CN108031008A - A kind of accurate temperature controlling magnetic hysteresis heating unit for localized treatment of lesions tissue - Google Patents
A kind of accurate temperature controlling magnetic hysteresis heating unit for localized treatment of lesions tissue Download PDFInfo
- Publication number
- CN108031008A CN108031008A CN201711244476.XA CN201711244476A CN108031008A CN 108031008 A CN108031008 A CN 108031008A CN 201711244476 A CN201711244476 A CN 201711244476A CN 108031008 A CN108031008 A CN 108031008A
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- Prior art keywords
- magnetic field
- magnetic
- field generator
- heating unit
- frequency
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N2/00—Magnetotherapy
- A61N2/02—Magnetotherapy using magnetic fields produced by coils, including single turn loops or electromagnets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F2007/009—Heating or cooling appliances for medical or therapeutic treatment of the human body with a varying magnetic field acting upon the human body, e.g. an implant therein
Abstract
The invention discloses a kind of accurate temperature controlling magnetic hysteresis heating unit for localized treatment of lesions tissue, belong to the field of medical instrument technology.The present apparatus includes magnetic Nano material, magnetic field generator, displacement mechanism, temperature probe, master controller and variable-frequency power sources；The magnetic Nano material is used to be placed at pathological tissues；The magnetic field generator is used to produce alternating magnetic field, makes the nano material movement magnetic hysteresis heat in the alternating magnetic field；Institute's displacement mechanism is used for the active position for adjusting magnetic field generator；The temperature probe is used to detect the temperature at pathological tissues；The master controller is used for the movement of command displacement mechanism, preset temperature and time；The external power frequency supply of input terminal of the variable-frequency power sources, output terminal connection magnetic field generator, suitable alternate electric energy is provided for magnetic field generator.The present invention has accurate control heating-up temperature, the advantages that reducing the damage of normal structure, efficiently remove pathological tissues.
Description
Technical field
The invention belongs to the field of medical instrument technology, is related to a kind of accurate temperature controlling magnetic hysteresis for localized treatment of lesions tissue
Heating unit.
Background technology
Thermotherapy is a kind of common physical therapy modalities, mainly by lesion body tissue heating in organism so that its is dead
The therapeutic modality died.During thermotherapy, when organism whole body or a certain regional area, which are heated its temperature, to be risen, it can lead
Blood vessel dilatation is caused, increases the blood flow of therapentic part.While therapentic part blood flow is increased, thermotherapy can accelerate body
Metabolism, allows nutriment quickly to reach the position of injury, promotes the healing of tissue.In addition, thermotherapy can also excite biology
Immune system elimination virus, germ and the parasite of body.And tumor thermotherapy is then heat labile compared with normal cell using cancer cell
Physiological phenomenon, tumour cell is killed after tumor tissues are heated, and is a kind of one of thermotherapy method for being known as Microwave, is after hand
" green remedy " after art, radiation and chemotherapy.Tumor thermotherapy is generally divided into two kinds of whole-body hyperthermia, local thermotherapy.Local thermotherapy
Tumor tissues local temperature is reached more than 42.5 DEG C, cancer cell can be killed within the relatively short time, and to surrounding just
Normal cell and tissue have less damage.At present, local thermotherapy according to mode of heating can be divided into microwave radiation, radio-frequency radiation,
The methods of focusing ultrasonic wave, resistance heating, alternating magnetic field heating magnetic particle.Microwave radiation, radio-frequency radiation, focusing ultrasonic wave, electricity
Traditional thermotherapy mode such as resistance heating is just progressively being substituted by various shortcomings by the mode of alternating magnetic field heating magnetic particle.
The mode of alternating magnetic field heating magnetic particle is the thermotherapy mode of more novel and high-efficiency.Main principle is by magnetic particles
Sub- material injection or targeting implantation pathological tissues, apply alternating magnetic field, due to eddy-current loss, the presence of magnetic hystersis loss in outside
Magnetic material is caused to produce heat, with the local slough of ablation or cancerous issue.It is entitled " by magnetic fields in magnetic
Described in the patent of the application process of grain " (Application No. 200610027027.5) after magnetic-particle is mixed with treatment articles
It is placed in biological tissue and cell, alternating magnetic field is applied to the place of inserting again afterwards, magnetic-particle is moved heat, so as to reach
The purpose for the treatment of.Although this kind of method is feasible in theory, how instrument is specifically utilized to realize the thermotherapy
Purpose does not refer to but.
