JPH03162829A - Conductive tacky adhesive agent for medical treatment - Google Patents

Abstract

PURPOSE:To obtain the conductive tacky adhesive agent for medical treatments which has an excellent electrical conductivity, tacky adhesiveness, cohesive property, and moisture resistance and is less in stimulation to skin by incorporating the blended polymer of a vinylpyrrolidone (co)polymer and a (meth)acrylic acid (salt) - (meth)acrylic alkyl ester copolymer, an electrolyte and a softening agent into this adhesive agent. CONSTITUTION:The vinylpyrrolidone (co)polymer includes vinylpyrrolidone homopolymer, copolymers of 1 or >=2 kinds of vinylpyrrolidone and acrylic acid, methyl methacrylate, maleic anhydride, vinyl alcohol, etc. The (meth)acrylic acid (salt) is incorporated as a copolymer component at 5 to 90mol% into the (meth)acrylic acid (salt) - (meth)acrylic alkyl ester copolymer which is incorporated at 1 to 30wt.% into the blended polymer. Moisture resistance and internal cohesion power are enhanced if an org. carboxylic acid (salt) is added to this tacky adhesive agent. The electrolyte is adequately inorg. salts, such as NaCl, KCl and CaCl2. The softening agent is adequately high boiling water-soluble or hydrophilic liquids, such as polyhydric alcohol and polyhydric alcohol derivatives.

Description

DETAILED DESCRIPTION OF THE INVENTION (Field of Industrial Application) The present invention relates to a medical conductive adhesive that has excellent conductivity, adhesiveness, cohesion, and moisture resistance, and does not cause skin irritation. (Prior art) When using medical electrical equipment such as electrocardiograms, electromyograms, electroencephalograms, low-frequency treatment devices, and surgical electric scalpels, signal electrodes and grounding electrodes are brought into contact with the living body. These devices are electrically connected to predetermined locations, and living bodies are grounded. Various types of conductive adhesives have been proposed as mediators between such living bodies and electrodes.

For example, ■The conductive adhesive disclosed in JP-A No. 52-95895 is an ester of an α,β-olefinically unsaturated carboxylic acid and a l-hydric or polyhydric alcohol whose terminal end is a quaternary ammonium group. Contains polymers and polyhydric alcohols.

■The conductive adhesive disclosed in JP-A-56-36939 contains salts of organic carboxylic acids (alkali metal salts, amine salts, etc.) such as (meth)acrylic acid and maleic acid in a proportion of 5 mol% or more. Polyhydric alcohol and a polymer comprising:

(2) The conductive adhesive disclosed in JP-A-56-36940 contains a nonionic hydrophilic polymer such as polyacrylic acid or polyvinyl alcohol, and a water-soluble softener such as glycerin.

■The conductive adhesive disclosed in JP-A No. 63-92638 consists of (A) a polymer having (anhydride) maleic acid and/or maleate salt and/or maleic acid partial ester in the molecule; ) polyhydric alcohol such as glycerin, (C) polyfunctional epoxy compound such as ethylene glycol diglycidyl ether, CD) low molecular electrolyte such as NaC1, (E) neutralizing agent such as NaOH, triethanolamine, and water. Contains.

However, all of the conductive adhesives according to the prior art including the above four examples have insufficient internal cohesive force and insufficient adhesiveness. Therefore, it has the disadvantage that it is not possible to firmly adhere the adhesive to the living body, and that residual adhesive remains when the adhesive is attached or detached. Furthermore, all conductive adhesives have poor moisture resistance; for example, when used under high humidity, their adhesiveness decreases and they peel off in a short period of time, or the fluidity of the adhesive becomes excessive and the electrode It has the disadvantage of causing poor contact between the skin and the skin. Also, JP-A-63-92
When it is necessary to contain water in the adhesive, such as the conductive adhesive disclosed in Publication No. 683, the conductivity and adhesiveness change due to evaporation of water during use or storage of the electrode, causing electrical This has the disadvantage that it affects the performance of the water, and it is expensive because it requires special packaging to prevent water evaporation.

(Problems to be Solved by the Invention) The present invention solves the above-mentioned conventional drawbacks, and aims to provide a material with excellent conductivity, adhesiveness, and moisture resistance that can be used in various medical electrical equipment. It is an object of the present invention to provide a conductive adhesive that has good properties, does not irritate the skin, and can be provided at a low cost.

