JPH03123452A - Production of royal jelly granule - Google Patents

Abstract

PURPOSE:To obtain in high purity the title granules convenient for carriage by forming royal jelly into a solid product of a specified diameter as prior stage for its granulation. CONSTITUTION:Royal jelly is formed into a solid product 15-30 mm in diameter suitable for its grinding as prior stage for its granulation through a crushing means.

Description

[Detailed description of the invention] "Industrial application field" The present invention relates to a method for producing royal jelly granules.

``Conventional technology'' Royal jelly is secreted by worker bees, and only one female bee who eats this becomes a queen bee.
Since ancient times, it has been said to have a tonic effect because it can spawn up to 2,000 eggs a day against thousands of male bees.
Numerous recent experiments have confirmed that it has anti-aging and rejuvenating effects. In addition, menopausal disorders, especially indeterminate complaints (hot flashes, headaches, palpitations, dizziness,
Complaints include depression, lower back pain, stiff shoulders, fatigue, feeling of weakness, and decreased energy. ) is known to have a significant effect.

How to eat this royal jelly: 1. It is said that it is good to leave it as it is, but there is a risk of deterioration, so to prevent this, conventionally it was stored in the refrigerator (5@C).

Furthermore, it is difficult to eat raw liquid, so conventionally,
Royal jelly was powdered by vacuum drying and then pulverized, or powdered royal jelly was taken in capsules or tablets.

``Problem to be solved by the invention'' There are two types of capsules for storing drugs: soft capsules and hard capsules. Of these, soft capsules are made of gelatin or glycerin, and the powder is mixed with high-quality vegetable oil such as linoleic acid. However, due to its shape, it is difficult to fill it with royal jelly powder, so there is a limit to the amount of royal jelly that can be filled, and one capsule can only contain 300 to 400 kg. Because capsules can only be filled with capsules, it is necessary to swallow many capsules in order to take the required amount, and gastrointestinal disorders may occur due to excessive intake of gelatin or glycerin.

In the case of hard capsules, they consist of a capsule body and a cap, so they can be filled with a large amount of royal jelly powder, but after filling, they must be sealed with gelatin to maintain airtightness, which reduces workability. Unfortunately, mechanization required sophisticated machinery, resulting in high costs.

In addition, in the case of tablets, 5% is added to the binding of royal jelly.
Since 0% of excipients and lubricants are required, and the content of royal jelly per tablet is only about 100 to 200 cm, there is a problem that the content is lower than that of capsules. As excipients and lubricants, lactose, starch, crystalline cellulose, etc. are used.

If royal jelly is filled into capsules or provided as tablets, it is convenient to carry and easy to take, but because of these disadvantages, royal jelly is often taken in powdered form.

In this case, as it absorbs moisture and deteriorates in quality, royal jelly powder is provided in bottles or packaged in bags. However, in any case, if there is even a slight lack of suitability for storage, the so-called caking phenomenon will occur, in which beads will form due to moisture absorption.
Further, there was a problem that variations in the amount of the sachets were inevitable, and that the powder was too fine to adhere to the oral cavity, making it difficult to swallow.

In view of the above-mentioned circumstances, the inventors attempted to make royal jelly into granules.

In other words, granules can prevent the caking phenomenon and are easy to swallow without the inconvenience of adhering to the oral cavity.

However, despite many years of experimentation and research with various changes in the type and amount of lubricant, granulation temperature, humidity conditions, granulation method, etc., the granulation of royal jelly has not been successful. The method of granulation that has repeatedly failed is to first form tablets (solidify) royal jelly by mixing a lubricant, and then crush and granulate it. Based on this method, we conducted many experiments, but in order to make tablets, there was the inconvenience of mixing in many excipients and lubricants as mentioned above, and in order to avoid this inconvenience, we decided to However, if the amount of excipient and lubricant is reduced, a caking phenomenon will occur due to moisture absorption during granulation, making it impossible to feed royal jelly powder into the mold, and even if feeding is done manually. However, it has been virtually impossible to granulate royal jelly due to high labor costs.

This invention allows even if a small amount of excipients and lubricants are mixed,
The object of the present invention is to provide a method for producing royal jelly granules that can mass-produce highly pure royal jelly granules since no caking phenomenon occurs when the material is supplied to a mold.

