JPH0350725B2 - - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a novel denture adhesive composition for improving denture base incompatibility. Complete dentures or partial denture bases generally become unfit due to the passage of time from the time of their preparation or due to physiological enlargement or shrinkage of the oral cavity. In particular, the gap between the alveolar ridge becomes large, and the denture base does not fit properly, causing looseness, making it impossible to maintain a perfect occlusion, making it inconvenient to speak, and causing problems such as lumps,
It becomes difficult to eat sticky foods such as candy,
This causes inconveniences such as food residue remaining between the denture base and the gums, resulting in unsanitary conditions. Furthermore, when eating something hard, a large amount of occlusal pressure is concentrated on one part of the gums, which can cause severe pain and damage the gums. Such misfits in denture bases should essentially be corrected by specialists such as dentists, but improving denture bases requires a considerable amount of time and is not economical. The burden is also large. In addition, patients who suffer from unfitting denture bases currently endure suffering for quite a long period of time before changing their denture bases. In order to alleviate the patient's suffering until the above-mentioned denture base incompatibility is corrected by a specialist,
As a temporary denture adhesive, pasty compositions based on gum arabic have been commercially available, but in addition to the inconvenience of having to apply them every day, they are not flexible enough to be eaten. They had the disadvantage that the hardness of food they could eat was considerably limited compared to healthy teeth. Also, acrylic ester polymer, vinyl acetate polymer or vinyl acetate polymer
Low-molecular plasticizer (for example,
Denture stabilizers have been proposed in which 10 to 65% of phthalate esters are added to give flexibility, but the plasticizers used there cannot be said to be harmless to the human body, so they cannot be put to practical use. is accompanied by anxiety. The present inventors have conducted various studies to develop a denture stabilizer that is substantially harmless to the human body and has appropriate flexibility without using low-molecular plasticizers, and as a result, it has been found that it is safe for the human body. It is guaranteed that a composition that uses a mixed plastic material with both high and low degrees of polymerization as polyvinyl acetate and further contains polybdenum and ethanol as essential components in a certain proportion has desirable physical properties as a denture stabilizer. He discovered this fact and succeeded in developing a denture adhesive based on this discovery (Japanese Patent Application Laid-open No. 76591/1983). The above denture adhesive has already been commercialized and has been well received, but as a result of further research aimed at further improving the fit and adhesion, we found that polyvinyl acetate, sucrose fatty acid ester, and ethanol were added as essential ingredients. The inventors have discovered that a composition containing these ingredients in a certain proportion has excellent fit and adhesion, and based on this knowledge, they have completed the present invention. The gist of the invention resides in a denture adhesive composition comprising about 55-85% by weight polyvinyl acetate, about 1-12% by weight sucrose fatty acid ester, and about 5-40% by weight ethanol. It should be noted that the denture stabilizer composition according to the present invention is different from the denture stabilizer composition of JP-A-53-76591 mentioned above, as in the latter, polybdenum is insoluble in ethanol. The composition of the former is essentially a suspension system, whereas the composition of the former is essentially a solution system because the sucrose fatty acid ester is soluble in ethanol. It is thought that due to this difference, the plasticizing effect of polyvinyl acetate is more fully exhibited in the former than in the latter, resulting in improved fit and adhesion. In addition to the above-mentioned advantages, the denture stability composition of the present invention has good fluidity before use, so it can be easily taken out from a container (for example, a tube), and the formed outer skin forms a film after use. Since the fluidity of the internal composition is maintained for a long period of time, it has the advantage of a long period of use, and is highly practical. Polyvinyl acetate preferably has a degree of polymerization in the range of about 200 to 6,000, and it is not necessary to use one type of polyvinyl acetate, but rather a mixture of two or more types of polymerization degree in an appropriate ratio. It's okay. Attempting to obtain the desired plasticity with types of polyvinyl acetate may not always be easy;
In such cases, it is particularly preferable to use a mixture of two or more types of polyvinyl acetate since the desired plasticity can be easily achieved. The sucrose fatty acid ester is an ester of sucrose and fatty acid, and a product that passes the Japanese Food Additives Standards is used. The number of carbon atoms in the fatty acid moiety is _C3 to _C20 ,
Any type of sucrose can be used, from mono-esterified to completely esterified hydroxyl groups of the eight esterifiable hydroxyl groups present in sucrose. In those with a degree of esterification of 100%, the ester portion is generally composed of relatively lower fatty acids. A typical example is SAIB (Sucrose acetate isobutyrate), in which two of the eight hydroxyl groups of sucrose are esterified with acetic acid groups and six with isobutyric acid groups.
can be mentioned. Those composed of relatively high-grade stearic acid, palmitic acid, and oleic acid derived from natural hardened beef tallow are generally mono-, di-, or triesters, and the degree of esterification is usually about 15 to 25%.
within the range of These are not necessarily esterified with a single fatty acid, but are often used in which one to three or more hydroxyl groups of sucrose are esterified with a mixed fatty acid. As the sucrose fatty acid ester, one of the representative ones listed above can be used alone. In addition, two or more types of sucrose fatty acid esters are mixed in order to balance various sometimes mutually contradictory properties such as plasticity, cushioning properties, durability, adhesiveness, and peelability required for the composition of the present invention. It can be used as The contents of polyvinyl acetate, sucrose fatty acid ester, and ethanol in the denture adhesive composition of the present invention need to be as described above. If the amount of polyvinyl acetate is less than about 55% by weight, solidification will be incomplete, and if it is more than about 85% by weight, flexibility will be insufficient. When the content of sucrose fatty acid ester is about 1% by weight, flexibility is poor, and when it is about 12% by weight or more, the adhesiveness is too high and it is difficult to handle, the elasticity is poor, and the cushioning properties are poor. If ethanol is less than about 5% by weight, the fluidity necessary for spreading to the denture base cannot be obtained, and if it is more than about 40% by weight, the irritation to the oral mucosa during installation is too strong, and the ethanol does not have enough elasticity or hardness to withstand occlusal pressure. is not obtained. In addition to the above-mentioned essential ingredients, JP-A-53-76591 may be added to the extent that the desired effect is not substantially impaired.
