JPH03277365A - Bag for medical treatment liquid - Google Patents
Bag for medical treatment liquidInfo
- Publication number
- JPH03277365A JPH03277365A JP2077448A JP7744890A JPH03277365A JP H03277365 A JPH03277365 A JP H03277365A JP 2077448 A JP2077448 A JP 2077448A JP 7744890 A JP7744890 A JP 7744890A JP H03277365 A JPH03277365 A JP H03277365A
- Authority
- JP
- Japan
- Prior art keywords
- density
- bag
- density polyethylene
- layer
- ethylene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000007788 liquid Substances 0.000 title claims abstract description 30
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims abstract description 25
- 239000005977 Ethylene Substances 0.000 claims abstract description 21
- 229920001577 copolymer Polymers 0.000 claims abstract description 20
- 229920001684 low density polyethylene Polymers 0.000 claims abstract description 19
- 239000004702 low-density polyethylene Substances 0.000 claims abstract description 19
- 238000000034 method Methods 0.000 claims abstract description 18
- 229920000092 linear low density polyethylene Polymers 0.000 claims description 19
- 239000004707 linear low-density polyethylene Substances 0.000 claims description 19
- 239000004698 Polyethylene Substances 0.000 abstract description 10
- 230000000903 blocking effect Effects 0.000 abstract description 9
- 229920000573 polyethylene Polymers 0.000 abstract description 8
- VXNZUUAINFGPBY-UHFFFAOYSA-N 1-Butene Chemical compound CCC=C VXNZUUAINFGPBY-UHFFFAOYSA-N 0.000 description 18
- -1 polyethylene Polymers 0.000 description 11
- 239000000463 material Substances 0.000 description 7
- 238000011156 evaluation Methods 0.000 description 6
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 description 6
- 230000000052 comparative effect Effects 0.000 description 5
- 239000005038 ethylene vinyl acetate Substances 0.000 description 4
- 230000001954 sterilising effect Effects 0.000 description 4
- 238000004659 sterilization and disinfection Methods 0.000 description 4
- WSSSPWUEQFSQQG-UHFFFAOYSA-N 4-methyl-1-pentene Chemical compound CC(C)CC=C WSSSPWUEQFSQQG-UHFFFAOYSA-N 0.000 description 3
- 239000004743 Polypropylene Substances 0.000 description 3
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 229920001155 polypropylene Polymers 0.000 description 3
- 238000010998 test method Methods 0.000 description 3
- LIKMAJRDDDTEIG-UHFFFAOYSA-N 1-hexene Chemical compound CCCCC=C LIKMAJRDDDTEIG-UHFFFAOYSA-N 0.000 description 2
- 101000650578 Salmonella phage P22 Regulatory protein C3 Proteins 0.000 description 2
- 101001040920 Triticum aestivum Alpha-amylase inhibitor 0.28 Proteins 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000004927 fusion Effects 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000004800 polyvinyl chloride Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- 229920001756 Polyvinyl chloride acetate Polymers 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 150000001336 alkenes Chemical class 0.000 description 1
- 239000002981 blocking agent Substances 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000007334 copolymerization reaction Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000010030 laminating Methods 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 239000008155 medical solution Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 230000000379 polymerizing effect Effects 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 230000000171 quenching effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
Landscapes
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Abstract
Description
【発明の詳細な説明】
〔発明の背景〕
〈産業上の利用分野〉
本発明は、医療液体用袋、特に柔軟性、透明性、耐熱性
、耐ブロッキング性および機械的強度に優れた血液もし
くはリンゲル液、栄養液、治療用薬液などの薬液を充填
するための医療液体用袋に関する。DETAILED DESCRIPTION OF THE INVENTION [Background of the Invention] [Industrial Field of Application] The present invention relates to a bag for medical liquids, particularly blood or blood bags having excellent flexibility, transparency, heat resistance, blocking resistance, and mechanical strength. The present invention relates to a medical liquid bag for filling medical liquids such as Ringer's solution, nutrient liquid, and therapeutic liquids.
