JPH0338507A - Production of powder for cosmetic covered with collagen - Google Patents
Production of powder for cosmetic covered with collagenInfo
- Publication number
- JPH0338507A JPH0338507A JP17185889A JP17185889A JPH0338507A JP H0338507 A JPH0338507 A JP H0338507A JP 17185889 A JP17185889 A JP 17185889A JP 17185889 A JP17185889 A JP 17185889A JP H0338507 A JPH0338507 A JP H0338507A
- Authority
- JP
- Japan
- Prior art keywords
- collagen
- powder
- cosmetic
- coated
- pigment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108010035532 Collagen Proteins 0.000 title claims abstract description 61
- 102000008186 Collagen Human genes 0.000 title claims abstract description 61
- 229920001436 collagen Polymers 0.000 title claims abstract description 61
- 239000000843 powder Substances 0.000 title claims abstract description 42
- 239000002537 cosmetic Substances 0.000 title claims abstract description 31
- 238000004519 manufacturing process Methods 0.000 title claims description 7
- 238000001035 drying Methods 0.000 claims abstract description 7
- 239000000049 pigment Substances 0.000 abstract description 41
- 239000004677 Nylon Substances 0.000 abstract description 13
- 229920001778 nylon Polymers 0.000 abstract description 13
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 abstract description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 11
- 238000010438 heat treatment Methods 0.000 abstract description 7
- 238000003756 stirring Methods 0.000 abstract description 5
- 230000007794 irritation Effects 0.000 abstract description 3
- 239000002245 particle Substances 0.000 abstract description 3
- 239000000454 talc Substances 0.000 abstract description 3
- 229910052623 talc Inorganic materials 0.000 abstract description 3
- 238000002156 mixing Methods 0.000 abstract description 2
- 238000000926 separation method Methods 0.000 abstract description 2
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 108010045569 atelocollagen Proteins 0.000 description 28
- 239000011248 coating agent Substances 0.000 description 12
- 238000000576 coating method Methods 0.000 description 9
- 238000000034 method Methods 0.000 description 7
- 239000000203 mixture Substances 0.000 description 7
- 239000008213 purified water Substances 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
- 238000012986 modification Methods 0.000 description 6
- 230000004048 modification Effects 0.000 description 6
- 239000006185 dispersion Substances 0.000 description 5
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000010445 mica Substances 0.000 description 4
- 229910052618 mica group Inorganic materials 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 210000003491 skin Anatomy 0.000 description 3
- 230000007423 decrease Effects 0.000 description 2
- 238000004925 denaturation Methods 0.000 description 2
- 230000036425 denaturation Effects 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000004408 titanium dioxide Substances 0.000 description 2
- FALRKNHUBBKYCC-UHFFFAOYSA-N 2-(chloromethyl)pyridine-3-carbonitrile Chemical compound ClCC1=NC=CC=C1C#N FALRKNHUBBKYCC-UHFFFAOYSA-N 0.000 description 1
- 108010022355 Fibroins Proteins 0.000 description 1
- PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 238000007922 dissolution test Methods 0.000 description 1
- PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229960002591 hydroxyproline Drugs 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 238000010297 mechanical methods and process Methods 0.000 description 1
- 238000010303 mechanochemical reaction Methods 0.000 description 1
- 239000011859 microparticle Substances 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 239000003607 modifier Substances 0.000 description 1
- 238000011197 physicochemical method Methods 0.000 description 1
- -1 polyethylene Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 229940014800 succinic anhydride Drugs 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- RCRYHUPTBJZEQS-UHFFFAOYSA-N tetradecanoyl tetradecanoate Chemical compound CCCCCCCCCCCCCC(=O)OC(=O)CCCCCCCCCCCCC RCRYHUPTBJZEQS-UHFFFAOYSA-N 0.000 description 1
- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 1
- 238000009834 vaporization Methods 0.000 description 1
- 230000008016 vaporization Effects 0.000 description 1
Abstract
Description
【発明の詳細な説明】
（産業上の利用分野）
本発明は化粧料に用いられる粉体に、コラーゲン及びｌ
又はその誘導体（以下、単にコラーゲンという）を被覆
した化粧料用粉体の製造方法に関する。Detailed Description of the Invention (Field of Industrial Application) The present invention provides a method for adding collagen and lactic acid to powder used in cosmetics.
