JPH03158176A - Cancer medical treating device - Google Patents

Abstract

PURPOSE:To perform enough high-efficient heating of the affected part, where a material having a high magnetic hysteresis loss is caused to deposit and reside, of an organism by a method wherein a cancer medical treating device comprises magnetic pole pairs for generating an AC magnetic field positioned facing each other in a position, where an affected part is nipped therebetween, in a manner to regulatable of a clearance, a magnetic field applying part to apply an AC magnetic field on the magnetic pole pair, and a magnetic field control part to control an AC magnetic field. CONSTITUTION:Magnetic pole pairs are arranged so that an affected part 32 is positioned between magnetic pole pairs 14 and 14''. It is desirable from a point of view of heating efficiency that a clearance between the tip parts of the two magnetic pole pairs is decreased to a value as low as possible. It is also desirable that a diameter is decreased to a low value enough for coincidence of it with the size of the affected part as much as possible. After the affected part 32 is brought to a given position in a manner described above and a clearance between the magnetic pole pairs is regulated to a given value, the system circuit of a magnetic field applying part B is operated. In which case, a magnetic field is applied from the magnetic pole pairs 14 and 14' toward the affected part 32 of a human body, and a heat generating substance previously embedded in the affected part is increased in temperature. A distance between the two magnetic poles is changeable according to the medical treating portion or the state of a patient.

Description

DETAILED DESCRIPTION OF THE INVENTION (Field of Industrial Application) The present invention relates to a cancer treatment device that generates an alternating magnetic field, particularly a cancer treatment device that deposits and retains a ferromagnetic heating element that is expected to generate heat essentially due to hysteresis loss. The present invention relates to a cancer treatment device used for thermotherapy of cancer, which applies an alternating magnetic field to the affected area from the outside to perform magnetic induction heating.

(Prior art) Cancer cells are said to be sensitive to heat, and when heated to around 43°C, they lose their ability to proliferate and eventually die.
For example, in treatments using anticancer drugs or radiation, there is a possibility that surviving cancer cells will proliferate again, but the academic society says that cancer cells that have been damaged by high temperatures of 43 degrees Celsius will not proliferate again even if they survive. This is a well-established theory. Moreover, since the affected area of cancer has less blood flow, it is more easily heated than the surrounding area, so thermotherapy that locally heats the affected area of cancer is an extremely effective cancer treatment method.

Conventionally, hot water, infrared rays, ultrasonic waves, electromagnetic waves, etc. have been tried as methods for heating the affected area of cancer, and some devices for this purpose have even been commercialized.

Since all of these methods generate or apply heat directly to the tissue of the human body, they naturally heat surrounding normal cells at the same time, and the harmful effects of this must also be taken into account. In addition, especially when the cancerous area is deep, it is easy to warm only the surface area of the human body, and it is not easy to effectively heat the important cancerous area.

Therefore, if a heating source with a lower frequency is selected to effectively heat the deep part, the Mi fabric of the human body cannot be used as a heat generation source, and a separate heat generation medium must be used. At present, such heat generation media are
430 m, low Curie point Ni-Cu alloy etc. are used (Japan Hyperthermia Magazine 3(2); 155~l
63). However, the inside of a living body is under an extremely harsh environment.
It is impossible to implant these alloys in vivo for long periods of time. .

Accordingly, the present inventors have found through various experiments that by utilizing heat generated by magnetic hysteresis using ceramic materials, even powder can generate enough heat to treat cancer, and is not harmful to living organisms. It was confirmed that it could be implanted in the living body for a long period of time, and the details were published in patent application No. 63-2387.
This was revealed in issue 86.

Furthermore, the magnitude and appropriate frequency of the applied magnetic field regarding the alternating current magnetic field generator necessary for this purpose are disclosed in Japanese Patent Laid-Open No. 1-244767.

(Problems to be Solved by the Invention) It is an object of the present invention to provide an external device that can heat the biological color area in which a substance with a large magnetic hysteresis loss as described above is deposited and retained, with sufficient efficiency during actual treatment. The present invention provides a cancer treatment device with magnetic induction heating.