The design that magnetic hysteresis heats to treat instrument will consider many factors.Effectively to realize that thermotherapy purpose will not only be seen to examine
Consider pathological tissues and be also contemplated that normal structure.Because in hyperthermia process, the region of heating can be subject to magnetic particle distribution of movement
Influence, so being inevitably diffused into normal tissue, such normal structure can also be damaged.Different tissues
Pathological characters correspond to different optimum heating-up temperatures, and the temperature that magnetic-particle movement produces is to be influenced to determine by more middle factors
Fixed, to make maintaining near the pathological tissues optimum heating-up temperature for temperature stabilization over the course for the treatment of, so could be real
Now optimal therapeutic effect reduces the damage of normal tissue again at the same time.
The content of the invention
In view of this, it is an object of the invention to provide a kind of accurate temperature controlling magnetic hysteresis for localized treatment of lesions tissue to add
Thermal.
To reach above-mentioned purpose, the present invention provides following technical solution：
A kind of accurate temperature controlling magnetic hysteresis heating unit for localized treatment of lesions tissue, including magnetic Nano material, magnetic field
Generator, displacement mechanism, temperature probe, master controller and variable-frequency power sources；
The magnetic Nano material is used to be placed at pathological tissues, and is in the magnetic field of an alternation；
The magnetic field generator is used to produce alternating magnetic field, makes the nano material movement magnetic hysteresis life in the alternating magnetic field
Heat；
Institute's displacement mechanism is connected with magnetic field generator, for adjusting the active position of magnetic field generator；
The temperature probe is used to detect the temperature at pathological tissues；
The master controller is used for the movement of command displacement mechanism, preset temperature and time, receives the signal of temperature probe
And control temperature by adjusting the output frequency of variable-frequency power sources, the field frequency of magnetic field generator and intensity；
The external power frequency supply of input terminal of the variable-frequency power sources, output terminal connection magnetic field generator, carries for magnetic field generator
For suitable alternate electric energy.
Further, the magnetic material is less than or equal to 7.5 × 10 in magnetic field intensity7During A/m.s, the magnetic efficiency of heating surface is extremely
It is 8 × 10 less-8J.m/A.g。
Further, the magnetic Nano material is used in ferroso-ferric oxide, di-iron trioxide, neodymium iron boron and ferrocobalt
It is one or more kinds of more than alloy, compound or mixture.
Further, the structure of the magnetic nano material is nano particle, nanometer rods, nano wire and nanoshell, multilayered shell
One kind in Rotating fields or cagelike structure.
Further, the surface modification of the magnetic Nano material is used without modification, PEG parcels, Electrostatic Absorption parcel, two
Silicon oxide-wrapped, dendrimer parcel, antibody modification, bioprotein modification, biological polyoses or glycoprotein modification and medicine are big
One kind in molecular modification.
Further, the external power frequency supply of the variable-frequency power sources is 50Hz, the alternating source of output for 20KHz~
200KHz。
Further, the variable-frequency power sources includes rectifier and bridge type inverse frequency generator, and the rectifier is used for will be outer
The alternating current connect is converted to direct current, the bridge type inverse frequency generator be used to changing the frequency of direct current and by direct current again
It is secondary to be converted to alternating current.
Further, the magnetic field generator is made of one or more inductance coils, and the electric magnetic induction loop uses
High temperature and pressure electric wire winding screw shape.
Further, institute's displacement mechanism is made of shell, step-servo motor, gear reducer, rail plate and pulley, institute
State shell to be placed on rail plate by pulley, the magnetic field generator is placed inside the housing, cage connection stepping servo
Motor and speed reducer.
The beneficial effects of the present invention are：Magnetic Nano material is placed to pathological tissues by the present invention, while magnetism is received
Rice material is placed in alternating magnetic field, is used to eliminate pathological tissues since hysteresis produces heat；Temperature probe is used to detect disease
Become the temperature at tissue, while the control using master controller into trip temperature, so the present invention can effectively remove lesion
Reduce the injury of normal tissue at the same time.
Brief description of the drawings
In order to make the purpose of the present invention, technical solution and beneficial effect clearer, the present invention provides drawings described below and carries out
Explanation：
Fig. 1 is the connection and interactively schematic diagram of the device of the invention；
Fig. 2 is the displacement mechanism structure diagram of the present invention；
Wherein：1- shells；2- step-servo motors；3- gear reducers；4- rail plates；5- pulleys；6- magnetic field generators.
Embodiment
Below with reference to attached drawing, the preferred embodiment of the present invention is described in detail；It should be appreciated that preferred embodiment
Only for the explanation present invention, the protection domain being not intended to be limiting of the invention.
Attached drawing 1 is the overall structure diagram of the present invention, as shown in Figure 1, a kind of essence for localized treatment of lesions tissue
True temperature control magnetic hysteresis heating unit, including magnetic Nano material, magnetic field generator, displacement mechanism, temperature probe, master controller and change
Frequency power；
The magnetic Nano material is used to be placed at pathological tissues, and is in the magnetic field of an alternation；
The magnetic field generator is used to produce alternating magnetic field, makes the nano material movement magnetic hysteresis life in the alternating magnetic field
Heat；
Institute's displacement mechanism is connected with magnetic field generator, for adjusting the active position of magnetic field generator；
The temperature probe is used to detect the temperature at pathological tissues；
The master controller is used for the movement of command displacement mechanism, preset temperature and time, receives the signal of temperature probe
And control temperature by adjusting the output frequency of variable-frequency power sources, the field frequency of magnetic field generator and intensity；
The external power frequency supply of input terminal of the variable-frequency power sources, output terminal connection magnetic field generator, carries for magnetic field generator
For suitable alternate electric energy.
The magnetic material is less than or equal to 7.5 × 10 in magnetic field intensity7During A/m.s, the magnetic efficiency of heating surface is at least 8 × 10-8J.m/A.g。
The magnetic Nano material use ferroso-ferric oxide, di-iron trioxide, neodymium iron boron and ferrocobalt in one kind or
Alloy, compound or mixture more than person is a variety of.
The structure of the magnetic nano material is nano particle, nanometer rods, nano wire and nanoshell, multilayer shell structurre or cage
One kind in type structure.
The surface modification of the magnetic Nano material is used without modification, PEG parcels, Electrostatic Absorption parcel, silica bag
Wrap up in, dendrimer parcel, antibody modification, bioprotein modification, biological polyoses or glycoprotein modification and medicine macromolecular modification
In one kind.
The external power frequency supply of the variable-frequency power sources is 50Hz, and the alternating source of output is 20KHz~200KHz.
The variable-frequency power sources includes rectifier and bridge type inverse frequency generator, and the rectifier is used for external alternating current
Direct current is converted to, the bridge type inverse frequency generator is used to change the frequency of direct current and is again converted to hand over by direct current
Galvanic electricity.
The magnetic field generator is made of one or more inductance coils, and the electric magnetic induction loop uses high temperature and high pressure electrical
Line winding screw shape.
Institute's displacement mechanism is waitd upon by shell 1, stepping to be taken motor 2, gear reducer 3, rail plate 4 and pulley 5 and forms, described outer
Shell 1 is placed on rail plate 4 by pulley 5, and the magnetic field generator 6 is placed on inside shell 1, and shell 1 connects stepping and watches
Take motor 2 and gear reducer 3.
First magnetic Nano material is placed at pathological tissues when in use, the alternation then sent using magnetic field generator
Magnetic field makes magnetic Nano material produce hysteresis fever, when temperature is increased to 40~50 degrees Celsius, can effectively eliminate
Lesion.Disposed at the same time in pathological tissues into temperature probe, the temperature signal collected is fed back into master controller, master controller leads to
The output frequency of variable-frequency power sources, the field frequency of magnetic field generator and intensity are overregulated to control temperature, avoid temperature too high right
Normal structure damages.Simultaneous displacement mechanism can make magnetic field generator according to actual conditions come shift position, accurate work
At pathological tissues.
The foregoing is merely the preferred embodiment of the present invention, is not intended to limit the invention, it is clear that those skilled in the art
Various changes and modifications can be made to the invention by member without departing from the spirit and scope of the present invention.If in this way, the present invention
These modifications and variations belong within the scope of the claims in the present invention and its equivalent technologies, then the present invention is also intended to include these
Including modification and variation.
