JPH0319884Y2 - - Google Patents
Info
- Publication number
- JPH0319884Y2 JPH0319884Y2 JP1981008222U JP822281U JPH0319884Y2 JP H0319884 Y2 JPH0319884 Y2 JP H0319884Y2 JP 1981008222 U JP1981008222 U JP 1981008222U JP 822281 U JP822281 U JP 822281U JP H0319884 Y2 JPH0319884 Y2 JP H0319884Y2
- Authority
- JP
- Japan
- Prior art keywords
- skin
- connector
- hydroxyapatite
- collagen
- living
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 210000000988 bone and bone Anatomy 0.000 claims description 11
- 108010035532 Collagen Proteins 0.000 claims description 7
- 102000008186 Collagen Human genes 0.000 claims description 7
- 229920001436 collagen Polymers 0.000 claims description 7
- 239000011248 coating agent Substances 0.000 claims 1
- 238000000576 coating method Methods 0.000 claims 1
- 238000000465 moulding Methods 0.000 claims 1
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 8
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 8
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 239000005416 organic matter Substances 0.000 description 5
- 210000001519 tissue Anatomy 0.000 description 5
- 108010045569 atelocollagen Proteins 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 229920001296 polysiloxane Polymers 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- 102000057297 Pepsin A Human genes 0.000 description 1
- 108090000284 Pepsin A Proteins 0.000 description 1
- 239000003929 acidic solution Substances 0.000 description 1
- 238000007605 air drying Methods 0.000 description 1
- 239000012670 alkaline solution Substances 0.000 description 1
- 235000011114 ammonium hydroxide Nutrition 0.000 description 1
- 229910052586 apatite Inorganic materials 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 238000001354 calcination Methods 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000010304 firing Methods 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Description
【考案の詳細な説明】
本考案は、生体の内外を連通させる為に用いら
れる生体適合性の良い皮膚用コネクタに関するも
のである。[Detailed Description of the Invention] The present invention relates to a skin connector with good biocompatibility that is used to communicate between the inside and outside of a living body.
近年、人工臓器や医療技術の発展に伴ない、生
体内に外部から人工物を、半永久的若しくは医療
行為の都度、挿入することがしばしば行なわれ
る。このような時、皮膚に安定な開口部を形成し
ておくことが必要になる。このような開口部を形
成する為の部材の外壁は周囲の皮膚組織とよく密
着して脱落が起らないような構造である必要があ
る。又このような部材の材質は生体組織と親和性
があり、拒絶反応や炎症反応を起さない材料であ
つて、しかも安定である必要がある。 In recent years, with the development of artificial organs and medical technology, artificial objects are often inserted into living bodies from the outside either semi-permanently or for each medical procedure. In such cases, it is necessary to form a stable opening in the skin. The outer wall of the member for forming such an opening needs to have a structure that makes good contact with the surrounding skin tissue and prevents it from falling off. Furthermore, the material of such a member must be compatible with living tissue, do not cause rejection or inflammatory reactions, and must be stable.
本考案はこのような問題点に鑑みてなされたも
のであつて、生体組織との親和性の良い皮膚用コ
ネクタを提供しようとするものである。 The present invention was devised in view of these problems, and aims to provide a skin connector that has good compatibility with living tissue.
動物の骨は細胞、タンパク質、ムコ多糖などの
有機質とハイドロオキシアパタイトから成る無機
質とから成り立つている。細胞やタンパク質は拒
絶反応の原因となる抗原−抗体反応を示すが、無
機質であるハイドロオキシアパタイトは抗原−抗
体反応を示さず、従つて動物の骨から精製したハ
イドロオキシアパタイトを人にインプラントする
ことが出来る。しかも、この場合、生体が持つて
いる結晶構造がそのまま保たれているので、他の
生体との親和性も良い。 Animal bones are composed of organic matter such as cells, proteins, and mucopolysaccharides, and inorganic matter consisting of hydroxyapatite. Cells and proteins exhibit antigen-antibody reactions that cause rejection reactions, but hydroxyapatite, which is an inorganic substance, does not exhibit antigen-antibody reactions.Therefore, hydroxyapatite purified from animal bone cannot be implanted into humans. I can do it. Moreover, in this case, the crystal structure of the living body is maintained, so it has good compatibility with other living organisms.
更に、このようなハイドロオキシアパタイト
は、切削加工などを行なうに充分な強度を有して
いる。このような性質を持つている動物の骨のハ
イドロオキシアパタイトは、皮膚開口部用インプ
ラント材即ち皮膚用コネクタの材料として極めて
適している。 Furthermore, such hydroxyapatite has sufficient strength for cutting and the like. Animal bone hydroxyapatite having such properties is extremely suitable as an implant material for skin openings, that is, as a material for skin connectors.
以下、本考案を実施例につき図面を参照して説
明する。 DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention will be described below with reference to embodiments and drawings.
まず動物の骨を出発原料とした時のハイドロオ
キシアパタイトの精製法を説明する。 First, a method for purifying hydroxyapatite using animal bones as a starting material will be explained.
骨髄を除いた骨をまずアルカリ溶液、例えば２
％NaOH水溶液に浸漬し、これにH2O2を全体に
対する割合が２％になるまで加え、この状態で１
夜放置して有機物を分解する。この時、NaOH
の濃度が１〜10％、H2O2の濃度が１〜５％の範
囲であれば有機物の抽出溶解が効果的に進行す
る。NaOH−H2O2液を１日に１回交換して、２
週間処理を続けた後、水洗すると純白な骨が得ら
れる。このような処理を受けた骨は大部分の有機
質を除去されているが、まだ100％の除去はなさ
れていない。そこで、これを600〜1000℃、例え
ば700℃の電気炉中で５時間焼却した後、更に
1000〜1200℃、例えば1100℃で３時間焼成する
と、有機質が完全に除かれたハイドロオキシアパ
タイトの焼成骨が得られる。 The bone with bone marrow removed is first soaked in an alkaline solution, e.g.
% NaOH aqueous solution, add H 2 O 2 to this until the proportion of the whole becomes 2%, and in this state 1
Leave it overnight to decompose organic matter. At this time, NaOH
If the concentration of H 2 O 2 is in the range of 1 to 10% and the concentration of H 2 O 2 is in the range of 1 to 5%, extraction and dissolution of organic matter will proceed effectively. Replace NaOH-H 2 O 2 solution once a day,
After continuing the treatment for a week, washing with water will yield pure white bones. Although most of the organic matter has been removed from bones that have undergone this type of treatment, it is still not 100% removed. Therefore, after incinerating this in an electric furnace at 600 to 1000℃, for example 700℃ for 5 hours,
By firing at 1000 to 1200°C, for example 1100°C, for 3 hours, fired bones of hydroxyapatite from which organic matter has been completely removed can be obtained.
このようにして得られた焼成骨を成形、例えば
切削加工して、第１図及び第２図に示すようなコ
ネクタ本体１を作製する。このコネクタ本体１は
筒状に構成されており、その両端部に外向フラン
ジ２，３が夫々設けられている。 The thus obtained baked bone is shaped, for example, cut, to produce a connector body 1 as shown in FIGS. 1 and 2. The connector main body 1 has a cylindrical shape, and outward flanges 2 and 3 are provided at both ends thereof, respectively.
更に、皮膚との接着が緊密に行なわれかつ脱落
や感染を防止する為に、第１図のように成形加工
されたコネクタ本体１はコラーゲン溶液に浸漬さ
れ、第３図に示すように、コネクタ本体１の表面
にコラーゲン４がコーテイングされる。 Furthermore, in order to ensure close adhesion to the skin and prevent shedding and infection, the connector body 1, which has been molded as shown in Figure 1, is immersed in a collagen solution, and as shown in Figure 3, the connector body Collagen 4 is coated on the surface of main body 1.
このコラーゲン４としては、牛皮をペプシンで
可溶化して精製した、テロペプチドのとれた抗原
性のないアテロコラーゲンが望ましい。アテロコ
ラーゲンは、細胞の足場としても優れ、生体組織
とよく密着して、しかも拒絶反応や炎症反応を起
さない。アテロコラーゲンはPH２〜４の酸性溶液
であるので、コネクタ本体１をアテロコラーゲン
溶液に浸漬した後、これを１％アンモニア水に浸
漬して中和し、水洗後、風乾すれば良い。風乾
後、紫外線殺菌燈下10cmの距離で紫外線を30〜60
分照射すると、コラーゲンに架橋が導入されて安
定化する。 As the collagen 4, it is desirable to use atelocollagen, which is purified by solubilizing cow skin with pepsin and is free of telopeptide and has no antigenicity. Atelocollagen is excellent as a scaffold for cells, adheres well to living tissue, and does not cause rejection or inflammatory reactions. Since atelocollagen is an acidic solution with a pH of 2 to 4, the connector body 1 may be immersed in the atelocollagen solution, neutralized by immersing it in 1% ammonia water, washed with water, and then air-dried. After air drying, apply ultraviolet rays at a distance of 10cm from 30~60cm under an ultraviolet sterilizing lamp.
