JPH0377815A - Compound for oral cavity - Google Patents
Compound for oral cavityInfo
- Publication number
- JPH0377815A JPH0377815A JP20659689A JP20659689A JPH0377815A JP H0377815 A JPH0377815 A JP H0377815A JP 20659689 A JP20659689 A JP 20659689A JP 20659689 A JP20659689 A JP 20659689A JP H0377815 A JPH0377815 A JP H0377815A
- Authority
- JP
- Japan
- Prior art keywords
- alumina
- zinc
- particle size
- trihydrate
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000000214 mouth Anatomy 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title description 3
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims abstract description 25
- 150000004684 trihydrates Chemical class 0.000 claims abstract description 20
- 239000002245 particle Substances 0.000 claims abstract description 19
- 239000000203 mixture Substances 0.000 claims abstract description 14
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 claims abstract description 7
- 229960004711 sodium monofluorophosphate Drugs 0.000 claims abstract description 7
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 claims abstract description 6
- 229940068475 zinc citrate Drugs 0.000 claims abstract description 6
- 235000006076 zinc citrate Nutrition 0.000 claims abstract description 6
- 239000011746 zinc citrate Substances 0.000 claims abstract description 6
- 150000003752 zinc compounds Chemical class 0.000 claims abstract description 6
- MXRIRQGCELJRSN-UHFFFAOYSA-N O.O.O.[Al] Chemical compound O.O.O.[Al] MXRIRQGCELJRSN-UHFFFAOYSA-N 0.000 claims description 5
- 239000000551 dentifrice Substances 0.000 abstract description 6
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 abstract description 5
- 229940074371 monofluorophosphate Drugs 0.000 abstract description 5
- 239000011701 zinc Substances 0.000 abstract description 5
- 229910052725 zinc Inorganic materials 0.000 abstract description 5
- 208000006558 Dental Calculus Diseases 0.000 abstract description 2
- 239000011230 binding agent Substances 0.000 abstract description 2
- 239000003906 humectant Substances 0.000 abstract description 2
- 239000004094 surface-active agent Substances 0.000 abstract description 2
- 239000002562 thickening agent Substances 0.000 abstract description 2
- 208000002064 Dental Plaque Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000002304 perfume Substances 0.000 abstract 1
- 238000005498 polishing Methods 0.000 abstract 1
- -1 zinc citrate) Chemical class 0.000 abstract 1
- 239000000606 toothpaste Substances 0.000 description 10
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 4
- 229940091249 fluoride supplement Drugs 0.000 description 4
- 229940034610 toothpaste Drugs 0.000 description 4
- 239000003082 abrasive agent Substances 0.000 description 3
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 3
- 229910052782 aluminium Inorganic materials 0.000 description 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000003801 milling Methods 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 238000004131 Bayer process Methods 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- RREGISFBPQOLTM-UHFFFAOYSA-N alumane;trihydrate Chemical compound O.O.O.[AlH3] RREGISFBPQOLTM-UHFFFAOYSA-N 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 230000000675 anti-caries Effects 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 208000002925 dental caries Diseases 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- GVGUFUZHNYFZLC-UHFFFAOYSA-N dodecyl benzenesulfonate;sodium Chemical compound [Na].CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 GVGUFUZHNYFZLC-UHFFFAOYSA-N 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 150000003014 phosphoric acid esters Chemical class 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- VSJRDSLPNMGNFG-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate;trihydrate Chemical compound O.O.O.[Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O VSJRDSLPNMGNFG-UHFFFAOYSA-H 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 229940085658 zinc citrate trihydrate Drugs 0.000 description 1
Landscapes
- Cosmetics (AREA)
Abstract
Description
【発明の詳細な説明】
本発明は口腔組成物、より詳細には研摩清浄剤として三
水和アルミナ粒子（＾Ｚ２０，３ＬＯ）を含有する口腔
組成物に係る。三水和アルミナ粒子はときには三水和ア
ルミニウムまたは水酸化アルミニウムとも指称される。DETAILED DESCRIPTION OF THE INVENTION The present invention relates to oral compositions, and more particularly to oral compositions containing trihydrated alumina particles (Z20,3LO) as an abrasive detergent. Trihydrated alumina particles are sometimes also referred to as aluminum trihydrate or aluminum hydroxide.
の公知の研摩剤であり、バイヤー法で粗いグレードの材
料を製造しこれを口腔組成物での使用に適した粒度に■
砕シフ１、用いられている。It is a well-known abrasive that uses the Bayer process to produce a coarse grade of material that is then reduced to a particle size suitable for use in oral compositions.
Shattered Schiff 1 is used.
英国特許公開第１，２フ゛７ 、５８５号（Ｉｎ ｉ
１ｅｖｅｒ）は、麿砕三水相アルミテを含有する練り歯
磨は練り歯磨のアルミニウムチューブを腐食すること、
モノフルオロリン酸ナトリウム及びその他のモノフルオ
ロリン酸イオン源がこの腐食防止に有効であることを開
示している。また、英国特許公開第１，４７５゜２５２
号（Ｃｏｌｇａｔｅ−ＰａｌＩＩｌｏｌｉｖｅ）はある
種のリン酸エステルが有効であることを開示している。British Patent Publication No. 1,2 7, 585 (In i
1ever) that toothpastes containing Marograin trihydric phase alumite corrode the aluminum tubes of toothpastes;
Sodium monofluorophosphate and other sources of monofluorophosphate ions are disclosed to be effective in preventing this corrosion. Also, British Patent Publication No. 1,475゜252
(Colgate-Pal II lolive) discloses that certain phosphoric acid esters are effective.
英国特許公ｒｊ！４第１，５３７，８２３号（Ｂｒｉｔ
ｉｓｈ Ａｌｕｍｉｎｉｕｍ Ｃｏ、 Ｌｔ、ｃｌ）及
び英国特許公ｒＭ第１，５４４，５３７号（ＣｏｌＦｉ
ａｔ、ｅ−ＰａｌＭｏ−１１ｖｅ）は、磨砕処理中のあ
る種の物質の存在が、アルミニウムチューブに収容され
る練り歯磨に混入できるように磨砕三水和アルミナ粒子
の表面を変性することを教示している。British patent official rj! 4 No. 1,537,823 (Brit
ish Aluminum Co, Lt, cl) and British Patent Publication No. 1,544,537 (ColFi
(at, e-PalMo-11ve) have shown that the presence of certain substances during the milling process modifies the surface of ground trihydrate alumina particles such that they can be incorporated into toothpastes contained in aluminum tubes. teaching.
虫歯予防のためのフッ化物源として歯磨剤にモノフルオ
ロリン酸ナトリウムを混合することはすでに常識である
。It is already common knowledge to mix sodium monofluorophosphate into toothpastes as a fluoride source to prevent dental caries.
発明者等は、モノフルオロリン酸ナトリウムと三水和ア
ルミナ研摩剤との間にある種の相互作用が生じ、歯磨剤
の保管中に可溶性フッ化物が失われ、この現象は高温に
なるほど顕著であることを知見した。従って、かかる練
り歯磨では虫歯予防効果がある程度失われる。The inventors believe that some interaction between sodium monofluorophosphate and the trihydrate alumina abrasive results in the loss of soluble fluoride during storage of the dentifrice, and that this phenomenon is more pronounced at higher temperatures. I discovered something. Therefore, such toothpastes lose their anti-caries effect to some extent.
磨砕三水和アルミナに代替して適当な粒度の非磨砕沈殿
三水和アルミナを使用すると三水和アルミナ研摩剤及び
クエン酸亜鉛を含有する歯磨剤中のモノフルオロリン酸
塩（ＭＦＰ）の安定性が顕著に改良されることが知見さ
れた。また歯磨剤中の可溶性亜鉛の安定性も改良される
。クエン酸亜鉛は、公知の歯石及び歯垢防止剤である（
米国特許第４゜１００．２６９号（Ｌｅｖｅｒ Ｂｒｏ
ｔｈｅｒｓ Ｃｏ、）参照）。Substituting ground trihydrate alumina with unground precipitated trihydrate alumina of appropriate particle size will reduce monofluorophosphate (MFP) in trihydrate alumina abrasives and dentifrices containing zinc citrate. It was found that the stability of was significantly improved. The stability of soluble zinc in dentifrices is also improved. Zinc citrate is a known tartar and plaque inhibitor (
U.S. Patent No. 4°100.269 (Lever Bro
Thers Co.).