Claims (9)
- A kind of 1. accurate temperature controlling magnetic hysteresis heating unit for localized treatment of lesions tissue, it is characterised in that：Including magnetic Nano Material, magnetic field generator, displacement mechanism, temperature probe, master controller and variable-frequency power sources；The magnetic Nano material is used to be placed at pathological tissues, and is in the magnetic field of an alternation；The magnetic field generator is used to produce alternating magnetic field, makes the nano material movement magnetic hysteresis heat in the alternating magnetic field；Institute's displacement mechanism is connected with magnetic field generator, for adjusting the active position of magnetic field generator；The temperature probe is used to detect the temperature at pathological tissues；The master controller is used for the movement of command displacement mechanism, preset temperature and time, receives the signal of temperature probe and leads to The output frequency of variable-frequency power sources, the field frequency of magnetic field generator and intensity are overregulated to control temperature；The external power frequency supply of input terminal of the variable-frequency power sources, output terminal connection magnetic field generator, conjunction is provided for magnetic field generator Suitable alternate electric energy.
- 2. a kind of accurate temperature controlling magnetic hysteresis heating unit for localized treatment of lesions tissue according to claim 1, it is special Sign is：The magnetic material is less than or equal to 7.5 × 10 in magnetic field intensity7During A/m.s, the magnetic efficiency of heating surface is at least 8 × 10- 8J.m/A.g。
- 3. a kind of accurate temperature controlling magnetic hysteresis heating unit for localized treatment of lesions tissue according to claim 1, it is special Sign is：The magnetic Nano material use ferroso-ferric oxide, di-iron trioxide, neodymium iron boron and ferrocobalt in one kind or Alloy, compound or mixture more than a variety of.
- 4. a kind of accurate temperature controlling magnetic hysteresis heating unit for localized treatment of lesions tissue according to claim 3, it is special Sign is：The structure of the magnetic nano material is nano particle, nanometer rods, nano wire and nanoshell, multilayer shell structurre or cage One kind in type structure.
- 5. a kind of accurate temperature controlling magnetic hysteresis heating unit for localized treatment of lesions tissue according to claim 4, it is special Sign is：The surface modification of the magnetic Nano material is used without modification, PEG parcels, Electrostatic Absorption parcel, silica bag Wrap up in, dendrimer parcel, antibody modification, bioprotein modification, biological polyoses or glycoprotein modification and medicine macromolecular modification In one kind.
- 6. a kind of accurate temperature controlling magnetic hysteresis heating unit for localized treatment of lesions tissue according to claim 1, it is special Sign is：The external power frequency supply of the variable-frequency power sources is 50Hz, and the alternating source of output is 20KHz~200KHz.
- 7. a kind of accurate temperature controlling magnetic hysteresis heating unit for localized treatment of lesions tissue according to claim 6, it is special Sign is：The variable-frequency power sources includes rectifier and bridge type inverse frequency generator, and the rectifier is used for external alternating current Direct current is converted to, the bridge type inverse frequency generator is used to change the frequency of direct current and is again converted to hand over by direct current Galvanic electricity.
- 8. a kind of accurate temperature controlling magnetic hysteresis heating unit for localized treatment of lesions tissue according to claim 1, it is special Sign is：The magnetic field generator is made of one or more inductance coils, and the electric magnetic induction loop uses high temperature and high pressure electrical Line winding screw shape.
- 9. a kind of accurate temperature controlling magnetic hysteresis heating unit for localized treatment of lesions tissue according to claim 1, it is special Sign is：Institute's displacement mechanism is made of shell, step-servo motor, gear reducer, rail plate and pulley, and the shell passes through Pulley is placed on rail plate, and the magnetic field generator is placed inside the housing, cage connection step-servo motor and deceleration Machine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711244476.XA CN108031008A (en) | 2017-11-30 | 2017-11-30 | A kind of accurate temperature controlling magnetic hysteresis heating unit for localized treatment of lesions tissue |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711244476.XA CN108031008A (en) | 2017-11-30 | 2017-11-30 | A kind of accurate temperature controlling magnetic hysteresis heating unit for localized treatment of lesions tissue |
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| CN108031008A true CN108031008A (en) | 2018-05-15 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110180076A (en) * | 2019-05-31 | 2019-08-30 | 重庆科技学院 | Magnetic particle regulating lens system in space |
| CN114533247A (en) * | 2022-01-12 | 2022-05-27 | 康达洲际医疗器械有限公司 | Three-dimensional magnetic heat control method and system based on photoacoustic imaging guidance |
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| CN110180076A (en) * | 2019-05-31 | 2019-08-30 | 重庆科技学院 | Magnetic particle regulating lens system in space |
| CN114533247A (en) * | 2022-01-12 | 2022-05-27 | 康达洲际医疗器械有限公司 | Three-dimensional magnetic heat control method and system based on photoacoustic imaging guidance |
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Application publication date: 20180515 |