JP3479811B2 - Denture stabilizer - Google Patents

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a denture stabilizer which is excellent in extrudability from a tube and releasability from a denture base as well as cushioning properties and durability during use.

[0002]

2. Description of the Related Art Japan has already entered the first half of an aging society, and the population of dentures has been increasing year by year, and it is said that the number is 20 million. According to the results of a survey of users of full dentures, it has been pointed out that there are many complaints about maintenance and chewing of dentures.

On the other hand, the main function of the denture stabilizer is to immobilize the denture by filling the gap between the denture base and the oral mucosa. As a result, the denture does not fall off and can be chewed well. It becomes difficult for food scraps to enter when
It has the effect of making it easier to talk. Therefore, the market for denture stabilizers is increasing year by year as a medical device that supports the improvement of comfort of dentures , which is said to be the third tooth following milk teeth and permanent teeth.

The denture stabilizers currently on the market can be broadly classified into two types, a contact type and an adhesive type, depending on the difference in the mechanism of action for maintaining and stabilizing the denture. The former adhesive type denture stabilizer, which is also called as a cushion type, is mainly based on vinyl acetate resin, and the formulation fills the gap between the denture and oral mucosa to expel the air inside and sucker. As described above, the denture is closely fixed. The latter adhesive type denture stabilizer is intended to swell a water-soluble polymer compound with saliva in the oral cavity and to maintain and stabilize the denture by its adhesive force.

Of the above two types, the contact type denture stabilizer has less discomfort due to dissolution of the preparation, the denture can be removed and washed with water during use, and it can be continuously used for 2 to 3 days. It has excellent features not found in adhesive types, and for this reason this type is the mainstream in Japan.

[0006] However, although the contact type denture stabilizer is excellent in functionality as described above, it has the drawback that it is difficult to extrude from the tube during use and is difficult to remove from the denture base after use, thus improving usability. It has become a challenge. In this case, in the adhesive type denture stabilizer based on vinyl acetate resin as a main base, functionality and usability, specifically, adhesiveness (functionality) and peelability (usability), elasticity (functionality) ) And extrudability (usability) and the like are in conflicting technical relations, and it is difficult to satisfy both at the same time. Therefore, a study is conducted to balance functionality and usability,
Various proposals have been made as described below. (1) Japanese Patent Publication No. 60-21123, vinyl acetate having a polymerization degree of 400 to 1000 and a polymerization degree of 3000
By combining vinyl acetate having a degree of polymerization of up to about 7,000 with vinyl acetate, the contradictory techniques of adhesiveness and peelability are simultaneously satisfied. (2) Japanese Examined Patent Publication No. Sho 64-9018 Vinyl acetate with a polymerization degree of 200 to 500 and a polymerization degree of 1000 to
By combining vinyl acetate having a degree of polymerization of 2000 and vinyl acetate having a degree of polymerization of 5000 to 7000 with different degrees of polymerization, extrudability at low temperature and stability at high temperature are improved. (3) JP-A-62-265209 A cushion-type denture stabilizer containing a polypropylene oxide-based polymer to improve the peelability from the denture base and the extrudability from the tube.

However, it is difficult to say that the above-mentioned preparations have satisfactory usability and functionality, and therefore, it is desired to develop a denture stabilizer which is more excellent in usability and functionality.

The present invention has been made in view of the above circumstances.
It is an object of the present invention to provide a denture stabilizer which is excellent in extrudability from a tube and is excellent in peelability from a denture base, and can exhibit excellent cushioning properties and its sustainability during use.

[0009]

Means and Actions for Solving the Problems As a result of intensive studies made by the present inventors in view of the above circumstances, as a result, a denture stabilizer containing a vinyl acetate resin as a main base was added to a polypropylene oxide polymer and glycerin. When used in combination with the acetyl derivative of or the acetyl derivative of ethylene glycol, it is easy to extrude from the tube before use and easy to peel off from the denture base after use, and exhibits excellent cushioning properties and its sustainability during use. It was found that comfortable chewing can be guaranteed.

That is, by adding a polypropylene oxide-based polymer to a denture stabilizer based on vinyl acetate resin as a main base, the usability is improved as described in JP-A-62-
Although it is publicly known as seen in Japanese Patent No. 265209, the functionality is still insufficient only by using a polypropylene oxide polymer alone, as will be apparent from an experimental example described later. Further, it is known to mix an acetyl derivative of glycerin into a denture base stabilizing sheet (Japanese Patent Publication No. 4-76707), but this is a sheet different from the adhesive type paste denture stabilizer, and glycerin is used. If the acetyl derivative (1) is mixed with the adhesive type denture stabilizer, the extrudability from the tube and the peelability from the denture base will be poor. However, for vinyl acetate resin,
When polypropylene oxide polymer and acetyl derivative of glycerin or acetyl derivative of ethylene glycol are used together, it is surprisingly usable (extrudability and peelability).
It was found that the two characteristics of the antinomy technology, namely, the functionality and the functionality (cushioning property and its sustainability), can be improved, and both properties are significantly improved as compared with conventional preparations, and the present invention has been accomplished. Is.