(Means for Solving the Problems) In order to achieve the above object, the present invention uses the technical means disclosed in the above-mentioned two inventions, and is the result of various experiments conducted using a device of a size that can be applied to the human body. discovered that the above-mentioned objective could be achieved by applying an alternating current magnetic field using opposed coils, and completed the present invention.

That is, the present invention includes: a pair of magnetic poles for generating an alternating magnetic field, which are installed facing each other at positions that sandwich an affected area so that the separation distance can be freely adjusted; a magnetic field applying section for applying an alternating magnetic field to the pair of magnetic poles; This cancer treatment device is characterized by comprising a magnetic field control section for controlling the magnetic field.

Here, the magnetic pole pair is of a type that forms a magnetic field directed from one side to the other, places the affected area between them, and locally heats only the heating element that has been implanted in advance. It will be clear to those skilled in the art from the description of this specification that the present invention is not limited to a specific form as long as it achieves such effects. This can be called a magnetic field method.

In other words, by pre-depositing a substance with large magnetic hysteresis loss on the cancerous area and holding the affected area between a pair of magnetic poles, the alternating magnetic field generated between the pair of magnetic poles is narrowed down to the lowest possible level. This is because only the affected area can be heated more effectively, and in the past, it was only recognized that it was sufficient to simply bring the affected area into the magnetic field formed by the coil. In the case of the present invention, the smaller the diameter of each coil, the more localized heating becomes possible.

Since the affected area is located within a narrow range within the area separating the magnetic pole pairs, local heating can be performed more effectively and damage to areas other than the affected area can be minimized.

Thus, according to the present invention, it can be said that it is practically superior to the conventional single coil system in the following points.

(1) A more uniform magnetic field space is obtained, so the amount of heat generation is less likely to fluctuate. These comparisons are shown graphically in Figure 1. In Figure 1, the solid line shows the strength of the magnetic field due to the magnetic pole method of the present invention and the horizontal This is the relationship with the directional distance, and the dotted line shows the relationship with the conventional coil method. Although the maximum strength of the magnetic field can reach the same level, the leakage magnetic flux is too large. on the other hand,
According to the method of the present invention, the uniformity and localization of the magnetic field are remarkable. It can be seen that more efficient heating is possible. Normally, the maximum diameter of 1ljX is about 100 mm, so the coil diameter can be determined accordingly.

(2) Only the tumor and its surroundings can be placed in the magnetic field space, making the device compact and highly safe.

(3) There is free space between the sides, allowing workers to move in and out smoothly, and in the event of an emergency, they can evacuate immediately.

(4) It is easy for doctors to administer treatment.

The reason why the present invention provides such excellent advantages is as follows.
This is because a pair of magnetic poles is used to concentrate the magnetic field in a narrow area as an oscillation method.

(Operation) Hereinafter, the specific configuration of the cancer treatment device according to the present invention (hereinafter also simply referred to as the device of the present invention) will be described based on Examples with reference to the drawings.

FIG. 2 is a block diagram schematically explaining the configuration of the apparatus of the present invention.

As shown in the figure, the device of the present invention includes a pair of magnetic poles 14 and 14' for generating a magnetic field, which are installed in a facing manner and whose separation distance can be adjusted by appropriate means, a breaker 16, a transformer 18,
A magnetic field application section B consisting of a power adjustment circuit 20 and a frequency oscillation circuit 22 for setting a predetermined frequency, a CPU device 24, a display 26, and a switch control circuit 2.
8 and a magnetic field control section C consisting of a temperature sensor 3o.
It is equipped with

A thyristor may be used for power adjustment, a transistor circuit may be used for frequency adjustment, the coil may be wound multiple times to secure the magnetic field, and if the pressure of cooling water into the coil increases, separate cooling water may be used. A commercial pump and tank (not shown) may be used.

Note that, if necessary, the temperature sensor 30 may be connected to the CPU through an A/D converter, or a controller that can perform FDI control without depending on the CPU may be used.

The opposed magnetic pole pairs 14.14' may be spaced apart in the vertical direction, for example as in the illustrated example, or may be installed horizontally if necessary. The effect of the ferrite core 15 in the coil is to increase the strength of the applied magnetic field.

Next, a method of operating the device of the present invention when performing heat treatment on an affected area using the device will be explained.