〈従来の技術〉
従来、血液や薬液などを充填する医療液体用容器として
は、ガラス、ポリエチレン、ポリプロピレン、軟質ポリ
塩化ビニル、エチレン・酢酸ビニル共重合体などが使用
されていた。<Prior Art> Conventionally, glass, polyethylene, polypropylene, soft polyvinyl chloride, ethylene/vinyl acetate copolymer, etc. have been used as containers for medical liquids filled with blood, medical solutions, etc.
これら容器の形態としては、一般に２種類あって、自立
性を重要視したガラス製やポリプロピレン製のボトルタ
イプと、柔軟性を特徴としたポリエチレン、軟質ポリ塩
化ビニルやエチレン・酢酸ビニル共重合体製の袋状のも
のが使用されている。There are generally two types of containers: bottle types made of glass or polypropylene, which emphasize independence, and bottles made of polyethylene, soft polyvinyl chloride, or ethylene-vinyl acetate copolymers, which are characterized by flexibility. A bag-like material is used.
上記袋状の容器は、取り扱い上から、より柔軟であるも
の、また、内容物がはっきり見えることから、より透明
であるものが好ましいとされ、そのような性質のものが
望まれている。It is preferable that the bag-shaped container is more flexible from the viewpoint of handling, and more transparent so that the contents can be clearly seen, and such a container is desired.
しかしながら、分岐状ポリエチレン及びエチレン・酢酸
ビニル共重合体（以下ＥＶＡと称す）材料においては、
より柔軟性、透明性を確保するために、分岐状ポリエチ
レンでは低密度品を、また、ＥＶＡでは高含有酢酸ビニ
ル品を使用することが好ましい。しかし、このような材
料では、高圧蒸気殺菌処理（一般に１１０〜１２０℃に
加熱）工程に於いて、袋状容器の内面がブロッキングし
たり、融着状態となり、後で医療用袋として使用できな
い状態となってしまうといった欠点がある。However, in branched polyethylene and ethylene-vinyl acetate copolymer (hereinafter referred to as EVA) materials,
In order to ensure greater flexibility and transparency, it is preferable to use a low-density product for branched polyethylene, and a high-content vinyl acetate product for EVA. However, with such materials, during the high-pressure steam sterilization process (generally heated to 110-120°C), the inner surface of the bag-like container becomes blocked or fused, making it impossible to use it later as a medical bag. There is a drawback that it becomes
また、特開昭６２−５７５５５号、特開昭６２−６４３
６３号の各公報などにて知られている柔軟で且つ透明性
、耐熱性の優れる直鎖状ポリエチレンは、低密度領域で
は低結晶成分がブリードアウトしてブロッキングする問
題があり、また、高密度領域では柔軟性、透明性が損な
われるといった欠点がある。例えば、直鎖状ポリエチレ
ンはエチレンと１−オレフィンとの共重合体であり、高
圧法で得られる分岐状低密度ポリエチレンより耐熱性お
よび機械的強度が優れたものである。Also, JP-A-62-57555, JP-A-62-643
Linear polyethylene, which is flexible, has excellent transparency, and heat resistance, and is known from various publications such as No. The drawback is that flexibility and transparency are lost in the area. For example, linear polyethylene is a copolymer of ethylene and 1-olefin, and has better heat resistance and mechanical strength than branched low-density polyethylene obtained by a high-pressure method.
しかしながら、柔軟性を重視した医療液体用袋において
は、生成される短鎖分岐を単に最適化して、選択的に低
密度化することによって柔軟性を確保しようとしても、
低結晶成分が生成されてしまうことから、高圧蒸気殺菌
処理工程におけるブロッキング並びに融着現象を発生さ
せることになり、好ましくない。However, in medical liquid bags where flexibility is important, even if we try to ensure flexibility by simply optimizing the short chain branches produced and selectively reducing the density,
Since low-crystalline components are produced, blocking and fusion phenomena occur in the high-pressure steam sterilization process, which is undesirable.
また、このようなブロッキング並びに融着現象を防止す
るため、高密度化しようとすると柔軟性、透明性が損な
われたものとなってしまう。Furthermore, if an attempt is made to increase the density in order to prevent such blocking and fusion phenomena, the flexibility and transparency will be impaired.
