JPH0311013A - Production of plaster for wet compressing agent - Google Patents
Production of plaster for wet compressing agentInfo
- Publication number
- JPH0311013A JPH0311013A JP1143473A JP14347389A JPH0311013A JP H0311013 A JPH0311013 A JP H0311013A JP 1143473 A JP1143473 A JP 1143473A JP 14347389 A JP14347389 A JP 14347389A JP H0311013 A JPH0311013 A JP H0311013A
- Authority
- JP
- Japan
- Prior art keywords
- weight
- parts
- solution
- water
- aqueous solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000011505 plaster Substances 0.000 title claims abstract description 7
- 238000004519 manufacturing process Methods 0.000 title claims description 7
- 229910052782 aluminium Inorganic materials 0.000 claims abstract description 11
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims abstract description 11
- 239000007864 aqueous solution Substances 0.000 claims abstract description 10
- 229920002125 Sokalan® Polymers 0.000 claims abstract description 7
- 239000004094 surface-active agent Substances 0.000 claims abstract description 7
- 239000004584 polyacrylic acid Substances 0.000 claims abstract description 6
- 230000001804 emulsifying effect Effects 0.000 claims abstract description 5
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 claims abstract description 5
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 claims abstract description 5
- 239000000243 solution Substances 0.000 abstract description 19
- 239000003431 cross linking reagent Substances 0.000 abstract description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract description 8
- 239000003795 chemical substances by application Substances 0.000 abstract description 6
- 238000004132 cross linking Methods 0.000 abstract description 6
- 239000000945 filler Substances 0.000 abstract description 5
- 229920000642 polymer Polymers 0.000 abstract description 5
- 235000011187 glycerol Nutrition 0.000 abstract description 4
- 229920000036 polyvinylpyrrolidone Polymers 0.000 abstract description 4
- 239000001267 polyvinylpyrrolidone Substances 0.000 abstract description 4
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract description 4
- 229920003169 water-soluble polymer Polymers 0.000 abstract description 4
- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 abstract description 3
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 abstract description 3
- 229920001214 Polysorbate 60 Polymers 0.000 abstract description 2
- 239000000839 emulsion Substances 0.000 abstract description 2
- 239000006185 dispersion Substances 0.000 abstract 1
- 150000002194 fatty esters Chemical class 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 13
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 9
- 150000001875 compounds Chemical class 0.000 description 8
- 239000000203 mixture Substances 0.000 description 7
- 239000003002 pH adjusting agent Substances 0.000 description 7
- LVYLCBNXHHHPSB-UHFFFAOYSA-N 2-hydroxyethyl salicylate Chemical compound OCCOC(=O)C1=CC=CC=C1O LVYLCBNXHHHPSB-UHFFFAOYSA-N 0.000 description 6
- -1 alum Chemical compound 0.000 description 6
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 6
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 6
- 238000002156 mixing Methods 0.000 description 5
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 4
- 239000004745 nonwoven fabric Substances 0.000 description 4
- 230000000704 physical effect Effects 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 4
- 239000005995 Aluminium silicate Substances 0.000 description 3
- 235000012211 aluminium silicate Nutrition 0.000 description 3
- 239000002585 base Substances 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 239000000499 gel Substances 0.000 description 3
- 229960002389 glycol salicylate Drugs 0.000 description 3
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 3
- 229960001047 methyl salicylate Drugs 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 2
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 229940037003 alum Drugs 0.000 description 2
- DIZPMCHEQGEION-UHFFFAOYSA-H aluminium sulfate (anhydrous) Chemical compound [Al+3].[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O DIZPMCHEQGEION-UHFFFAOYSA-H 0.000 description 2
- 239000004359 castor oil Substances 0.000 description 2
- 235000019438 castor oil Nutrition 0.000 description 2
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 2