First, a substance with a large magnetic hysteresis loss is deposited and retained in the cancerous part 32 of the human body to be subjected to heating treatment, and a temperature sensor 30, such as a fluorescent temperature probe manufactured by Luxtron, for example, is inserted into the affected part 32. .

The material with large magnetic hysteresis loss at this time may be, for example, a biocompatible ceramic glass material, but this is not the only material. If biocompatible ceramics or crystallized glass, in which magnetite, ferrite, etc. are precipitated, are used, the heat generation efficiency will be further improved.

Next, the magnetic pole pair is arranged so that the affected part 32 is placed between the M1 poles 14.14 degrees that are set oppositely.

In terms of heating efficiency, it is preferable that the distance between the two tips be as small as possible. It is also preferable to make the diameter as small as possible to match the size of the affected area. The frequency at this time is preferably an alternating magnetic field of 5000 e or less at a frequency of 100 to 300 kHz, as also disclosed in the above-mentioned Japanese Patent Application Laid-Open No. 1-244767.

After the affected part 32 is brought to a predetermined position and the separation distance between the magnetic pole pairs is adjusted to a predetermined value, when the system circuit of the magnetic field application section B is activated, the magnetic pole pair 14. A magnetic field is applied in the opposite direction, raising the temperature of a heating element that has been previously embedded in the affected area. The spacing between the two magnetic poles can be varied depending on the treatment area or condition of each patient. In addition, as mentioned above, hold the affected area at 42 to 45 degrees.
It is desirable to continue heating within the range of C.

The heating temperature of the affected area is detected by the temperature sensor 30, and C
is input to the power adjustment circuit 20 through the PU device 24,
When the temperature of the affected area 32 is low, the power adjustment circuit 20 increases its output to raise the temperature of the affected area.
When the temperature is high, its output is reduced to lower the temperature of the affected area. At this time, display 26 as necessary.
may be displayed as appropriate.

In this way, the temperature of the affected area is regulated so that it is always within the range of 42-45°C. According to the invention, such temperature regulation is performed automatically.

Next, the effects of the present invention will be explained in more detail with reference to Examples.

Example Using the device shown in Figure 2, 200V, 3-phase output 25kW
A heating test was conducted under an alternating current magnetic field of 100 kHz and 2000 e. As a heat generating medium, that is, an object to be heated by induction,
A bioactive crystallized glass containing Cab, 5i02+ FexO:+ B2O3 and P2O was used.

Magnetic pole pair 14.14° separation pressure M 250mm, diameter 15
It was 0 mm. The induced heating body implanted in the affected area was spherical with a diameter of 2 to 3 mm. This induced heating element was covered with agar that simulated the soft tissues of a living body. Although this agar was approximately 30 cm thick, almost no temperature increase was observed in that area.

The heating curve at this time is shown in FIG. The horizontal axis shows the elapsed time, and the vertical axis shows the reached temperature. As is clear from the results shown in Figure 3, the temperature reached 43°C in about 1 minute. After reaching 43"C the magnetic field decreases, i.e. the magnetic pole pair 14.14"
The temperature was maintained by means of a reduction in the current flowing through the tube. In the figure, dotted lines indicate changes in magnetic field strength as a general trend.

(Effects of the Invention) As described above, the device of the present invention is extremely easy to handle and can effectively heat only the affected area of cancer, making it effective in cancer treatment.

[Brief explanation of the drawing]

FIG. 1 is a graph showing the relationship between the horizontal distance of the coil and the strength of the fff field; FIG. 2 is a bronch diagram of the device of the present invention; and FIG.
It is a graph showing a heating situation in an example. 14; Magnetic pole 15; Core 16: Breaker 18 Nidorance 20: Power adjustment circuit 1B22: Frequency oscillation circuit 24: CPU
26; Display 28: Switch control circuit 30: Temperature sensor

Claims (1)

[Claims] A pair of magnetic poles for generating an alternating magnetic field, which are arranged opposite to each other at positions that sandwich the affected area so that the separation distance can be freely adjusted; a magnetic field applying section for applying an alternating magnetic field to the pair of magnetic poles; and a magnetic field control for controlling the alternating magnetic field. A cancer treatment device comprising: