JPH0323864A - Filler for living body tissue - Google Patents
Filler for living body tissueInfo
- Publication number
- JPH0323864A JPH0323864A JP1159307A JP15930789A JPH0323864A JP H0323864 A JPH0323864 A JP H0323864A JP 1159307 A JP1159307 A JP 1159307A JP 15930789 A JP15930789 A JP 15930789A JP H0323864 A JPH0323864 A JP H0323864A
- Authority
- JP
- Japan
- Prior art keywords
- filler
- sponge
- biodegradable
- long period
- lactic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000945 filler Substances 0.000 title claims abstract description 13
- 239000000463 material Substances 0.000 claims abstract description 13
- 239000000515 collagen sponge Substances 0.000 claims abstract description 10
- 239000002861 polymer material Substances 0.000 claims abstract description 7
- 239000002131 composite material Substances 0.000 claims abstract description 6
- 229920001432 poly(L-lactide) Polymers 0.000 claims abstract description 5
- 238000011049 filling Methods 0.000 claims description 8
- 210000002950 fibroblast Anatomy 0.000 abstract description 7
- 230000035876 healing Effects 0.000 abstract description 5
- 238000013329 compounding Methods 0.000 abstract description 3
- 238000002156 mixing Methods 0.000 abstract description 2
- 239000011148 porous material Substances 0.000 abstract description 2
- 230000015556 catabolic process Effects 0.000 abstract 1
- 238000006731 degradation reaction Methods 0.000 abstract 1
- 206010062575 Muscle contracture Diseases 0.000 description 5
- 208000006111 contracture Diseases 0.000 description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- 230000035755 proliferation Effects 0.000 description 4
- 238000001356 surgical procedure Methods 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- 108010035532 Collagen Proteins 0.000 description 3
- 102000008186 Collagen Human genes 0.000 description 3
- 229920001436 collagen Polymers 0.000 description 3
- 230000007547 defect Effects 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 108010045569 atelocollagen Proteins 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 239000004744 fabric Substances 0.000 description 2
- 238000010562 histological examination Methods 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 230000000399 orthopedic effect Effects 0.000 description 2
- 230000017423 tissue regeneration Effects 0.000 description 2
- 241000723353 Chrysanthemum Species 0.000 description 1
- 235000005633 Chrysanthemum balsamita Nutrition 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000700157 Rattus norvegicus Species 0.000 description 1
- 210000003969 blast cell Anatomy 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000004709 cell invasion Effects 0.000 description 1
- 239000003431 cross linking reagent Substances 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Abstract
Description
【発明の詳細な説明】
（産業上の利用分舒）
本発明は、損傷、欠損等の外科的治療、整形外科手術等
に便川される充填材に関一づ−る。DETAILED DESCRIPTION OF THE INVENTION (Industrial Application) The present invention relates to a filling material used for surgical treatment of injuries, defects, etc., orthopedic surgery, etc.
（従来技術）
損傷、欠損等の外科的治療、及び、整形外科手｛ホＩ等
においては組織の再生、拘縮を防止する目的において、
欠損部に充填材が埋入される。(Prior art) For surgical treatment of injuries, defects, etc., and for orthopedic surgery, etc., for the purpose of tissue regeneration and prevention of contracture,
A filling material is inserted into the defect.
かかる素材としては、紹織反応が少なく、線維芽細胞の
増殖を促し． ，ＩＩＩ織が再生するまで長Ｍにわたっ
てその強度、形状が維持される機能が求められる。また
、特に適用中においては糺織の拘縮を防止する目的にお
いて保形性を有する機能が求められ、また、組織の再生
後においては異物として体内に残留することなく速やか
に消失することが理想とされる。Such a material has a low fibrous reaction and promotes the proliferation of fibroblasts. , III is required to maintain its strength and shape over the length M until the weave is regenerated. In addition, shape-retaining properties are required to prevent the contracture of the daisy weave, especially during application, and ideally, after tissue regeneration, it should disappear quickly without remaining in the body as a foreign substance. It is said that
かかる目的に対し、 ミクロポーラスなコラーゲンスポ
ンジが提案されているが、」二記の機能を満足しない。Microporous collagen sponges have been proposed for this purpose, but they do not satisfy the functions listed in item 2.
