JPH03109498A - Cleaning agent composition having low stimulating property - Google Patents

Abstract

PURPOSE:To obtain the title composition containing specific anionic surfactant and specific amphoteric surfactant as active ingredients and being extremely low in stimulating properties to skin while satisfying foaming properties and cleaning properties. CONSTITUTION:The aimed composition containing (A) an anionic surfactant expressed by formula I (R1 is 6-20 alkyl or alkenyl; M1 is alkali metal or alkanolamine; n is 1-10) and (B) amphoteric surfactant expressed by formula II (R2 is 10-16C alkyl; M2 is alkali metal) as active ingredients, preferably at weight ratio of ingredient A: ingredient B of 5:1-1:20 and at an amount of total amount of the ingredients A and B of 10-50wt.%.

Description

DETAILED DESCRIPTION OF THE INVENTION [Field of Industrial Application] The present invention relates to a detergent composition that satisfies essential requirements for a detergent, such as foaming properties and cleansing properties, and has extremely low irritation to the skin. It is.

[Conventional technology]

Conventionally, surfactants and surfactant compositions with strong protein denaturing power have caused severe roughness when used repeatedly, whereas surfactants and surfactant compositions with low protein denaturing power (for example, shampoos) ) is well known to be less likely to cause skin disorders such as rough hands even when used for a long period of time, and to have extremely low irritation to the skin.

On the other hand, anionic surfactant □ represented by the general formula (A) below is used in cleansers such as facial cleansers and shampoos due to its excellent cleaning power, but it also has protein denaturing power and skin irritation. (The drawback is that it tends to cause skin problems such as rough hands.) Against this background and with the advancement of living standards, surfactants and detergents with low skin irritation that are highly safe for the human body are being developed. Currently, there is a strong demand for the development of compositions.

[Problem to be solved by the invention]

As a result of intensive research aimed at improving the drawbacks of the above-mentioned conventional techniques, the inventors of the present invention have discovered the following.
When an appropriate amount of the amphoteric surfactant represented by the general formula (B) described in No. 2-71528 is mixed with the anionic surfactant represented by the general formula (8) described below, foaming, While satisfying the essential requirements as a cleaning agent such as detergency,
The present inventors have discovered that a detergent composition that has low protein denaturing power, is less likely to cause skin disorders such as rough hands, and has extremely low skin irritation has been completed, and the present invention has been completed.

An object of the present invention is to provide a detergent composition that satisfies essential requirements for a detergent such as foaming properties and cleansing properties, and has extremely low irritation to the skin.

[Means to solve the problem]

The present invention has the general formula (A) RIO(CHfCH!O), CIIZCOO1'll
・・・・・・・・・・・・・・・(A) (In the above formula, R+ is an alkyl group having 6 to 20 carbon atoms or alkenyl a
, MI is an alkali metal or ) (in the above formula, R1 represents a number of carbon atoms of 6 to 1 o); 10-16 alkyl group 1
This is a mild detergent composition containing as an active ingredient an amphoteric surfactant represented by (M8 represents an alkali metal).

The anionic surfactant represented by the general formula (^) in the present invention is, for example, polyoxyethylene (2E, O
,) Sodium dodecyl ether carboxylate, polyoxyethylene (3E, O,) Tridecyl ether carboxylic acid triethanolamine, polyoxyethylene (
6E, O,) sodium tetradecyl ether carboxylate, polyoxyethylene (2E, O,”) potassium pentadecyl ether carboxylate, polyoxyethylene (4
E.

0,) hexadecyl ether carboxylic acid triethanolamine, polyoxyethylene (8E, O.

) Sodium octadecyl ether carboxylate.

Polyoxyethylene (2E, O,) decyl ether carboxylic acid triethanolamine, polyoxyethylene (I
Examples include sodium oeicosyl ether carboxylate (OE, O,), triethanolamine polyoxyethylene (IEO2) octyl ether carboxylate, and triethanolamine (52,0,) octadecenyl ether carboxylate.

Examples of the amphoteric surfactant represented by the general formula (B) include 2-(N-tetradecyl-N-methylamino)ethyl phosphate monosodium salt (hereinafter referred to as
Compound 1), 2-(N-tetradecyl-N-methylamine)ethyl phosphate monopotassium salt (Compound 2), '2-(N-dodecyl-N-methylamino)ethyl phosphate monosodium salt (Compound 3) , 2-
(N-dodecyl-N-methylamino)ethyl phosphate monopotassium salt (Compound 4), 2-(N-;hexadecyl-N-methylamine)ethyl phosphate monosodium salt (Compound 5), 2-(N- Hexadecyl
N-methylamino)ethyl phosphate monopotassium salt (compound 6) 2-(N-decyl-N-methylamino)
Ethyl phosphate monosodium salt (compound 7),
2-(N-decyl>-N-methylamino)ethyl phosphate monopotassium salt (Compound 8), and the like.

The anionic surfactant represented by the general formula (A) has sufficient surfactant properties such as foaming properties and detergent properties, but has somewhat strong protein denaturing power, and when used alone, it does not reach the desired low level. No irritating cleaning agents are obtained.

On the other hand, the amphoteric surfactant represented by the general formula (B) has very low protein denaturation power and weak irritation, but has foaming and
It has only moderate surfactant ability such as detergency.

By combining the anionic surfactant represented by the general formula (A) and the amphoteric surfactant represented by the general formula (B), the viscosity increases and critical micelles increase compared to the case of each alone. Phenomena such as a decrease in concentration occur, and surfactant abilities such as foaming properties and detergent properties are determined by the general formula (
A) is superior to the anionic surfactant alone, and at the same time, the protein denaturation power is expressed by the general formula (B).
) It was possible to significantly reduce the amount of water to almost the same level as when using the amphoteric surfactant alone.