Appropriate amounts of optional ingredients such as polybutene, colorants, flavoring agents, flavoring agents, and deodorants used in the above may be used. By kneading the above-mentioned essential components and, if necessary, optional components at room temperature or under heating or cooling, a denture stabilizer composition is obtained as a transparent or translucent semi-fluid having appropriate viscoelasticity. Since the denture stabilizer composition obtained here has appropriate viscoelasticity, it can be easily spread onto a denture base. After spreading to the denture base,
When this is washed with water or placed in the oral cavity, the ethanol in the contact area is eluted by contact with water or saliva, and a flexible and tough outer skin is formed at the outer edge. A semi-fluid is contained inside the outer skin, which helps provide cushioning and flexibility. Hereinafter, the present invention will be explained in more detail with reference to Examples. Note that % represents weight %. Example 1 Purified to a residual monomer content of 1.0% or less,
40% polyvinyl acetate with an average degree of polymerization of 300, 25% similarly purified polyvinyl acetate with an average degree of polymerization of 5500,
5% sucrose fatty acid ester 100% esterified with _C3 - _C5 fatty acids, 2% sucrose fatty acid ester esterified with fatty acids from hardened beef tallow, 27% ethanol and 1% natural color are stirred under heat. Dissolve and filter to obtain a homogeneous semi-liquid denture adhesive composition. Fill the tube with this. Rinse the denture base with water and dry it thoroughly with a cloth, especially the area that touches the gums. The denture stabilizer composition is extruded from the tube, applied and spread to a thickness of about 0.5 mm on the part of the denture base that contacts the gums, and left for 2 to 3 minutes. Next, this denture base is placed in the oral cavity, and the patient bites down firmly with an even force on both sides. Once the denture base is removed, it is washed with water, and then reattached to the mouth. As a result, patients who previously had unfit denture bases can now achieve complete occlusion. Example 2 35% polyvinyl acetate with an average degree of polymerization of 500 purified to a residual monomer content of 1.0% or less, 20% polyvinyl acetate with an average degree of polymerization of 1800 purified in the same way, and 35% of polyvinyl acetate purified in the same way with an average degree of polymerization of 3500. polyvinyl acetate
20%, fully esterified sucrose fatty acid ester, 10%, and ethanol 15% are stirred and dissolved under heat to obtain a homogeneous semi-liquid denture adhesive composition. Fill the tube with this. Example 3 70% polyvinyl acetate with an average degree of polymerization of 1900, purified to a residual monomer content of 1.0% or less, 4% 100% esterified sucrose fatty acid ester, and 26% ethanol were dissolved by stirring under heating. A homogeneous semi-fluid denture adhesive composition is obtained. Fill the tube with this. Example 4 45% polyvinyl acetate with an average degree of polymerization of 350 purified to a residual monomer content of 1.0% or less, 22% polyvinyl acetate with an average degree of polymerization of 6500 purified in the same way, 1.5% polybutene with an average molecular weight of about 1300, 3% of 100% esterified sucrose fatty acid ester and 28.5% of ethanol are stirred and dissolved under heat to obtain a homogeneous semi-liquid denture adhesive composition. Fill the tube with this. Example 5 48% polyvinyl acetate with an average degree of polymerization of 200 purified to a residual monomer content of 1.0% or less, 15% polyvinyl acetate with an average degree of polymerization of 5000 purified in the same manner, and esterified with fatty acids from hardened beef tallow. 12% sucrose fatty acid ester and 25% ethanol are stirred and dissolved under heat to obtain a homogeneous semi-liquid denture adhesive composition. Fill the tube with this. The denture stabilizer compositions obtained in each of the above examples and commercially available products were tested on people who were dissatisfied with their dentures (20
I followed the name). The results are shown in Table 1. The symbols in the table have the following meanings. ◎……Improvement effect for 17 or more people. ○…Improvement effect was seen in 15 to 17 people. □……Improvement effect for 10 to 15 people. △……No improvement effect for 10 to 15 people. ×...No improvement effect for 15 or more people. 【table】

Claims (1)

[Claims] 1. About 55-85% by weight of polyvinyl acetate, about 1-12% by weight of sucrose fatty acid ester, and about 5% by weight of ethanol.
A semi-fluid denture adhesive composition comprising ~40% by weight. 2. The composition according to item 1, wherein the sucrose fatty acid ester is one in which the number of carbon atoms in the fatty acid moiety is _C3 to _C20 . 3. The composition according to item 2, wherein the sucrose fatty acid ester is one in which 1 to 8 of the OH groups of sucrose have been converted into fatty acid ester. 4. The composition according to item 2 or 3, wherein a mixture of two or more types of sucrose fatty acid ester is used as the sucrose fatty acid ester.