（発明が解決しようとする問題点）
即ち、例えば、グルタールアルデヒドを用いて架橋させ
たコラーゲンスポンシは、生体に埋入後２〜３ケ月後に
は完全に生体に分解吸収されて消失してしまい治癒に必
要な長期の強度、保形性を維持しない。(Problems to be Solved by the Invention) That is, for example, a collagen spongy crosslinked using glutaraldehyde is completely decomposed and absorbed by the living body and disappears 2 to 3 months after being implanted in the living body. It does not maintain the long-term strength and shape retention required for healing.
本発明は、かかる従来の欠点を解消し、組織反応が少な
く、且つ、線維芽細胞の増殖を促すと共に、長期にわた
って形状、強度が維持され、また治癒後は生体に吸収さ
れる新規な充填材を提供したものである。The present invention solves these conventional drawbacks, and provides a novel filling material that causes less tissue reaction, promotes the proliferation of fibroblasts, maintains its shape and strength over a long period of time, and is absorbed by the body after healing. was provided.
（問題を解決するための手段）
しかるに、本発明はコラーゲンスポンジと生体分解吸収
性高分子材料との複合材料より成り、かかる生体分解吸
収性高分子材料として繊維状のボリーＬ一乳酸を用いた
こと、およびこれをコラーゲンスポンジ中に混在、もし
くは埋入させて構成したことに特徴を有するものである
。(Means for Solving the Problem) However, the present invention consists of a composite material of a collagen sponge and a biodegradable and absorbable polymer material, and uses fibrous Bory-L monolactic acid as the biodegradable and absorbable polymer material. It is characterized by the fact that it is mixed with or embedded in a collagen sponge.
（イ乍用）
本発明は、コラーゲンスポンジ中に生体内での分解速度
の遅いポリ−Ｌ一乳酸を混在させて複合化させたことに
よってスポンジ構造のｐｏｒｅを長期にわたって維持で
き、また、繊維状のボリーＬ一乳酸との複合化によって
内部への線維芽細胞の増殖を促すと共に、治癒に必要な
長期にわたっての強度、形状の維持を可能としたもので
ある。(For use) The present invention can maintain the pores of the sponge structure over a long period of time by mixing and compounding poly-L monolactic acid, which has a slow decomposition rate in vivo, into the collagen sponge. By combining with Bory-L-lactic acid, it is possible to promote the proliferation of fibroblasts inside the body and maintain the strength and shape over a long period of time, which is necessary for healing.
以下、その構成について、例示する。The configuration will be illustrated below.
（構成例）
３デニールのポリ−Ｌ一乳酸糸（分子量８００００１０
３ｇをからめてスライバー状とし、これを縦、横、深
さが夫々６Ｘ２Ｘ２ｃｍの容器に入れ、これに豚由来の
アテロコラーゲン０．３％塩酸溶液５０ｇを１８００ｒ
ｐｍにて６０分間撹拌して注いだ。次いで、これを４８
時間凍結乾燥し、アルコールにて滅菌して本発明充填材
を構成した。(Configuration example) 3 denier poly-L monolactic acid thread (molecular weight 8000010
3 g was mixed to form a sliver, and this was placed in a container measuring 6 x 2 x 2 cm in length, width, and depth, and 50 g of a 0.3% hydrochloric acid solution of pig-derived atelocollagen was added to it at 1800 r.
Stir and pour at pm for 60 minutes. Next, convert this to 48
The filler material of the present invention was prepared by freeze-drying the product and sterilizing it with alcohol.
このようにして得た充填材は、ミクロポーラスなスポン
ジ構造の間にポリ−Ｌ一乳酸糸がランダムに埋入されて
複合化された外観を呈した。The filler thus obtained had a composite appearance in which poly-L monolactic acid threads were randomly embedded between the microporous sponge structure.
また、その物性値は第ｌ表に示すように従来のコラーゲ
ン単独のスポンジと比較し、破断強度、破断伸度、ヤン
グ率が格段に高い値を示し、著しい改善が成された。ま
た、ＰｏｒｅＳｉｚｅも大きくなっている。Furthermore, as shown in Table 1, the physical properties of the sponge were significantly improved in terms of breaking strength, breaking elongation, and Young's modulus, which were significantly higher than conventional sponges made of collagen alone. Moreover, PoreSize is also large.