That is, by mixing the anionic surfactant represented by the general formula (A) and the amphoteric surfactant represented by the general formula (B) to form a composite, a synergistic effect is clearly exerted. It has become possible to obtain a hypoallergenic detergent composition with low protein denaturation ability while maintaining excellent surfactant ability.

The mixing ratio (weight ratio) of (A):(B) is 5:
1 to 1:20, and the content of (A) + (B) is preferably 10 to 50% by weight based on the total amount of the cleaning composition. Mixing ratios outside this range or other anionic surfactants may be used. If the system is unbalanced by adding a large amount of
The desired effect of lowering protein denaturation ability cannot be obtained.

The cleaning composition of the present invention may optionally contain ingredients commonly added to cleaning agents, such as higher alcohols, lanolin derivatives, protein derivatives, oily ingredients such as fatty acid esters of polyethylene glycol, propylene glycol, glycerin, polyethylene glycol, etc. Insulating ingredients such as glycol, nonionic surfactants such as fatty acid alkalolamide, polyoxyethylene alkyl ether, and alkylamine oxide, water-soluble polymer substances (anionic, nonionic,
(including cationic ones), sequestering agents, preservatives, bactericidal agents, pH adjusters, ultraviolet absorbers, antioxidants, pigments, fragrances, and the like.

〔Example〕

Next, the present invention will be explained in detail with examples, but the present invention is not limited thereto.Prior to the examples, the test methods adopted in each example will be explained.

(Foaming test method) Test was performed using the Ross Miles test method (ASTMD 1173-53). In addition, the evaluation criteria were set as follows.

O...Good foaming Foam ff1200ml or more...
Foaming shed Foam ff1150m1 or more, less than 200m42×...poor foaming Foam ffi150mj! Less than (Cleanability test method) A 5 cm x 5 cm wool muslin cloth was coated with a solution of 7% lanolin and Sudan I [l 0.005% in chloroform.
mj! Apply it evenly, let it dry, and remove the contaminated cloth by 3%.
Approximately 100mj containing 40me of detergent solution! The contaminated cloth was placed in a glass cylinder and placed in a constant temperature bath at 40°C for 15 minutes, and the contaminated cloth was thoroughly rinsed under running water and dried.The reflectance was examined and the cleaning rate was determined using the following formula.

In addition, the evaluation criteria were set as follows.

O: Good cleaning performance Washing efficiency 80% or more Δ: Normal cleaning performance Washing efficiency 60% or more but less than 80% The ovalbumin denaturation rate when a sample was added to an albumin pH 7 buffer solution at a sample concentration of 1% was measured using an absorption peak at 220 nm.

Ho: Height of the 220 nm absorption peak of ovalbumin Hl: 22 when the sample is added to the ovalbumin buffer solution
The criteria for evaluating the height of the 0 nm absorption peak was set as follows.

◎: Ovalbumin denaturation rate less than 30% O: Ovalbumin denaturation rate 30% or more and less than 60% Δ: Ovalbumin denaturation rate 60% or more and less than 80% ×: Ovalbumin denaturation rate 80% or more (rough hand test method) For each sample , using a panel of 10 people, 5 men and 5 men in total, with either the left or right hand at a sample concentration of 5% and a temperature of 35°.
An operation of immersing the other hand in the aqueous solution of C and water at the same temperature for 10 minutes was performed twice a day for 2 consecutive days, and the difference in rough skin between the left and right hands was visually determined.

◎... Extremely weak hand roughness O~1 out of 10 people found rough hands on the sample side ○... Slightly weak hand roughness 2-4 out of 10 people found hand roughness on the sample side Δ... Slightly rough hands: 5 to 7 out of 10 people Rough hands were observed on the sample side×: Extremely rough hands: 8 out of 10 people. ~lO Name Examples 1 to 8, Comparative Examples 1 to 2 in which rough hands were observed on the sample side A shampoo consisting of the formulation shown in Table 1 was prepared,
Table 1 shows the results of examining its foaming properties, cleaning properties, protein denaturation rate, and roughness.

As is clear from Table 1, Comparative Example 1 of the shampoo of the present invention has a protein denaturation ratio of 1 and is undesirable in terms of roughness, and Comparative Example 2 lacking the anionic surfactant represented by the general formula (A) Foaming and Cleaning Properties Example 9 A body shampoo having the following composition was prepared.

(Weight%) Compound 16 Compound 56 Glycerin 2 Flavor
0.3 water
As a result of examining the foaming properties, cleaning properties, protein denaturation rate, and roughness of hands of this body shampoo, the results were ○ and O, respectively.
It was 20, ◎.

Example 10 A band shampoo consisting of the following formulation was prepared.

(% by weight) Compound 48 Compound 6 Coconut fatty acid jetanolamide 5 Flavor
0.3 water
Residual As a result of investigating the foaming property, detergency, protein denaturation rate, and roughness of hands of this paulownia N shampoo, it was found that
It was 2◎, ◎.

[Effects of the Invention] As described above, the present invention is highly safe, has mild effects with little irritation to the skin and hair, and
It is clear that the present invention provides a mild detergent composition having excellent foaming and detergent properties.

Claims (1)

[Claims] General formula (A) R_1O(CH_2CH_2O)_nCH_2COOM
_1………………(A) (In the above formula, R_1 has a carbon number of 6 to
20 alkyl or alkenyl groups, M_1 represents an alkali metal or an alkanolamine. n represents a number from 1 to 10. ) An anionic surfactant represented by the general formula (B) ▲There are mathematical formulas, chemical formulas, tables, etc.▼…………(B) (In the above formula, R_2 is an alkyl group having 10 to 16 carbon atoms. , M_2 represents an alkali metal.) A mild detergent composition containing an amphoteric surfactant as an active ingredient.