〈発明が解決しようとする課題〉
従って、本発明は、従来技術のこの様な欠点を解消した
透明性、柔軟性、耐熱性、耐ブロッキング性、機械的強
度に優れた医療液体用袋を提供することを目的とするも
のである。<Problems to be Solved by the Invention> Therefore, the present invention provides a bag for medical liquids that overcomes these drawbacks of the prior art and has excellent transparency, flexibility, heat resistance, blocking resistance, and mechanical strength. The purpose is to
く要旨〉
本発明者は、上記課題を鑑みて鋭意研究を重ねた結果、
内層に高圧法で得られた特定の分岐状低密度ポリエチレ
ンを用い、中間層および外層にそれぞれ特定の直鎖状ポ
リエチレンを用いることにより、医療液体用袋の柔軟性
を維持し、耐ブロッキング性、透明性が飛躍的に改良さ
れて上記の目的が達成されることを見い出し本発明を完
成するに至った。Summary> As a result of intensive research in view of the above problems, the present inventor has discovered that
By using a specific branched low-density polyethylene obtained by high-pressure method for the inner layer and specific linear polyethylene for the middle and outer layers, the medical liquid bag maintains its flexibility, has anti-blocking properties, The present invention was completed based on the discovery that the above object can be achieved by dramatically improving transparency.
すなわち、本発明の医療液体用袋は、内層が高圧法で得
られた密度０．９１８ｒ／ＣＩＩＩ以上の分岐状低密度
ポリエチレン、中間層が密度０．９１５ｔｒ／ｄ以下の
エチレンと１−オレフィンとの共重合体である直鎖状低
密度ポリエチレンおよび、外層が密度０．９２０ｇ／ｃ
ｄ以上の直鎖状低密度ポリエチレンである積層体からな
ることを特徴とするものである。That is, the medical liquid bag of the present invention has an inner layer made of branched low-density polyethylene with a density of 0.918 r/CIII or more obtained by a high-pressure method, and an intermediate layer made of ethylene and 1-olefin with a density of 0.915 tr/d or less. Linear low density polyethylene, which is a copolymer of
It is characterized by being made of a laminate made of linear low-density polyethylene of d or more.
く効果〉
本発明の医療液体用袋は、内層に高圧法で得られた密度
０．９１８ｇ／ｃｄ以上の分岐状低密度ポリエチレンを
、中間層に密度０．９１５ｇ／ｃＩｊ以下のエチレンと
１−オレフィンとの共重合体である直鎖状低密度ポリエ
チレンを、外層に密度０．９２０ｓｒ／ｄ以上の直鎖状
低密度ポリエチレンを用いた積層体とすることにより、
柔軟性、透明性、耐熱性、耐ブロッキング性および機械
的強度に優れたものとすることができ、これによって従
来問題となっていた医療液体用袋の実用性能を一段と向
上させることができる。Effect> The bag for medical liquids of the present invention has branched low-density polyethylene with a density of 0.918 g/cd or more obtained by a high-pressure method in the inner layer, and ethylene with a density of 0.915 g/cIj or less in the middle layer. By forming a laminate using linear low density polyethylene, which is a copolymer with olefin, as the outer layer, linear low density polyethylene with a density of 0.920 sr/d or more,
It can be made to have excellent flexibility, transparency, heat resistance, blocking resistance, and mechanical strength, thereby further improving the practical performance of medical liquid bags, which have been problems in the past.
〔１〕医療液体用袋
（１）構造
本発明の医療液体用袋は、リンゲル液、栄養液、治療用
薬液などの薬液などを充填するためのもので、基本的に
中間層の表裏面に内層および外層を積層したフィルム状
、シート状の積層体の内層同志を内側にして重ね合わせ
たものをヒートシールして袋状に形成したものである。[1] Bag for medical liquids (1) Structure The bag for medical liquids of the present invention is for filling medical liquids such as Ringer's solution, nutritional liquids, therapeutic liquids, etc., and basically has inner layers on the front and back surfaces of the intermediate layer. A bag-like product is formed by heat-sealing a film-like or sheet-like laminate in which outer layers are laminated with the inner layers on the inside.
該袋には吊り下げ用具や口部が形成されているのが普通
である。The bag typically has a hanging device or a mouth formed therein.
（ａ）内層
本発明の医療液体用袋の内層に使用する分岐状低密度ポ
リエチレンは、エチレンを高圧法で重合して得られた密
度０．９１８ｇ／Ｃ１１以上、好ましくは０．９２０〜
０．９３０ｒ／ＣＩＩＩの材質のものである。低密度で
あるので密度の上限は０．９３５ｇ／ｄ程度であるが、
本発明の効果が奏されるものであれば、これに限られな
い。(a) Inner layer The branched low-density polyethylene used for the inner layer of the medical liquid bag of the present invention is obtained by polymerizing ethylene using a high-pressure method and has a density of 0.918 g/C11 or more, preferably 0.920 to
It is made of 0.930r/CIII material. Since it has a low density, the upper limit of the density is about 0.935 g/d,
It is not limited to this, as long as the effects of the present invention can be achieved.
ただ、密度がこれより高いと柔軟性が失われ易く、一方
、上記未満では耐熱性が低下して高圧蒸気殺菌処理耐性
が劣るようになる。However, if the density is higher than this, flexibility is likely to be lost, while if the density is lower than this, the heat resistance will decrease and the high-pressure steam sterilization resistance will be inferior.
なお、高圧法以外の方法で得られる低密度ポリエチレン
を用いたときは、例えば、後記の比較例１のとおり、ブ
ロッキング性、透明性が満足するものとはならない。Note that when low-density polyethylene obtained by a method other than the high-pressure method is used, the blocking property and transparency will not be satisfactory, for example, as in Comparative Example 1 described later.
なお、本発明の医療液体用袋においては、内面のブロッ
キング現象を防止する目的で内層面に凹凸を施すこと（
特公昭５７−６９４７号および特開昭６０−２４６７５
７号各公報参照）においても、内層の特定の分岐状低密
度ポリエチレンゆえに微小かつ均質な凹凸をより簡易に
施し易い。In addition, in the medical liquid bag of the present invention, the inner layer surface is provided with irregularities (
Japanese Patent Publication No. 57-6947 and Japanese Patent Publication No. 60-24675
7), it is easier to form fine and homogeneous irregularities because the inner layer is made of a specific branched low-density polyethylene.
（ｂ） 中間層および外層
また、本発明の医療液体用袋の中間層及び外層に使用す
る直鎖状低密度ポリエチレンは、エチレンと通常炭素数
が１２個以下の１−オレフィンとの共重合体であり、そ
の１−オレフィンの代表例としては、ブテン−１、ヘキ
セン−１，４−メチルペンテン−１、オクテン−１など
が好適である。(b) Intermediate layer and outer layer Furthermore, the linear low-density polyethylene used for the intermediate layer and outer layer of the medical liquid bag of the present invention is a copolymer of ethylene and a 1-olefin having usually 12 or less carbon atoms. As representative examples of the 1-olefin, butene-1, hexene-1,4-methylpentene-1, octene-1, etc. are suitable.
これら１−オレフィンは、共重合割合により短鎖分岐の
数ひいては密度の低下につながり種々の物性に影響する
。Depending on the copolymerization ratio, these 1-olefins lead to a decrease in the number of short chain branches and thus to a decrease in density, which affects various physical properties.
このような直鎖状低密度ポリエチレンのうち、素手袋の
中間層には密度０．９１５ｇ／ｃｄ以下、好ましくは０
．９１０ｇ／ｃｍ３以下の材質のものが用いられ、また
、外層には密度０．９２０ｇ／ｄ以上、好ましくは０．
９２３ｇ／ａｄ以上の材質のものが用いられる。Of such linear low density polyethylene, the intermediate layer of bare gloves has a density of 0.915 g/cd or less, preferably 0.
．． A material having a density of 910 g/cm3 or less is used, and the outer layer has a density of 0.920 g/d or more, preferably 0.920 g/d or more.
A material having a weight of 923 g/ad or more is used.