The present invention relates to a method for producing cosmetic powder coated with collagen or a derivative thereof (hereinafter simply referred to as collagen).
（従来の技術及び解決しようとする課題）従来より顔料
の表面を親油性にしたり、或は、親水性にしたりするよ
うに、顔料の表面に種々の改質剤を被覆して顔料の表面
特性を変えることは行われている。(Prior art and problems to be solved) Conventionally, various modifiers are coated on the surface of pigments to make the surface of pigments lipophilic or hydrophilic. Changes are being made.
例えば、顔料表面の改質方法を例示すると、次のような
ものがある。For example, examples of methods for modifying the surface of pigments include the following.
（１）界面活性剤、高分子、無機物などを利用したコー
ティングによる改質
（２）表面科学的な手段によるトポケミカルな改質
（３）顔料を粉砕しながら新しくできた表面に被覆剤を
吸着させるメカノケミカル反応による改質（４）化学的
手法、物理化学的手法、機械的手法によって顔料をカプ
セル化することによる改質（５）放射線照射による改質
化粧料の顔料についても、種々の改質方法が報告されて
いる。例えば、フィブロインにより、化粧用顔料を被覆
する方法（特開昭５９−１９６８０８号公報）、コラー
ゲンにより化粧料顔料を被覆する方法（特公平１−１３
６８６号、特開昭６１−２８２３０７号公報）等がある
。(1) Modification by coating using surfactants, polymers, inorganic substances, etc. (2) Topochemical modification by surface scientific means (3) Adsorption of coating agent onto the newly created surface while crushing the pigment Modification by mechanochemical reactions (4) Modification by encapsulating pigments using chemical, physicochemical, and mechanical methods (5) Modification by radiation irradiation Various modifications can also be made to pigments in cosmetics. A method has been reported. For example, a method of coating cosmetic pigments with fibroin (Japanese Unexamined Patent Application Publication No. 196808/1983), a method of coating cosmetic pigments with collagen (Japanese Patent Publication No. 1-13-1998),
No. 686, Japanese Unexamined Patent Publication No. 61-282307), etc.
しかし、これらの報告によると、被覆顔料の製遣方法は
、単に顔料表面に被覆剤となるものを析出させ、これを
乾燥しているため、得られた被覆顔料を水系の化粧料に
配合した場合、顔料表面より被覆剤が溶解してしまい、
顔料と被覆剤を別々に配合した場合と同じ状態になり、
被覆する意味がなくなってしまうという欠点があった。However, according to these reports, the method for producing coated pigments is simply to precipitate a coating agent on the pigment surface and dry it, so it is difficult to incorporate the resulting coated pigments into water-based cosmetics. In this case, the coating agent dissolves from the pigment surface,
The result is the same as when pigments and coating materials are mixed separately,
The drawback was that there was no point in covering it.
そこで、本発明者は、このような欠点を改良するため種
々検討した結果、化粧用顔料にコラーゲン及び／又はコ
ラーゲン誘導体を被覆する場合。Therefore, as a result of various studies in order to improve such drawbacks, the present inventor has developed a method for coating cosmetic pigments with collagen and/or collagen derivatives.
