JPH0366608A - Remedy for tragomaschalia comprising adrenocortical steroid as main agent - Google Patents

Abstract

PURPOSE:To obtain a remedy for tragomaschalia observed to have extremely treating effects on tragomaschalia which has been difficult to exterminate by a conventional external preparation by administration in an extremely short period, containing an effective amount of adrenocortical steroid as a main agent and an effective amount of an antibacterial agent as an auxiliary. CONSTITUTION:An effective amount of an adrenocortical steroid such as generally known predinisone, methylpredonisone or cortisone as a main agent is blended with an effective amount of an antibacterial substance effective against bacteria of metabolizing secretion of epithelial steroid to cause a smell of tragomaschalia as an auxiliary to give a remedy for tragomaschalia which can completely cure tragomaschalia, which has been difficult to exterminate by an external preparation, by synergistic actions of both the components through treatment in a short period. Adrenocortical steroid is estimated to suppress secretion of bad-smelling steroid causing substance from epithelial secretion tissue of the armpit by inhibitory action on steroid synthesis and secretion of organism tissue.

Description

DETAILED DESCRIPTION OF THE INVENTION (Industrial Application Field) The powder relates to a drug for treating armpit irritation using corticosteroids.

(Prior art) Up until now, countermeasures or treatments for armpit rash have included neutralizing the odor using deodorants, suppressing the bacterial breeding environment using antiperspirants, and using antibacterial substances such as antibiotics and bactericidal agents. Numerous attempts have been made to suppress its activity and sterilize it.

Epithelial steroids such as apocrine glands related to armpit syndrome)'
Molecule l1m metabolizes and secretes steroid compounds such as cholesterol and sex hormones, but the types of steroids secreted are diverse. In particular, secretion (during secretion,
Intermediate products in the steroid metabolic pathway are also excreted from avoccrine glands, where some of the glandular cells produce secretions at the constriction (a type of secretion in which the glandular cells cut off and exit while containing some of the cytoplasm). The types of steroid compounds secreted are extremely diverse.

Armpit odor is caused by certain steroid compounds among these.
5 α-and odorous steroid compounds, metabolized and produced by the bacterial flora that colonize and proliferate in the axillary epithelium.
rost-16-en-3-on (5α-A).

However, this compound itself has not been detected in the fluid secreted from the axillary secretory tissue, and the 5αA-compound is secreted and metabolized in the body, and the steroid compound settles in the armpit. The Funatsuri theory holds that it is re-metabolized and produced by the bacteria in the body.

Bacteria that colonize the epithelium include aerobic bacteria Staphylococcus, aerobic Coryneform bacteria, and anaerobic bacteria Propionibacterium, among which Coryneform bacteria group, Propionibacterium There are many species of Staphylococcus and some Staphylococci that have steroid metabolism functions.

(Problem to be Solved by the Invention) The mechanism of armpit odor is as described above, and therefore, the main method of preventing armpit odor is to apply antibiotics and other antibacterial substances to the armpits to kill the bacteria colonized in the armpit epithelium. This is done by suppressing the production of odorous steroids by removing them.

However, these effects are only temporary until the antibacterial effect disappears and the bacteria recolonize, and current eradication treatment for armpit irritation relies solely on surgical treatment.

The present inventors have endeavored to develop a treatment method for armpit moth whose main effect is to suppress the synthesis and secretion of steroid compounds in biological tissues.
He has focused his efforts on research to find a drug that can quickly eradicate armpit moths without surgical treatment.

(Means for Solving the Problems) The problems of the prior art described above are solved by a drug for treating armpit irritation, which is characterized by containing effective amounts of a corticosteroid as a main ingredient and an antibacterial substance as an adjuvant.

(Action) The drug for treating armpit irritation of the present invention eliminates armpit irritation in an extremely short period of time due to the synergistic action of the corticosteroid as the main agent and the antibacterial substance as an adjuvant. Complete recovery can be achieved through treatment.

