JPH03252330A - Glass for blood collecting tube - Google Patents
Glass for blood collecting tubeInfo
- Publication number
- JPH03252330A JPH03252330A JP4704090A JP4704090A JPH03252330A JP H03252330 A JPH03252330 A JP H03252330A JP 4704090 A JP4704090 A JP 4704090A JP 4704090 A JP4704090 A JP 4704090A JP H03252330 A JPH03252330 A JP H03252330A
- Authority
- JP
- Japan
- Prior art keywords
- glass
- blood collection
- irradiation
- coloring
- collection tubes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000011521 glass Substances 0.000 title claims abstract description 46
- 239000008280 blood Substances 0.000 title claims description 21
- 210000004369 blood Anatomy 0.000 title claims description 21
- 239000000203 mixture Substances 0.000 claims abstract description 5
- 238000010828 elution Methods 0.000 abstract description 9
- MCMNRKCIXSYSNV-UHFFFAOYSA-N Zirconium dioxide Chemical compound O=[Zr]=O MCMNRKCIXSYSNV-UHFFFAOYSA-N 0.000 abstract description 6
- 239000003513 alkali Substances 0.000 abstract description 6
- CETPSERCERDGAM-UHFFFAOYSA-N ceric oxide Chemical compound O=[Ce]=O CETPSERCERDGAM-UHFFFAOYSA-N 0.000 abstract description 4
- 229910000422 cerium(IV) oxide Inorganic materials 0.000 abstract description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 abstract 2
- FUJCRWPEOMXPAD-UHFFFAOYSA-N Li2O Inorganic materials [Li+].[Li+].[O-2] FUJCRWPEOMXPAD-UHFFFAOYSA-N 0.000 abstract 1
- KKCBUQHMOMHUOY-UHFFFAOYSA-N Na2O Inorganic materials [O-2].[Na+].[Na+] KKCBUQHMOMHUOY-UHFFFAOYSA-N 0.000 abstract 1
- 229910002637 Pr6O11 Inorganic materials 0.000 abstract 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 abstract 1
- 229910052681 coesite Inorganic materials 0.000 abstract 1
- 229910052593 corundum Inorganic materials 0.000 abstract 1
- 229910052906 cristobalite Inorganic materials 0.000 abstract 1
- XUCJHNOBJLKZNU-UHFFFAOYSA-M dilithium;hydroxide Chemical compound [Li+].[Li+].[OH-] XUCJHNOBJLKZNU-UHFFFAOYSA-M 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- MRELNEQAGSRDBK-UHFFFAOYSA-N lanthanum oxide Inorganic materials [O-2].[O-2].[O-2].[La+3].[La+3] MRELNEQAGSRDBK-UHFFFAOYSA-N 0.000 abstract 1
- PLDDOISOJJCEMH-UHFFFAOYSA-N neodymium oxide Inorganic materials [O-2].[O-2].[O-2].[Nd+3].[Nd+3] PLDDOISOJJCEMH-UHFFFAOYSA-N 0.000 abstract 1
- KTUFCUMIWABKDW-UHFFFAOYSA-N oxo(oxolanthaniooxy)lanthanum Chemical compound O=[La]O[La]=O KTUFCUMIWABKDW-UHFFFAOYSA-N 0.000 abstract 1
- FKTOIHSPIPYAPE-UHFFFAOYSA-N samarium(III) oxide Inorganic materials [O-2].[O-2].[O-2].[Sm+3].[Sm+3] FKTOIHSPIPYAPE-UHFFFAOYSA-N 0.000 abstract 1
- 239000000377 silicon dioxide Substances 0.000 abstract 1
- 235000012239 silicon dioxide Nutrition 0.000 abstract 1
- HUAUNKAZQWMVFY-UHFFFAOYSA-M sodium;oxocalcium;hydroxide Chemical compound [OH-].[Na+].[Ca]=O HUAUNKAZQWMVFY-UHFFFAOYSA-M 0.000 abstract 1
- 229910052682 stishovite Inorganic materials 0.000 abstract 1
- 229910052905 tridymite Inorganic materials 0.000 abstract 1
- 229910001845 yogo sapphire Inorganic materials 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 17
- 238000004040 coloring Methods 0.000 description 16
- 238000002834 transmittance Methods 0.000 description 8
- 238000000034 method Methods 0.000 description 7
- 230000001954 sterilising effect Effects 0.000 description 7
- 238000004659 sterilization and disinfection Methods 0.000 description 7
- 239000000126 substance Substances 0.000 description 7
- 230000002265 prevention Effects 0.000 description 6
- 239000000463 material Substances 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- 230000003449 preventive effect Effects 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 239000005361 soda-lime glass Substances 0.000 description 2
- 101100481408 Danio rerio tie2 gene Proteins 0.000 description 1
- 101100128281 Enterobacteria phage T4 rIII gene Proteins 0.000 description 1
- 206010073306 Exposure to radiation Diseases 0.000 description 1
- 101100481410 Mus musculus Tek gene Proteins 0.000 description 1
- 240000001970 Raphanus sativus var. sativus Species 0.000 description 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical class [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
- 229910021626 Tin(II) chloride Inorganic materials 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 239000005388 borosilicate glass Substances 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000003749 cleanliness Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000004031 devitrification Methods 0.000 description 1
- 230000005251 gamma ray Effects 0.000 description 1
- 238000012812 general test Methods 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000031700 light absorption Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000004381 surface treatment Methods 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
Landscapes
- Glass Compositions (AREA)
Abstract
Description
【発明の詳細な説明】
〔発明の目的〕
（産業上の利用分野）
本発明は採血管用ガラスに係ｐ１特にｒｌｉｉ）照射に
よって着色を生じない採血Ｖ用ガフス組成物に関する。DETAILED DESCRIPTION OF THE INVENTION [Object of the Invention] (Industrial Field of Application) The present invention relates to glass for blood collection tubes, and particularly to a gaff composition for blood collection V that does not cause coloring upon irradiation.
（従来の技術）
従来、採血管にはソーダライムガラス製または硼珪酸ガ
ラス製の細管が使用されている。採血管等の医療器具は
、ガス滅菌または高圧蒸気滅菌によシ滅菌処理が行われ
ているが、これらの方決は有害物質が残留し、これを除
去しなければならないことや処理温度が高温になること
等の欠点がある。このため、このような欠点のない滅菌
法として近年、ｒｔＪＩ照射による方法が普及しつつあ
る。(Prior Art) Conventionally, thin tubes made of soda lime glass or borosilicate glass have been used for blood collection tubes. Medical instruments such as blood collection tubes are sterilized by gas sterilization or high-pressure steam sterilization, but these methods leave behind harmful substances that must be removed and require high processing temperatures. There are disadvantages such as becoming Therefore, in recent years, a method using rtJI irradiation has become popular as a sterilization method that does not have such drawbacks.
しかし、ｒｌｔＡ照射による滅菌法ではｒＩｉ！被曝に
よる器具材質の劣化が問題となシ、採血管に関してはガ
ラスの着色が問題となっている。However, in the sterilization method using rltA irradiation, rIi! Deterioration of instrument materials due to exposure to radiation is a problem, and coloring of the glass of blood collection tubes is a problem.
ガラスの着色を防止する方法としては、ガラスにＣ６０
３を添加することが古くから知られている。As a way to prevent glass from discoloring, apply C60 to the glass.
It has been known for a long time to add 3.
また、ガラスの着色防止に関しては陰極ｌ１ｉｌｔ用ガ
ラスに例が多い。たとえば、特公昭４７−２９５６５号
公報にはＸ１ｖｌｌによるガラスの褐色化を防止するた
めにＣ・０２とＴＩＯ，とを共存させて、Ｃｃ０２の添
加量が少ない場合にも褐色化防止効果を奏するようにし
たテレビジ冒ンパルブ用ガラスが記載されている。また
、特公昭４９−４８４４８号公報、ｅ開昭４８−６２８
１２号公報には同様の目的でＣ・０２とＺｒＯ２とを組
合せて添加したものが開示されている。Further, regarding prevention of coloring of glass, there are many examples of glass for cathode 11ilt. For example, Japanese Patent Publication No. 47-29565 discloses that in order to prevent the browning of glass caused by It is listed as a glass for the television set. Also, Japanese Patent Publication No. 49-48448, e-Kokai No. 48-628
Publication No. 12 discloses a material in which a combination of C.02 and ZrO2 is added for the same purpose.
（発明が解決しようとする課題）
上記特公昭４７−２９５６５号公報および特公昭４９−
４８４４８号公報に記載されたガラスはいずれもＸ線遮
断の必要性からＰｂＯを含有している、ＰｂＯは、ｒ線
照射に対して着色中心となるほか、医療器具である採血
管ではｐｂの溶出が問題となる。またこれらのガラスは
、 １０ｋＧｙ（１０’ｒ）相当のｘ＠前照射対して４
００ｆｌｔｎにおける光の吸収率が５〜２０外程度であ
る。医療器具の滅Ｉｉ＠理では通常２５ｋＧｙ以上のｒ
線が照射されるため、前記光の吸収率は増加し、実質的
外着色防止効果が得られない。(Problem to be solved by the invention) The above-mentioned Japanese Patent Publication No. 47-29565 and Japanese Patent Publication No. 49-
All of the glasses described in Publication No. 48448 contain PbO due to the necessity of blocking X-rays.PbO is the main coloring agent when exposed to r-ray irradiation, and it also prevents the elution of Pb in blood collection tubes, which are medical instruments. becomes a problem. These glasses also have a
The light absorption rate at 00fltn is about 5 to 20. In the case of sterilization of medical equipment, r is usually 25 kGy or more.
Since the light is irradiated, the absorption rate of the light increases, and a substantial effect of preventing external coloration cannot be obtained.
上記％開１１１８４ｇ−６２８１２号公報に開示された
ガラスは、５ｂ２ｏ、を含有しておｊ）、ＰｂＯと同様
ｒ４１照射によシ着色を生じやすい。また、このガラス
のようにＢａＯを多く含むガラスは、粘性の変化が激し
いため成形性が悪く、採血管のような細管成形には適さ
ない。The glass disclosed in the above-mentioned Publication No. 11184g-62812 contains 5b2o, which, like PbO, tends to be colored by r41 irradiation. In addition, glass containing a large amount of BaO, such as this glass, has poor moldability due to drastic changes in viscosity, and is not suitable for molding into thin tubes such as blood collection tubes.
採血管は、医師による血液の目視検査の必要性および清
潔感など取扱管理上の要求から着色に対して非常に厳し
い特性が求められておシ、２５ｋａｙのｒＷＭ照射に対
して４００ ｎｍでの光の吸収率が５％以下であること
が望ましいとされている。このため、採血管においては
ソーダライムガラスにＣｅ ０２を添加して着色防止を
はかっているが、十分な効果を上げるためには少なくと
も１重量％以上のＣｅＯ２を含有させなければならない
。Blood collection tubes are required to have very strict characteristics against coloring due to the need for visual inspection of blood by doctors and handling management requirements such as cleanliness. It is said that it is desirable that the absorption rate is 5% or less. For this reason, in blood collection tubes, CeO2 is added to soda lime glass to prevent coloring, but in order to achieve a sufficient effect, at least 1% by weight of CeO2 must be contained.
Ｃ６０，は非常に高価な原料であるため、着色防止をＣ
＠０２に依存することは製品のコストを高くすることに
なる。Since C60 is a very expensive raw material, C60 is used to prevent coloring.
Relying on @02 will increase the cost of the product.
また、採血管は血液に直接触れる容器であることから、
アルカリ溶出量が規定されている。この規定を満足する
ために、従来はガラス表面にＳｉＯ８膜を被覆していた
が、細管状に成形した後に１０゜膜被覆を行うため、工
程が複雑になシ、生産性向上の防げとなっていた。In addition, since blood collection tubes are containers that come into direct contact with blood,
The amount of alkaline elution is specified. In order to satisfy this regulation, the glass surface was conventionally coated with a SiO8 film, but since the 10° film was coated after forming it into a thin tube, the process was complicated and it prevented productivity improvement. was.
本発明は、このような串悄を考慮してなされたもので、
アルカリ等の溶出がなく、ｒ線照射によって着色を生じ
ない安価な採血管用ガラスを提供することを目的とする
。The present invention was made in consideration of such concerns.
It is an object of the present invention to provide an inexpensive glass for blood collection tubes that does not elute alkali or the like and does not become colored by r-ray irradiation.
（課題を解決する丸めの手段と作用）
本発明は、上記目的を達成するために、特定組成のソー
ダライム系ガラスに少量のＣｅＯ２と、Ｌａ１０Ｂ 、
Ｎｄ、０３ ｔ Ｐｒ６Ｏ１１ｓ ８ｍ１ＯＢから選
はれる少なくとも１櫨の成分と、Ｐ２Ｏ１１、ＺｇｓＯ
ｅ ＺｒＯ２から選ばれる少なくともｌｌｋの成分とを
共存添加したものである。すなわち本発明は、真意百分
率で ８量０２６０〜７５％１人−６２０１０，５〜５
％。(Means and effects of rounding to solve the problem) In order to achieve the above object, the present invention adds a small amount of CeO2, La10B,
At least one component selected from Nd, 03t Pr6O11s 8m1OB, and P2O11, ZgsO
e) At least 1k components selected from ZrO2 are co-added. That is, the present invention has a true percentage of 80260 to 75% per person -62010,5 to 5
%.
Ｎｌ、Ｏ＋に、Ｏ＋Ｌｉ、０ １ ３〜２ ０ ％ 、
ＣａＯ−１−Ｍｇ０１〜１３％＊ ＢＩＯＯ””
’ ５ ％ ｅ Ｂｏｏ＠ Ｏ”’ ５％ｔ ｅｌ！０
．０．１〜２％、 Ｌａ１Ｏ１−）−Ｎｄ！０１ ＋Ｐ
ｒ＠Ｏｕ＋ ８ｍ１Ｏ１０，００５〜１％、 Ｐ、Ｏ
，＋ ＺｎＯ十Ｚ ｒ Ｏｓ Ｏ，０１〜５％、Ｔｉ０
，０〜２％からなろ組成を有する採血管用ガラスである
。Nl, O+, O+Li, 0 1 3 to 2 0%,
CaO-1-Mg01~13%* BIOO””
' 5%e Boo@O"' 5%t el!0
．． 0.1-2%, La1O1-)-Nd! 01 +P
r@Ou+ 8m1O10,005~1%, P, O
, + ZnO + Z r Os O, 01~5%, Ti0
, 0 to 2%.
次に上記ガラスの各成分値を限定した理由について説明
する。Next, the reason for limiting the values of each component of the glass will be explained.
８ＳＯ３はガラスを形成する主成分であるが、６０％未
満では熱膨張係数が大きくなシ化学的耐久性が低下する
。また７５％を越えると軟化温度が高くなシガラス管成
形が困難となる。人ノ８０３は化学的耐久性改善に効果
があるが、０．５％未満ではその効果がなく、５％を越
えると溶融時の粘度が高くなシ均質なガラスが得られな
い。Ｎ１□０゜Ｋ、Ｏ，Ｌｌ、０は、その含量が１３％
未満ではガラスの軟化温度が高くなり細管成形が困難と
なる。8SO3 is a main component forming glass, but if it is less than 60%, the coefficient of thermal expansion is large and the chemical durability is reduced. If it exceeds 75%, the softening temperature will be high, making it difficult to form glass tubes. Jinno 803 is effective in improving chemical durability, but if it is less than 0.5%, it has no effect, and if it exceeds 5%, the viscosity during melting is high and a homogeneous glass cannot be obtained. N1□0°K, O, Ll, 0 has a content of 13%
If it is less than this, the softening temperature of the glass becomes high, making it difficult to form a thin tube.
また２０％を越えると化学的耐久性が劣化し、アルカリ
成分の溶出をまねく。ＣａＯ，ＭｇＯはガラスの化学的
耐久性・溶融性を向上させ、高温粘性を調整する作用を
するが、合量で１％未満ではその効果が得られず、溶融
性が悪くなり、１３％を越えると高温粘性は低下するも
のの軟化温度が高くなシ失透傾向が強くなる、ＢａＯは
軟化温度を下け、ガラス溶融時の泡切れを良好にするが
、５弾を越えると逆に泡切れ性が悪化するとともに成形
性を低下させる、Ｂ２０．は溶融性・化学的耐久性を向
上させる効果があるが、５％を越えると軟化温度が上昇
しＳまたｒｌｌＡ被照射時にガラスの着色を増長するｃ
）ＣｅＯｇはｒｌｔＡ照射に対する着色防止剤として顕
著な効果を示すが、０．１％未満では断値の着色防止効
果が得られず、２％を越えて添加しても２％添加時以上
には着色防止効果は改善されず、Ｃｏ自体によシガラス
が着色される。Moreover, if it exceeds 20%, chemical durability deteriorates, leading to elution of alkaline components. CaO and MgO improve the chemical durability and meltability of glass and adjust the high temperature viscosity, but if the total amount is less than 1%, the effect cannot be obtained, and the meltability deteriorates, If it exceeds 5 bullets, the high temperature viscosity will decrease, but the softening temperature will be high and the tendency for devitrification will become stronger. B20. has the effect of improving meltability and chemical durability, but if it exceeds 5%, the softening temperature increases and the coloring of the glass increases when exposed to S or rllA radiation.
) CeOg shows a remarkable effect as a coloring preventive agent against rltA irradiation, but if it is less than 0.1%, the cut-off coloring preventive effect cannot be obtained, and even if it is added in excess of 2%, the The coloring prevention effect is not improved, and the glass is colored by Co itself.
Ｌａ２Ｏ３ｌ Ｎｄ、ｏ、 Ｉ Ｐ ｒ＠ＯＨｌ ８ａ
ｈｌＯｓは、各々Ｃｅ Ｏ＠と併用した場合、着色防止
助剤としてガラスの着色防止に顕著な効果を示し、Ｃｅ
０１添加量を減少させることができるので、これらのう
ち少なくとも１槍を添加するが、その合波が０．００５
鶴未満ではその効果が認められず、１襲を越えて添加し
ても１％添加時以上の改善効果はなく、各成分固有の＠
収によりガラスが着色されるので好ましくない、Ｐ２Ｏ
６＃ Ｚｎ０１ Ｚｒ０１には化学的耐久性を向上させ
アルカリの溶出を抑制する効果があり、少なくとも１橋
を添加するが、合鰍で０．０１％未満ではその効果がな
く、５％を越えると溶融性が悪くなり失透傾向が強くな
る０ＴＩＯ漏ｔｉ Ｃａ ０１と共存させた場合に着色
防止助剤として作用し、ガラスを着色しにくくするが、
２％を越えるとＴｉｅ２自体の吸取によりガラスに着色
を与えるので好ましくない。La2O3l Nd, o, I P r@OHl 8a
When used in combination with CeO@, hlOs has a remarkable effect on preventing glass coloration as a coloration prevention aid, and
Since it is possible to reduce the amount of 0.01 added, at least one of these is added, but the combined amount is 0.005.
The effect is not recognized at less than 1%, and even when added for more than 1 time, there is no improvement effect greater than when added at 1%, and @
P2O is undesirable because it colors the glass.
6# Zn01 Zr01 has the effect of improving chemical durability and suppressing the elution of alkali, and at least one bridge is added to it, but it has no effect if it is less than 0.01%, and if it exceeds 5%. When coexisting with OTIO leakage TiCa 01, which has poor meltability and a strong tendency to devitrify, it acts as a coloring prevention aid and makes the glass difficult to color.
If it exceeds 2%, the Tie2 itself will absorb and color the glass, which is not preferable.
また、Ｐ ｂｏ ｌ ８ｂ２０ｇ ＋ Ａｓ１０ｇは、
ガラス中で各々の陽イオンがγ線照射によシ着色中心を
生成し、ガラスの可視光透過率を著しく損なうので、実
質的に含有しないことがくましい。Also, P bol 8b20g + As10g is
Each cation generates colored centers in the glass upon irradiation with gamma rays, which significantly impairs the visible light transmittance of the glass, so it is preferable not to substantially contain them.
（実施例）
次に本発明の実施例について説明する。本発明の実施例
を下表に示す。表中の組成は重量百分率で示し、試料Ａ
１〜１５が本発明に係る実施例のガラス、試料４１６が
比較例のガラスである。(Example) Next, an example of the present invention will be described. Examples of the present invention are shown in the table below. The composition in the table is shown in weight percentage, and sample A
Samples 1 to 15 are examples of glasses according to the present invention, and Sample 416 is a comparative example.
下表のガラスは、いずれも所定の成分組成が得られるよ
うに原料を調合し、白金ルツボに収容して１４００〜１
５００℃の温度で溶融し、攪拌・清澄後金型内に鋳込み
、徐冷した後、切断・研磨して肉厚１．０鶴の平板状に
成形し、透過率測定用の試料とした。以上のようにして
作製した試料ガラスにラジエ工業■製ＴＩＭ照射装置１
ＲＩｃ Ｉ管用いてｒＭ２５ｋＧ）／を照射し、照射前
後の波長４００ ｎｍにおける透過率を測定し、透過率
の変化量（透過率差）によ＃）着色の度合を評価した。The glasses listed in the table below are made by mixing raw materials to obtain a predetermined composition, and then storing the materials in a platinum crucible.
It was melted at a temperature of 500°C, stirred and clarified, then cast into a mold, slowly cooled, cut and polished to form a flat plate with a wall thickness of 1.0 mm, which was used as a sample for transmittance measurement. The TIM irradiation device 1 manufactured by Radie Kogyo Co., Ltd. was applied to the sample glass produced as described above.
The sample was irradiated with rM25kG) using an RIc I tube, the transmittance at a wavelength of 400 nm before and after irradiation was measured, and the degree of coloring was evaluated based on the amount of change in transmittance (transmittance difference).
なお、透過率の測定は日立製作所■部分光光度計３４０
型によシ行った。また、アルカリ溶出量についてはＪＩ
８−Ｒ−３５１１に規定された日本薬局方一般試験法２
０注射剤用ガラス容器試験法（４）Ｋ従りて測定を行っ
た。これらの測定結果を表中に示す。The transmittance was measured using a Hitachi Partial Photometer 340.
I went to the mold. In addition, regarding the amount of alkali elution, JI
Japanese Pharmacopoeia General Test Method 2 specified in 8-R-3511
0 Glass Container Test Method for Injectables (4)K Measurements were performed accordingly. These measurement results are shown in the table.
下表から本実施例のガラスは、ｒｓ照射後の透過率変化
が小さく、ｒＩＩＩ照射に対する着色防止効果の優れた
ものであることがわかる。また本実施例のガラスはいず
れもｒｍ照射前に９０％以上の高い透過率を有し、γ線
照射後も外観上の変化はなく無色透明の非常にクリアな
状態を保つていた。From the table below, it can be seen that the glass of this example has a small change in transmittance after rs irradiation, and has an excellent coloring prevention effect against rIII irradiation. Moreover, all the glasses of this example had high transmittance of 90% or more before irradiation with rm, and remained colorless and transparent with no change in appearance even after irradiation with gamma rays.
これによυ本発明のガラスを用いた採血管は、γ線照射
による滅菌錫塩を行つた後も光を用いた検査や目視によ
る判断を誤シなく行うことができる。As a result, the blood collection tube using the glass of the present invention can be inspected using light or visually judged without error even after sterilization of tin salt by γ-ray irradiation.
また、アルカリ溶出量についても本実施例のガラスは従
来用いられていた比較例のガラスに較べて半分以下の低
い値であ）、特にアルカリ溶出を防ぐ目的で８曇０□被
優等の表面処理を施す必要がない〇
〔発明の効果〕
以上のように本発明の採血管用ガラスは、■ 着色防止
剤としてＣａ Ｏ＠を単独で添加したものに較べて少な
いＣ＠０２含有量で、ｒＨ照射に対して従来以上の着色
防止効果が得られるので低コストでｒ＠照射滅菌による
着色を生じない採血管が得られる。Furthermore, regarding the amount of alkali elution, the glass of this example has a value that is less than half that of the glass of the comparative example used conventionally. [Effects of the Invention] As described above, the glass for blood collection tubes of the present invention has a lower C@02 content than a glass containing CaO@ alone as a coloring inhibitor, and is resistant to rH irradiation. Since it is possible to obtain a coloring prevention effect higher than that of the conventional method, it is possible to obtain a blood collection tube that does not cause coloring due to r@ irradiation sterilization at low cost.