尚、表における比較例は架橋剤としてグルタールアルデ
ヒトを使用した豚由来のアテロコラーゲン０．２％塩酸
溶液５０ｇを前記と同様の方法によって処理して得たコ
ラーゲン単独のスポンジである。The comparative example in the table is a collagen-only sponge obtained by treating 50 g of a 0.2% hydrochloric acid solution of pig-derived atelocollagen using glutaraldehyde as a crosslinking agent in the same manner as described above.
第１表
尚、これの測定はＪＩＳ法に準じた。また、その単位は
以下の通りである。Table 1 Note that this measurement was conducted in accordance with the JIS method. In addition, the units are as follows.
強度：破断強度（Ｘｌｏ’ ｌ ． ［ｄｙｎｅ／ｃｍ
２１伸度：破断伸度（％）
ヤング率： （ Ｘ １０’ ｌ ． （ｄｙｎｅ
／ｃｌＩ１２１ＰｏｒｅＳｉｚｅ ： （μｌＩ１）
上記の方法により得た本発明充填材を以下の方法により
動物実験に供し、組織学的検討と拘縮の状態を観察した
。Strength: Breaking strength (Xlo' l. [dyne/cm
21 Elongation: Elongation at break (%) Young's modulus: (X 10' l. (dyne
/clI121PoreSize: (μlI1) The filling material of the present invention obtained by the above method was subjected to animal experiments according to the following method, and histological examination and the state of contracture were observed.
（適用例）
体重３５０ｇのウィスター系ラットの背部筋層上を２Ｘ
２ｃｍ大に剥離し、その部分に約２ｃｍ３大の本発明充
填材を埋植し、経過を観察した。(Application example) 2X on the back muscle layer of a Wistar rat weighing 350g
It was peeled off to a size of 2 cm, and a filler of the present invention of about 2 cm and 3 sizes was implanted in that part, and the progress was observed.
〈ｌケ月後〉
スポンジ内周部分で線維芽細胞の侵入が認められるが中
央部では細胞未侵入。<1 month later> Invasion of fibroblasts is observed in the inner circumference of the sponge, but no cells have invaded in the central area.
〈３ケ月後〉
スポンジ中央部への細胞侵入は２ケ月後に比べて増加し
ている。<3 months later> Cell invasion into the center of the sponge increased compared to 2 months later.
く６ケ月後〉
スポンジ中央部へ線維芽細胞が一定の方向で並ぶ部分が
できた。6 months later> A region was formed in the center of the sponge where fibroblasts were lined up in a fixed direction.
組織学的検討において埋植３〜４ケ月後にスポンシの中
央部まで線維芽細胞が十分に侵入し、６ケ月後において
は完全に組織が構築された。Histological examination showed that fibroblasts had sufficiently invaded the center of the sponge 3 to 4 months after implantation, and a complete tissue was established 6 months later.
方、拘縮の状態については石膏模型により、その容積を
測定する方法によって行なったが、上記比較例によるも
のは２ケ月後で初期体積の５〜１５％しか残存せず、４
ケ月後では殆ど生体内に吸収され、消失するという結果
であったが、本発明充填材によると６ケｎ後においても
初期体積の３５〜５０％が残存し、かかる面においても
顕著な差が見られた。On the other hand, the state of contracture was measured by measuring the volume using a plaster model, but in the case of the above comparative example, only 5 to 15% of the initial volume remained after 2 months.
The results showed that most of the filler was absorbed into the body and disappeared after 6 months, but with the present filling material, 35-50% of the initial volume remained even after 6 months, and there was a significant difference in this aspect as well. It was seen.
（発明の効果）
以上のように本発明による充填材は、その実用結果から
も明らかなように、用途上の要求特付である、組織反足
、かないこと５線雑芽細胞の増殖を促ずこと、絹織が再
生１−るまで長１リｊにわたってその強度、形状が維持
されること、紹織の拘縮を防止ずる機能を有すこと、組
織の再生後は体内に分解吸収されて消失してしまうこと
等、この種の用途に必要な機能を全て兼ね嘲えたもので
あり、効果的な適用が可能なものである。(Effects of the Invention) As described above, the filling material according to the present invention promotes the proliferation of 5-line miscellaneous blast cells, which is a special requirement for its use, as is clear from its practical results. The main reason for this is that the strength and shape of the silk fabric is maintained over a long period of time until it is regenerated, that it has the function of preventing contracture of the silk fabric, and that it is decomposed and absorbed into the body after the tissue is regenerated. It has all the functions necessary for this type of use, such as the fact that it disappears when it disappears, and can be effectively applied.