Therefore, the antibacterial substance used as an auxiliary agent in the drug for treating armpit irritation of the present invention has been used in the past, and therefore, the above-mentioned surprising effects of the present invention are mainly due to the use of corticosteroids as the main agent. This is thought to be due to the effect.

Corticosteroids have never been used for the treatment of armpit odor, and therefore their specific pharmacological effects on armpit odor are not necessarily clear, but one of the physiological effects of corticosteroids is the steroid absorption in living tissue. This is thought to be due to the secretion of odorous steroids from the axillary epithelial secretory tissue being inhibited by the secretion suppressing effect.

For example, since the presence of Δ''-CI9 steroids is essential for bacterial production of the 5α-A armpit odor compound, it is possible to prevent irreversible and long-term effects by locally applying corticosteroids at high concentrations. This is presumed to be due to the suppression of steroid secretion from the avocrine glands.

Conventionally, the anti-inflammatory effect of corticosteroids when used externally to treat skin inflammation, for example, is thought to be due to the reduction in the production of prostaglandins and leukotrienes, which are important chemical mediators of inflammation. Therefore, the inhibition of the production of armpit odor compounds by corticosteroids through the metabolism of microorganisms from apocrine gland secretions is different from the mechanism of anti-inflammatory action described above, and cannot be easily predicted from these mechanisms. It is something.

The corticosteroid used as the main agent in the present invention is selected from commonly known ones such as cortiscin, cortisol, hydrocortiscin, prednisone, prednisolone, methylprednisone, methylprednisolone, triamcinolone, dexamethasone, valamethasone, betamethasone, and betamethasone. can do.

When applying corticosteroids to treat armpit irritation, the physiological effects of corticosteroids may be inhibited due to uptake of the corticosteroid by bacteria in the armpit epithelium and the production of compounds that inhibit its action. If large amounts of corticosteroids are applied, there is a risk of inducing infection as a side effect.

For this reason, the therapeutic agent of the present invention contains one or more antibacterial substances as an adjuvant to prevent bacteria colonized in the axillary epithelium from being removed or to suppress their activity. ing. Therefore, the adjuvant is used to effectively obtain the effect of the corticosteroid as the main agent at a minimum dose, rather than the bactericidal or antibacterial function itself in conventional arm odor treatment agents.

The antibacterial substance used in combination with the base agent can be appropriately selected from known antibiotics and chemical disinfectants effective against bacteria that metabolize the secretions of the epithelial steroids.

The therapeutic effect of corticosteroids on armpit rash is extremely pronounced and rapid, and according to bed experiments shown in the Examples below, complete cure can be achieved with one or two administrations of approximately 2 mg or less of the active ingredient. Most of them are.

Furthermore, according to the results of experimental treatments to date, the treatment period is about 6 months to 1 month after treatment.
There have been almost no cases of recurrence over the 8 months a year, and there has been no need for long-term continuous use, so no side effects have been observed.

EXAMPLES The present invention will be explained below with reference to the results of clinical trials on actual patients with armpit syndrome. Approximately 170 patients were tested during the period from January 1987 to June 1989.

For such patients, a therapeutic drug in the form of an ointment containing 2 mg of prednisolone as a corticosteroid and valadiomycin 3B as an antibiotic per gram was applied to the armpits once a day in the usual manner.

Most of the 170 patients showed a remarkable effect (odor-free) after one application, and complete therapeutic effects were observed for the other patients after up to two applications.

After the lapse of the above period, it was confirmed that no armpit irritation occurred at all, except for some patients who were unable to be followed up.

Recently, there have been reports of two cases where armpit odor recurred after healing.
These were all patients who underwent hair removal treatment on their armpits after treatment.

Subsequent tests using drugs containing methylprednisolone and cortiscin as the main ingredients of adrenal corticosteroids yielded therapeutic effects similar to X'.

(Effects of the Invention) According to the present invention, a remarkable therapeutic effect was observed for armpit rash, which was conventionally thought to be difficult to cure, by administering medication for a very short period of time.

Claims (1)

[Claims] A drug for treating armpit irritation, characterized by containing an adrenal corticosteroid as a main ingredient and an antibacterial substance as an adjuvant in effective amounts.