JPH04115065U - automatic chemical analyzer - Google Patents

Abstract

(57) [Summary] [Purpose] In an automatic chemical analyzer equipped with a plurality of reagent containers, by providing a communication tube for mutual circulation of reagents in each reagent container, in a series of analysis operations,
Increasing the amount of reagent that can be dispensed and maintaining the same components and concentrations of reagents in each reagent container 6, the reagents 6 in both reagent containers 1 communicate with each other due to the siphon effect.

Description

[Detailed explanation of the idea]

0001

[Industrial application field]

This invention is for clinical biochemistry that automatically performs biochemical analysis of serum, urine, lymph fluid, etc. The present invention relates to automatic chemical analyzers, and particularly to improvements in reagent containers.

0002

[Conventional technology]

Traditionally, liquid samples such as serum, urine, and lymph fluid were individually placed in sample containers and transferred. After storing it in a transport rack, it is transported continuously, and a sample pipette is placed in the middle of the transport path. Dispense the amount necessary for biochemical analysis into separate reaction containers for each individual using a nozzle. This is transported via a different transport route, and the desired biochemical analysis items are Pour the appropriate reagent into the reaction container according to the instructions, let the sample and reagent react chemically, and then Automatic chemical analyzers that perform quantitative measurements such as post-absorbance measurements have been proposed. Figure 6 is an overall perspective view of this automatic chemical analyzer.

0003 In such a device, (1) A large number of samples are generated in mass health examinations, so they can be processed quickly and in large quantities. Measurement and analysis must be carried out. (2) Extremely high precision is required for the measured values in order to avoid incorrect judgment results. Ru. (3) Measured values immediately after the start of analysis and measurements just before the end of analysis for a series of samples The values must match, and the same measurement conditions must be maintained throughout the analysis. stomach. There are such requests.

0004

[Problem that the idea aims to solve]

However, with conventional automatic chemical analyzers, it is difficult to increase the versatility of biochemical analysis items. To improve the operability of the device, all reagent containers used have the same shape and volume. It is formed so that Therefore, it should be used for items that are frequently analyzed or for one-time analysis. For items requiring a large amount of reagent, the reagent in the container often ran out in a short time.

[0005] Therefore, out of many reagent containers, only one reagent container The device was stopped every time the drug ran out, and the reagent in the reagent container was frequently replenished. Manual work such as preparation is essential, which slows down the analytical processing speed. , problems such as contamination of foreign objects, reduction in measurement accuracy, damage to reagent containers, and spillage of reagents occur. There was an issue of

[0006] In addition, for this problem, we put reagents of the same item in multiple reagent containers and It is possible to increase the amount of reagents that can be dispensed for analysis, but Because each reagent is separated, the components and concentrations of the reagents are not completely the same, and the If the reagent container to be poured is changed, the problem arises that errors occur in the measured values.

[0007] In particular, in biochemical analysis, impurities present in reagents and decreased enzyme activity ``Fluctuations in reagent blank values'' caused by Changes in reagent sensitivity caused by changes over time can greatly affect measurement accuracy. Therefore, it is necessary to keep the measurement conditions, especially the identity of the reagent composition, constant at all times. .

[0008] In order to solve the above-mentioned conventional problems, the present invention has a simple structure and a series of separations. In analytical work, you can increase the amount of reagent that can be dispensed and also We aim to provide an automatic chemical analyzer equipped with a mechanism to maintain the same concentration and concentration. purpose.

[0009]

[Means to solve the problem]

In order to achieve the above object, the present invention provides an automatic chemical analysis device equipped with multiple reagent containers. The apparatus is equipped with a communication tube for mutual circulation of the reagents in the reagent containers. It is characterized by.

0010

[Effect]

According to the configuration of the present invention, each reaction container containing individual samples is continuously transported. The reagent container table can be moved in parallel with the transfer to the reagent dispensing station. Transfer the reagent container containing the desired reagent to the reagent dispensing station and pipette it. A series of work processes in which reagents are aspirated using a nozzle and injected into each reaction container. Insert communication tubes into multiple reagent containers to allow reagents in the reagent containers to flow mutually. By doing so, the reagent capacity that can be placed on the automatic chemical analyzer is increased by connecting the reagent containers. The number of reagents can be increased by the number of containers, increasing the amount of reagents that can be dispensed for a series of analyses. .

[0011] In addition, since the reagents in each reagent container are mutually distributed, the components and concentrations of both reagents are The concentration will be the same, and the reagent composition will be the same no matter which reagent container is in communication. This eliminates errors in measured values for each reagent container.

0012

【Example】

An embodiment of the automatic chemical analyzer according to the present invention will be described below. FIG. 1 is an outline drawing of a reagent container 1 used in an automatic chemical analyzer according to the present invention. . The automatic chemical analyzer 70 is equipped with reagent container stands 79 and 80 such as a rotating table. A plurality of reagent containers 1 are placed therein. In order to improve the space utilization efficiency of the equipment, The outer shape approximates the shape of a column divided equally in the circumferential direction, and the top surface is used to insert and remove reagents. An opening 2 is formed through which a dispensing probe can be inserted. inside the container A space is formed in the part for the reagent liquid to enter. The top surface of the reagent container 1 has a communication A hole 3 is drilled for inserting a tube. In addition, in Figure 1, only one hole 3 is provided. However, it is also a preferable configuration to make a plurality of holes 3 in one reagent container 1. be. In addition, the hole is not limited to the upper part of the reagent container 1, and the reagent inside the reagent container It can be drilled in a place where it can communicate with the drug.

