JPH0390030A - Calcium preparation - Google Patents

Abstract

PURPOSE:To provide a calcium agent having good taste and oral administration touch, readily ingested and suitable for long period continuous administration by containing a calcium salt, xylitol, an organic acid and a carbonate salt. CONSTITUTION:A calcium agent contains a calcium salt (any one of organic and inorganic calcium salts can be used), 5-90wt.%, especially 40-70wt.%, of xylitol as an excipient, 0.5-50wt.%, particularly 1-10wt.%, of an organic acid (e.g. ascorbic acid or succinic acid) and 0.5-50wt.%, especially 1-10wt.%, of a carbonate salt. When calcium carbonate is used as the calcium salt, the calcium agent does not require any other carbonate salt and contains 5-80wt.%, particularly 30-60wt.%, of the calcium carbonate. The agent has a good oral administration touch due to an oral stimulating touch caused by the foaming of the agent, due to the improvement of the dissolution of the calcium caused by the generated carbon dioxide gas and to the cooling touch of the xylitol.

Description

[Detailed description of the invention] [Industrial application field] The present invention relates to a calcium preparation that is comfortable to take.

[Prior art] According to the National Nutrition Survey, today the intake of each nutrient exceeds the average required amount, but the intake of calcium is low at 553I1g per day compared to the required amount of 600ng. It remains in Therefore, it can be said that all Japanese people are at risk of calcium deficiency (bone lesions). In particular, pregnant women, nursing mothers, growing children, and elderly people who require a large amount of calcium per day, such as the elderly who have a weak ability to absorb calcium, require regular use of calcium preparations to prevent or treat calcium deficiency.

[Problems to be Solved by the Invention] Since such calcium preparations require continuous administration over a long period of time as described above, it is desirable that they be in a dosage form that is comfortable to take.

However, when inorganic calcium with a high calcium content is used, the amount of the preparation to be taken is reduced, but the inorganic calcium is irritating and has poor solubility, resulting in a preparation with a bad texture.

Furthermore, when organic calcium is used, the texture becomes better on the tongue, but since the calcium content is low, the amount of the preparation that must be taken increases, making it difficult to take it continuously for a long period of time. Therefore, efforts have been made to improve the feeling of taking the drug by using a combination of inorganic calcium and organic calcium, but no satisfactory effect has been achieved.

Therefore, an object of the present invention is to provide a calcium preparation that has good taste and feeling, is easy to take, and is suitable for long-term continuous administration.

[Means for Solving the Problems] Under these circumstances, the present inventors conducted intensive research and found that an effervescent formulation using xylitol as an excipient can solve the above problems. , completed the invention.

That is, the present invention provides a calcium preparation characterized by containing a calcium salt, xylitol, an organic acid, and a carbonate, and a calcium preparation characterized by containing calcium carbonate, xylitol, and an organic acid. .

Examples of calcium salts that can be used in the present invention include inorganic calcium such as calcium chloride, calcium hydrogen phosphate, precipitated calcium carbonate, and boley, and organic calcium such as calcium gluconate, calcium lactate, calcium aspartate, and calcium glycerophosphate. Can be mentioned.

These can be used alone or in combination of two or more.

In the present invention, xylitol is used as an excipient, and the amount used is 5 to 90% by weight of the calcium preparation of the present invention.
, particularly preferably 40 to 70% by weight.

In addition, organic acids that can be used in the present invention include ascorbic acid, succinic acid, tartaric acid, citric acid, malic acid,
Examples include fumaric acid, lactic acid, and gluconic acid. These can be used alone or in combination of two or more. The amount of organic acid used is preferably 0.5 to 50% by weight, particularly 1 to 10% by weight, based on the calcium preparation of the present invention.

Further, carbonates that can be used in the present invention include sodium hydrogen carbonate, calcium carbonate, sodium carbonate, potassium carbonate, ammonium carbonate, magnesium carbonate, and the like. These can be used alone or in combination of two or more. The amount of carbonate used is 0.5 to 50% by weight, especially 1 to 50% by weight, based on the calcium preparation of the present invention.
10% by weight is preferred. Note that when calcium carbonate is used as the calcium salt, since this itself is a carbonate, there is no need to further use another carbonate.

In this case, the amount of calcium carbonate used is 5 to 80% by weight, particularly 30 to 60% by weight, based on the calcium preparation of the present invention.
is preferred.

The calcium preparation of the present invention can be made into various dosage forms, but in consideration of ease of ingestion, dosage forms such as granules, fine granules, and tablets are preferred.

If necessary, other nutritional ingredients or commonly used excipients, binders, disintegrants, lubricants, etc. may be added to the calcium preparation of the present invention depending on its dosage form. Excipients include starch, crystalline cellulose, mannitol, lactose, sucrose, sorbitol, dextrin, light silicic anhydride, and the like. Examples of the binder include cellulose derivatives and synthetic polymer compounds, with hydroxypropyl cellulose being particularly preferred. Moreover, it is preferable to coat some or all of the components of the calcium preparation of the present invention with the binder. Examples of the disintegrant include starch, crystalline cellulose, carboxymethylcellulose calcium, and the like. In addition, examples of lubricants for tablets include talc, stearic acid, magnesium stearate, paraffin, and the like.

The calcium preparation of the present invention is manufactured, for example, as follows. That is, granules or fine granules can be obtained by adding xylitol, an organic acid, a carbonate, a binder, a disintegrant, etc. to a calcium salt, and granulating or sizing the mixture by a conventional method. Further, tablets can be obtained by adding a lubricant and tabletting by a conventional method.