(Means for Solving the Problems) The conductive adhesive of the present invention comprises a blend polymer of a vinylpyrrolidone (co)polymer and a (meth)acrylic acid (salt)-(meth)acrylic acid alkyl ester copolymer, It contains an electrolyte and a softener as main components, thereby achieving the above purpose.

That is, the adhesive (Adhesive I) consisting of vinylpyrrolidone (co)polymer, electrolyte, and softener does not irritate the skin and has good conductivity, but has poor moisture resistance.
The internal cohesive force is weak, which causes problems when attaching and detaching, and is not preferred as a medical conductive adhesive. This adhesive component I
By blending (meth)acrylic acid (salt) with (meth)acrylic acid alkyl ester copolymer, it retains the original excellent properties of adhesive component 1, namely non-irritation to the skin and good electrical conductivity. It was discovered that the moisture resistance and internal cohesive force can be improved while maintaining the temperature, and the present invention has been achieved.

Furthermore, the inventors have discovered that moisture resistance and internal cohesion can be further enhanced by adding an organic carboxylic acid (salt) to the adhesive containing the blended polymer, electrolyte, and softener of the invention, and have thus arrived at the present invention.

Examples of the vinylpyrrolidone (co)polymer include vinylpyrrolidone homopolymer, and copolymers of vinylpyrrolidone and one or more of acrylic acid, methyl methacrylate, maleic anhydride, vinyl alcohol, and the like. Such a vinylpyrrolidone (co)polymer is preferably used if it is soluble in water and/or alcohol, and by adding a softener, it can be made to have adhesive properties even if its internal cohesive force is weak. There is a need. In addition, the vinylpyrrolidone content in the copolymer is determined to have excellent properties as an adhesive, that is, non-irritant to the skin and good conductivity, and (meth)acrylic acid (salt) -( Meta)
In order to improve moisture resistance and internal cohesive force by blending the acrylic acid alkyl ester copolymer, the amount is preferably 70 mol% or more, preferably 90 mol% or more.

The gti (meth)acrylic acid (salt)-(meth)acrylic acid alkyl ester copolymer is obtained by copolymerizing (meth)acrylic acid (salt) and (meth)acrylic acid alkyl ester. Examples of (meth)acrylic acid (salt) include acrylic acid, methacrylic acid, etc., and examples of (meth)acrylic acid alkyl ester include methyl (meth)acrylate, ethyl (meth)acrylate, (
Butyl meth)acrylate, 2-ethylhexyl (meth)acrylate, and the like.

The reason why moisture resistance and internal cohesive force are significantly increased by the addition of the (meth)acrylic acid (salt)-(meth)acrylic acid alkyl ester copolymer is not understood in detail, but the reason why the moisture resistance and internal cohesive force are significantly increased by the addition of the (meth)acrylic acid (salt)-(meth)acrylic acid alkyl ester copolymer is unknown, but the reason is that the carboxylic acid and This is thought to be due to an unexpected interaction between the pyrrolidone ring of the vinylpyrrolidone (co)polymer.

To obtain the desired additive effect, vinylpyrrolidone (
The co)polymer and the polymer must be compatible with each other in the compounded liquid, and therefore, it is preferable that the copolymer be soluble in water and/or alcohol with a pH of 4 or more. If the content of (meth)acrylic acid (salt) as a copolymerization component of the copolymer is less than 5 mol%, the moisture resistance and internal
a The effect of increasing concentration cannot be obtained, and if it exceeds 90 mol%, the blended liquid will gel and it will be difficult to obtain a uniform solution, so the preferred range is 5 mol% to 90 mol%, and more preferably 20 mol%. 80 mol% is more preferable. Moreover, the (meth)acrylic acid (salt) mono(meth) in the blend polymer
If the content of the acrylic acid alkyl ester copolymer is less than 1% by weight, the effect of increasing moisture resistance and internal cohesive force will not be obtained, and if it exceeds 30% by weight, the above-mentioned original properties of the polyvinyl pyrrolidone (co)polymer will not be obtained. from losing its excellent properties,
A range of 1% to 30% by weight is preferred, and a range of 5% to 25% by weight is more preferred.

Examples of the organic carboxylic acid (salt) include acetic acid, stearic acid, fumaric acid, maleic acid, citric acid, phthalic acid, polyacrylic acid, and their sodium salts, potassium salts, and calcium salts. The amount added to 100 parts by weight of the blend polymer is O. 1 part by weight ~ 2 parts by weight
0 parts by weight, preferably 1 part by weight to 10 parts by weight, O.
If it is less than 1 part by weight, it is difficult to exhibit the effect of addition, and if it exceeds 20 parts by weight, it becomes supersaturated in the adhesive and crystal precipitation etc. tend to occur.

The softener is used to soften the blended polymer described above, but it is more preferable if it also has the property of solubilizing the electrolyte. Aqueous or hydrophilic liquids are preferred.

Specific examples include ethylene glycol, brobylene glycol, dipropylene glycol, polyethylene glycol, and glycerin. The amount added to 100 parts by weight of the blend polymer is 20 parts by weight to 500 parts by weight, preferably 50 parts by weight to 300 parts by weight. If it is less than 20 parts by weight, the softening effect will not be sufficient, and if it exceeds 500 parts by weight, it will lead out. It becomes easier to do.

The electrolyte contains other components, namely vinylpyrrolidone (co-)
Polymers, (meth)acrylic acid (salt)-(meth)acrylic acid alkyl ester copolymers, and softeners have low electrical conductivity, so they are added for the purpose of imparting electrical conductivity to the adhesive. The higher the mobility in the adhesive, the better the conductivity.
For example, inorganic salts such as NaCL, KCL, C a C Lx, etc. are suitable. The amount added to 100 parts by weight of the blend polymer is 0.1 parts by weight to 30 parts by weight, preferably 1 part to 20 parts by weight, and 0.1 parts by weight to 30 parts by weight, preferably 1 part to 20 parts by weight. If it is less than 1 part by weight, it is difficult to develop conductivity, and if it exceeds 30 parts by weight, it becomes supersaturated in the adhesive and crystal precipitation etc. tend to occur.

Furthermore, the adhesive of the present invention may contain medicinal ingredients, additives (for example, bactericidal agents, fragrances, coloring agents, etc.) as necessary.

(Example) The present invention will be specifically explained with reference to Examples.

(A) Preparation of adhesive solution: Vinylpyrrolidone homobolymer (manufactured by BASPS, K
ollidon90) 90 parts by weight of methanol 20
It was uniformly dissolved in 0 parts by weight (solution ■). 1 part by weight of NaCL was dissolved in 10 parts by weight of JP purified water (solution ■).

Methacrylic acid-methyl methacrylate copolymer (Ro
10 parts by weight of Euidragit S (methacrylic acid content: 25.0-34.5%) manufactured by Hai Pharma was dissolved in 50 parts by weight of methanol (solution ■). The above solutions (1), (2), and (2) and 300 parts by weight of glycerin (manufactured by NOF Corporation, Japan Standards) were uniformly mixed to obtain a colorless and transparent adhesive solution.

(B) Adhesive sheet etiquette and adhesive strength performance evaluation: (A)
The adhesive solution obtained in Section 1 was cast onto a polyethylene terephthalate (PET)/ethylene-vinyl acetate copolymer (EVA) laminate film with a thickness of 32 μm so that the thickness after drying was 11wII1 or more. It was dried to obtain an adhesive sheet. This adhesive sheet is 4cm x 4
The adhesive sheet was cut to a size cI1 and applied to the skin surface for 6 hours, but the adhesive sheet did not peel off due to daily exercise. When this sheet was peeled off, the adhesive layer was temporarily stretched and peeled off from the skin surface. At the time of peeling, moderate adhesion was felt on the skin, but no peeling of the stratum corneum or inflammation of the skin was observed. Furthermore, no phenomenon was observed in which a portion of the adhesive remained on the skin surface after peeling.

The above adhesive sheet is 2.5cm x 5. The adhesive force substitute characteristic value (holding force) was measured in accordance with the Japanese Industrial Standards "Adhesive Tape/Adhesive Sheet (z 0237-191+1) J" with a tape cut into 0 cm.The value was 3
0 minutes or more, indicating that the internal cohesive force is sufficient. Also, use an adhesive sheet of 1.5cm x 20cm. The tape was cut into 0 cm pieces, and the adhesive force substitute characteristic value (180° folding and peeling method) was measured in accordance with the Japanese Industrial Standards "Adhesive Tapes and Adhesive Sheets (Z 0237-1, .)". The value was 800g/15mm or more.

(C) Evaluation of electrical conductivity of adhesive layer: The adhesive solution obtained in section (A) was cast onto a silicone release paper to a dry thickness of 1 mm, and dried. Cut this adhesive layer into 2 cm x 2 cm, and
A sandwich-shaped test piece was obtained by sandwiching two sheets of mX I Oc+a copper foil (60 μm) from both sides. Using this test piece, the impedance between two pieces of copper foil was measured at IKHz, 10ll.
When measured using an LCR meter under the conditions of lv and contact pressure of 100 g/cj, the value was 264 Ω.

