８を備え
たヘッダー１０が血液流入口ポートを形成し、また血液
流出口９を備えたヘッダー１１が血液流出口ポートを形
成している。しかして、本発明によれば、前記血液流入
口ポートの内部形状と前記血液流出口ポートの内部形状
とが互いに異なる形状であることが必要である。As mentioned above, in the artificial kidney, the header 10 with the blood inlet 8 forms the blood inlet port, and the header 11 with the blood outlet 9 forms the blood outlet port. According to the present invention, it is necessary that the internal shape of the blood inlet port and the internal shape of the blood outlet port be different from each other.
例えば、第２図および第３図に示すように、血液流入口
ポートの内部形状として、ヘッダー１０の内部形状を大
きく、特に隔壁８の面に対するヘッダー１０の内部傾斜
を大きくするとともに、血液流出口ポートの内部形状と
して、ヘッダー１１の内部形状を小さく、特に隔！！１
￥９の面に対するヘッダー１１の内面傾斜を小さくとっ
て両ポートを形成する。For example, as shown in FIGS. 2 and 3, the internal shape of the blood inlet port is increased by increasing the internal shape of the header 10, especially by increasing the internal slope of the header 10 with respect to the surface of the partition wall 8, and by increasing the internal shape of the blood inlet port. As for the internal shape of the port, the internal shape of the header 11 should be made small, especially the distance! ! 1
Both ports are formed by making the inner surface slope of the header 11 small with respect to the plane of ¥9.
このように両ポートを形成することにより、第２図に示
すように、内径４〜１１０ｌｌ１の体外血液循環回路（
図示せず）を流通してきて血液流入口８より流入した血
液は、血液流入口ポート内において、ヘッダー１０の内
面傾斜が大きいために徐々に均一に広がりながら均一の
流速を保って中空糸内へと流入していく。一方、該中空
糸内を流通した血液は、血液流出ロポート内において、
ヘッダー１１の内面傾斜が小さいために、第３図に示す
ように、血液流出口ポートの内壁を均一に洗い流しなが
ら血液回路（図示せず）内へと流出して人工腎臓より排
出される。By forming both ports in this way, as shown in Fig. 2, an extracorporeal blood circulation circuit (
(not shown) and flows into the blood inlet port 8, the blood gradually spreads uniformly in the blood inlet port because the inner surface of the header 10 has a large slope, maintains a uniform flow rate, and enters the hollow fiber. And it's flowing in. On the other hand, the blood that has passed through the hollow fibers is stored in the blood outflow port.
Since the inner surface slope of the header 11 is small, as shown in FIG. 3, the blood flows into the blood circuit (not shown) while uniformly flushing the inner wall of the blood outlet port and is discharged from the artificial kidney.
つぎに、前記血液流入口ポートと血液流出口ポートとを
逆に付した場合のポート内の血液の流れを第４図および
′：ｆＪ５図に示す。この場合、ポート内の流速は均一
にならず、第４図に示すようにヘッダ７１０の内面傾斜
が小さいため、周辺部に血液が滞留したりあるいは流れ
ない部分が生じてくるために、血栓を生じる要因を住み
出す結果となる。−ノｉ’、’Ｆ５５図に示すように、
ヘッダー１１の内面傾斜が大きいため、中心部のみ流速
が速く、周辺に滞留部が生じることにより血Ｉ↑を望じ
る要因を生み出す。Next, FIG. 4 and FIG. fJ5 show the flow of blood in the ports when the blood inlet port and the blood outlet port are reversely attached. In this case, the flow velocity within the port is not uniform, and as shown in FIG. 4, the inner surface slope of the header 710 is small, so blood stagnates around the periphery or there are areas where it does not flow, which can prevent blood clots. The result is to inhabit the factors that occur. -noi', 'F55 As shown in figure,
Since the inner surface of the header 11 has a large inclination, the flow velocity is high only in the center, and a stagnation part is generated around the periphery, which causes a desire for blood I↑.
しかして、本発明においては、血液流入ロポー）・の内
面傾斜角θ１と、血液流出口ボー）・の内面傾斜角θ２
との比θ１／θ２が１．１〜３． ０、特に１．１９〜
２．５であることが好ましい。また、血液流入口ポート
の内面傾斜角θ１が１０’〜３０°１特に１２°〜２６
°の範囲であることが好ましい。なお、本明細書におい
て、各血液流出入ポーｊ・の内面傾ネ１角θとは、第６
図に示すように、中空系束を固定する隔壁ないしはこれ
と平行な而Ａに対するヘッダー１０または１１の内壁面
Ｂの角度を意味する。Therefore, in the present invention, the inner surface inclination angle θ1 of the blood inflow port) and the inner surface inclination angle θ2 of the blood outlet port
The ratio θ1/θ2 is 1.1 to 3. 0, especially 1.19~
Preferably it is 2.5. In addition, the inner surface inclination angle θ1 of the blood inlet port is 10' to 30°1, especially 12° to 26°.
