JPH0362112B2 - - Google Patents

Description

[Detailed Description of the Invention] (1) Industrial Application Field The present invention relates to a subcutaneously implantable drug solution injection catheter used for repeatedly injecting a drug solution such as an anticancer drug into the vascular system of a patient with an unresectable advanced malignant tumor. It is related to.

(2) Prior Art As a conventional catheter of this type, the one shown in FIG. 8 is known. 101 is a lumen 10 with an opening at the upper end.
3, and is a generally conical main body made of plastic that is implanted subcutaneously, and the main body 101 has a horizontal communication hole 104 opened on the side that communicates with the lower part of the inner cavity 103, and the communication hole 104 A rear end opening of a catheter tube 105 of a predetermined length made of silicone rubber is connected to the opening. A puncture part 110 made of silicone rubber is fitted in a compressed state into a large diameter recess formed in the upper part of the inner cavity 103.

In order to inject the medicinal solution into the affected area, the injection needle 111 is pierced into the puncture part 110 of the main body 101, and the medicinal solution in the syringe is injected into the lumen 10 from the needle tip.
3 and further from the lower part of the lumen 103 through the catheter tube 105 to the affected area where the distal opening of the tube is located.

(3) Problems to be Solved by the Invention By the way, in the case of the conventional catheter described above, it is undeniable that the concentration of the medicinal solution becomes considerably diluted with blood when the medicinal solution is injected into the affected area. The problem was that effective treatment of the affected area could not be performed because there was no means available.

SUMMARY OF THE INVENTION Therefore, the present invention aims to provide a catheter that eliminates the problems of the conventional catheters, prevents the concentration of the injected drug solution from diluting with blood, and allows more effective treatment of the affected area. purpose.

(4) Means for Solving the Problems In order to achieve the above object, the catheter of the present invention includes a main body having two lumens with an upper end opening,
A needle receiving container made of a rigid material and having an open top is fitted into each lumen of this main body, and puncture parts made of an elastic material having self-closing properties are fitted into the upper part of these needle receiving containers. Through holes are formed in the side wall of the needle receiving container located lower below, and the rear end openings of the first and second catheter tubes communicate with the interior of the needle receiving container below the puncture portion through these holes. The present invention is characterized in that a balloon for occluding blood vessels is connected to the main body and attached to the opening at the distal end of the first catheter tube.

(5) Effect When injecting the medicinal solution into the affected area, the balloon attached to the opening at the tip of the first catheter tube can compress and occlude the blood vessels near the affected area, so the injected medicinal solution can be The concentration will no longer be diluted by blood.

(6) Embodiment FIG. 1 shows a plan view of a drug solution injection catheter with a blood vessel occlusion balloon. In the figure, the lower catheter section A is configured to inject a medical solution, and the upper catheter section B is configured to occlude blood vessels. The structure of the catheter section A through which the drug is injected is as shown in FIG. Reference numeral 1 denotes a substantially conical main body made of silicone rubber having a lumen 3 with an open upper end, and a horizontal communication hole 4 that communicates with the lower part of the lumen 3 is formed in the main body 1 and opens on the side surface. A needle receiving container 5 made of stainless steel is fixed to the inner cavity 3 of the main body 1 by the main body 1 around the inner cavity 3 and is fitted in a manner that cannot be removed. A tactile section 6 is provided around the upper end opening of the inner cavity 3 into which the needle receiving container 5 is fitted. The tactile part 6 has a convex padding so that the upper end opening of the inner cavity 3 can be confirmed from above the skin when the main body 1 is implanted subcutaneously. Needle receiver container 5
The cylindrical portion 5a is fitted into the lower part of the inner cavity 3, and the expanded cylindrical part 5a is connected to the upper end of the cylindrical part in an enlarged shape with the diameter gradually increasing upward from the upper end of the cylindrical part, and which is fitted into the upper part of the inner cavity 3. A through hole 7 communicating with the communication hole 4 is bored in the side wall of the cylindrical part 5a, and an opening communicating with the upper end opening of the inner cavity 3 is formed in the top wall of the expanding cylindrical part 5b. 8 is drilled. A puncture part 10 made of silicone rubber is fitted into the expansion tube part 5b in a compressed state, and the outer peripheral surface of the upper end of the puncture part 10 has a flange 11 around the opening 8 of the expansion tube part 5b so that the puncture part 10 does not slip out. is being held down. Since the puncture part 10 is made of silicone rubber, it can be punctured with the injection needle many times, and when the punctured needle is removed, its own elasticity allows the needle to pass through. It has good self-closing properties to prevent leakage of chemical solution. Like the lower part of the lumen of a conventional catheter in the container 5 below the puncture part 10, there is a reservoir 13 in which a medicinal solution can be temporarily stored.