顔料表面でコラーゲンを不溶化させることによって上記
の欠点を解消することを見出し、本発明を完成したもの
で、本発明の目的は、化粧料に用いられる粉体に、コラ
ーゲン及び／又はその誘導体く以下、単にコラーゲンと
いう）を被覆し粉体表面でコラーゲンを不溶化すること
を特徴とする化粧料用粉体の製造方法に関するものを提
供するにある。The present invention was completed by discovering that the above-mentioned drawbacks could be solved by insolubilizing collagen on the surface of pigments.An object of the present invention is to incorporate collagen and/or its derivatives into powder used in cosmetics. The present invention relates to a method for producing powder for cosmetics, which is characterized in that the powder is coated with collagen (simply referred to as collagen) and insolubilized on the surface of the powder.
（課題を解決するための手段）
本発明の要旨は、化粧料に用いられる粉体を、コラーゲ
ン及び／又はコラーゲン誘導体の溶液に懸濁させて粉体
表面をコラーゲン及び／又はコラーゲン誘導体で被覆し
、乾燥後、６０〜１５０℃の範囲の温度で加熱処理を施
して粉体表面上のコラーゲン及び／又はコラーゲン誘導
体を不溶化させることを特徴とするコラーゲン被覆化粧
料用粉体の製造方法である。(Means for Solving the Problems) The gist of the present invention is to suspend powder used in cosmetics in a solution of collagen and/or collagen derivatives, and coat the powder surface with collagen and/or collagen derivatives. This is a method for producing a collagen-coated powder for cosmetics, which is characterized in that after drying, heat treatment is performed at a temperature in the range of 60 to 150°C to insolubilize collagen and/or collagen derivatives on the surface of the powder.
即ち、本発明は、化粧料用粉体の表面をコラーゲン及び
又はコラーゲン誘導体で被覆し、乾燥後、６０〜１５０
℃の範囲の温度で加熱処理を施して粉体表面を被覆して
いるコラーゲンを不溶化させるものであって、このよう
な処理を施した粉体を化粧料に配合すると、粉体と被覆
剤が分離することなく、顔料の刺激を低減させ、肌への
付着性、伸展性、化粧もち等の優れた化粧料を得ること
ができる。That is, in the present invention, the surface of a powder for cosmetics is coated with collagen and/or a collagen derivative, and after drying,
The collagen coating the surface of the powder is insolubilized by heat treatment at a temperature in the range of It is possible to reduce the irritation of pigments without separation, and to obtain cosmetics with excellent adhesion to the skin, spreadability, makeup retention, etc.
一般にコラーゲンは溶液状態で、３７℃以上の温度に加
熱すると変性するということは良く知られている。しか
し、コラーゲンの変性温度は、コラーゲン中の希釈剤の
体積分率に依存し、希釈剤の体積分率が小さくなると、
変性温度は上昇するという報告がある（Ｐ、Ｊ、Ｆｌｏ
ｒｙ％Ｇａｒｒｅｔｔ：Ｊ、Ａｍ、Ｃｈｅｍ。It is well known that collagen is generally denatured in a solution state when heated to a temperature of 37° C. or higher. However, the denaturation temperature of collagen depends on the volume fraction of diluent in collagen, and as the volume fraction of diluent decreases,
It has been reported that the denaturation temperature increases (P, J, Flo
ry% Garrett: J, Am, Chem.
Ｓｉｃ、、８０，４８３６．１９５８）。Sic, 80, 4836.1958).
従って、コラーゲン被覆顔料を製造する場合、コラーゲ
ン溶液に粉体を浸漬し、濾過、遠心等の方法で回収し、
乾燥した後、６ＯＮ１５０℃で加熱処理を行なうか、ま
たは、顔料をコラーゲン溶液に浸漬、濾過した後に６０
〜１５０℃に加熱し、乾燥すると、水分量が多いときに
は気化熱により、品温は、２０℃〜３０℃の範囲であり
、また水分が少なくなるにつれて品温は上昇するが、前
述の理由により、コラーゲンは変性することなく、短時
間のうちに顔料表面で乾燥され熱架橋により不溶化する
。Therefore, when producing collagen-coated pigments, powder is immersed in a collagen solution and collected by filtration, centrifugation, etc.