尚、コラーゲンスボンジと生体分解吸収性高分子材料と
の複合化比率、およびポリ−Ｌ一乳酸繊維の繊度等はそ
の用途、必要機能等に応じて任意に選択可能なものであ
る。The composite ratio of the collagen sponge and the biodegradable and absorbable polymer material, the fineness of the poly-L-lactic acid fibers, etc. can be arbitrarily selected depending on the use, required functions, etc.
以」二のように本発明は、従来にない新規な構成の生体
組織用充填材を提供したものである。As described above, the present invention provides a filling material for living tissue with a novel configuration not seen before.
Claims (1)
の複合材料より成ることを特徴とする生体組織用充填材
。 ２、繊維状の生体分解吸収性高分子材料がコラコラーゲ
ンスポンジ中に混在し、もしくは埋入されて成ることを
特徴とする請求項（１）項記載の生体組織用充填材。 ３、生体分解吸収性高分子材料がポリ−Ｌ−乳酸である
ことを特徴とする請求項（１）、（２）項記載の生体組
織用充填材。[Scope of Claims] 1. A filler for living tissue, characterized by being made of a composite material of a collagen sponge and a biodegradable and absorbable polymer material. 2. The filling material for biological tissue according to claim (1), characterized in that a fibrous biodegradable and absorbable polymeric material is mixed or embedded in the collagen sponge. 3. The filler for living tissue according to claims (1) and (2), wherein the biodegradable and absorbable polymeric material is poly-L-lactic acid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1159307A JP2805086B2 (en) | 1989-06-20 | 1989-06-20 | Filler for living tissue |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1159307A JP2805086B2 (en) | 1989-06-20 | 1989-06-20 | Filler for living tissue |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH0323864A true JPH0323864A (en) | 1991-01-31 |
| JP2805086B2 JP2805086B2 (en) | 1998-09-30 |
Family
ID=15690945
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1159307A Expired - Lifetime JP2805086B2 (en) | 1989-06-20 | 1989-06-20 | Filler for living tissue |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2805086B2 (en) |
Cited By (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0648480A2 (en) * | 1993-09-21 | 1995-04-19 | JOHNSON & JOHNSON MEDICAL, INC. | Wound implant materials |
| US5466462A (en) * | 1992-03-25 | 1995-11-14 | Johnson & Johnson Medical, Inc. | Heteromorphic sponges containing active agents |
| WO1996010426A1 (en) * | 1994-09-30 | 1996-04-11 | Yamanouchi Pharmaceutical Co., Ltd. | Osteoplastic graft |
| JPH08247751A (en) * | 1995-03-09 | 1996-09-27 | Nissan Motor Co Ltd | Ultrasonic thickness measuring sensor |
| JPH08257045A (en) * | 1993-05-12 | 1996-10-08 | Shuji Ichinohe | Sponge belt resuscitation reaction |
| US5565210A (en) * | 1993-03-22 | 1996-10-15 | Johnson & Johnson Medical, Inc. | Bioabsorbable wound implant materials |
| US5935594A (en) * | 1993-10-28 | 1999-08-10 | Thm Biomedical, Inc. | Process and device for treating and healing a tissue deficiency |
| EP1053758A1 (en) * | 1999-05-19 | 2000-11-22 | Resorba Chirurgisches Nahtmaterial Franz Hiltner GmbH & Co. | Bioabsorbable implant |
| US6264701B1 (en) | 1994-05-13 | 2001-07-24 | Kensey Nash Corporation | Device and methods for in vivo culturing of diverse tissue cells |
| WO2001070293A1 (en) * | 2000-03-18 | 2001-09-27 | The University Of Nottingham | Polymeric composite materials and their manufacture |
| WO2003018077A1 (en) * | 2001-08-22 | 2003-03-06 | National Institute Of Advanced Industrial Science And Technology | Method of bone regeneration |
| WO2003028782A1 (en) * | 2001-09-27 | 2003-04-10 | Nitta Gelatin Inc. | Composite material for tissue regeneration |
| KR20030032420A (en) * | 2001-10-18 | 2003-04-26 | 한국과학기술연구원 | Porous Scaffold Made of Biodegradable Polymer for Reconstructing Damaged Ocular Tissue |
| JP2005087641A (en) * | 2003-09-19 | 2005-04-07 | Jms Co Ltd | Bio-absorbent high polymer film |
| US7514097B1 (en) | 1999-11-09 | 2009-04-07 | Denki Kagaku Kogyo Kabushiki Kaisha | Use of soluble cellulose derivative having been made hardly soluble in water and process for producing the same |
| JP2010029684A (en) * | 1998-03-06 | 2010-02-12 | Yoshihiko Shimizu | Collagen material and process for producing the same |
| US8057818B2 (en) | 2000-11-07 | 2011-11-15 | Cryolife, Inc. | Methods of making expandable foam-like biomaterials |
| US8372433B2 (en) | 2007-01-18 | 2013-02-12 | Gunze Limited | Substrate for culture of cardiovascular tissue |
| US8748142B2 (en) | 1999-09-09 | 2014-06-10 | Gunze Limited | Culture of cardiovascular cells on a matrix and method for regenerating cardiovascular tissue |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5553214A (en) * | 1978-10-09 | 1980-04-18 | Merck Patent Gmbh | Molded mixture based on reabsorbent collagen in body*its manufacture and its medical use |
| JPS5841559A (en) * | 1980-10-03 | 1983-03-10 | ドクタ−・ル−ラント・ナハフオルガ−・ゲ−エムベ−ハ− | Collagen bandage material |
| JPS60261460A (en) * | 1984-06-11 | 1985-12-24 | 株式会社 高研 | Artifical skin comprising collagen and poly-alpha-amino acidmembrane |
-
1989
- 1989-06-20 JP JP1159307A patent/JP2805086B2/en not_active Expired - Lifetime
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5553214A (en) * | 1978-10-09 | 1980-04-18 | Merck Patent Gmbh | Molded mixture based on reabsorbent collagen in body*its manufacture and its medical use |
| JPS5841559A (en) * | 1980-10-03 | 1983-03-10 | ドクタ−・ル−ラント・ナハフオルガ−・ゲ−エムベ−ハ− | Collagen bandage material |
| JPS60261460A (en) * | 1984-06-11 | 1985-12-24 | 株式会社 高研 | Artifical skin comprising collagen and poly-alpha-amino acidmembrane |
Cited By (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5466462A (en) * | 1992-03-25 | 1995-11-14 | Johnson & Johnson Medical, Inc. | Heteromorphic sponges containing active agents |
| US5700476A (en) * | 1992-03-25 | 1997-12-23 | Johnson & Johnson Medical, Inc. | Heteromorphic sponges containing active agents |
| US5565210A (en) * | 1993-03-22 | 1996-10-15 | Johnson & Johnson Medical, Inc. | Bioabsorbable wound implant materials |
| JPH08257045A (en) * | 1993-05-12 | 1996-10-08 | Shuji Ichinohe | Sponge belt resuscitation reaction |
| US5766631A (en) * | 1993-09-21 | 1998-06-16 | Arnold; Peter Stuart | Wound implant materials |
| EP0648480A3 (en) * | 1993-09-21 | 1995-06-14 | Johnson & Johnson Medical | Wound implant materials. |
| EP0648480A2 (en) * | 1993-09-21 | 1995-04-19 | JOHNSON & JOHNSON MEDICAL, INC. | Wound implant materials |
| US5935594A (en) * | 1993-10-28 | 1999-08-10 | Thm Biomedical, Inc. | Process and device for treating and healing a tissue deficiency |
| US6264701B1 (en) | 1994-05-13 | 2001-07-24 | Kensey Nash Corporation | Device and methods for in vivo culturing of diverse tissue cells |
| WO1996010426A1 (en) * | 1994-09-30 | 1996-04-11 | Yamanouchi Pharmaceutical Co., Ltd. | Osteoplastic graft |
| US5830493A (en) * | 1994-09-30 | 1998-11-03 | Yamanouchi Pharmaceutical Co., Ltd. | Bone-forming graft |
| JPH08247751A (en) * | 1995-03-09 | 1996-09-27 | Nissan Motor Co Ltd | Ultrasonic thickness measuring sensor |
| JP2010029684A (en) * | 1998-03-06 | 2010-02-12 | Yoshihiko Shimizu | Collagen material and process for producing the same |
| EP1053758A1 (en) * | 1999-05-19 | 2000-11-22 | Resorba Chirurgisches Nahtmaterial Franz Hiltner GmbH & Co. | Bioabsorbable implant |
| US8748142B2 (en) | 1999-09-09 | 2014-06-10 | Gunze Limited | Culture of cardiovascular cells on a matrix and method for regenerating cardiovascular tissue |
| US7514097B1 (en) | 1999-11-09 | 2009-04-07 | Denki Kagaku Kogyo Kabushiki Kaisha | Use of soluble cellulose derivative having been made hardly soluble in water and process for producing the same |
| WO2001070293A1 (en) * | 2000-03-18 | 2001-09-27 | The University Of Nottingham | Polymeric composite materials and their manufacture |
| US8057818B2 (en) | 2000-11-07 | 2011-11-15 | Cryolife, Inc. | Methods of making expandable foam-like biomaterials |
| WO2003018077A1 (en) * | 2001-08-22 | 2003-03-06 | National Institute Of Advanced Industrial Science And Technology | Method of bone regeneration |
| JPWO2003028782A1 (en) * | 2001-09-27 | 2005-01-13 | 田畑 泰彦 | Biological tissue regeneration composite material |
| EP1437149A4 (en) * | 2001-09-27 | 2009-11-11 | Nitta Gelatin Kk | Composite material for tissue regeneration |
| WO2003028782A1 (en) * | 2001-09-27 | 2003-04-10 | Nitta Gelatin Inc. | Composite material for tissue regeneration |
| KR20030032420A (en) * | 2001-10-18 | 2003-04-26 | 한국과학기술연구원 | Porous Scaffold Made of Biodegradable Polymer for Reconstructing Damaged Ocular Tissue |
| JP2005087641A (en) * | 2003-09-19 | 2005-04-07 | Jms Co Ltd | Bio-absorbent high polymer film |
| US8372433B2 (en) | 2007-01-18 | 2013-02-12 | Gunze Limited | Substrate for culture of cardiovascular tissue |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2805086B2 (en) | 1998-09-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPH0323864A (en) | Filler for living body tissue | |
| CA2745934C (en) | Sustained release systems of ascorbic acid phosphate | |
| US4409332A (en) | Collagen-enzyme conjugates that exhibit no inflammatory response and method for making the same | |
| US3982543A (en) | Reducing capillarity of polyglycolic acid sutures | |
| US7084082B1 (en) | Collagen material and its production process | |
| RU2176525C2 (en) | Surgical implant material or bandage material releasing medication preparation | |
| US5607686A (en) | Polymeric composition | |
| AU624847B2 (en) | Periodontium-regenerative materials | |
| JP2001523999A (en) | Biologically degradable polymerizable semi-penetrating network alloy for orthopedic plates and bone cement and method of making same | |
| Hong et al. | Bone regeneration at rabbit skull defects treated with transforming growth factor—β1 incorporated into hydrogels with different levels of biodegradability | |
| JPS6341586B2 (en) | ||
| JPH05504941A (en) | Biodegradation system for periodontal tissue regeneration | |
| JPH09509082A (en) | Biocompatible porous matrix of bioabsorbable materials | |
| JPH1170160A (en) | Occlusive dressing consisting essentially of silk fibroin and silk sericin and its production | |
| AU708720B2 (en) | Method of producing polysaccharide foams | |
| JP2004529687A (en) | Complex for attachment, growth and / or repair of biological tissue, and use of the complex | |
| JPH06292716A (en) | Medical material | |
| Ölmez et al. | Chitosan and alginate scaffolds for bone tissue regeneration | |
| Kinoshita et al. | Study on the efficacy of biodegradable polyf (l-lactide) mesh for supporting transplanted particulate cancellous bone and marrow: experiment involving subcutaneous implantation in dogs | |
| ES2211446T3 (en) | COMPOSITE MATERIALS OF CERAMICS AND POLYMERS. | |
| KR20080066980A (en) | Scleral buckling band and method for making the same | |
| KR0180585B1 (en) | Biodegradability shielding film for alveolar organ | |
| JP4671596B2 (en) | Porous bone repair material and method for producing the same | |
| JP3217861B2 (en) | Materials for treating periodontal disease | |
| JP2508105B2 (en) | Biodegradable and absorbable antithrombotic medical material and method for producing the same |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20080724 Year of fee payment: 10 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20080724 Year of fee payment: 10 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20090724 Year of fee payment: 11 |
|
| EXPY | Cancellation because of completion of term |