中間層のものの密度の下限は０．８９０ｇ／ｃｄ程度で
あり、これより低いものでは機械的強度、耐熱性が劣り
、一方、上記密度より高い材質のものでは柔軟性が満足
しなくなる。The lower limit of the density of the intermediate layer is about 0.890 g/cd, and if the density is lower than this, the mechanical strength and heat resistance will be poor, while if the density is higher than the above-mentioned density, the flexibility will be unsatisfactory.
また、外層の材質の密度の上限は０． ９３５ｓｒ／ｃ
Ｉｉ程度であり、これより高い密度のものでは柔軟性が
劣り、一方、上記密度未満では耐熱性が劣って好ましく
ない。Also, the upper limit of the density of the outer layer material is 0. 935sr/c
If the density is higher than this, the flexibility will be poor, while if the density is less than the above, the heat resistance will be poor, which is not preferable.
（ｃ） その他の配合成分
本発明の医療液体用袋を構成する各成分は上記のとおり
であるが、これら成分においては、本発明の効果を著し
く損なわない限り、他の樹脂成分、ゴム、安定剤、着色
剤、滑剤、アンチブロッキング剤、充填剤等の付加的成
分を含有していても構わない。(c) Other components The components constituting the bag for medical liquid of the present invention are as described above. The composition may contain additional components such as additives, colorants, lubricants, anti-blocking agents, and fillers.
（２）肉厚
また、この医療液体用袋の各層の厚みは、内層が通常１
０〜１００μｍ１好ましくは３０〜６０μｍ１中間層が
通常５０〜５００μｍ１好ましくは１５０〜３００μｍ
１外層が通常１０〜１００μｍ１好ましくは３０〜６０
μｍであり、これら層を積層してなる積層体全体の厚み
の好適な範囲は０．１５〜０．５ｍｍである。０．１５
ｗ未満では質量感が損なわれやすく、一方、０．５ｍ■
を越えると、柔軟性が不足気味となる。各層の厚み割合
は特に制限するものではないが、柔軟性を十分に付与す
るには、中間層の厚みを積層体全体の厚みの６０％以上
、特に７０〜８５％とすることが好ましい。(2) Thickness Also, the thickness of each layer of this medical liquid bag is such that the inner layer is usually 1
0 to 100 μm, preferably 30 to 60 μm, intermediate layer usually 50 to 500 μm, preferably 150 to 300 μm
1 outer layer is usually 10 to 100 μm 1 preferably 30 to 60 μm
[mu]m, and the preferred range of the thickness of the entire laminate formed by laminating these layers is 0.15 to 0.5 mm. 0.15
If it is less than w, the sense of mass is likely to be lost; on the other hand, if it is less than 0.5 m
If it exceeds this, there will be a lack of flexibility. Although the thickness ratio of each layer is not particularly limited, in order to provide sufficient flexibility, the thickness of the intermediate layer is preferably 60% or more, particularly 70 to 85% of the thickness of the entire laminate.
［ｎ）医療液体用袋の製造
本発明の医療液体用袋は、ポリエチレン、ＥＶＡ、ポリ
プロピレンなどに使用されている一般の共押出インフレ
ーション法、共押出Ｔダイ法などのフィルム製造法によ
って製造することができ、透明性の観点より水冷式、急
冷式の共押出方法を採用することができる。特に、使用
される上記各層の低密度ポリエチレンのＭＦＲはＪＩＳ
−に６７６０によるＭＦＲで０．１〜１０ ｇ／ｌ ０
分のものが好ましい。[n) Manufacture of bag for medical liquid The bag for medical liquid of the present invention can be manufactured by a film manufacturing method such as a general coextrusion inflation method or a coextrusion T-die method used for polyethylene, EVA, polypropylene, etc. From the viewpoint of transparency, water-cooling and quenching co-extrusion methods can be used. In particular, the MFR of the low density polyethylene used in each of the above layers is JIS
- 0.1 to 10 g/l at MFR by 6760 0
Preferably.
以下に示す実施例および比較例における評価は下記に示
す方法によって行なった。Evaluations in the Examples and Comparative Examples shown below were performed by the methods shown below.