After irradiation, crosslinks are introduced into the collagen and stabilized.
このようにして得られた皮膚用コネクタ５は、
第３図に示すように、生体の皮膚６に取付けられ
る。即ち、皮膚６は、この皮膚用コネクタ５の上
下両フランジ２，３間に挾まれるようにして接合
される。そして、外部から生体内に挿入される物
体は、この皮膚用コネクタ５の挿通孔７を通じて
挿入される。物体を挿入しない時には、例えばシ
リコーン製の栓によりこの挿通孔７を塞いでおけ
ば、病原菌等による感染を防止することが出来
る。 The skin connector 5 obtained in this way is
As shown in FIG. 3, it is attached to the skin 6 of a living body. That is, the skin 6 is sandwiched and joined between the upper and lower flanges 2 and 3 of the skin connector 5. An object to be inserted into the living body from the outside is inserted through the insertion hole 7 of the skin connector 5. When no object is inserted, this insertion hole 7 can be closed with a plug made of silicone, for example, to prevent infection by pathogenic bacteria and the like.
以上説明したように、本考案による皮膚用コネ
クタは、動物の骨からタンパク質等の有機成分を
除去し、更にこれを焼却、焼成して得られたハイ
ドロオキシアパタイトを利用しており、このハイ
ドロオキシアパタイトを所定形状に成形加工した
後、その表面にコラーゲンをコーテイングしてい
る。従つて、本考案による皮膚用コネクタは、生
体内と外部との導通口として有効に機能し、しか
も皮膚組織と親密によく密着するので脱落がな
く、安定した機能を長期間保持する。又、このよ
うにして形成された開口部を使用しない時には、
例えばシリコーン製の栓にて密栓をするのみで感
染を防ぐことが出来る。 As explained above, the skin connector according to the present invention uses hydroxyapatite obtained by removing organic components such as proteins from animal bones and then incinerating and calcining this. After apatite is molded into a predetermined shape, its surface is coated with collagen. Therefore, the skin connector according to the present invention effectively functions as a communication port between the inside of the body and the outside, and since it is in intimate contact with the skin tissue, it does not fall off and maintains stable function for a long period of time. Also, when the opening formed in this way is not used,
For example, simply sealing the bottle with a silicone stopper can prevent infection.
第１図は本考案の一実施例による皮膚用コネク
タ本体を示す平面図、第２図は第１図の−線
断面図、第３図は上記実施例の皮膚用コネクタを
生体に取付けた状態を示す断面図である。
なお図面に用いた符号において、１……コネク
タ本体、４……コラーゲン、５……皮膚用コネク
タ、である。
Fig. 1 is a plan view showing a skin connector main body according to an embodiment of the present invention, Fig. 2 is a sectional view taken along the line - - in Fig. 1, and Fig. 3 is a state in which the skin connector of the above embodiment is attached to a living body. FIG. In addition, in the reference numerals used in the drawings, 1...connector body, 4...collagen, 5...skin connector.
Claims (1)
フランジを有する筒状体に成形した後、この成形
体の表面にコラーゲンをコーテイングして成る皮
膚用コネクタ。 A skin connector made by molding animal bone from which organic components have been removed into a cylindrical body having outward flanges at both ends, and then coating the surface of this molded body with collagen.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1981008222U JPH0319884Y2 (en) | 1981-01-23 | 1981-01-23 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1981008222U JPH0319884Y2 (en) | 1981-01-23 | 1981-01-23 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS57123111U JPS57123111U (en) | 1982-07-31 |
| JPH0319884Y2 true JPH0319884Y2 (en) | 1991-04-26 |
Family
ID=29806380
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1981008222U Expired JPH0319884Y2 (en) | 1981-01-23 | 1981-01-23 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0319884Y2 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8968189B2 (en) * | 2009-05-07 | 2015-03-03 | Covidien Lp | Flexible access assembly with multiple ports |
-
1981
- 1981-01-23 JP JP1981008222U patent/JPH0319884Y2/ja not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| JPS57123111U (en) | 1982-07-31 |
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