■ アルカリ成分の溶出が少ないので、採血管の内容物
に形番を与えることがない。またアルカリ溶出防止のた
めの表面処理を必要としないので、躯造工程が簡略化で
色、生産性向上とコストの低減がはかれる。■ Since there is little elution of alkaline components, there is no need to give a model number to the contents of the blood collection tube. Furthermore, since no surface treatment is required to prevent alkali elution, the fabrication process is simplified, improving color, productivity, and reducing costs.
■ 高温粘性の変化がゆるやかで、成形性に優れている
九め、細管成形が容易である。■ The change in high temperature viscosity is gradual and has excellent formability, making it easy to form into thin tubes.
等、採血管用のガラスとして極めて優れた効果を有する
。It has extremely excellent effects as glass for blood collection tubes.
Claims (2)
２Ｏ＿３０．５〜５％、Ｎａ＿２Ｏ＋Ｋ＿２Ｏ＋Ｌｉ＿
２Ｏ１３〜２０％、ＣａＯ＋ＭｇＯ１〜１３％、ＢａＯ
０〜５％、Ｂ＿２Ｏ＿３０〜５％、ＣｅＯ＿２０．１〜
２％、Ｌａ＿２Ｏ＿３＋Ｎｄ＿２Ｏ＿３＋Ｐｒ＿６Ｏ＿
１＿１＋Ｓｍ＿２Ｏ＿３０．００５〜１％、Ｐ＿２Ｏ＿
５＋ＺｎＯ＋ＺｒＯ＿２０．０１〜５％、ＴｉＯ＿２０
〜２％からなる組成を有することを特徴とする採血管用
ガラス。(1) In weight percentage, SiO_260-75%, Al_
2O_30.5-5%, Na_2O+K_2O+Li_
2O13-20%, CaO+MgO1-13%, BaO
0-5%, B_2O_30-5%, CeO_20.1-
2%, La_2O_3+Nd_2O_3+Pr_6O_
1_1+Sm_2O_30.005~1%, P_2O_
5+ZnO+ZrO_20.01~5%, TiO_20
A glass for blood collection tubes characterized by having a composition consisting of ~2%.
５を含まないことを特徴とする請求項１記載の採血管用
ガラス。(2) Substantially PbO, Sb_2O_3, Al_2O_
The glass for blood collection tubes according to claim 1, characterized in that the glass does not contain 5.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4704090A JP2687251B2 (en) | 1990-02-27 | 1990-02-27 | Glass for blood collection tube |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4704090A JP2687251B2 (en) | 1990-02-27 | 1990-02-27 | Glass for blood collection tube |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH03252330A true JPH03252330A (en) | 1991-11-11 |
| JP2687251B2 JP2687251B2 (en) | 1997-12-08 |
Family
ID=12764053
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP4704090A Expired - Fee Related JP2687251B2 (en) | 1990-02-27 | 1990-02-27 | Glass for blood collection tube |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2687251B2 (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006321680A (en) * | 2005-05-19 | 2006-11-30 | Nippon Electric Glass Co Ltd | Glass composition for lighting, and glass tube, fluorescent lamp bulb, stem tube and incandescent lamp bulb using the same |
| JP2011016713A (en) * | 2009-06-12 | 2011-01-27 | Schott Ag | Boron-deficient neutral glass with titanium oxide and zirconium oxide |
| JP2017036202A (en) * | 2015-07-29 | 2017-02-16 | ショット アクチエンゲゼルシャフトＳｃｈｏｔｔ ＡＧ | Low-boron zirconium-free neutral glass having optimized alkali metal ratio |
-
1990
- 1990-02-27 JP JP4704090A patent/JP2687251B2/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006321680A (en) * | 2005-05-19 | 2006-11-30 | Nippon Electric Glass Co Ltd | Glass composition for lighting, and glass tube, fluorescent lamp bulb, stem tube and incandescent lamp bulb using the same |
| JP2011016713A (en) * | 2009-06-12 | 2011-01-27 | Schott Ag | Boron-deficient neutral glass with titanium oxide and zirconium oxide |
| JP2017036202A (en) * | 2015-07-29 | 2017-02-16 | ショット アクチエンゲゼルシャフトＳｃｈｏｔｔ ＡＧ | Low-boron zirconium-free neutral glass having optimized alkali metal ratio |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2687251B2 (en) | 1997-12-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| LAPS | Cancellation because of no payment of annual fees |