JPH03240652A - Inner container stopper - Google Patents
Inner container stopperInfo
- Publication number
- JPH03240652A JPH03240652A JP2024002A JP2400290A JPH03240652A JP H03240652 A JPH03240652 A JP H03240652A JP 2024002 A JP2024002 A JP 2024002A JP 2400290 A JP2400290 A JP 2400290A JP H03240652 A JPH03240652 A JP H03240652A
- Authority
- JP
- Japan
- Prior art keywords
- vitamin
- synthetic resin
- polyethylene
- amount
- container
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 88
- 229930003427 Vitamin E Natural products 0.000 claims abstract description 44
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims abstract description 44
- 229940046009 vitamin E Drugs 0.000 claims abstract description 44
- 239000011709 vitamin E Substances 0.000 claims abstract description 44
- 235000019165 vitamin E Nutrition 0.000 claims abstract description 44
- 229920003002 synthetic resin Polymers 0.000 claims abstract description 15
- 239000000057 synthetic resin Substances 0.000 claims abstract description 15
- 239000000463 material Substances 0.000 claims abstract description 13
- 239000004698 Polyethylene Substances 0.000 abstract description 11
- -1 polyethylene Polymers 0.000 abstract description 11
- 229920000573 polyethylene Polymers 0.000 abstract description 11
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 abstract description 6
- 239000007788 liquid Substances 0.000 abstract description 6
- 229940042585 tocopherol acetate Drugs 0.000 abstract description 6
- 238000001746 injection moulding Methods 0.000 abstract description 3
- 239000012778 molding material Substances 0.000 abstract description 2
- 239000000203 mixture Substances 0.000 abstract 1
- 230000007423 decrease Effects 0.000 description 6
- 239000008188 pellet Substances 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 229940079593 drug Drugs 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 239000003889 eye drop Substances 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 1
- 229940012356 eye drops Drugs 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 238000004898 kneading Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229920000139 polyethylene terephthalate Polymers 0.000 description 1
- 239000005020 polyethylene terephthalate Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Packages (AREA)
- Closures For Containers (AREA)
Abstract
Description
【発明の詳細な説明】
〔産業上の利用分野〕
この発明は、例えば目薬容器等のように、内容液中にビ
タミンEを含む場合、内容液中のビタミンEが軟質合成
樹脂製の中栓に吸着するのを防止した容器中栓に関する
ものである。[Detailed Description of the Invention] [Industrial Field of Application] This invention provides that when vitamin E is contained in the liquid content, such as in an eye drop container, the vitamin E in the liquid content is absorbed by the inner stopper made of soft synthetic resin. This invention relates to a container stopper that prevents adsorption to the inside of a container.
ビタミンEを含む内容物を収容する容器は、ビタミンE
が吸着しない硬質合成樹脂製の容器本体を備えている。Containers containing contents containing vitamin E are
The container body is made of hard synthetic resin that does not absorb water.
点眼剤等の容器では、容器本体の口部に口部やキャップ
との嵌合性、密閉性を図るために軟質合成樹脂材料から
成る中栓を取付けている。In containers for eye drops and the like, an inner stopper made of a soft synthetic resin material is attached to the mouth of the container body in order to ensure a good fit and seal with the mouth and the cap.
従来の容器にビタミンEを含む内容物を収容しておくと
、期間の経過によりビタミンEが減少する。これは軟質
合成樹脂材料から戊る中栓にビタミンEが吸着されるた
めである。When contents containing vitamin E are stored in a conventional container, the vitamin E content decreases over time. This is because vitamin E is adsorbed to the inner stopper, which is made of a soft synthetic resin material.
そこで、この発明は容器本体の口部やキャップとの嵌合
性、密閉性を損なわず、ビタミンEが吸着しにくい容器
中栓を提供することを目的とするものである。SUMMARY OF THE INVENTION Therefore, an object of the present invention is to provide a container stopper that does not impair the fitting and sealing properties with the mouth of the container body or the cap, and which does not easily absorb vitamin E.
上述の目的を達成するため、第1の発明は、軟質合成樹
脂材料から成り、当該材料中にビタミンEを含むもので
ある。第2の発明は、ビタミンEを含む軟質合成樹脂材
料から成る中栓のビタミンE含有量を2〜2.5%とし
たものである。In order to achieve the above-mentioned object, the first invention is made of a soft synthetic resin material and contains vitamin E in the material. In the second invention, the inner stopper made of a soft synthetic resin material containing vitamin E has a vitamin E content of 2 to 2.5%.
