JPH0325181B2 - - Google Patents
Info
- Publication number
- JPH0325181B2 JPH0325181B2 JP62266204A JP26620487A JPH0325181B2 JP H0325181 B2 JPH0325181 B2 JP H0325181B2 JP 62266204 A JP62266204 A JP 62266204A JP 26620487 A JP26620487 A JP 26620487A JP H0325181 B2 JPH0325181 B2 JP H0325181B2
- Authority
- JP
- Japan
- Prior art keywords
- bone
- hydroxyapatite
- parts
- weight
- particle size
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 210000000988 bone and bone Anatomy 0.000 claims description 61
- 239000000463 material Substances 0.000 claims description 25
- 239000002245 particle Substances 0.000 claims description 21
- 239000008187 granular material Substances 0.000 claims description 18
- 239000001913 cellulose Substances 0.000 claims description 13
- 229920002678 cellulose Polymers 0.000 claims description 13
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 13
- 238000010304 firing Methods 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 4
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 25
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 25
- 239000011148 porous material Substances 0.000 description 23
- 230000007547 defect Effects 0.000 description 10
- 238000001356 surgical procedure Methods 0.000 description 10
- 239000001506 calcium phosphate Substances 0.000 description 6
- 239000000843 powder Substances 0.000 description 6
- 210000001519 tissue Anatomy 0.000 description 6
- 206010061218 Inflammation Diseases 0.000 description 5
- 206010072170 Skin wound Diseases 0.000 description 5
- 229910000389 calcium phosphate Inorganic materials 0.000 description 5
- 235000011010 calcium phosphates Nutrition 0.000 description 5
- 210000004027 cell Anatomy 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 230000004054 inflammatory process Effects 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 239000002504 physiological saline solution Substances 0.000 description 5
- 239000002002 slurry Substances 0.000 description 4
- 229910052586 apatite Inorganic materials 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- -1 calcium phosphate compound Chemical class 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 239000013078 crystal Substances 0.000 description 3
- 238000011049 filling Methods 0.000 description 3
- 230000012010 growth Effects 0.000 description 3
- 230000035876 healing Effects 0.000 description 3
- 230000000399 orthopedic effect Effects 0.000 description 3
- 210000002997 osteoclast Anatomy 0.000 description 3
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 3
- 238000005245 sintering Methods 0.000 description 3
- 238000011282 treatment Methods 0.000 description 3
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 210000002808 connective tissue Anatomy 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- 238000002513 implantation Methods 0.000 description 2
- 210000004373 mandible Anatomy 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 208000018084 Bone neoplasm Diseases 0.000 description 1
- 241000195493 Cryptophyta Species 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 206010039203 Road traffic accident Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 230000010478 bone regeneration Effects 0.000 description 1
- 230000010072 bone remodeling Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000023753 dehiscence Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 210000001564 haversian system Anatomy 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000011164 ossification Effects 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- 229940078499 tricalcium phosphate Drugs 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Dental Preparations (AREA)
- Compositions Of Oxide Ceramics (AREA)
- Materials For Medical Uses (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62266204A JPS63294864A (ja) | 1987-10-23 | 1987-10-23 | 人工骨材料の製造方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62266204A JPS63294864A (ja) | 1987-10-23 | 1987-10-23 | 人工骨材料の製造方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP59200131A Division JPS6179464A (ja) | 1984-09-25 | 1984-09-25 | 人工骨材料用組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS63294864A JPS63294864A (ja) | 1988-12-01 |
| JPH0325181B2 true JPH0325181B2 (enrdf_load_stackoverflow) | 1991-04-05 |
Family
ID=17427708
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP62266204A Granted JPS63294864A (ja) | 1987-10-23 | 1987-10-23 | 人工骨材料の製造方法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS63294864A (enrdf_load_stackoverflow) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03191963A (ja) * | 1989-12-22 | 1991-08-21 | Mitsubishi Materials Corp | リン酸カルシウム質多孔体骨補填材 |
| JPH0440961A (ja) * | 1990-06-06 | 1992-02-12 | Mitsubishi Materials Corp | 骨欠損部及び骨空隙部ならびに骨吸収部充填材 |
| JP2008173238A (ja) * | 2007-01-17 | 2008-07-31 | Olympus Terumo Biomaterials Corp | 生体組織補填材の製造方法 |
| EP3338815A1 (en) * | 2016-12-23 | 2018-06-27 | Sunstar Suisse SA | Bone graft substitute |
-
1987
- 1987-10-23 JP JP62266204A patent/JPS63294864A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS63294864A (ja) | 1988-12-01 |
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