JPH03206886A - ヒト腫瘍細胞抗原に対し特異性を持つマウス―ヒトキメラａ１０抗体 - Google Patents
ヒト腫瘍細胞抗原に対し特異性を持つマウス―ヒトキメラａ１０抗体Info
- Publication number
- JPH03206886A JPH03206886A JP2308453A JP30845390A JPH03206886A JP H03206886 A JPH03206886 A JP H03206886A JP 2308453 A JP2308453 A JP 2308453A JP 30845390 A JP30845390 A JP 30845390A JP H03206886 A JPH03206886 A JP H03206886A
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- Prior art keywords
- antibody
- chain
- antigen
- fragment
- heavy chain
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
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- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
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- A61K51/1084—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody the antibody being a hybrid immunoglobulin
- A61K51/1087—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody the antibody being a hybrid immunoglobulin the immunoglobulin comprises domains from different animal species, e.g. chimeric immunoglobulins
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- C07—ORGANIC CHEMISTRY
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- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
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- C07K16/46—Hybrid immunoglobulins
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C07K2319/00—Fusion polypeptide
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/034—Fusion polypeptide containing a localisation/targetting motif containing a motif for targeting to the periplasmic space of Gram negative bacteria as a soluble protein, i.e. signal sequence should be cleaved
Landscapes
- Health & Medical Sciences (AREA)
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- Chemical & Material Sciences (AREA)
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- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43501289A | 1989-11-13 | 1989-11-13 | |
| US435,012 | 1989-11-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH03206886A true JPH03206886A (ja) | 1991-09-10 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| JP2308453A Pending JPH03206886A (ja) | 1989-11-13 | 1990-11-13 | ヒト腫瘍細胞抗原に対し特異性を持つマウス―ヒトキメラａ１０抗体 |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0457875A4 (fr) |
| JP (1) | JPH03206886A (fr) |
| KR (1) | KR910009284A (fr) |
| AU (1) | AU634314B2 (fr) |
| CA (1) | CA2044590A1 (fr) |
| WO (1) | WO1991007418A1 (fr) |
Families Citing this family (28)
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| US6080407A (en) | 1993-05-17 | 2000-06-27 | The Picower Institute For Medical Research | Diagnostic assays for MIF |
| US5641751A (en) * | 1995-05-01 | 1997-06-24 | Centocor, Inc. | Tumor necrosis factor inhibitors |
| DE69726674T2 (de) * | 1996-04-10 | 2004-10-21 | Sangstat Medical Corp | Zellmodulierende konjugate aus elementen aus spezifischen bindungspaaren |
| IT1289608B1 (it) * | 1997-02-05 | 1998-10-15 | Angelini Ricerche Spa | Composizione per uso terapeutico o diagnostico somministrabile per via intranasale,sublinguale o vaginale |
| US20030035798A1 (en) | 2000-08-16 | 2003-02-20 | Fang Fang | Humanized antibodies |
| HUP0300421A2 (hu) | 2000-03-31 | 2003-06-28 | Purdue Research Foundation | Kezelési eljárás ligand-immunogén konjugátumok felhasználásával |
| JP2005522192A (ja) | 2001-07-19 | 2005-07-28 | パーラン セラピューティクス， インコーポレイテッド | マルチマータンパク質およびマルチマータンパク質を作製および使用する方法 |
| KR20040106547A (ko) | 2002-05-15 | 2004-12-17 | 엔도사이트, 인코포레이티드 | 비타민-마이토마이신 공액체 |
| EP2517730A3 (fr) | 2003-01-27 | 2013-01-02 | Endocyte, Inc. | Conjugués d'administration de médicaments à liaison au récepteur de vitamines |
| US8288557B2 (en) | 2004-07-23 | 2012-10-16 | Endocyte, Inc. | Bivalent linkers and conjugates thereof |
| JP2009504783A (ja) | 2005-08-19 | 2009-02-05 | エンドサイト，インコーポレイテッド | ビンカアルカロイド、類似体および誘導体のリガンド結合体 |
| ES2468240T3 (es) | 2005-08-19 | 2014-06-16 | Endocyte, Inc. | Conjugados de ligando de múltiples fármacos |
| US8168164B2 (en) | 2006-02-03 | 2012-05-01 | Purdue Research Foundation | Targeted conjugates and radiation |
| EP2481427A1 (fr) | 2007-03-14 | 2012-08-01 | Endocyte, Inc. | Conjugués de folate et de tubulysine |
| CN101784565B (zh) | 2007-06-25 | 2014-12-10 | 恩多塞特公司 | 含有亲水性间隔区接头的共轭物 |
| US9877965B2 (en) | 2007-06-25 | 2018-01-30 | Endocyte, Inc. | Vitamin receptor drug delivery conjugates for treating inflammation |
| US9193763B2 (en) | 2007-08-17 | 2015-11-24 | Purdue Research Foundation | PSMA binding ligand-linker conjugates and methods for using |
| CA2703491C (fr) | 2007-10-25 | 2017-06-13 | Endocyte, Inc. | Tubulysines et leurs procedes de preparation |
| US9951324B2 (en) | 2010-02-25 | 2018-04-24 | Purdue Research Foundation | PSMA binding ligand-linker conjugates and methods for using |
| EP2748613B1 (fr) | 2011-10-07 | 2021-05-05 | Baxalta GmbH | Oxmif en tant que marqueur de diagnostic |
| US10080805B2 (en) | 2012-02-24 | 2018-09-25 | Purdue Research Foundation | Cholecystokinin B receptor targeting for imaging and therapy |
| US20140080175A1 (en) | 2012-03-29 | 2014-03-20 | Endocyte, Inc. | Processes for preparing tubulysin derivatives and conjugates thereof |
| AU2013331440A1 (en) | 2012-10-16 | 2015-04-30 | Endocyte, Inc. | Drug delivery conjugates containing unnatural amino acids and methods for using |
| US9636413B2 (en) | 2012-11-15 | 2017-05-02 | Endocyte, Inc. | Conjugates for treating diseases caused by PSMA expressing cells |
| MX2016005013A (es) | 2013-10-18 | 2017-02-28 | Deutsches Krebsforsch | Inhibidores marcados de antigeno prostatico especifico de membrana (psma), su uso como agentes formadores de imagenes y agentes farmaceuticos para el tratamiento de cancer de prostata. |
| US10188759B2 (en) | 2015-01-07 | 2019-01-29 | Endocyte, Inc. | Conjugates for imaging |
| CA2979527A1 (fr) | 2015-03-13 | 2016-09-22 | Endocyte, Inc. | Conjugues de promedicaments de pyrrolobenzodiazepine (pbd) pour le traitement de maladies |
| BR112023021189A2 (pt) | 2021-04-16 | 2024-02-06 | Novartis Ag | Agentes radioterapêuticos que têm o receptor de folato como alvo e uso do mesmo |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) * | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| AU625613B2 (en) * | 1988-01-05 | 1992-07-16 | Novartis Ag | Novel chimeric antibodies |
| GB8800078D0 (en) * | 1988-01-05 | 1988-02-10 | Ciba Geigy Ag | Novel antibodies |
| IL89489A0 (en) * | 1988-03-09 | 1989-09-10 | Hybritech Inc | Chimeric antibodies directed against human carcinoembryonic antigen |
-
1990
- 1990-11-13 AU AU66641/90A patent/AU634314B2/en not_active Ceased
- 1990-11-13 JP JP2308453A patent/JPH03206886A/ja active Pending
- 1990-11-13 WO PCT/US1990/006620 patent/WO1991007418A1/fr not_active Application Discontinuation
- 1990-11-13 KR KR1019900018568A patent/KR910009284A/ko not_active Application Discontinuation
- 1990-11-13 CA CA002044590A patent/CA2044590A1/fr not_active Abandoned
- 1990-11-13 EP EP19910900650 patent/EP0457875A4/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| CA2044590A1 (fr) | 1991-05-14 |
| WO1991007418A1 (fr) | 1991-05-30 |
| AU6664190A (en) | 1991-05-23 |
| AU634314B2 (en) | 1993-02-18 |
| KR910009284A (ko) | 1991-06-28 |
| EP0457875A1 (fr) | 1991-11-27 |
| EP0457875A4 (en) | 1993-03-03 |
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