- 238000004898 kneading Methods 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 239000001525 mentha piperita l. herb oil Substances 0.000 description 2
- 229940041616 menthol Drugs 0.000 description 2
- 235000019477 peppermint oil Nutrition 0.000 description 2
- 229920001083 polybutene Polymers 0.000 description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 description 2
- 229940042585 tocopherol acetate Drugs 0.000 description 2
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 1
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 1
- WJQZZLQMLJPKQH-UHFFFAOYSA-N 2,4-dichloro-6-methylphenol Chemical compound CC1=CC(Cl)=CC(Cl)=C1O WJQZZLQMLJPKQH-UHFFFAOYSA-N 0.000 description 1
- CIVCELMLGDGMKZ-UHFFFAOYSA-N 2,4-dichloro-6-methylpyridine-3-carboxylic acid Chemical compound CC1=CC(Cl)=C(C(O)=O)C(Cl)=N1 CIVCELMLGDGMKZ-UHFFFAOYSA-N 0.000 description 1
- HBTAOSGHCXUEKI-UHFFFAOYSA-N 4-chloro-n,n-dimethyl-3-nitrobenzenesulfonamide Chemical compound CN(C)S(=O)(=O)C1=CC=C(Cl)C([N+]([O-])=O)=C1 HBTAOSGHCXUEKI-UHFFFAOYSA-N 0.000 description 1
- DEXFNLNNUZKHNO-UHFFFAOYSA-N 6-[3-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]piperidin-1-yl]-3-oxopropyl]-3H-1,3-benzoxazol-2-one Chemical group C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C1CCN(CC1)C(CCC1=CC2=C(NC(O2)=O)C=C1)=O DEXFNLNNUZKHNO-UHFFFAOYSA-N 0.000 description 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- 239000004322 Butylated hydroxytoluene Substances 0.000 description 1
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- 208000006558 Dental Calculus Diseases 0.000 description 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 240000002989 Euphorbia neriifolia Species 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 150000005215 alkyl ethers Chemical class 0.000 description 1
- 235000010354 butylated hydroxytoluene Nutrition 0.000 description 1
- 229940095259 butylated hydroxytoluene Drugs 0.000 description 1
- 229960000846 camphor Drugs 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 229920006037 cross link polymer Polymers 0.000 description 1
- 229940031578 diisopropyl adipate Drugs 0.000 description 1
- 229960000525 diphenhydramine hydrochloride Drugs 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 229940074928 isopropyl myristate Drugs 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
Landscapes
- Compositions Of Macromolecular Compounds (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
【発明の詳細な説明】
髪莱上五上月次で
本発明は高分子化合物のアルミニウム架橋体の湿布剤用
膏体の製造方法に関するものである。DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a method for producing a plaster for poultices made of an aluminum crosslinked polymer compound.
従迷！ｌ支賓
湿布剤の基剤としては、ポリアクリル酸などの高分子化
合物のアルミニウムなどの多価金属塩により架橋された
膏体が夏場及び皮膚適用時のブレの解消、成形湿布剤と
しての物性のよさから多く使われている。Obedience! l As a base for guest poultices, a paste crosslinked with a polyvalent metal salt such as aluminum of a polymer compound such as polyacrylic acid is used to eliminate blurring in summer and when applied to the skin, and has physical properties as a molded poultice. It is widely used because of its good quality.
明が しようとする
しかし、これらの製造において溶解性の架橋剤を使用し
た場合、添加時にその架橋の速さから高分子化合物溶液
と架橋剤溶液の急激な架橋が起こり、不均一な膏体とな
る。また、難溶性の架橋剤の場合、塗工時に適度な硬さ
を得るため架橋剤量を若干多く必要とすることで経時的
な架橋の進行による物性の変化が問題となる。However, when a soluble crosslinking agent is used in the production of these products, the speed of crosslinking upon addition causes rapid crosslinking between the polymer compound solution and the crosslinking agent solution, resulting in a non-uniform paste. Become. In addition, in the case of a poorly soluble crosslinking agent, a slightly larger amount of crosslinking agent is required to obtain appropriate hardness during coating, which poses a problem of changes in physical properties due to progress of crosslinking over time.
課 を するための手段
本発明者らは、これらの問題を解決するために研究を重
ねた結果、架橋剤としてのアルミニウムの希薄溶液と湿
布剤中に配合する油性成分を界面活性剤で乳化、・分散
した後、膏体中に配合することで均一に経時的な物性の
変化のない、良好な湿布剤が得られることを知見し、本
発明に至った。As a result of repeated research to solve these problems, the inventors of the present invention have developed a method of emulsifying a dilute solution of aluminum as a crosslinking agent and an oily component to be mixed into a poultice with a surfactant. - It was discovered that a good poultice with no change in physical properties over time can be obtained uniformly by blending it into a plaster after being dispersed, leading to the present invention.