第1の発明においては、中栓を形成する軟質合成樹脂材
料中にビタミンEを含まないものに比較して内容物中の
ビタミンEの減少が改善された。In the first invention, the decrease in vitamin E in the contents was improved compared to a soft synthetic resin material forming the inner stopper that does not contain vitamin E.
第2の発明においては、内容物中のビタミンEの増減が
10%未満であることが判明した。In the second invention, it was found that the increase/decrease in vitamin E in the contents was less than 10%.
以下にこの発明の詳細な説明する。 This invention will be explained in detail below.
第1の発明の各実施例として、軟質合成樹脂としてポリ
エチレンを使用し、このポリエチレンにビタミンEとし
て酢酸トコフェロールを練込み、所望の形状の中栓を形
成した。酢酸トコフェロールは粘性の液であり、この液
をポリエチレンと混練したものを成形用素材とし、射出
成形等の手段により中栓を成形する。成形された中栓全
体の中で酢酸トコフェロールが占める割合(%)が、0
゜1.0.3.0.75.1.5.2.0.2,5.3
.0のものを夫々製造した。容器本体は耐薬品性及びビ
タミンEを吸着しないポリエチレンテレフタレート等の
硬質合成樹脂材料から成形し、この容器本体の口部に上
述のビタミンEを含む軟質合成樹脂材料から成形された
中栓を嵌合させた。中栓は軟質であるため口部との嵌合
性も良く、キャップとの嵌合性にも優れるのみならず、
口部やキャップとの密閉性にも優れていた。このような
容器にビタミンEを含んだ薬液を収容し、薬液が中栓に
触れるようにして24時間(50℃)放置した結果、ビ
タミンEを0.1%含む中栓であっても薬液中のビタミ
ンEの減少は、ビタミンEを全く含まない中栓に比較し
て2倍近い残存量が確認された。In each Example of the first invention, polyethylene was used as the soft synthetic resin, and tocopherol acetate as vitamin E was kneaded into the polyethylene to form an inner plug of a desired shape. Tocopherol acetate is a viscous liquid, and this liquid is kneaded with polyethylene, used as a molding material, and the inner plug is molded by means such as injection molding. The proportion (%) of tocopherol acetate in the entire molded inner plug is 0.
゜1.0.3.0.75.1.5.2.0.2,5.3
.. 0 of each were manufactured. The container body is molded from a hard synthetic resin material such as polyethylene terephthalate, which is chemical resistant and does not adsorb vitamin E, and an inner stopper molded from the above-mentioned soft synthetic resin material containing vitamin E is fitted into the mouth of the container body. I let it happen. Since the inner plug is soft, it not only fits well with the mouth part, but also has excellent fit with the cap.
It also had excellent sealing properties with the mouth and cap. As a result of storing a drug solution containing vitamin E in such a container and leaving it for 24 hours (50℃) with the drug solution touching the inner stopper, it was found that even if the inner stopper contained 0.1% vitamin E, the drug solution It was confirmed that the amount of vitamin E remaining in the bottle was almost twice that of the inner stopper that did not contain any vitamin E.
ポリエチレンに酢酸トコフェロールを0.1.0゜3.
0.75.1.5.2.0.2.5.3.0の割合(%
)で練込んだプレートとポリエチレンだけから成形され
たプレート (ビタミンE練込量0%)を夫々ビタミン
E配合薬液中に50℃、24時間浸漬し、薬液中のビタ
ミンE残存量を測定した結果は、次表及び図面に示す通
りであった。Add tocopherol acetate to polyethylene at 0.1.0°3.
0.75.1.5.2.0.2.5.3.0 ratio (%
) and a plate molded only from polyethylene (vitamin E mixing amount: 0%) were immersed in a vitamin E-containing chemical solution at 50°C for 24 hours, and the residual amount of vitamin E in the chemical solution was measured. were as shown in the following table and drawings.