柔軟性二 ｌ５Ｏ−Ｒ−１１８４の試験法により弾性率
をｉｌｌ定し判断した。Flexibility The elastic modulus was determined and judged by the test method of 15O-R-1184.
透明性： 得られた医療液体用袋に生理食塩水を投入し
、目視観察により判断した。Transparency: Physiological saline was poured into the obtained medical liquid bag and judged by visual observation.
ブロッキング性： 水冷共押出インフレーションフィル
ム内面に於けるフィルム同志の粘着状態を観察し判断し
た。Blocking property: Judgment was made by observing the state of adhesion between the films on the inner surface of the water-cooled coextruded blown film.
耐熱性： 高圧蒸気殺菌処理（１１０℃）後に於ける外
観を観察し、目視判定した。Heat resistance: Visual judgment was made by observing the appearance after high-pressure steam sterilization treatment (110°C).
引張強度： ＪＩＳ−に６７６０の試験法により引張
破断時に於Ｃする強度を測定し判断した。Tensile strength: Judgment was made by measuring the strength at C at tensile breakage according to the JIS-6760 test method.
実施例１
内層に高圧法で得られたＭＦＲが１．０ｇ／１０分、（
Ｊ Ｉ Ｓ Ｋ−６７６０試験法で測定）かつ密度が
０．９２０ｇ／ａＩｌの分岐状低密度ポリエチレンを、
また、中間層にエチレンとヘキセン−１との共重合体で
、ＭＦＲが２．０ｇ／１０分、かつ密度が０．９０Ｏｒ
／ｒｉの直鎖状低密度ポリエチレンを、さらに外層にエ
チレンとヘキセン−１との共重合体で、ＭＦＲが２．０
ｓｒ／１０分、かつ密度が０．９２０ｆｒ／ｍの直鎖状
低密度ポリエチレンを用い、水冷共押出インフレーショ
ンフィルム成形機（厚み０．３ｍ＋＊）を使用して、第
１表に示す各層厚みの積層フィルムとした後、これをヒ
ートシールとして袋を製造した。Example 1 The inner layer had an MFR of 1.0 g/10 min, (
JIS K-6760 test method) and a density of 0.920 g/al,
In addition, the middle layer is made of a copolymer of ethylene and hexene-1, and has an MFR of 2.0 g/10 minutes and a density of 0.90 Or.
/ri linear low-density polyethylene, and the outer layer is a copolymer of ethylene and hexene-1, and the MFR is 2.0.
sr/10 minutes and a density of 0.920 fr/m, and using a water-cooled coextrusion blown film forming machine (thickness 0.3 m + *), each layer thickness shown in Table 1 was formed. After forming a laminated film, this was heat-sealed to produce a bag.
この積層フィルムについての評価を行なって、第１表に
示す結果を得た。This laminated film was evaluated and the results shown in Table 1 were obtained.
実施例２
内層に高圧法で得られたＭＦＲが１．０ｇ／１０分、か
つ密度が０．９２０ｇ／ａｒｔの分岐状低密度ポリエチ
レンを、また、中間層にエチレンと４−メチルペンテン
−１との共重合体で、ＭＦＲが２．０ｇ／１０分、かつ
密度が０．９００ｓｒ／ｄの直鎖状低密度ポリエチレン
を、さらに外層にエチレンと４−メチルペンテン−１と
の共重合体で、ＭＦＲが２．０ｇ／１０分、かつ密度が
０．９２Ｏｒ／ｒｉの直鎖状低密度ポリエチレンを用い
て、実施例１と同様にして評価した。Example 2 Branched low-density polyethylene with an MFR of 1.0 g/10 min and a density of 0.920 g/art obtained by a high-pressure method was used as the inner layer, and ethylene and 4-methylpentene-1 were used as the intermediate layer. A copolymer of linear low density polyethylene with an MFR of 2.0 g/10 min and a density of 0.900 sr/d, and an outer layer of a copolymer of ethylene and 4-methylpentene-1, Evaluation was performed in the same manner as in Example 1 using linear low density polyethylene having an MFR of 2.0 g/10 min and a density of 0.92 Or/ri.