Therefore, according to the present invention, a polypropylene oxide polymer and an acetyl derivative of glycerin or an acetyl derivative of ethylene glycol are added to a denture stabilizer containing a vinyl acetate resin as a main base in an amount of 0.
Provided is a denture stabilizer characterized by being used in combination with 5 to 15% by weight.

The present invention will be described in more detail below. The denture stabilizer of the present invention comprises a vinyl acetate resin as a main base and a polypropylene oxide polymer, an acetyl derivative of glycerin or an acetyl derivative of ethylene glycol. It is prepared as a paste and is housed in an extruded tube.

The vinyl acetate resin as the main base preferably has an average degree of polymerization of 500 to 3000, but vinyl acetate having different average degrees of polymerization may be used even if one of them is used alone. Two or more kinds of resins may be used, for example, those having an average polymerization degree of 50 to 1000 and those having an average polymerization degree of 2000 to 6000 may be mixed and used.

The blending amount of vinyl acetate resin is 3 for the whole preparation.
0 to 80% (weight%, the same applies below), more preferably 40
˜75%, and more preferably 50 to 70%.

The polypropylene oxide polymer has a polyoxypropylene chain having an average degree of polymerization of 2 to 120, and the content of the polyoxypropylene chain is 60% or more of all polyoxyalkylene chains. Is preferably used. Examples of such a polypropylene oxide-based polymer include a polypropylene oxide homopolymer in which all polyoxyalkylene chains are polyoxypropylene chains, or 60 of polyoxyalkylene chains.
Examples thereof include polyethylene oxide polypropylene oxide copolymers in which polyoxypropylene chains account for at least%, and the rest are, for example, polyoxyethylene chains.

As such a polypropylene oxide polymer, one synthesized by addition-polymerizing propylene oxide or ethylene oxide and propylene oxide with a monovalent or polyvalent alcohol or a monobasic or polybasic carboxylic acid, particularly The terminal of the polypropylene oxide polymer is preferably a hydroxyl group, a monovalent or polyvalent alcohol ester, or a monobasic or polybasic carboxylic acid ester or a salt thereof.

Among them, the average molecular weight is 10
Most preferably polypropylene polypropylene glycol of 00-6000 is used.

The amount of the polypropylene oxide polymer compounded is preferably 0.5 to 20%, more preferably 1 to 10%, still more preferably 3 to 8% based on the whole preparation. If the blending amount is less than 0.5%, the desired effect may not be sufficiently exerted, and if it exceeds 20%, it may be difficult to adhere to the denture or defects such as liquid separation may easily occur.

Further, as the acetyl derivative of glycerin or the acetyl derivative of ethylene glycol, those represented by the following formula are preferably used.

[0020]

[Chemical 1]

However, in the formula, R ^{1 to} R ⁵ are hydrogen atoms or acetyl groups, and at least one of R ¹ NR ³ or R ⁴ and R ⁵ is an acetyl group. Such acetyl derivatives include triacetyl glycerin, 1,2-diacetyl glycerin, ethylene glycol diacetate, acetic acid 2
-Hydroxyethyl and 1,3-diacetylglycerin are mentioned, and among these, triacetylglycerin is particularly preferable.

The amount of the above-mentioned acetyl derivative of glycerin or acetyl derivative of ethylene glycol is 0.5 to 15%, more preferably 0.8 to 13% of the whole preparation.
More preferably, it should be 1 to 10%. If the blending amount is less than 0.5%, the predetermined effect may not be sufficiently exhibited, and if it exceeds 15%, defects such as difficulty in sticking to the denture and difficulty in extruding from the tube may occur. .

The denture stabilizer of the present invention may contain other optional components in addition to the above components, if desired. Examples of the optional component include non-toxic oils / waxes, emulsifiers, water-insoluble powders, enzymes, bactericides, water, ethanol, pigments, and the like. Specifically, beeswax as non-toxic oils / waxes, Wood wax, candelilla wax, microcrystalline wax, paraffin wax, carnauba wax, etc. as stearic acid monoglyceride, oleic acid monoglyceride, acetylated glyceryl fatty acid ester, sorbitan monostearate, sucrose fatty acid ester, etc. Calcium, titanium oxide, calcium hydrogen phosphate, calcium sulfate, zeolite, silicon dioxide, plastic powder, cellulose powder, etc. As enzymes, dextranase, mutanase, β-1,3-glucanase, amylase, etc. Triclosan, cetyl pyridinium chloride, benzethonium chloride, chlorhexidine and the like. In addition, the compounding amount of these optional components can be a usual amount within a range that does not impair the effects of the present invention.

The denture stabilizer of the present invention usually has a viscosity of 100 to 100.
It is prepared in the form of a paste of 1,000,000 poise, particularly 1000 to 500,000 poise (25 ° C). In addition, a metal tube such as an aluminum tube, a plastic tube, or a tube such as an aluminum foil laminated plastic tube is filled and used.