従って本発明は、２０〜７０重量％の平均粒度３〜１５
μ好ましくは５〜１０μの非磨砕沈殿三水和アルミナと
０６１〜２重量％のモノフルオロリン酸ナトリウムと０
６０２〜５重量％のクエン酸亜鉛とを含む口腔組成物に
係る。Therefore, the present invention provides an average particle size of 3 to 15% by weight of 20 to 70%.
Preferably 5-10μ of unground precipitated trihydrate alumina and 1-2% by weight of sodium monofluorophosphate and 0
602 to 5% by weight of zinc citrate.
本発明の口腔組成物において使用されるアルミナ研摩剤
は、平均粒度１〜２μ以下の極めて微細なアルミナ沈澱
物を製造するための従来の沈殿法を改良した方法で製造
される。この方法では、より大きい結晶凝結体が成長す
るように沈殿条件を調整する。アルミナの適当な製造方
法は、Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｓｙｍｐｏｓｉｕ
＋＊ ｏｎ ｔｈｅ Ｅｘｔｒａｃｔｉｖｅ Ｍｅｔａ
ｌｌｕｒ−ｇｙ ｏｆ＾ｌｕｅｉｉｎｉｕｍ、 Ｎｅｗ
Ｙｏｒｋ、 Ｆｅｂｒｕａｒｙ １９６２に発表され
たＪ、５ｃｏｔｔの論文ｒＴｈｅ ｅｆｆｅｃｔ ｏｆ
５ｅｅｄ ａｎｄＴｅｍｐｅｒａｔｕｒｅ ｏｎ ｔ
ｈｅ Ｐａｒｔｉｃｌｅ ５ｉｚｅ ｏｒ Ｂａｙｅｒ
Ｈｙｄｒａｔｅ」に記載されている。The alumina abrasives used in the oral compositions of the present invention are produced by a modification of conventional precipitation methods to produce extremely fine alumina precipitates with an average particle size of 1-2 microns or less. In this method, precipitation conditions are adjusted to grow larger crystal aggregates. A suitable method for producing alumina is
＋＊ on the Extractive Meta
llur-gy of^lueiinium, New
York, February 1962, J. 5cott's paper rThe effect of
5eed and Temperature on t
he Particle 5ize or Bayer
"Hydrate".
上記のごとく、非磨砕沈殿アルミナ研摩剤が可溶性亜鉛
との適合性を向上させることが判明した。As noted above, unground precipitated alumina abrasives have been found to improve compatibility with soluble zinc.
従って本発明の別の目的は、非磨砕沈殿三水和アルミナ
研摩剤と水溶性亜鉛化合物との組み合わせを含む口腔組
成物を提供することである０口腔組成物が水溶性亜鉛化
合物を含有することは公知である。前出の米国特許第４
，１００，２６９号に多くの亜鉛化合物が開示されてい
る。また、別の化合物が米国特許第４，０２２，８８０
号、第４，１４４，３２３号、第４，６５６゜０３１号
及び第４，１６０，８２１号に開示されている。亜鉛化
合物の量は口腔組成物゛の約０．０２重量％〜約５重量
％でよい。It is therefore another object of the present invention to provide an oral composition comprising a combination of a non-milled precipitated trihydrate alumina abrasive and a water-soluble zinc compound. This is well known. U.S. Patent No. 4 mentioned above
, 100,269 discloses many zinc compounds. Another compound is disclosed in U.S. Patent No. 4,022,880.
No. 4,144,323, No. 4,656°031 and No. 4,160,821. The amount of zinc compound may be from about 0.02% to about 5% by weight of the oral composition.