After drying, heat treatment is performed at 6ON at 150°C, or the pigment is immersed in a collagen solution and filtered, followed by 60°C.
When heated to ~150°C and dried, the product temperature will be in the range of 20°C to 30°C due to the heat of vaporization when the moisture content is high, and the product temperature will rise as the moisture content decreases, but for the reasons mentioned above. , collagen dries on the pigment surface within a short time without being denatured and becomes insolubilized by thermal crosslinking.
本発明に使用するコラーゲンには、動物の真皮より得ら
れる可溶性コラーゲン、或いはプロテアーゼ処理により
得られるアテロコラーゲンなどが含まれ、コラーゲン誘
導体としてはアテロコラーゲンを無水コハク酸で処理し
たサクシニル化コラーゲン、無水ミリスチン酸で処理し
たミリスチル化アテロコラーゲン等のアシル化、エステ
ル化されたコラーゲン誘導体が含まれる。Collagen used in the present invention includes soluble collagen obtained from animal dermis, atelocollagen obtained by protease treatment, etc. Collagen derivatives include succinylated collagen obtained by treating atelocollagen with succinic anhydride, and myristic anhydride. Includes acylated and esterified collagen derivatives such as treated myristylated atelocollagen.
これらの水溶性コラーゲン及び／又はコラーゲン誘導体
のパウダーを、０．０１−１０重量２濃度になる様に精
製水又は親水性有機溶媒と水との混液等に溶解させる。These water-soluble collagen and/or collagen derivative powders are dissolved in purified water or a mixture of a hydrophilic organic solvent and water to a concentration of 0.01 to 10% by weight.
次いで、得られた溶液に、顔料を浸漬し、均一に撹拌混
合した後、ン濾過、又は脱水遠心機等により、被覆粉体
を回収し必要に応じメタノール、アセトン等の有機溶剤
で洗浄する。Next, the pigment is immersed in the obtained solution, and after stirring and mixing uniformly, the coated powder is collected by filtration or a dehydrating centrifuge, and if necessary, washed with an organic solvent such as methanol or acetone.
顔料としては、通常化粧料顔料として使用されているも
のであれば、いずれでも良く、例えば、酸化チタン、タ
ルク、マイカ、ナイロンパウダーポリエチレン等である
。The pigment may be any pigment commonly used as a cosmetic pigment, such as titanium oxide, talc, mica, nylon powder polyethylene, and the like.
又、溶液に、添加する顔料の量としては、ｌ〜５０重量
Ｘ程度である。The amount of pigment added to the solution is approximately 1 to 50X by weight.
得られたコラーゲン−顔料複合物を乾燥し、６０℃〜１
５０℃で加熱し、不溶化させた後、アトマイザ−、パワ
ーミル等の粉砕機により均一の粒子とする。その他に、
コラーゲンと顔料との混合溶液を直接噴霧乾燥すること
により被覆することもできる。コラーゲンの被覆量は、
粉体に対し０．０１〜ｌＯ％、好ましくは０．０５〜２
％の割合が望ましい。被重量が０．０１％以下の場合、
コラーゲンの効果が発揮されず、また１０％以上の場合
、粉体の特性が失われてしまう。The obtained collagen-pigment composite was dried and heated at 60°C to 1
After heating at 50°C to insolubilize the mixture, it is pulverized into uniform particles using a pulverizer such as an atomizer or a power mill. Other,
Coating can also be achieved by direct spray drying of a mixed solution of collagen and pigment. The amount of collagen coverage is
0.01 to 1O%, preferably 0.05 to 2% based on powder
% is desirable. If the covered weight is 0.01% or less,
The effect of collagen is not exhibited, and if it exceeds 10%, the properties of the powder will be lost.