[0025]

EFFECTS OF THE INVENTION The denture stabilizer of the present invention is excellent in extrudability from a tube and is excellent in peelability from a denture base after use, and also exhibits excellent cushioning properties and its sustainability during use. It can be used suitably for immobilization of dentures.

[0026]

EXAMPLES The present invention will be specifically described below by showing experimental examples and examples, but the present invention is not limited to the following examples. In addition,% in each example is% by weight.

[Experimental Example 1] Extrudability and peelability of the denture stabilizer were evaluated by the following methods. A denture stabilizer having the composition shown in Table 1 was produced by a conventional method, and then filled in a white plain aluminum tube of 40 g / piece to obtain a sample. Using 14 full denture users as a panel, one panel evaluated all the samples, and a usage test of extrudability and peelability was performed based on the following evaluation criteria. The questionnaire was collected after use, and the average value of the following scores was used as the result. The results are shown in Table 1. Rating: 5 points Easy 4 points Somewhat easy 3 points 2 points Somewhat difficult 1 point Somewhat difficult 1 Criterion evaluation criteria: ◎ 5.0-4.5 ○ 4.4-3.5 △ 3.4-2.4 × 2.3 From the results in Table 1 below, it was found that the combination of polypropylene glycol and triacetylglycerin dramatically improved the effects of extrudability from a tube and releasability from a denture base.

[0028]

[Table 1]

[Experimental Example 2] The cushioning property persistence (solidification resistance) of the denture stabilizer was evaluated by the following method. Diameter 3.6
A denture stabilizer (formulation 1 to 4) produced in Experimental Example 1 was filled in a glass cup having a size of cm × height 2.3 cm to prepare a sample. Immerse in a constant temperature water bath at 37 ° C, take out after a predetermined time and remove the Boucher Electronic Jell.
The jelly strength was measured using yTester (manufactured by Kett Science Laboratories) and evaluated according to the following evaluation criteria. The results are shown in Table 2. Evaluation criteria for hardness: ◎ Jelly strength 80 to 110 ○ Jelly strength 111 to 140 △ Jelly strength 141 to 160 × Jelly strength 161 or more Evaluation criteria for cushioning durability: ○ Jelly strength 140 or less after 48 hours △ 48 hours Jelly strength after 160 × Jelly strength after 48 hours 161 or more From the results in Table 2, it was found that the combination effect of polypropylene glycol and triacetylglycerin improves the sustaining effect of cushioning property.

[0030]

[Table 2]

Example 1 Vinyl acetate resin 65% Pluronic L-1015 triacetylglycerin 1 β-1,3-glucanase 0.5 60% Ethanol balance meter 100.0%

Example 2 Vinyl acetate resin 50% Polypropylene glycol 3 1,3-diacetylglycerin 15 Beeswax 1 Stearate monoglyceride 1 Calcium carbonate 5 60% Ethanol balance meter 100.0%

Example 3 Vinyl acetate resin 60% Polypropylene glycol 8 Triacetylglycerin 5 Stearate monoglyceride 1 Calcium carbonate 3 β-1,3-glucanase 1 60% Ethanol balance meter 100.0%

Example 4 Vinyl acetate resin 63% Polypropylene glycol 5 Triacetylglycerin 10 60% Ethanol balance meter 100.0%

Example 5 Vinyl acetate resin 70% Pluronic L-101 10 1,3-diacetylglycerin 1 60% Ethanol balance meter 100.0%

Example 6 Vinyl acetate resin 65% Polypropylene glycol 7 Triacetylglycerin 1 Beeswax 1 Stearate monoglyceride 1 Calcium carbonate 3 β-1,3-glucanase 0.1 60% Ethanol balance meter 100.0%

Example 7 Vinyl acetate resin 60% Polypropylene glycol 5 Ethylene glycol diacetate 10 Beeswax 2 60% Ethanol balance meter 100.0%

─────────────────────────────────────────────────── ─── Continuation of the front page (56) Reference JP-A-5-65210 (JP, A) JP-A-62-265209 (JP, A) JP-A-5-65211 (JP, A) JP-A-62- 129210 (JP, A) JP-A-57-99512 (JP, A) (58) Fields investigated (Int.Cl. ⁷ , DB name) A61K 6/00 A61C 13/23 C08L 29/02 C08L 71/02

Claims (2)

(57) [Claims] 1. A denture stabilizer containing a vinyl acetate resin as a main base, and a polypropylene oxide polymer and an acetyl derivative of glycerin or an acetyl derivative of ethylene glycol in an amount of 0.5 to 15% by weight of the whole preparation. A denture stabilizer, which is characterized in that it is used in combination. 2. The denture stabilizer according to claim 1, wherein the polypropylene oxide polymer is polypropylene glycol having an average molecular weight of 1,000 to 6000, and the acetyl derivative of glycerin is triacetylglycerin.