The rear end opening of a catheter tube 15 of a predetermined length made of silicone rubber is connected to the opening of the communication hole 4, and the rear end opening of a catheter tube 16 of a similar predetermined length is connected to the distal end opening of the tube 15. The parts are communicatively connected via a connector 17. An annular protrusion 18 is provided near the tip opening (outlet) of the catheter tube 16 for fixing the tip. Reference numeral 20 denotes a check valve that prevents blood from flowing back toward the reservoir 13 from the catheter tubes 15 and 16, and is fitted into the communication hole 4. Reference numeral 21 indicates a suture hole drilled in the lower periphery of the main body 1 for sewing and fixing the main body 1 to the fascia of the subcutaneous tissue. Reference numeral 22 indicates a reinforcing hole attached to the bottom of the main body 1 including the suture hole 21. It is polyester mesh.

On the other hand, the configuration of the catheter portion B that performs occlusion of the blood vessel is as shown in FIG. The configuration of this catheter section B is basically the same as the configuration of the catheter section A described above, except that the check valve 20 is not provided. Therefore, similar parts will be given the same reference numerals with dashes, detailed explanations will be omitted, and different configurations will be explained below. A catheter tube 2 of a predetermined length made of silicone rubber and whose rear end opening is connected to the opening of the communication hole 4'.
The tip opening of No. 4 is a silicone rubber balloon consisting of a bendable outer support part 25 made by cutting out a tube, and a thin sheet-like inner balloon part 26 whose peripheral edge is adhered to the inner peripheral surface of the support part. It is fixed to the support part 25 of 27 in communication with the inside of the balloon 27. When a liquid such as physiological saline is injected into the balloon 27 from the catheter tube 24, the balloon portion 26 of the balloon 27 expands by pushing the support portion 25 apart from the bent state shown in FIG. 3 as shown in FIG. It's getting old. Reference numeral 28 denotes protrusions provided on the outer circumferential surface of both ends of the support section 25 to prevent the threads wound around the support section 25 from slipping off when the balloon 27 is fixed to the blood vessel.

In order to facilitate use of the above-mentioned drug solution injection catheter, the main bodies 1 and 1' are fixed together in parallel using an adhesive or the like so that the catheter tubes 15 and 16 and the catheter tube 24 are approximately parallel to each other. ing. In addition, a first contact portion 6′ of the main body 1′ of the catheter portion B for occluding blood vessels is provided with a first contact portion 6′.
As shown in the figure, a marking part 31 is attached to the catheter part A to identify it from the main body 1.

Next, the operation of the above embodiment will be explained.

To implant the catheter subcutaneously, step 5
As shown in the figure, the catheter tube 16 is inserted into the blood vessel from the distal end of the hepatic artery 81 of the liver 80, for example, and the distal opening is advanced to the affected area to be treated and fixed, and the balloon 27 of the catheter tube 24 is inserted into the blood vessel. The tube is placed in the intended hepatic artery 81, and the string 82 is wound and fixed with the balloon portion 26 facing inside as shown in FIG.

On the other hand, the main bodies 1 and 1' are also sewn and fixed to the fascia of the subcutaneous tissue through the suture holes 21 and 21'.

In order to inject an anticancer drug as a medicinal solution into an affected area in the catheter implanted subcutaneously as described above, lightly place a finger on the tactile part 6 of the main body 1 identified by the marking part 31 to confirm the upper end opening of the lumen 3, As shown in FIG. 7, an injection needle 83 is inserted into the puncture section 10, and the anticancer agent in the syringe is injected into the reservoir 13 from the needle tip. When piercing this injection needle 83,
Even if the injection needle 83 is not inserted almost perpendicularly, the needle tip hits the tapered surface on the inner surface of the expanding tube portion 5b of the needle receiving container 5, and then is guided to the reservoir 13 by the tapered surface, and the needle tip I never get tired of it. Furthermore, since the needle receiving container 5 is made of stainless steel, the needle tip will not penetrate through it. The anticancer drug injected into the reservoir 13 passes through the through hole 7, the check valve 20 in the communicating hole 4, and the catheter tubes 15 and 16, and flows from the distal opening of the tube 16 to the affected area.