本発明は、ポリアクリル酸および／またはポリアクリル
酸ナトリウムを含有せしめた水溶液に溶解したアルミニ
ウムの希薄水溶液を油性成分に界面活性剤で乳化または
分散した液を添加し、反応きせることを特徴とする湿布
剤用膏体の製造方法である。The present invention is characterized in that a dilute aqueous solution of aluminum dissolved in an aqueous solution containing polyacrylic acid and/or sodium polyacrylate is emulsified or dispersed with a surfactant in an oily component, and a solution is added thereto to cause a reaction. This is a method for producing a plaster for a poultice.
本発明に用いるアルミニウムとは、水に溶解後、希薄な
状態で使用可能なものであればよく、例えば塩化アルミ
ニウム、ミョウバン、硫酸アルミニウム、酒石酸アルミ
ニウムなどである。その使用量は高分子化合物に対して
０．０１〜２重量％の範囲である。また、希薄溶液とは
、１重量％以下の水溶液をいう。The aluminum used in the present invention may be any aluminum that can be used in a diluted state after being dissolved in water, such as aluminum chloride, alum, aluminum sulfate, and aluminum tartrate. The amount used is in the range of 0.01 to 2% by weight based on the polymer compound. Moreover, a dilute solution refers to an aqueous solution of 1% by weight or less.
油性成分とは、例えば湿布剤の有効成分であるｄＰ−カ
ンフル、！−メントール、サリチル酸メチル、サリチル
酸グリコール、ビタミンＥ＃酸エステルなど及び添加成
分であるミリスチン酸イソプロピル、アジピン酸ジイソ
プロピル、ブチルヒドロキシトルエン、ポリブテンなど
をいう。The oily component is, for example, dP-camphor, which is an active ingredient in poultices. - Refers to menthol, methyl salicylate, glycol salicylate, vitamin E# acid ester, etc., and additional components such as isopropyl myristate, diisopropyl adipate, butylated hydroxytoluene, polybutene, etc.
界面活性剤とは、ポリオキシエチレンソルビタン詣肪酸
エステル、ポリエチレングリコール脂肪酸エステル、ポ
リオキシエチレンヒマシ油及び硬化ヒマシ油、ポリオキ
シエチレンポリオキシプロピレンアルキルエーテルなど
であり、ＨＬＢの比較的高いものがよく、ＨＬＢとして
は８以上のものが好ましい。Surfactants include polyoxyethylene sorbitan fatty acid ester, polyethylene glycol fatty acid ester, polyoxyethylene castor oil and hydrogenated castor oil, polyoxyethylene polyoxypropylene alkyl ether, and those with relatively high HLB are preferred. , HLB of 8 or more is preferable.
また、必要に応じて、その他の水溶性高分子化合物、例
えば、ゼラチン、ポリビニルアルコール、ボＩ＋エチレ
ンオキサイド、ポリビニルピロリドン、アルギン酸塩、
カルボキシビニルポリマー、ヒドロキシプロピルセルロ
ース、ペクチンなど、保水剤としては、グリセリン、プ
ロピレングリコール、マクロゴール４００．ブチレング
リコールなどを配合することが可能である。In addition, if necessary, other water-soluble polymer compounds such as gelatin, polyvinyl alcohol, boI + ethylene oxide, polyvinylpyrrolidone, alginate,
Carboxyvinyl polymer, hydroxypropyl cellulose, pectin, etc. Water retention agents include glycerin, propylene glycol, macrogol 400. It is possible to incorporate butylene glycol and the like.
さらに、必要に応じてｐＨ調整剤を添加することができ
、ｐＨ調整剤として当該分野で使用可能な酸又はアルカ
リ、充填剤としてカオリン、酸化亜鉛、酸化チタン、無
水ケイ酸、炭酸力ルシュウムなどを添加することができ
る。Furthermore, a pH adjuster can be added as necessary, and acids or alkalis usable in the field can be used as the pH adjuster, and kaolin, zinc oxide, titanium oxide, silicic anhydride, rhusium carbonate, etc. can be used as the filler. Can be added.
本発明の製造方法は、水溶性高分子化合物を、必要に応
じて保水剤（プロピレングリコール、グツセリンなど）
や充填剤を用いて分散し、水を加えた後、さらに必要に
応じて加熱溶解する。これに、その他の保水剤および充
填剤を加えて混練する。別に基剤中の油状成分である生
薬成分、基剤成分および界面活性剤とアルミニウムの希
薄溶液の乳化液を調整する。これを先の水溶性高分子化
合物の混練物と合わせて均一に混練した後、必要に応じ
てｐＨ調整剤を添加して膏体のｐＨを調整した後、水で
全量補正を行ない湿布側膏体を製造する。In the production method of the present invention, a water-soluble polymer compound is added to a water-retaining agent (propylene glycol, gutsselin, etc.) as necessary.
After dispersing with filler or filler, adding water, and dissolving by heating if necessary. Other water retention agents and fillers are added to this and kneaded. Separately, an emulsion of a dilute solution of aluminum, the oily component in the base, the base component, and a surfactant is prepared. After uniformly kneading this with the previous water-soluble polymer compound kneading mixture, adding a pH adjuster as necessary to adjust the pH of the paste, correcting the total amount with water and making a compress. Manufacture the body.
さらに、このようにして得られた湿布側膏体を混練、攪
拌で均質な粘度状態を保ちながら膏体を定量的に送り出
す、ポンプでライナー（ポリエステル、ポリプロピレン
、ポリエチレンなど）または支持体（不織布、布など）
上に、所定の厚みで展延し、前面にライナーまたは支持
体を貼りあわせた後、裁断して湿布剤とすることができ
る。Furthermore, the poultice side paste obtained in this way is kneaded and stirred to quantitatively deliver the paste while maintaining a homogeneous viscosity state, and a liner (polyester, polypropylene, polyethylene, etc.) or support (non-woven fabric, cloth, etc.)
It can be spread on top to a predetermined thickness, laminated with a liner or support on the front side, and then cut to make a poultice.
光泗１υ迩朱
本発明により、従来からの溶解性の架橋剤を使用する場
合欠点であった高分子化合物溶液と架橋剤溶液の急激な
架橋反応を防止し、均一な膏体を得ることが可能となっ
た。According to the present invention, it is possible to prevent the rapid crosslinking reaction between the polymer compound solution and the crosslinking agent solution, which was a drawback when using a conventional soluble crosslinking agent, and to obtain a uniform plaster. It has become possible.
また、架橋剤として溶解した希薄なアルミニウムを使用
するので、経時的な架橋の進行による物性の変化が問題
無くなった。Furthermore, since dilute dissolved aluminum is used as a crosslinking agent, there is no problem with changes in physical properties due to progression of crosslinking over time.
火」１例 以下、実施例を挙げて本発明を具体的に説明する。Fire” 1 case The present invention will be specifically described below with reference to Examples.
実施例１
ポリアクリル酸８重量部、ポリビニルピロリドン６重量
部をグリセリン１５重量部に分散後、水４０重量部を加
えて溶解した。これにカオリン１５重量部、酸化チタン
１重量部を加えて混合した後、サフチル酸メチル１重量
部、ｌ−メントール１．２重量部、ｄｌ−カンフ）し０
．５重量部、ハツカ油０．５重量部にニラコールＨＣＯ
−４０を０．５重量部加えて加熱、溶解した液と０．５
重量％塩化アルミニウム溶液１０重量部を合わせて高速
攪拌して乳化した液を加えて均一に混合した。Example 1 After dispersing 8 parts by weight of polyacrylic acid and 6 parts by weight of polyvinylpyrrolidone in 15 parts by weight of glycerin, 40 parts by weight of water was added and dissolved. After adding and mixing 15 parts by weight of kaolin and 1 part by weight of titanium oxide, 1 part by weight of methyl saphtylate, 1.2 parts by weight of l-menthol, 0
．． 5 parts by weight, 0.5 parts by weight of peppermint oil and Niracol HCO
Add 0.5 parts by weight of -40 and heat to dissolve the solution and 0.5 parts by weight.
10 parts by weight of a wt% aluminum chloride solution were combined and emulsified by stirring at high speed, and the resulting mixture was added and mixed uniformly.
さらに口Ｈ調整剤として酒石８１重量部を水５重量部に
溶解した液でｐＨを約５に調整した。さらに水を加えて
１００重量部とした後、均一に混合した。Furthermore, the pH was adjusted to about 5 using a solution prepared by dissolving 81 parts by weight of tartar in 5 parts by weight of water as a mouth pH adjusting agent. Further, water was added to make 100 parts by weight, and the mixture was uniformly mixed.
このゲル膏体を直ちに攪拌機で可搬化した後、定量吐出
ポンプを通して不織布上に約ｉｍｍの厚さに展延し、ラ
イナーを貼り合わせた後、裁断して湿布剤を得た。This gel paste was immediately made portable using a stirrer, and then spread on a nonwoven fabric to a thickness of about imm through a metering pump, a liner was attached, and then cut to obtain a poultice.
実施例２
グリセリン１５重量部にポリアクリル酸５重量部、ポリ
アクリル酸ナトリウム３重量部を加えて分散し、ポリビ
ニルアルコール１重量部を水５０重量部に溶解した液を
合わせて混合、溶解した。さらに酸化チタン１重量部、
無水ケイ酸１重量部、カオリン５重量部を均一に混合し
た。これにサリチル酸メチル０．５重量部、サリチル酸
グリコール１重量部、λ−メントール１重量部、ビタミ
ンＥ酢酸エステル０．３重量部、ポリブテン１重量部、
ハツカ油０．５重量部、ニラコールＭＭＳ−１００，５
重量部を加熱、溶解した液と０．５％ミョウバン水溶液
１２重量部を合わせて高速攪拌して乳化させた液を加え
て混合した後、ｐＨ調整剤として乳酸０゜８重量部と水
を加えて全１００重量部とした後、均一に混合した。Example 2 5 parts by weight of polyacrylic acid and 3 parts by weight of sodium polyacrylate were added and dispersed in 15 parts by weight of glycerin, and a solution prepared by dissolving 1 part by weight of polyvinyl alcohol in 50 parts by weight of water was combined and mixed and dissolved. Furthermore, 1 part by weight of titanium oxide,
1 part by weight of silicic anhydride and 5 parts by weight of kaolin were uniformly mixed. To this, 0.5 part by weight of methyl salicylate, 1 part by weight of glycol salicylate, 1 part by weight of λ-menthol, 0.3 part by weight of vitamin E acetate, 1 part by weight of polybutene,
Peppermint oil 0.5 parts by weight, Niracol MMS-100.5
Heat and mix parts by weight of the dissolved liquid and 12 parts by weight of a 0.5% alum aqueous solution and stir at high speed to emulsify the mixture. After mixing, add 0.8 parts by weight of lactic acid and water as a pH adjuster. The mixture was mixed uniformly to make a total of 100 parts by weight.
以下、実施例１と同様にして膏体の展延を行い湿布剤を
得た。Thereafter, the paste was spread in the same manner as in Example 1 to obtain a poultice.
実施例３
ゼラチン０．４重量部、酸化チタン１重量部、グツセリ
ン２０重量部、ポリビニルピロリドン８重量部、水４０
重量部を加熱混合して均一にし、ポリアクリル酸ナトリ
ウム３重量部をプロピレングリフール５重量部に溶解し
た液を混合した。これにサリチル酸メチル０．５重量部
、サリチル酸グリコール１重量部、ミリスチン酸イソプ
ロピル０．５重量部、ビタミンＥ酢酸エステル０．３重
量部、ｄｌ−カンフル０．５重量部、ニラコールＰＢＣ
−３４０，５重量部を合わせて加熱、溶解した液と０．
３％硫酸アルミニウム水溶液１２重量部を合わせて高速
攪拌して乳化した液を加えて混合した後、ｐＨ調整剤と
してクエン酸０．２重量部を水２重量部に溶解した液を
加え、ｐＨを約５６５に調整し、さらに水を加えて全１
００重量部とした後、均一に混合した。 このゲル膏体
をニーグーで混練可塑化し、定量吐出ポンプで不織布上
に押し出して約１１の厚さに展延してライナーを貼り合
わせた後、裁断して湿布剤を得た。Example 3 0.4 parts by weight of gelatin, 1 part by weight of titanium oxide, 20 parts by weight of gutserin, 8 parts by weight of polyvinylpyrrolidone, 40 parts by weight of water
Parts by weight were heated and mixed to make it homogeneous, and a solution obtained by dissolving 3 parts by weight of sodium polyacrylate in 5 parts by weight of propylene glycol was mixed. To this, 0.5 parts by weight of methyl salicylate, 1 part by weight of glycol salicylate, 0.5 parts by weight of isopropyl myristate, 0.3 parts by weight of vitamin E acetate, 0.5 parts by weight of dl-camphor, and Niracol PBC.