[Actions and Effects of the Invention] The calcium preparation of the present invention is configured as described above, so that when taken, the foaming causes a feeling of irritation during the day, the carbon dioxide generated improves the solubility of calcium, and the xylitol provides a cooling sensation. Therefore, it has a good feel and is easy to take, and is particularly suitable for long-term use.

[Examples] Hereinafter, the present invention will be explained in more detail by giving examples, but the present invention is not limited thereto.

Example 1 Precipitated calcium carbonate 1500g, xylitol 2863
．． 2 g of hydroxypropyl cellulose and 220 g of hydroxypropyl cellulose were uniformly mixed, ethanol was added and kneaded, and then dried at 50° C. and sieved to obtain a product that passed through a No. 12 sieve and remained on a No. 42 sieve. To this, 192 g of tartaric acid coated with 20 g of hydroxypropyl cellulose and 4.8 g of fragrance were added using a fluid phase coating device and mixed uniformly to obtain granules.

Usage/Capacity: 1 packet (1.6 g) at a time, taken 3 times a day Example 2 Precipitated calcium carbonate 1500 g, lysine hydrochloride 125 g.

75g of aminoethylsulfonic acid, 10g of ergocalciferol, 2g of xylitol 2663, 240g of hydroxypropylcellulose and 192g of tartaric acid were mixed uniformly, ethanol was added and kneaded, then dried at 50°C and sieved through a No. 30 sieve. It passed through the sieve, and a No. 200 sieve residue was obtained. 4.8 g of fragrance was added to this to obtain fine granules.

Usage/Capacity: 1 packet (1.6 g) at a time, taken 3 times a day Example 3 Calcium hydrogen phosphate 2576 g, xylitol 140
After uniformly mixing 3.2 g and 240 g of hydroxypropyl cellulose, adding ethanol and kneading, the mixture was heated to 50°C.
It was dried and passed through a No. 20 sieve. To this, 192 g each of tartaric acid, sodium hydrogen carbonate, and magnesium stearate, and 4.8 g of fragrance were added, and tablets were made using a rotary tablet press manufactured by Kikusui Co., Ltd. to obtain chewable tablets with a diameter of 15 mm and a weight of 1.6 g. .

Dosage/Capacity: 1 tablet at a time, 3 times a day, dissolve or chew during the day. Example 4: 1850 g of calcium hydrogen phosphate, 1850 g of calcium gluconate, 279.2 g of xylitol, and 240 g of hydroxypropyl cellulose are uniformly mixed together. After adding ethanol and kneading, the mixture was dried at 50°C and passed through a No. 20 sieve. To this was added 192 g each of tartaric acid, sodium hydrogen carbonate, magnesium stearate, and 4.8 g of fragrance, and the tablets were made using a rotary tablet machine manufactured by Kikusui Co., Ltd., with a diameter of 15 mm.
Chewable tablets weighing 1.6 g were obtained.

Dosage/Capacity: 1 tablet at a time, 3 times a day, dissolve or chew during the day Comparative Example 1 Precipitated calcium carbonate 1500g, refined white sugar 3055g,
2 g of hydroxypropylcellulose and 240 g of hydroxypropyl cellulose were uniformly mixed, ethanol was added and kneaded, and then dried at 50° C. and sieved to obtain a product that passed through a No. 12 sieve and remained on a No. 42 sieve. 4.8 g of fragrance was added and mixed to obtain granules.

Comparative example 2 1500 g of precipitated calcium carbonate, 125 g of lysine hydrochloride.

75 g of aminoethyl sulfonic acid, 10 mg of ergocalciferol, 2855.2 g of D-vnitol and 240 g of hydroxypropyl cellulose were uniformly mixed,
After adding ethanol and kneading, the mixture was dried at 50°C and sieved to obtain a product that passed through a No. 30 sieve and remained on a No. 200 sieve. 4.8 g of fragrance was added to this to obtain fine granules.

Comparative Example 3 Calcium hydrogen phosphate 2576g, lactose 1787.2g
and 240 g of hydroxypropyl cellulose were uniformly mixed, ethanol was added and kneaded, and the mixture was dried at 50° C. and passed through a No. 20 sieve. This includes magnesium stearate 19
2 g and 4.8 g of fragrance were added, and tablets were made using a rotary tablet press manufactured by Kikusui Co., Ltd. to obtain chewable tablets with a diameter of 15 m and a weight of 1.6 g.

Comparative Example 4 1850 g of calcium hydrogen phosphate, 1850 g of calcium gluconate, 663.2 g of refined white sugar and 240 g of hydroxypropyl cellulose were uniformly mixed, ethanol was added and kneaded, then dried at 50° C. and passed through a No. 20 sieve.

Add to this 192g of magnesium stearate and 4.
8 g was added and tablets were made using a rotary tablet press manufactured by Kikusuisha Co., Ltd. to obtain chewable tablets with a diameter of 15 circles and a weight of 1.6 g.

Test Example 1 Six panelists compared the feeling of taking the calcium preparations obtained in Examples 1 to 4 and Comparative Examples 1 to 4.

The calcium preparations of the present invention in Examples 1 to 4 all had good taste, were not powdery, and had a good texture, whereas the calcium preparations in Comparative Examples 1 to 4 were all powdery and had a poor feeling when taking. .

that's all

Claims (5)

[Claims] (1) A calcium preparation characterized by containing a calcium salt, xylitol, an organic acid, and a carbonate. (2) The contents of organic acid and carbonate are each 0.5 to 0.5
The calcium preparation according to claim 1, which is 50% by weight. (3) A calcium preparation containing calcium carbonate, xylitol, and an organic acid. (4) The calcium preparation according to claim 3, wherein the content of calcium carbonate is 5 to 80% by weight. (5) The calcium preparation according to claim 1 or 3, wherein the content of xylitol is 5 to 90% by weight.