本発明の口腔組成物はまた、その他の従来の成分を含有
する。クリーム状またはゲル状の歯磨剤は通常は保湿剤
、界面活性剤、結合剤または増粘剤及び香料を含有する
。その他の微量成分、例えば１重量％未満の２°、４．
４’−トリクロロ−２−ヒドロキシ−ジフェニルエーテ
ルが抗菌剤として含まれてもよい。The oral compositions of the present invention also contain other conventional ingredients. Cream or gel dentifrices typically contain humectants, surfactants, binders or thickeners, and fragrances. Other minor components, such as less than 1% by weight of 2°, 4.
4'-trichloro-2-hydroxy-diphenyl ether may be included as an antimicrobial agent.
英国特許公開第２，００９，５９６号（Ｕｎｉｌｅｖｅ
ｒ）は、ＭＦＰと三水和アルミナ研摩剤とを含有し亜鉛
イオン発・生化合物を含有しない練り歯磨を開示してい
る。British Patent Publication No. 2,009,596 (Unilev)
r) discloses a toothpaste containing MFP and a trihydrate alumina abrasive and free of zinc ion generating compounds.
この研摩剤は平均粒度５〜１３μの三水和アルミナと平
均粒度１μ未満の三水和アルミナとの重量比３０ニア０
〜７０：３０の混合物から成る０ミクロン未満の三水和
アルミナ粒子の平均粒度は０．２〜０．８μ、特に約０
．５μであると記載されている。このような粒子は商業
的に、より大きい粒子の粉砕によって製造されるのでな
く微細沈澱物として製造されている。This abrasive has a weight ratio of trihydrate alumina with an average particle size of 5 to 13μ and trihydrate alumina with an average particle size of less than 1μ.
The average particle size of the sub-0 micron trihydrate alumina particles of the ~70:30 mixture is between 0.2 and 0.8 μ, especially around 0
．． It is stated that it is 5μ. Such particles are commercially produced as fine precipitates rather than by milling of larger particles.
本発明の実施例を以下に示す。Examples of the present invention are shown below.
数値は重量％である。Values are in % by weight.
以下の組成の練り歯磨を調製した。A toothpaste with the following composition was prepared.
えた ぎ
三水和アルミナ ５０．０ソル
ビトールシロツプ（７０％溶液） ２７．０ラ
ウリル硫酸ナトリウム １．８７５ド
デシルベンゼンスルホン酸ナトリウム ０．６カルボキ
シメチルセルロースナトリウム ０．８三水和クエン酸
亜鉛 ０．５モノフルオロリン酸
ナトリウム ０．８５香料
１．２サツカリンナＩ〜リウム
０．２ホルマリン
０．０４色素
ｏ、ｏｏｅ水
１．００まで以下の種々
のグレードの三水和アルミナを使用して数種の練り歯磨
を調製した。Etagi trihydrate alumina 50.0 Sorbitol syrup (70% solution) 27.0 Sodium lauryl sulfate 1.875 Sodium dodecylbenzenesulfonate 0.6 Sodium carboxymethylcellulose 0.8 Zinc citrate trihydrate 0.5 Sodium monofluorophosphate 0.85 fragrance
1.2 Satsukarinna I ~ Rium
0.2 formalin
0.04 dye
o, ooe water
Several toothpastes were prepared using various grades of trihydrated alumina down to 1.00.
１、平均粒度６〜８μの磨砕三水和アルミナ（Ｂ＾Ｃｈ
ｅｍｉｃａｌｓから＾Ｆ２８０として販売）、２、平均
粒成約１０μの磨砕三水和アルミナ（Ｂ＾Ｃｈｅｍｉｃ
ａｌｓから＾Ｆ２４０として販売）、３、平均粒成約６
μの沈殿（非磨砕）三水和アルミナ。1. Ground trihydrate alumina (B^Ch
2. Ground trihydrate alumina with an average particle size of approximately 10μ (B^Chemical)
sold as ^F240 from als), 3, average grain size approx. 6
μ precipitated (unground) trihydrated alumina.