本発明におけるコラーゲン被覆顔料は、乾燥時の加熱処
理によりコラーゲンに熱架橋が入り不溶化しているため
、化粧料に配合しても顔料より溶解してこないという特
徴をもっている。そのため、本発明の被覆顔料を配合し
た化粧料は被覆された顔料とコラーゲンとの両者の特色
を持つものであり、顔料の刺激を低減させ、肌への付着
性、伸展性、化粧もち等の優れた効果を持つものである
。The collagen-coated pigment of the present invention has the characteristic that it is less soluble than the pigment even when incorporated into cosmetics because the collagen is thermally crosslinked and insolubilized by heat treatment during drying. Therefore, cosmetics containing the coated pigment of the present invention have the characteristics of both the coated pigment and collagen, reduce pigment irritation, and improve adhesion to the skin, spreadability, and makeup retention. It has excellent effects.
得られたコラーゲン被覆顔料の化粧料への添加量は、パ
ウダー状の化粧料の場合は、ｌ−１００重量％（重量％
は、組成物の重量基準）、ケーキ状の化粧料及び、練物
化粧料の場合は、金粉体の重量を基準として１〜１００
重量ｉである。The amount of the obtained collagen-coated pigment added to cosmetics is 1-100% by weight (% by weight) in the case of powdered cosmetics.
is based on the weight of the composition), and in the case of cake-like cosmetics and paste cosmetics, it is 1 to 100 based on the weight of the gold powder.
The weight is i.
次に、実施例をもって、更に具体的に本発明を説明する
。Next, the present invention will be explained in more detail with reference to Examples.
実施例
［１］被覆顔料の製造
（１）アテロコラーゲン被覆酸化チタンアテロコラーゲ
ン５ｇを精製水５００ｍ［に溶かした後、エタノールを
徐々に加え、全量を５Ｑとする。Example [1] Production of coated pigment (1) Atelocollagen coating After dissolving 5 g of titanium oxide atelocollagen in 500 m of purified water, ethanol is gradually added to bring the total amount to 5Q.
これに二酸化チタン１ｋｇを加えて、混合撹拌し、均一
に分散させる。分散液をン濾過し、乾燥した後３０分間
加熱処理を行ない、アトマイザ−により粉砕し、アテロ
コラーゲン被覆二酸化チタンを得る。Add 1 kg of titanium dioxide to this and mix and stir to uniformly disperse. The dispersion is filtered, dried, heated for 30 minutes, and pulverized with an atomizer to obtain atelocollagen-coated titanium dioxide.
（２）ミリスチル化アテロコラーゲン（高所アテロコラ
ーゲンＭ）被覆６−ナイロンパウダーミリスチル化アテ
ロコラーゲン５ｇを精製水２Ｑに溶かした後、エタノー
ルを徐々に加え、全量を５Ｑとする。これに６−ナイロ
ンパウダー１ｋｇを加え、均一に混合撹拌する。分散液
を遠心脱水し、乾燥した後、７０℃で３０分間加熱処理
を行ない、パワーミルにより粉砕し、ミリスチル化アテ
ロコラーゲン被覆６−ナイロンパウダーを得る。(2) Myristylated atelocollagen (high-altitude atelocollagen M) coated 6-nylon powder After dissolving 5 g of myristylated atelocollagen in 2Q of purified water, ethanol is gradually added to bring the total amount to 5Q. Add 1 kg of 6-nylon powder to this and mix and stir evenly. After the dispersion is centrifugally dehydrated and dried, it is heated at 70° C. for 30 minutes and pulverized using a power mill to obtain myristylated atelocollagen-coated 6-nylon powder.
（３）サクシニル化アテロコラーゲン被覆タルクサクシ
ニル化アテロコラーゲン（高所アテロコラーゲンＳＳ）
ｌＯｇを精製水２Ｑに溶かした後、アセトンを徐々に加
え、全量を５Ｑとする。これにタルク１ｋｇを加えて混
合撹拌し５均一に分散させる。(3) Succinylated atelocollagen coated talc-succinylated atelocollagen (high-altitude atelocollagen SS)
After dissolving 10g in 2Q of purified water, acetone is gradually added to bring the total amount to 5Q. Add 1 kg of talc to this and mix and stir to uniformly disperse the mixture.