Preparation of adhesive solution (A): Vinyl pyrrolidone homopolymer (BASFS M, K
ollidon90) 90 parts by weight of methanol 20
It was uniformly dissolved in 0 parts by weight (Solution I). trisodium citric acid
2 parts by weight and 1 part by weight of NaCL were dissolved in 10 parts by weight of JP purified water (solution ■). Methacrylic acid-methyl methacrylate copolymer (Robn+ Phar+sa, E
uidragit S (methacrylic acid content 25.0
~34.5%)] was dissolved in 50 parts by weight of methanol (Solution I [1). The above solutions I, ①, ② and 300 parts by weight of glycerin (manufactured by NOF Corporation, diurnal standard) were uniformly mixed to obtain a colorless and transparent adhesive solution.

(B) Performance evaluation of tackiness and adhesion of the PSA sheet 2. The adhesive solution obtained in Example 1 (A) was used to prepare an PSA sheet in the same manner as in Example 1 (B). We evaluated the power. The results were similar to those in Example 1 (B). However, the adhesive force substitute characteristic value (holding force) is 50 minutes or more,
Adhesive force substitute characteristic value (180' folding peeling method) is 8
It was 0 0 g/15DIII+ or more.

(C) Conductivity evaluation of adhesive layer; Example 1 using the adhesive solution obtained in section (A) of this example
Impedance was measured in the same manner as in section (C).

The impedance of the test piece was 237Ω.

Preparation of adhesive solution by Huarashi Hanji (A): A methacrylic acid-methyl methacrylate copolymer was prepared by changing the methacrylic acid content in the ratio shown in Table 1, and each copolymer was used. Nine types of adhesive solutions were prepared in the same manner as in Example 1.

(B) Preparation of adhesive sheets and performance evaluation of adhesive strength: Using each adhesive solution obtained in Section (A) of this Example, adhesive sheets were prepared in the same manner as in Section (B) of Example 1. Then, the adhesive force (holding force) was evaluated. The results are shown in Table 1.

(Left below) From the above, the (meth)acrylic acid content of the (meth)acrylic acid-(meth)acrylic acid ester copolymer that has internal cohesive force and provides a uniform solution is 5 mol% to 90%.
The preferred range is 20 mol% to 80 mol%.

Fumasu Group (A) Preparation of adhesive solution The procedure was repeated in the same manner as in Example 1, except that a blend polymer obtained by blending the amount of dimethacrylic acid-methyl methacrylate copolymer in the ratio shown in Table 2 was used. An adhesive solution was prepared.

(B) Performance evaluation of tackiness and adhesion of adhesive sheets 2 Using each of the adhesive solutions obtained in Example 1 (A), adhesive sheets were prepared in the same manner as in Example 1 (B). death,
The adhesion to the skin and adhesive strength (holding strength) were evaluated. The results are shown in Table 2.

(Left below) From the above, the amount of (meth)acrylic acid-(meth)acrylic acid ester copolymer in the blend polymer that has internal cohesive force and maintains the original excellent properties of vinylpyrrolidone (co)polymer. The range is preferably from 1% by weight to 30% by weight, and more preferably from 5% by weight to 25% by weight.

Preparation of adhesive solution (A); Vinylpyrrolidone homobolymer (manufactured by BASF, Ko1
1idon 90) 7 5 parts by weight of methanol 2
00 parts by weight (solution {). Na CL
1 part by weight was dissolved in IO parts by weight of JP purified water (solution ■)
．． Methacrylic acid-methyl methacrylate copolymer (R
Eudragit LIO manufactured by ohm Pharma
25 parts by weight of O-55 (methacrylic acid content: 38-52%) was dissolved in 50 parts by weight of methanol (solution ■). The above melt & I, ■, ■ and polyethylene glycol 6
250 parts by weight of 00 (manufactured by Nippon Oil & Fats Co., Ltd., Japan External Standards) were mixed uniformly to obtain a colorless and transparent adhesive solution.

(B) Performance evaluation of adhesive sheet discipline and adhesive strength: The adhesive solution obtained in section (A) of this example was used to prepare an adhesive sheet in the same manner as in Example 1 (B). We evaluated the power. The results were similar to those in Example 1 (B).