実施例３
内層に高圧法で得られたＭＦＲが１．０ｇ／１０分、か
つ密度が０．９２０ｇ／ｃ１１の分岐状低密度ポリエチ
レンを、また、中間層にエチレンとブテン−１との共重
合体で、ＭＦＲが２．０ｇ／１０分、かつ密度が０．９
００の直鎖状低密度ポリエチレンを、さらに外層にエチ
レンとブテン−１との共重合体で、ＭＦＲが２．Ｏｒ／
１０分、かつ密度が０．９２０ｇ／ｃｍ３の直鎖状低密
度ポリエチレンを用いて、実施例１と同様にして評価し
た。Example 3 Branched low-density polyethylene with an MFR of 1.0 g/10 min and a density of 0.920 g/c11 obtained by a high-pressure method was used as the inner layer, and a copolymer of ethylene and butene-1 was used as the intermediate layer. Combined, MFR is 2.0g/10min and density is 0.9
00 linear low-density polyethylene and a copolymer of ethylene and butene-1 for the outer layer, the MFR is 2. Or/
Evaluation was performed in the same manner as in Example 1 using linear low-density polyethylene having a density of 0.920 g/cm3.
実施例４
内層に高圧法で得られたＭＦＲが１．０ｒ／１０分、か
つ密度が０． ９２８ｔｒ／ｃｉｆ）分岐状低密度ポリ
エチレンを、また、中間層にエチレンとブテン−１との
共重合体で、ＭＦＲが２．０ｇ／１０分、かつ密度が０
．９００ｇ／ｃ１！の直鎖状低密度ポリエチレンを、さ
らに外層にエチレンとブテン−１との共重合体で、ＭＦ
Ｒが２．０ｇ／ｌＯ分、かつ密度が０．９２０ｇ／ｄの
直鎖状低密度ポリエチレンを用いて、実施例１と同様に
して評価した。Example 4 The inner layer has an MFR of 1.0 r/10 min obtained by high pressure method and a density of 0. 928tr/cif) branched low density polyethylene, and the middle layer is a copolymer of ethylene and butene-1, with an MFR of 2.0 g/10 min and a density of 0.
．． 900g/c1! Linear low-density polyethylene is further coated with a copolymer of ethylene and butene-1 in the outer layer to form MF.
Evaluation was performed in the same manner as in Example 1 using linear low-density polyethylene with an R of 2.0 g/lO and a density of 0.920 g/d.
比較例１
内外層にエチレンとブテン−１との共重合体で、ＭＦＲ
が２．Ｏｇ／１０分、かつ密度が０．９２Ｏｒ／ｒｉの
直鎖状低密度ポリエチレンを、また、中間層にエチレン
とブテン−１との共重合体で、ＭＦＲが２．Ｏｇ／１０
分、かつ密度が０．９００ｇ：／ｍの直鎖状低密度ポリ
エチレンを用いて、実施例１と同様にして評価した。Comparative Example 1 A copolymer of ethylene and butene-1 is used for the inner and outer layers, and the MFR
2. A linear low-density polyethylene with a density of 0.92 Or/ri and a density of 0.92 Or/ri is used, and a copolymer of ethylene and butene-1 is used as the intermediate layer, and the MFR is 2. Og/10
Evaluation was conducted in the same manner as in Example 1 using linear low-density polyethylene having a density of 0.900 g:/m and a density of 0.900 g:/m.
比較例２
内外層に高圧法で得られたＭＦＲが１．０ｇ／１０分か
つ密度が０．９２０ｇ／ｃＩｊの分岐状低密度ポリエチ
レンを、また、中間層にエチレンとブテン−１との共重
合体で、ＭＦＲが２． Ｏｔｒ／１０分、かつ密度が
０．９００ｇ／Ｃｌｌ１の直鎖状低密度ポリエチレンを
用いて、実施例１と同様にして評価した。Comparative Example 2 Branched low-density polyethylene with an MFR of 1.0 g/10 min and a density of 0.920 g/cIj obtained by a high-pressure method was used for the inner and outer layers, and a copolymer of ethylene and butene-1 was used for the intermediate layer. So, the MFR is 2. Evaluation was performed in the same manner as in Example 1 using linear low-density polyethylene having Otr/10 minutes and a density of 0.900 g/Cll1.
比較例３
内外層にエチレンとブテン−１との共重合体で、ＭＦＲ
が２．Ｏｇ／１０分、がっ密度が０．９２０の直鎖状低
密度ポリエチレンを、また、中間層にエチレンと酢酸ビ
ニルとの共重合体で、ＭＦＲが２．０ｇ／１０分、かつ
酢酸ビニル含量が２０重量％のものを用いて、実施例１
と同様にして評価した。Comparative Example 3 A copolymer of ethylene and butene-1 is used for the inner and outer layers, and the MFR
2. 0g/10 min, linear low density polyethylene with a density of 0.920, and a copolymer of ethylene and vinyl acetate in the middle layer, with an MFR of 2.0 g/10 min and a vinyl acetate content. Example 1
It was evaluated in the same manner.
Claims (1)
上の分岐状低密度ポリエチレン、中間層が密度０．９１
５ｇ／ｃｍ＾３以下のエチレンと１−オレフィンとの共
重合体である直鎖状低密度ポリエチレンおよび、外層が
密度０．９２０ｇ／ｃｍ＾３以上の直鎖状低密度ポリエ
チレンである積層体からなることを特徴とする医療液体
用袋。The inner layer is branched low-density polyethylene with a density of 0.918 g/cm^3 or more obtained by high-pressure method, and the middle layer is made of branched low-density polyethylene with a density of 0.91.
From linear low density polyethylene which is a copolymer of ethylene and 1-olefin with a density of 5 g/cm^3 or less and a laminate whose outer layer is linear low density polyethylene with a density of 0.920 g/cm^3 or more. A medical liquid bag characterized by:
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP02077448A JP3110435B2 (en) | 1990-03-27 | 1990-03-27 | Medical liquid bag |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP02077448A JP3110435B2 (en) | 1990-03-27 | 1990-03-27 | Medical liquid bag |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH03277365A true JPH03277365A (en) | 1991-12-09 |
| JP3110435B2 JP3110435B2 (en) | 2000-11-20 |
Family
ID=13634301
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP02077448A Expired - Fee Related JP3110435B2 (en) | 1990-03-27 | 1990-03-27 | Medical liquid bag |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3110435B2 (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06105888A (en) * | 1992-09-29 | 1994-04-19 | Otsuka Pharmaceut Factory Inc | Laminated film for medical treatment container and medical treatment container using it |
| WO2000035673A1 (en) | 1998-12-14 | 2000-06-22 | Otsuka Pharmaceutical Factory, Inc. | Multilayered film and container |
| US6306473B1 (en) | 1997-07-17 | 2001-10-23 | Otsuka Pharmaceutical Factory Inc. | Multilayer film and container |
| CN100377871C (en) * | 2002-05-17 | 2008-04-02 | 株式会社大塚制药工厂 | Multi-layer film and medicine container using the same |
-
1990
- 1990-03-27 JP JP02077448A patent/JP3110435B2/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06105888A (en) * | 1992-09-29 | 1994-04-19 | Otsuka Pharmaceut Factory Inc | Laminated film for medical treatment container and medical treatment container using it |
| US6306473B1 (en) | 1997-07-17 | 2001-10-23 | Otsuka Pharmaceutical Factory Inc. | Multilayer film and container |
| WO2000035673A1 (en) | 1998-12-14 | 2000-06-22 | Otsuka Pharmaceutical Factory, Inc. | Multilayered film and container |
| US6905744B1 (en) | 1998-12-14 | 2005-06-14 | Otsuka Pharmaceutical Factory, Inc. | Multilayered film and container |
| CN100377871C (en) * | 2002-05-17 | 2008-04-02 | 株式会社大塚制药工厂 | Multi-layer film and medicine container using the same |
Also Published As
| Publication number | Publication date |
|---|---|
| JP3110435B2 (en) | 2000-11-20 |
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