分散液を濾過し、過剰のアセトンで脱水した後、９０℃
で乾燥し、粉砕する。The dispersion was filtered, dehydrated with excess acetone, and then heated to 90°C.
Dry and crush.
（４）ミリスチルサクシニル化アテロコラーゲン被覆雲
母
ミリスチルサクシニル化アテロコラーゲン（高所アテロ
コラーゲンＭＳ）ｌＯｇを精製水に溶かし、全量を５Ｑ
とする。これに雲母１ｋｇを加え、均一に分散させる。(4) Dissolve 10g of myristylsuccinylated atelocollagen-coated mica myristylsuccinylated atelocollagen (high-altitude atelocollagen MS) in purified water and add 5Q to the total amount.
shall be. Add 1 kg of mica to this and disperse it evenly.
分散液を濾過し１００℃で乾燥した後、アトマイザ−に
より粉砕し、ミリスチルサクシニル化アテロコラーゲン
被覆雲母を得る。The dispersion is filtered, dried at 100° C., and then pulverized with an atomizer to obtain myristylsuccinylated atelocollagen-coated mica.
（５）ミリスチル化アテロコラーゲン被覆微粒子酸化チ
タン
ミリスチル化アテロコラーゲン２．５ｇを精製水（ｐＨ
３）５ Ｑに溶かし、粒径１〜５μｍの酸化チタン５０
０ｇを加えて均一に分散させる。この分散液を噴霧乾燥
し、ミリスチル化アテロコラーゲン被覆酸化チタンを得
た後、８０℃で５分間加熱することにより、コラーゲン
を不溶化して製する。(5) 2.5 g of myristylated atelocollagen-coated microparticle titanium oxide myristylated atelocollagen was added to purified water (pH
3) Titanium oxide 50 with a particle size of 1 to 5 μm dissolved in 5Q
Add 0g and disperse evenly. This dispersion is spray-dried to obtain myristylated atelocollagen-coated titanium oxide, and then heated at 80° C. for 5 minutes to insolubilize the collagen.
各実施例で得られた被覆顔料の特性について試験する。The properties of the coated pigments obtained in each example are tested.
（１）溶出性試験
実施例［１］−（２）のミリスチル化アテロコラーゲン
被覆６−ナイロンパウダーを用い、溶出してくるコラー
ゲン量を調べた。対照として乾燥時の温度が２０℃のも
のを用いた。(1) Dissolution Test Using the myristylated atelocollagen-coated 6-nylon powders of Examples [1]-(2), the amount of collagen eluted was investigated. As a control, one whose drying temperature was 20°C was used.
測定方法としては次の通りである。The measurement method is as follows.
被覆顔料１ｇに５ｇの精製水を加え、均一に分散させて
１０分間放置した後、濾過する。ン戸液＋ｍＱをとり、
コラーゲン特有のアミノ酸であるハイドロキシプロリン
量の測定を行なう。Add 5 g of purified water to 1 g of coated pigment, disperse uniformly, leave for 10 minutes, and then filter. Take the solution + mQ,
The amount of hydroxyproline, an amino acid unique to collagen, is measured.
得られた結果を次に示す。The results obtained are shown below.
コラーゲン
総被重量 ０．２％
２０℃ ０．１８％
８０℃ ０．０２％
本発明におけるミリスチル化アテロコラーゲン被覆６−
ナイロンパウダーは非水系の化粧料のみならず、水系の
化粧料に配合した場合でも、均一に顔料を被覆し溶出し
てこないという特徴を持つものである。Total collagen coverage 0.2% 20°C 0.18% 80°C 0.02% Myristylated atelocollagen coating in the present invention 6-
Nylon powder has the characteristic that it uniformly covers pigments and does not elute, even when added to water-based cosmetics as well as non-aqueous cosmetics.