-340.5 parts by weight were heated and dissolved together and 0.5 parts by weight was heated and dissolved.
After adding and mixing 12 parts by weight of a 3% aqueous aluminum sulfate solution and emulsifying it by stirring at high speed, a solution prepared by dissolving 0.2 parts by weight of citric acid in 2 parts by weight of water as a pH adjuster was added to adjust the pH. Adjust to about 565 and add more water to make a total of 1
00 parts by weight, and then mixed uniformly. This gel paste was kneaded and plasticized using a Ni-Goo, extruded onto a nonwoven fabric using a metering pump, spread to a thickness of about 11 mm, a liner was attached, and then cut to obtain a poultice.
トール０．５重量部、塩酸ジフェンヒドラミン０．０１
重量部を合わせて加熱溶解した液と０．５％塩化アル
ミニラム水溶液１４重量部を合わせて高速攪拌して乳化
した液を加えて混合した後、ｐＨ調整剤として酒石＃０
．５重量部を水５重量部に溶解した液を加え、ｐＨを約
６に調整した。さらに水を加えて全１００重量部とした
後、均一に混合した。Thor 0.5 parts by weight, diphenhydramine hydrochloride 0.01
Combine the weight parts and heat-dissolve the solution and 0.5% aluminum chloride.
After adding and mixing 14 parts by weight of Minirum aqueous solution and emulsifying it by stirring at high speed, tartarite #0 was added as a pH adjuster.
．． A solution of 5 parts by weight dissolved in 5 parts by weight of water was added, and the pH was adjusted to about 6. Further, water was added to make a total of 100 parts by weight, and the mixture was uniformly mixed.
このゲル膏体を直ちに攪拌機で可塑化し、定量ポンプで
不織布上に押し出して約１ｍｍの厚さに展延してライナ
ーを貼り合わせた後、裁断して湿布剤を得た。This gel paste was immediately plasticized with a stirrer, extruded onto a nonwoven fabric using a metering pump, spread to a thickness of about 1 mm, a liner was attached, and then cut to obtain a poultice.
実施例４Example 4
Claims (1)
酸ナトリウムを含有せしめた水溶液に（Ｂ）溶解したア
ルミニウムの希薄水溶液を油性成分に界面活性剤で乳化
または分散した液を添加し、反応させることを特徴とす
る湿布剤用膏体の製造方法。1) Adding (A) a dilute aqueous solution of dissolved aluminum to an aqueous solution containing polyacrylic acid and/or sodium polyacrylate and emulsifying or dispersing it in an oily component with a surfactant, and causing a reaction. A method for producing a plaster for a poultice, characterized by:
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1143473A JPH0311013A (en) | 1989-06-06 | 1989-06-06 | Production of plaster for wet compressing agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1143473A JPH0311013A (en) | 1989-06-06 | 1989-06-06 | Production of plaster for wet compressing agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH0311013A true JPH0311013A (en) | 1991-01-18 |
Family
ID=15339517
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1143473A Pending JPH0311013A (en) | 1989-06-06 | 1989-06-06 | Production of plaster for wet compressing agent |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0311013A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006206540A (en) * | 2005-01-31 | 2006-08-10 | Hisamitsu Pharmaceut Co Inc | Sheet-like pack preparation and method for producing the same |
| WO2011151171A1 (en) * | 2010-05-31 | 2011-12-08 | Unilever Nv | Skin treatment composition |
| US9693941B2 (en) | 2011-11-03 | 2017-07-04 | Conopco, Inc. | Liquid personal wash composition |
-
1989
- 1989-06-06 JP JP1143473A patent/JPH0311013A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006206540A (en) * | 2005-01-31 | 2006-08-10 | Hisamitsu Pharmaceut Co Inc | Sheet-like pack preparation and method for producing the same |
| WO2011151171A1 (en) * | 2010-05-31 | 2011-12-08 | Unilever Nv | Skin treatment composition |
| US9693941B2 (en) | 2011-11-03 | 2017-07-04 | Conopco, Inc. | Liquid personal wash composition |
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