In this way, the anticancer drug flows into the affected area.

When injecting the anticancer drug into the affected area, in order to prevent the concentration of the anticancer drug from becoming diluted, another injection needle (not shown) is inserted into the puncture part 10 of the main body 1' in advance, and physiological saline is injected into the reservoir 13'. The liquid is injected into the balloon 27 through the catheter tube 24, and the balloon portion 26 is inflated, compressing the hepatic artery 81 to occlude it and temporarily cutting off blood flow. As a result, the concentration of the anticancer agent flowing to the affected area does not become diluted, making it possible to treat the affected area more effectively with a highly concentrated anticancer agent. A method of blocking blood flow using such an occlusion balloon 27 is the conventional BOAI (Balloon Balloon 27).
Compared to a method called occlusion arterial infusion, which blocks blood flow using a balloon catheter inserted into a blood vessel, this method does not cause the formation of blood clots in the hepatic artery and is extremely effective.

After use, the injected liquid such as physiological saline is drawn out by inserting the injection needle into the puncture portion 10' again.

In each of the above embodiments, the needle receiving container 5,
Although 5' is made of stainless steel, it may be made of a relatively light and rigid material other than stainless steel, such as metal, ceramic, or hard plastic, as long as it does not allow the injection needle to penetrate upon piercing. In addition, the two inner cavities 3 and 3' are connected to separate bodies 1 and 3' respectively.
1', but it may be formed into one body.

(7) Effects of the Invention This invention has the above-mentioned configuration, and when injecting a drug solution, it is possible to occlude a blood vessel near the affected area with the balloon provided at the opening at the tip of the first catheter tube. It is possible to prevent the concentration of the medicinal solution injected into the patient from becoming diluted, thus making it possible to treat the affected area more effectively with a highly concentrated medicinal solution. In addition, there is no need to use separate catheters for injecting the drug and occluding the blood vessel; it is possible to use a single catheter that has both functions.
In addition to being extremely easy to inject medical fluids and handle vascular occlusion, the main body only needs to be sewn and fixed once when implanted into subcutaneous tissue.
It has excellent effects such as good workability.

[Brief explanation of drawings]

FIG. 1 is a partially omitted plan view of a catheter for injecting a drug solution according to an embodiment of the present invention, FIG. A partially omitted longitudinal sectional front view of the catheter section for occluding the blood vessel as above, Fig. 4 is a partial perspective view of the balloon section as above, Fig. 5 is an explanatory view of the operation, and Fig. 6 is a state in which the balloon section is fixed as above. FIG. 7 is a perspective view showing a state in which a drug solution is being injected using a syringe in the same device as above, and FIG. 8 is a longitudinal sectional front view showing a conventional example. 1, 1'...Main body, 3, 3'...Inner cavity, 4, 4'
...Communication hole, 5,5'...Needle receiver container, 6,6'...
...Touch portion, 7,7'...Through hole, 8,8'...Opening, 10,10'...Puncture portion, 15,16...Catheter tube, 20...Check valve, 25... Support part, 26...Balloon part, 27...Balloon, 31...Indication part.

Claims (1)

[Scope of Claims] 1. A main body having two lumens with an opening at the top, a needle receiving container made of a rigid material and having an opening at the top fitted into each lumen of the main body, and a needle receiving container made of a rigid material and having an opening at the top. Puncture parts made of an elastic material with self-closing properties are fitted, and through holes are made in the side wall of the needle receiver container below the puncture parts, and through these holes, the needle receiver container below the puncture part is inserted. The rear end openings of the first and second catheter tubes are connected to the main body so as to communicate with the inside of the body, and a balloon for occluding blood vessels is attached to the front end opening of the first catheter tube. A subcutaneously implantable drug injection catheter. 2. The subcutaneous device according to claim 1, wherein a check valve is provided between the rear end opening of the second catheter tube and the through hole to prevent blood from flowing backward from the catheter tube toward the through hole. Implantable infusion catheter.