"Means for Solving the Problem" In order to achieve the above purpose, the inventors, etc.
By changing the size of the tablet as a solid substance to be crushed, it was discovered that the occurrence of caking could be prevented in a range larger than that of a normal tablet, and the present invention was completed.

That is, in this invention, as a step before granulating royal jelly by a crushing means, a solid material suitable for crushing is formed, and the diameter of the solid material is approximately 15 to 30 mm.

"Function" According to the above configuration, in order to solidify royal jelly, it is molded by filling a mold with royal jelly powder in the same way as when molding tablets. When the diameter, that is, the inner diameter of the mold, was 15 mm or more, no caking phenomenon occurred. Moreover, if the inner diameter is too large, it will take a long time to fill the mold and caking phenomenon will easily occur, and if the mold becomes large, the cost will be very high.

Conventionally, when forming tablets, the diameter has been set to about 5 to 121 M1 to make them easier to swallow. However, if a mold with an inner diameter of this size is used, a caking phenomenon may occur during filling. Whereas it was not possible to stably supply the material into the mold, a mold having an inner diameter within the above range allows the material to be stably supplied into the mold without causing the caking phenomenon.

The size of the feed port for the royal jelly powder is set to a size that makes it easy to feed the material into the mold, but the size of the feed port does not particularly matter as long as it is appropriate in that sense.

To solidify royal jelly powder, a dry granulation method is used, for example, using a lubricant such as talc, magnesium stearate, or sucrose fatty acid ester.

Generally, dry granulation or wet granulation is used to granulate tablets, etc., but in the case of wet granulation, water, ethanol, and a binder are added to make the granules, so this is not the case for royal jelly. If so, it is not suitable for granulation (solidification) because it becomes sticky with water and does not dry easily.

Therefore, although dry granulation is used, the solid material only needs to have a hardness suitable for crushing, and the stability of the shape is not required like that of tablets, so the amount of lubricant mixed is 3 to 10.
About % is sufficient. If more than that is mixed in, it becomes difficult to crush the solid material, which is rather inconvenient for granulation.

In addition, when filling the mold with royal jelly powder, the humidity is 4.
It is desirable to carry out the process under conditions of 0 to 50%, and it is easy to stably supply the material within this range.

"Example" Royal jelly that had been stored raw in the refrigerator at 5°C was taken out, purified to a purity close to 100% (reduced to about one third of the amount), and then vacuum freeze-dried. The powder is then crushed to obtain a pure powder with a mesh size of approximately 80 to 100 microns.

Next, add 3% by weight to the pure powdered royal jelly.
The mixture is mixed as a sucrose fatty acid ester lubricant, poured into a mold having an inner diameter of 18 plates, and compressed to form a tablet-shaped solid having the same diameter.

The solid material is crushed by crushing rolls and then crushed by 300-
Sort into a mesh of about 1400μ.

The sized royal jelly granules are packaged in individual doses into airtight bags that prevent moisture from entering.

The royal jelly granules produced as above are 90%
As the purity is close to 100%, the number of doses required each time is small (approximately 1,000 ml), and since it is a granule, it is easy to swallow, and the bag can be carried in your pocket or bag. Convenient to carry.

In addition, the royal jelly granules may be packaged in bags or bottles, but in any case, they are smooth and caking does not occur easily, so you can drink the required amount at once, and it is a fine powder. Unlike the case of , it does not stick to the oral cavity, and as mentioned above, it is not only easy to drink, but also easy to divide, so it can be packed into bags.
You can evenly package the right amount without making any mistakes.

"Effects of the Invention" As explained above, according to the present invention, as a step before granulating royal jelly by a crushing means, a solid material suitable for crushing is formed, and the diameter of the solid material is 15 to 15 mm. By making it approximately 30 mm, we have succeeded in granulating royal jelly, which was previously considered impossible, and because we can use less excipients and lubricants, we have created a royal jelly that is convenient to carry and easy to drink. It has the excellent effect of being able to provide high purity.

Claims (1)

[Claims] 1) A method for producing royal jelly granules, which is characterized in that, as a step before granulating royal jelly by a crushing means, a solid material suitable for crushing is molded to a diameter of about 15 to 30 mm.