この表及び図面からも明らかなように、ビタミンEの練
込量と残存量の関係は比例し、この練込量をコントロー
ルすることにより薬液中のビタミンE残存量をコントロ
ールすることが容易に行えることが判明した。As is clear from this table and drawing, the relationship between the amount of vitamin E kneaded and the remaining amount is proportional, and by controlling the amount of kneaded, it is easy to control the amount of vitamin E remaining in the medicinal solution. It has been found.
この測定結果から、第2の発明は、ビタミンEの練込量
を2〜2.5%とし、残存量の増減を10%未満にコン
トロールした。From this measurement result, in the second invention, the kneaded amount of vitamin E was set at 2 to 2.5%, and the increase/decrease in the remaining amount was controlled to less than 10%.
製造例
1、混練機にポリエチレンとビタミンEとを所定の割合
で投入し、混練してペレットを得る。このペレットを射
出成形して所定量のビタミンEが練り込まれた中栓を得
た。Production Example 1: Polyethylene and vitamin E are put into a kneader at a predetermined ratio and kneaded to obtain pellets. This pellet was injection molded to obtain an inner plug into which a predetermined amount of vitamin E was kneaded.
■、上述の製造例と同様にしてペレットを得るが、ビタ
ミンEの量を予め最終的に希望する量の10倍程度多く
した濃縮ペレットを一旦作り、そのペレットとナチュラ
ルのポリエチレンのペレットとを混練して射出成形によ
り所定量のビタミンEが練り込まれた中栓を得た。この
製造例では色ムラを防止し、ポリエチレンとビタミンE
との割合がより正確に調整できる。■. Obtain pellets in the same manner as in the production example above, but first make concentrated pellets with the amount of vitamin E about 10 times greater than the final desired amount, and knead the pellets with natural polyethylene pellets. Then, an inner stopper into which a predetermined amount of vitamin E was kneaded was obtained by injection molding. This manufacturing example prevents color unevenness and uses polyethylene and vitamin E.
The ratio can be adjusted more accurately.
以上説明したように、第1の発明によれば、内容物中の
ビタミンEが中栓に吸着される量を減少させ、残存量を
増大させることができた。第2の発明では、内容物中の
ビタミンEの増減を10%未満とし、より効率的にビタ
ミンEの減少を防止できた。As explained above, according to the first invention, it was possible to reduce the amount of vitamin E in the contents adsorbed to the inner stopper and increase the remaining amount. In the second invention, the increase/decrease in vitamin E in the contents was less than 10%, and the decrease in vitamin E could be more efficiently prevented.
図面は中栓を形成する軟質合成樹脂材料へのビタミンE
練込量と内容物中のビタミンE残存量との関係を示すグ
ラフである。The drawing shows vitamin E added to the soft synthetic resin material that forms the inner plug.
It is a graph showing the relationship between the amount of kneading and the amount of vitamin E remaining in the contents.
Claims (1)
に取付けられる容器中栓において、軟質合成樹脂材料か
ら成り、当該材料中にビタミンEを含むことを特徴とす
る容器中栓。 2、ビタミンEを含む軟質合成樹脂材料から成る中栓の
ビタミンE含有量を2〜2.5%としたことを特徴とす
る請求項1に記載の容器中栓。[Claims] 1. A container stopper attached to the mouth of a container containing contents containing vitamin E, characterized in that it is made of a soft synthetic resin material and contains vitamin E in the material. Container stopper. 2. The container inner stopper according to claim 1, wherein the inner stopper is made of a soft synthetic resin material containing vitamin E and has a vitamin E content of 2 to 2.5%.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2024002A JPH03240652A (en) | 1990-02-02 | 1990-02-02 | Inner container stopper |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2024002A JPH03240652A (en) | 1990-02-02 | 1990-02-02 | Inner container stopper |
Publications (1)
Publication Number | Publication Date |
---|---|
JPH03240652A true JPH03240652A (en) | 1991-10-28 |
Family
ID=12126363
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2024002A Pending JPH03240652A (en) | 1990-02-02 | 1990-02-02 | Inner container stopper |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPH03240652A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8409643B2 (en) | 2005-09-02 | 2013-04-02 | Kraft Foods Group Brands Llc | Methods for the application of ingredients to the inside of a straw |
-
1990
- 1990-02-02 JP JP2024002A patent/JPH03240652A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8409643B2 (en) | 2005-09-02 | 2013-04-02 | Kraft Foods Group Brands Llc | Methods for the application of ingredients to the inside of a straw |
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