However, the adhesive force substitute characteristic value (holding force) is 30 minutes or more, and the adhesive force substitute characteristic value (l80° folding peeling method) is 7.
0 0 g/15m++ or more.

(C) Conductivity evaluation of adhesive layer: Example 1 using the adhesive solution obtained in section (A) of this example.
Impedance was measured in the same manner as in section (C).

The impedance of the test piece was 269Ω.

(A) Preparation of adhesive solution: Vinyl pyrrolidone homobolymer (manufactured by BASP, Ko1
1idon 90) 7 5 parts by weight of methanol 2
00 parts by weight (solution ■). maleic acid 2
2 parts by weight of Na and 1 part by weight of NaCL were dissolved in 10 parts by weight of JP purified water (solution ■). Methacrylic acid monoethyl acrylate copolymer (manufactured by Rohm Pharma, Eui
dragit L100-55 (methacrylic acid content 3
8-52%)] was dissolved in 50 parts by weight of methanol (Solution ■). The above solutions ■, ■, ■ and polyethylene glycol 600 (manufactured by Nippon Oil & Fats Co., Ltd., Japanese non-prescription standard) 25
0 parts by weight were mixed uniformly to obtain a colorless and transparent adhesive solution.

(B) Performance evaluation of adhesive sheet discipline and adhesive strength: An adhesive sheet was prepared using the adhesive solution obtained in section (A) of this example in the same manner as in Example 1 (B), and the adhesive strength was evaluated. The results were similar to Example I(B).

However, the adhesive force substitute characteristic value (holding force) is 50 minutes or more, and the adhesive force substitute characteristic value (180° folding and peeling method) is 7.
It was 0.0 g/15 mm or more.

(C) Conductivity evaluation of adhesive layer: Example 1 using the adhesive solution obtained in section (A) of this example.
Impedance was measured in the same manner as in section (C).

The impedance of the test piece was 312Ω.

Preparation of adhesive solution (A): Vinylpyrrolidone homopolymer (manufactured by BASF, Ko1
1idon 90) 9 5 parts by weight with 2 parts of methanol
00 parts by weight (solution I). 1 part by weight of NaCL was dissolved in 10 parts by weight of Japanese Pharmacopoeia purified water (solution ■).

Methacrylic acid-methyl methacrylate copolymer (Ro
Made by hm Pharma, Euidragit LIOO
(Methacrylic acid content: 38.0-52.0%)]5
Part by weight was dissolved in 20 parts by weight of methanol (solution ■).

The above solutions (1), (2), and (2) and 250 parts by weight of glycerin (manufactured by NOF Corporation, Japan Standards) were uniformly mixed to obtain a colorless and transparent adhesive solution.

(B) Preparation of pressure-sensitive adhesive sheet and performance evaluation of adhesive strength (2) The pressure-sensitive adhesive solution obtained in Example 1 (A) was prepared into a pressure-sensitive adhesive sheet in the same manner as in Example 1 (B). We evaluated the power. The results were similar to those in Example 1 (B).

However, the adhesive force substitute characteristic value (holding force) is 30 minutes or more, and the adhesive force substitute characteristic value (180" folding and peeling method) is 8.
It was 91g/15 or more.

(C) Conductivity evaluation of adhesive layer: Example 1 using the adhesive solution obtained in section (A) of this example.
Impedance was measured in the same manner as in section (C).

The impedance of the test piece was 228Ω.

Example 104 (A) Preparation of adhesive solution: Prepare vinylpyrrolidone-methyl methacrylate copolymer (molar ratio: 95:5) and uniformly dissolve 95 parts by weight of this copolymer in 200 parts by weight of methanol. (Solution I).

Parts by weight of KCLIO and 5 parts by weight of acetic acid/Na were dissolved in 50 parts by weight of JP purified water (solution ■). A monoacrylic acid-2-ethylhexyl acrylate copolymer (acrylic acid content: 70%) was prepared, and 5 parts by weight of this copolymer was dissolved in 50 parts by weight of methanol (solution 2). The above solutions■,■
, (2) and 100 parts by weight of polyethylene glycol 600 (manufactured by Wako Pure Chemical Industries, Ltd., special grade) were uniformly mixed to obtain a colorless and transparent adhesive solution.

(B) Performance evaluation of adhesive strength and adhesion of adhesive sheet: The adhesive solution obtained in section (A) of this example was applied to an adhesive sheet in the same manner as in section (B) of Example 1. We evaluated the power. The results were similar to those in Example 1(B).

However, the adhesive force substitute characteristic value (holding force) is 20 minutes or more, and the adhesive force substitute characteristic value (180° folding and peeling method) is 5 minutes.
It was 0.0 g/15 mm or more.

(C) Conductivity evaluation of adhesive layer: Example 1 using the adhesive solution obtained in section (A) of this example.
Impedance was measured in the same manner as in section (C).

The impedance of the test piece was 348Ω.

Fruit 104i (A) Preparation of adhesive solution: Vinylpyrrolidone-acrylic acid copolymer (monoole ratio: 9
0:10), and 80 parts by weight of this copolymer was uniformly dissolved in 200 parts by weight of methanol (solution I). K.C.L.
5 parts by weight was dissolved in 50 parts by weight of JP purified water (solution ■)
. A copolymer of acrylic acid and butyl acrylate (acrylic acid content: 30% N) was prepared, and 20 parts by weight of this copolymer was dissolved in 50 parts by weight of methanol (solution 2). Solution I above
, ■, ■ and 200 parts by weight of polyethylene glycol 600 (manufactured by Wako Pure Chemical Industries, Ltd., special grade) were uniformly mixed to obtain a colorless and transparent adhesive solution.

(B) Preparation of adhesive sheet and performance evaluation of adhesive force (2) The adhesive solution obtained in Example 1 (A) was prepared into an adhesive sheet in the same manner as in Example 1 (B), and the adhesive strength was evaluated. The results were similar to those in Example 1(B).
However, the adhesive force substitute characteristic value (holding force) is 40 minutes or more, and the adhesive force substitute characteristic value (180° folding and peeling method) is 7.
It was 50 g/15 mm or more.

(C) Conductivity evaluation of adhesive layer: Example 1 using the adhesive solution obtained in section (A) of this example.
Impedance was measured in the same manner as in section (C').

The impedance of the test piece was 306Ω.

(Effects of the Invention) According to the present invention, a conductive adhesive having such excellent conductivity and adhesiveness can be obtained. Skin electrodes using this conductive adhesive can be easily applied to the skin surface and do not require any auxiliary means for fixation.

This conductive adhesive does not need to contain water, so
There is no change in conductivity or adhesion due to water evaporation during use or storage of the electrode, and thus electrical performance is not affected. Furthermore, since there is no need for special packaging to prevent water evaporation), the conductive adhesive can be provided at low cost. Furthermore, since it does not contain metal powder or the like, electrical noise is hardly detected. In addition, since the adhesive does not contain natural polymeric materials, microorganisms do not grow during storage, and they do not cause unpleasant odors or skin irritation. The main structural monomer of the present conductive adhesive polymer is vinylpyrrolidone, which is a homopolymer listed in the Japanese Pharmacopoeia, so it is highly safe for living organisms.

In particular, by containing 5 mol % to 90 mol % of (meth)acrylic acid (salt) as a copolymerization component of the copolymer and 1 wt % to 30 wt % of the copolymer in the blend polymer, By incorporating an organic carboxylic acid (salt) into the adhesive, the internal cohesive force of the conductive adhesive can be increased, making it possible to form a thick adhesive layer and increasing the cohesive force. There is no particular need for reinforcing materials such as non-woven fabric. Moreover, so-called adhesive cracking phenomenon and adhesive remaining phenomenon do not occur. Such a conductive adhesive can be easily and usefully used in various medical devices.

Claims (1)

[Scope of Claims] 1. Medical conductive material containing a blend polymer of vinylpyrrolidone (co)polymer and (meth)acrylic acid (salt)-(meth)acrylic acid alkyl ester copolymer, an electrolyte and a softener. adhesive. 2. A medical conductive adhesive containing a blend polymer of vinylpyrrolidone (co)polymer and (meth)acrylic acid (salt)-(meth)acrylic acid alkyl ester copolymer, an electrolyte, and a softener. The (meth)acrylic acid (salt)-(meth)acrylic acid alkyl ester copolymer contains 5 mol% to 90 mol% of (meth)acrylic acid (salt) as a copolymer component; ) Acrylic acid (salt) - (meth)acrylic acid alkyl ester copolymer is 1% by weight in the blend polymer.
Medical conductive adhesive containing ~30% by weight. 3. Medical conductive adhesive containing a blend polymer of vinylpyrrolidone (co)polymer and (meth)acrylic acid (salt)-(meth)acrylic acid alkyl ester copolymer, electrolyte, softener, and organic carboxylic acid agent.