各線り歯磨を３７℃で６ケ月間保管した。製造直後に得
られた水溶性フッ化物のｌに対する保管後に得られた水
溶性フッ化物の量の％を成人に示す。Each wire toothpaste was stored at 37°C for 6 months. Adults are shown the % amount of water-soluble fluoride obtained after storage relative to l of water-soluble fluoride obtained immediately after production.
成人はまた可溶性亜鉛の％も示ず。Adults also showed no % soluble zinc.
■」■１町 狂旦ｎ
磨砕三水和アルミナミルｓ車６〜８μ ８１４８磨砕
三水相アルミナａｐｓ＊約１０μ ９２３フ沈殿三水
和アルミナ＆ｐ８ｍ約６μ ９９５４車平均粒度
これらの結果より本発明の練り歯磨のずぐれた特性が明
らかである。■''■1 town madan n ground trihydrate alumina mill s car 6~8μ 8148 ground trihydrate alumina aps *approx. 10μ 923 precipitated trihydrate alumina & p8m approx. 6μ 9954 car average particle size Based on these results The extraordinary properties of the inventive toothpaste are evident.
Claims (3)
ムと０．０２〜５重量％の水溶性亜鉛化合物と２０〜７
０重量％の平均粒度３〜１５μの非磨砕沈殿三水和アル
ミナとを含む口腔組成物。(1) 0.1-2% by weight of sodium monofluorophosphate and 0.02-5% by weight of a water-soluble zinc compound and 20-7
0% by weight of unground precipitated trihydrated alumina having an average particle size of 3 to 15 microns.
る請求項１に記載の組成物。(2) The composition according to claim 1, wherein the zinc compound is zinc citrate.
を特徴とする請求項１に記載の組成物。(3) The composition according to claim 1, characterized in that the trihydrate alumina has an average particle size of 5 to 10 microns.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP20659689A JPH0377815A (en) | 1989-08-09 | 1989-08-09 | Compound for oral cavity |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP20659689A JPH0377815A (en) | 1989-08-09 | 1989-08-09 | Compound for oral cavity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH0377815A true JPH0377815A (en) | 1991-04-03 |
Family
ID=16526018
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP20659689A Pending JPH0377815A (en) | 1989-08-09 | 1989-08-09 | Compound for oral cavity |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0377815A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8819939B2 (en) | 2008-09-04 | 2014-09-02 | Koyo Bearings Usa Llc | Method of manufacturing a split bearing ring |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5489042A (en) * | 1977-12-07 | 1979-07-14 | Unilever Nv | Tooth paste |
| JPS60239410A (en) * | 1984-05-09 | 1985-11-28 | ユニリーバー・ナームローゼ・ベンノートシヤープ | Dentifrice composition |
| JPS6345215A (en) * | 1986-06-27 | 1988-02-26 | ブレンダツクス−ヴエルケ エル シユナイダ− ゲゼルシヤフト ミツト ベシユレンクテル ハフツンク ウント コンパニ− | Oral sanitary composition |
| JPH01104005A (en) * | 1987-08-21 | 1989-04-21 | Unilever Nv | Dentfrice |
-
1989
- 1989-08-09 JP JP20659689A patent/JPH0377815A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5489042A (en) * | 1977-12-07 | 1979-07-14 | Unilever Nv | Tooth paste |
| JPS60239410A (en) * | 1984-05-09 | 1985-11-28 | ユニリーバー・ナームローゼ・ベンノートシヤープ | Dentifrice composition |
| JPS6345215A (en) * | 1986-06-27 | 1988-02-26 | ブレンダツクス−ヴエルケ エル シユナイダ− ゲゼルシヤフト ミツト ベシユレンクテル ハフツンク ウント コンパニ− | Oral sanitary composition |
| JPH01104005A (en) * | 1987-08-21 | 1989-04-21 | Unilever Nv | Dentfrice |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8819939B2 (en) | 2008-09-04 | 2014-09-02 | Koyo Bearings Usa Llc | Method of manufacturing a split bearing ring |
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