Preferably, it is in the range of . In addition, in this specification, the inner inclination angle θ of each blood inflow/outflow port j is the sixth
As shown in the figure, it means the angle of the inner wall surface B of the header 10 or 11 with respect to the partition wall that fixes the hollow system bundle or to the wall A parallel thereto.
（実施例）
つぎに、実施例を挙げて本発明をさらに詳細に説明する
。(Example) Next, the present invention will be described in further detail by giving examples.
実施例
第１〜３図に示す中空糸型人工腎臓１において、血液流
入口ポートの内面傾斜角θ１および血液流出口ポートの
内面傾斜角θ２を、第１表に示すように形成し、中空糸
膜（再生セルロース製）の総面積を１．２ハとして、牛
血液による血液透析実験（ｅｘ ｖｉｖｏ）を実施し
た。このときのＱ Ｂ ＝ ２００ｒｎｌ／ｍｉｎで、
Ｑ ｐ＝ ５００ ｏｗｌ／ｍｉｎであった。なお、ヘ
パリン投与は、牛血液採取時の１，０００単位のみとし
た。Example In the hollow fiber artificial kidney 1 shown in FIGS. 1 to 3, the inner surface inclination angle θ1 of the blood inlet port and the inner surface inclination angle θ2 of the blood outlet port are formed as shown in Table 1, and the hollow fiber A hemodialysis experiment (ex vivo) using bovine blood was conducted using a membrane (made of regenerated cellulose) with a total area of 1.2 ha. At this time, Q B = 200rnl/min,
Q p = 500 owl/min. Note that only 1,000 units of heparin was administered at the time of bovine blood collection.
第 表 このときの実験結果を第２表に示す。No. table The experimental results at this time are shown in Table 2.
５１づ
表
表内は循環可能時間を示す（ｈｒ）
（発明の効果）
以」−述べたように、本発明は、両端にそれぞれ血液流
入口ポートおよび血液流出口ポートを備えかつ側壁部に
物質移動流体流入口および物質移動流体出口を備えた円
筒状本体と、該円筒状本体内に収容されるとともにその
両端を隔壁により該円筒状本体に固定されかつその両端
部が前記両ポートに連通してなる多数の中空糸とよりな
る中空糸型血液処理装置において、前記血液流入口ポー
トと血液流出口ポートの内部形状が互いに異なる形状で
あることを特徴とする中空糸型血液処理装置であるから
、各中空糸内に均一に血液が配分されて血液の偏流がな
くなるので、両ポート内と各中空糸内での血液の流れが
整備されて理想的な抗血栓性モジュール形状が得られる
のである。Table 51 shows the possible circulation time (hr) (Effects of the Invention) As described above, the present invention has a blood inlet port and a blood outlet port at both ends, and a material on the side wall. a cylindrical body having a transfer fluid inlet and a mass transfer fluid outlet; housed within the cylindrical body; both ends fixed to the cylindrical body by partition walls; both ends communicating with the ports; A hollow fiber type blood processing device comprising a large number of hollow fibers, characterized in that the internal shapes of the blood inlet port and the blood outlet port are different from each other. Since blood is evenly distributed within each hollow fiber and there is no unbalanced flow of blood, the blood flow within both ports and within each hollow fiber is maintained, resulting in an ideal antithrombotic module shape. .
また、血液流入口ポートの内面傾斜ｆ４θ１と、血液流
出口ポートの内面傾斜角θ２との比θＩ／θ２を１．１
〜３．０とすることにより、血栓を生じることなく長期
間にわたって血液の体外循環が可能となるのである。In addition, the ratio θI/θ2 of the inner surface inclination f4θ1 of the blood inlet port and the inner surface inclination angle θ2 of the blood outlet port is 1.1.
By setting the value to 3.0, extracorporeal circulation of blood becomes possible for a long period of time without causing thrombus.