[0013] FIG. 2 is a front view of a communication tube used in the automatic chemical analyzer according to the present invention. A flexible material such as rubber or resin is formed into a tubular shape to form the communication pipe 4, and a A suction section 5 with a space for suction is provided.

[0014] FIG. 3 is a front view of another communication tube used in the automatic chemical analyzer according to the present invention. . The difference from the communication pipe shown in FIG. 2 is that the side surface of the suction part 5 is formed into a bellows shape. Therefore, the capacity of the suction section 5 can be increased, and the suction amount and pressure can be increased. I can do that.

[0015] Figure 4 shows the insertion of the communication tube used in the automatic chemical analyzer according to the present invention into each reagent container. FIG. Both ends of this communication tube 4 are inserted into the reagent 6 through the holes 3 made in the two reagent containers 1. After the suction part 5 is inserted into the The inside of the passage tube 4 is filled with the reagent 6, and the reagents 6 in both reagent containers 1 are communicated with each other. Therefore, even if you continue dispensing from only one reagent container, the liquid level of both reagents will remain in the wallet. Due to the It can be seen that the amount of reagent that can be dispensed is apparently increased, almost doubling.

[0016] Note that although Figure 4 shows the case where two reagent containers are connected, it is possible to connect multiple reagent containers. By inserting tubes across multiple reagent containers, desired amounts of reagent can be communicated. is possible.

[0017] FIG. 5 is a perspective view of the reagent container stand of the automatic chemical analyzer according to the present invention. A plurality of reagent containers 1 are placed on a reagent container stand 79 such as a rotary table. trial At the center of rotation of the medicine container table 79, there is a robot arm that can move vertically and in the rotational direction. A system will be provided. The dispensing probe 76 attached to its tip is not shown. It moves driven by a control circuit, is inserted into the opening 2 of each reagent container 1, and dispenses a predetermined amount. reagents are dispensed, moved again, and injected into another reaction vessel.

[0018] Each reagent container 1 has one or more holes 3 for inserting the communication tube 4. It will be done. Reagents that are expected to be used in large quantities depending on the analysis item are stored in multiple reagent containers. The reagents are separated and placed on the reagent container stand 79, and the communication tube 4 is inserted. Next, the wallet The operator compresses and expands the suction section 5 several times in order to communicate the reagent through the ion phenomenon. Repeat as many times as you like.

[0019] Furthermore, even if the inside of the communication tube 4 is already in a communicating state, before, during or after the analysis work, By performing the compression and expansion procedure of the suction section 5, the reagent in the communication tube 4 moves in and out vigorously. As a result, the reagents in the reagent container can be easily stirred and the reagent concentration can be adjusted. It is possible to achieve uniformity.

[0020] In the above embodiment, the surface where the communication tube 4 and the reagent 6 come into contact is By covering it with an inert material, deterioration of the reagent 3 and communication tube 4 can be prevented. It can be prevented.

[0021] In addition, by adopting a joint structure in which the communication pipe 4 and the suction part 5 can be separated, cleaning is possible. Easy to clean and replace parts.

[0022]

[Effect of the idea]

As explained above, according to the automatic chemical analyzer of the present invention, a series of automatic analysis operations can be performed. The amount of reagent that can be dispensed can be increased by the number of connected reagent containers. , reducing work such as replenishing reagents, improving equipment utilization efficiency and analysis processing speed. It has the effect of rising.

[0023] In addition, since the reagents in each reagent container are mutually distributed, the components and concentrations of both reagents are data is highly reliable, with the same degree of accuracy and no measurement error in analysis. This has the effect that it can be obtained.

[0024] In addition, the reagent capacity can be changed without making large-scale modifications to the existing automatic chemical analyzer main body. It can be implemented with simple modifications such as improving the equipment, so large effects can be obtained at low cost. .

[Brief explanation of drawings]

FIG. 1 is an outline diagram of a reagent container 1 used in an automatic chemical analyzer according to the present invention.

FIG. 2 is a front view of the communication tube 4 used in the automatic chemical analyzer according to the present invention.

FIG. 3 is a front view of another communication tube 4 used in the automatic chemical analyzer according to the present invention.

FIG. 4 is a cross-sectional view of the communication tube 4 used in the automatic chemical analyzer according to the present invention inserted into each reagent container 1.

[Fig. 5] Reagent container stand 7 of the automatic chemical analyzer according to the present invention
9 is a perspective view of FIG.

FIG. 6 is an overall perspective view of an automatic chemical analyzer to which the present invention is applied.

[Explanation of symbols]

1 Reagent container 3 holes 4 Communication pipe 5 Suction part 6 Reagent 70 Automatic chemical analyzer 71 Rack supply section 72 Rack collection department 73 Rack transport outbound line 74 Rack transport return line 75 Sample pipettor nozzle 76 Dispensing probe 77 Dispensing probe 78 Reaction part 79 Reagent container stand 80 Reagent container stand

Claims (1)

[Scope of utility model registration request] 1. An automatic chemical analyzer equipped with a plurality of reagent containers, characterized in that the automatic chemical analyzer is equipped with a communication tube for mutually circulating reagents of the same type in the reagent containers.