（２）吸湿性試験
実施例［１］−（２）のミリスチル化アテロコラーゲン
被覆６−ナイロンパウダーを用い、相対湿度８５％下で
の吸湿性を調べた。対照として未被覆の６−ナイロンパ
ウダー及びミリスチル化アテロコラーゲンパウダーを用
いた。(2) Hygroscopicity test Using the myristylated atelocollagen-coated 6-nylon powder of Example [1]-(2), the hygroscopicity was investigated at a relative humidity of 85%. Uncoated 6-nylon powder and myristylated atelocollagen powder were used as controls.
その結果を第１図に示す。第１図において、■は、本発
明に係るミリスチル化アテロコラーゲン被覆６−ナイロ
ンパウダーの吸湿量を示す曲線であり、■は未被覆の６
−ナイロンパウダー、■はミリスチル化アテロコラーゲ
ンパウダーのそれぞれの吸湿量を示す曲線である。The results are shown in FIG. In FIG. 1, ■ is a curve showing the moisture absorption amount of myristylated atelocollagen-coated 6-nylon powder according to the present invention, and ■ is a curve showing the moisture absorption amount of the myristylated atelocollagen-coated 6-nylon powder, and
-Nylon powder, ■ is a curve showing the moisture absorption amount of myristylated atelocollagen powder.
（発明の効果）
本発明の方法によるコラーゲンを被覆した顔料は、分散
性が良好で、これを配合した化粧料は、顔料の皮膚刺激
の少ないスキンケア効果を持つものである。(Effects of the Invention) The pigment coated with collagen obtained by the method of the present invention has good dispersibility, and the cosmetic containing the pigment has a skin care effect with less skin irritation caused by the pigment.
第１図は、本発明によるミリスチル化アテロコラーゲン
被覆６ナイロンパウダーの吸湿性試験の結果を示す。FIG. 1 shows the results of a hygroscopicity test of myristylated atelocollagen-coated 6-nylon powder according to the present invention.
Claims (1)
コラーゲン誘導体の溶液に懸濁させて粉体表面にコラー
ゲン及び／又はコラーゲン誘導体を被覆、乾燥後、６０
〜１５０℃の範囲の温度で加熱処理を施して粉体表面上
のコラーゲン及び／又はコラーゲン誘導体を不溶化させ
ることを特徴とするコラーゲン被覆化粧料用粉体の製造
方法。1. Powder used for cosmetics is suspended in a solution of collagen and/or collagen derivatives, the powder surface is coated with collagen and/or collagen derivatives, and after drying,
A method for producing collagen-coated powder for cosmetics, which comprises heat-treating at a temperature in the range of ~150°C to insolubilize collagen and/or collagen derivatives on the surface of the powder.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP17185889A JPH0338507A (en) | 1989-07-05 | 1989-07-05 | Production of powder for cosmetic covered with collagen |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP17185889A JPH0338507A (en) | 1989-07-05 | 1989-07-05 | Production of powder for cosmetic covered with collagen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH0338507A true JPH0338507A (en) | 1991-02-19 |
Family
ID=15931089
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP17185889A Pending JPH0338507A (en) | 1989-07-05 | 1989-07-05 | Production of powder for cosmetic covered with collagen |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0338507A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1132075A2 (en) | 2000-03-09 | 2001-09-12 | INTERCOS ITALIA S.p.A. | Coated cosmetic powder |
-
1989
- 1989-07-05 JP JP17185889A patent/JPH0338507A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1132075A2 (en) | 2000-03-09 | 2001-09-12 | INTERCOS ITALIA S.p.A. | Coated cosmetic powder |
| EP1132075A3 (en) * | 2000-03-09 | 2004-02-04 | INTERCOS ITALIA S.p.A. | Coated cosmetic powder |
| US6893646B2 (en) | 2000-03-09 | 2005-05-17 | Intercos Italia S.P.A. | Coated cosmetic powder |
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