JPH0333687B2 - - Google Patents

Description

[Detailed description of the invention]

INDUSTRIAL APPLICATION FIELD The present invention relates to a poultice applied to an affected area for the purpose of anti-inflammatory and analgesic treatment, which has enhanced adhesiveness and high water content. Prior Art and Problems to be Solved by the Invention Conventionally, the physical properties required of poultices are as follows. Adhesiveness: When applied to the skin, it follows the movement of the affected area well and is difficult to peel off. Peelability: Peel off cleanly without leaving any chemical residue when removed. Stability: Does not harden or sag due to temperature changes, storage, etc. Furthermore, from a pharmacological and chemical perspective, a poultice that has both the above properties and high water content is desired. This means that poultices with high water content (over 50%) are
The rate of water saturation in the stratum corneum of the skin is faster, and during drug application, a sustained increase in serum concentration was observed than in low-hydration (20% or less) poultices, and 4 hours after drug application, the serum concentration was nearly three times as high. This is to indicate concentration. As a highly water-containing poultice, the present inventors developed a poultice based on anionic dialdehyde starch (hereinafter referred to as DAS) and a highly water-containing gelatin gel (Japanese Patent Publication No. 54-11365, Japanese Patent Publication No. 11365, No. 56). −30329
No.) was invented. This substance has the advantage of being medicinal since it can conjugate more than 50% of water. However, although gelatin and DAS as the main base maintain high water content, they lack adhesiveness, so when applied to the skin, they are fixed with auxiliary means such as bandages to prevent peeling. I needed to. Therefore, there is a disadvantage that it cannot follow the movement of the skin. In addition, a plaster containing polyacrylic acid or a metal salt thereof cross-linked with an aluminum compound as a main component has been applied for and is known (Japanese Patent Laid-Open No. 1985-1999-1).
No. 15413, JP-A-58-43365, JP-A-59-118719
No., JP-A-60-226808, JP-A-61-41926, etc.). This material is intended for high water content and tackiness. However, in the case of polyacrylic acid or its metal salt cross-linked with only an aluminum compound, it can relatively contain water;
There are disadvantages in that the crosslinking reaction between the aluminum compound and the polyacrylate salt occurs locally, which tends to cause so-called flocculation, resulting in a lack of stability. Therefore, in view of the drawbacks of the prior art, it is an object of the present invention to provide a poultice having excellent adhesiveness, high water content, and stability. Means for Solving the Problems That is, the present invention uses polyacrylic acid or its metal salt crosslinked with a newly created water-soluble cationic polymer compound or water-soluble amphoteric polymer compound as a base. This objective is achieved by using a highly water-containing poultice. The active ingredients to be mixed into the poultice include methyl salicylate, glycol salicylate, salicylic acid, indomethacin, diclofenac sodium, ketoprofen, ibuprofen, piroxicam, flurbiprofen, propionic acid derivatives, diphenhydramine, menthol, peppermint oil, Use camphor etc. As the metal salt of polyacrylic acid, a metal salt with an alkali metal such as sodium, potassium, or lithium, an alkaline earth metal such as calcium or magnesium, or a trivalent metal such as aluminum or iron is used. The polyacrylic acid or metal salt of polyacrylic acid is used in an amount of 1 to 20% by weight, preferably 3 to 10% by weight, based on the total weight of the poultice. As the water-soluble cationic polymer compound, cationic dialdehyde starch, cationic polyacrylamide, polyamide polyamine epichlorohydrin, cationic starch, polyethyleneimine, etc. are used. As the water-soluble amphoteric polymer compound, amphoteric dialdehyde starch or polyacrylamide is used. The water-soluble cationic polymer compound or water-soluble amphoteric polymer compound used for crosslinking is used in an amount of 0.1 to 40% by weight, preferably 0.5 to 10% by weight, based on the total weight of the poultice. The poultice according to the present invention may contain adsorbents, humectants, adhesives, surfactants, PH regulators, etc. as base components other than those mentioned above. Kaolin, cyclodextrin, etc. can be used as the adsorbent. As the humectant, glycerin, propylene glycol, polyethylene glycol, D-sorbitol, etc. are used. As the adhesive, carboxyvinyl polymer,
Synthetic polymer compounds such as polyvinyl alcohol or natural polymer compounds such as gum arabic and xanthan gum are used. Citric acid, tartaric acid, phosphoric acid, etc. are used as the pH adjuster. As the surfactant, polysorbate 80, sorbitan sesquioleate, etc. are used. In the present invention, gelatin may be used in combination to enhance the high water content, and an aluminum compound may also be used in a small amount. Further, calcium hydrogen phosphate and the like can also be used as a gel stabilizer. Effect In the plaster according to the present invention, the electrostatic charge between the negative charge of the carboxyl group (RCOO ^- ) of polyacrylic acid or its metal salt and the positive charge of the water-soluble cationic polymer compound or the amphoteric polymer compound This combination of crosslinking through physical bonds and three-dimensional bonding strength due to the mutual entanglement of polymer compounds results in a new polymer gel with high hydrophilicity (water-containing property). The polymer gel after crosslinking also exhibits strong adhesiveness, so
It does not easily peel off when applied to the skin. EXAMPLES The present invention will be described in detail below with reference to Examples. A poultice as shown in Table 1 below was prepared, and its water-retentivity and adhesiveness were examined.

[Table] Manufacturing method Mix the glycerin of ingredient A of each example shown in Table 1 well in a mixer, add the remaining ingredients of A and active ingredients in the usual manner, and make into a paste for 10 minutes. Mix well. Next, add purified water to component B and stir well, then add emulsifier, preservative, adhesive, etc. and dissolve thoroughly. Add the mixture and mix well for 45 minutes. The paste prepared as described above is uniformly spread on a non-woven fabric, cut and packaged to obtain a poultice. Test method Place the plasters of the present invention and comparative examples prepared in Table 1 above on an inclined surface at an angle of 30° with respect to the horizontal, with the adhesive side facing upward. And upper 10cm, lower 15cm
was covered with a suitable paper, leaving a 5 cm adhesive surface in the center. Next, roll a series of steel balls as shown in Table 2 from the top of the paper covered on each poultice, and see if you can stop the balls from falling with the adhesive surface (5 cm long) in the center. Examined.

【table】 The results were as shown in Table 3 below.

[Table] Effects As stated above, the poultice according to the present invention has the following effects:
It has superior adhesiveness compared to conventional DAS-gelatin based poultices, and has superior water absorption compared to polyacrylate-aluminum compound based poultices. Furthermore, since the crosslinking reaction is an electrostatic bond, the reaction occurs all at once in a short period of time, so that so-called flocculation is less likely to occur and the material is stable.

Claims (1)

[Scope of Claims] 1. A highly water-containing poultice based on polyacrylic acid or a metal salt thereof crosslinked with a water-soluble cationic polymer compound or a water-soluble amphoteric polymer compound. 2. The highly water-containing poultice according to claim 1, wherein the metal salt of polyacrylic acid is an alkali metal salt, an alkaline earth metal salt, or a trivalent metal salt. 3. Claims 1 or 2, characterized in that the water-soluble cationic polymer compound is cationic dialdehyde starch, cationic polyacrylamide, cationic starch, polyethyleneimine, or polyamide polyamine epichlorohydrin.
Highly water-containing poultices as described in Section 1. 4. The highly water-containing poultice according to claim 1 or 2, wherein the water-soluble amphoteric polymer compound is an amphoteric dialdehyde starch or an amphoteric polyacrylamide.