第１図は本発明による中空糸型人工腎臓の部分断面全体
図、第２図は血液流入口ポートの拡大断面図、第３図は
血液流出口ポートの拡大断面図、第４図は血液流入口ポ
ートの他の例を示す拡大断面図、第５図は血液流出口ポ
ートの他の例を示す拡大断面図であり、また第６図は内
面傾斜角を説明するための模式図である。
１・・・人工腎臓、４・・・筒状本体、５・・・中空糸
束、６．７・・・隔壁、８・・・血液流入口、９・・・
血液流出口、１１．１２・・・ヘッダー
２面の冷−、？伊り容に変更なし）Fig. 1 is an overall partially sectional view of the hollow fiber artificial kidney according to the present invention, Fig. 2 is an enlarged sectional view of the blood inlet port, Fig. 3 is an enlarged sectional view of the blood outlet port, and Fig. 4 is the blood flow. FIG. 5 is an enlarged sectional view showing another example of the inlet port, FIG. 5 is an enlarged sectional view showing another example of the blood outlet port, and FIG. 6 is a schematic diagram for explaining the inner surface inclination angle. DESCRIPTION OF SYMBOLS 1... Artificial kidney, 4... Cylindrical main body, 5... Hollow fiber bundle, 6.7... Partition wall, 8... Blood inlet, 9...
Blood outflow port, 11.12... cold on the 2nd side of the header, ? (No change in appearance)
Claims (4)
口ポートを備えかつ側壁部に物質移動流体流入口および
物質移動流体出口を備えた円筒状本体と、該円筒状本体
内に収容されるとともにその両端を隔壁により該円筒状
本体に固定されかつその両端部が前記両ポートに連通し
てなる多数の中空糸とよりなる中空糸型血液処理装置に
おいて、前記血液流入口ポートと血液流出口ポートの内
部形状が互いに異なる形状であることを特徴とする中空
糸型血液処理装置。(1) A cylindrical body having a blood inlet port and a blood outlet port at both ends, respectively, and a mass transfer fluid inlet and a mass transfer fluid outlet on the side wall; In a hollow fiber type blood processing device comprising a large number of hollow fibers whose both ends are fixed to the cylindrical main body by partition walls and whose both ends communicate with the two ports, the blood inlet port and the blood outlet port are connected to each other. A hollow fiber blood processing device characterized in that the internal shapes are different from each other.
出口ポートの内面傾斜角θ＿２との比θ＿１／θ＿２が
１．１〜３．０である請求項１に記載の中空糸型血液処
理装置。(2) The hollow fiber type blood treatment according to claim 1, wherein the ratio θ_1/θ_2 of the inner surface inclination angle θ_1 of the blood inlet port and the inner surface inclination angle θ_2 of the blood outlet port is 1.1 to 3.0. Device.
３０゜の範囲である請求項１または２に記載の中空糸型
血液処理装置。(3) The inner inclination angle θ_1 of the blood inlet port is 10°~
The hollow fiber type blood processing device according to claim 1 or 2, wherein the angle is within the range of 30°.
のいずれか一つに記載の中空糸型血液処理装置。(4) Claims 1 to 3, wherein the blood processing device is an artificial kidney.
The hollow fiber blood processing device according to any one of the above.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2116461A JPH0817810B2 (en) | 1990-05-02 | 1990-05-02 | Hollow fiber blood treatment device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2116461A JPH0817810B2 (en) | 1990-05-02 | 1990-05-02 | Hollow fiber blood treatment device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH0412759A true JPH0412759A (en) | 1992-01-17 |
| JPH0817810B2 JPH0817810B2 (en) | 1996-02-28 |
Family
ID=14687689
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2116461A Expired - Fee Related JPH0817810B2 (en) | 1990-05-02 | 1990-05-02 | Hollow fiber blood treatment device |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0817810B2 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0613843U (en) * | 1992-07-27 | 1994-02-22 | 株式会社クラレ | Blood processing module |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6071225U (en) * | 1983-10-25 | 1985-05-20 | 旭メデイカル株式会社 | blood processing equipment |
| JPS63156646U (en) * | 1987-04-02 | 1988-10-14 | ||
| JPS6417246U (en) * | 1987-07-17 | 1989-01-27 |
-
1990
- 1990-05-02 JP JP2116461A patent/JPH0817810B2/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6071225U (en) * | 1983-10-25 | 1985-05-20 | 旭メデイカル株式会社 | blood processing equipment |
| JPS63156646U (en) * | 1987-04-02 | 1988-10-14 | ||
| JPS6417246U (en) * | 1987-07-17 | 1989-01-27 |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0613843U (en) * | 1992-07-27 | 1994-02-22 | 株式会社クラレ | Blood processing module |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0817810B2 (en) | 1996-02-28 |
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