JPH0278432A - Transparent composition - Google Patents

Abstract

PURPOSE:To improve the transparency and aging stability of a transparent compsn. and to prevent irritation by use of a large amt. surfactant by blending and mixing an amphipatic substance with the surfactant, an oily component and water to prepare the transparent compsn. CONSTITUTION:A mixed dispersion liq. consisting essentially of an amphipatic substance, a surfactant, an oily component and water is treated with an emulsifier generally used to produce cosmetics, e.g., a homo-mixer to prepare a transparent compsn. The transparency, safety and stability of the compsn. are further improved by applying higher shearing force with an emulsifier capable of applying higher shearing force than the homo-mixer, e.g., Manton-Gaulin or a French press. The amphipatic substance may be lecithin or dialkyldimethylammonium chloride. The oily component may be avocado oil, tsubaki oil or turtle oil.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Application Field] The present invention relates to a transparent composition formed from an aggregate dispersion of a highly safe amphipathic substance such as lecithin, and an external preparation containing the same. More specifically, it is formed from a dispersion of an aggregate obtained by mixing a highly safe amphiphilic substance such as lecithin with a small amount of surfactant as a solubilization aid, and has excellent transparency, stability over time, and safety. The present invention relates to a novel transparent composition with excellent properties and an external preparation containing the same.

[Prior Art 1] Many effective substances for the skin, physiologically active substances, drugs, etc. are oily substances, and it is desired to develop a transparent base that can stably incorporate these substances. Conventionally, in order to obtain a transparent system in which oily components are stably blended, a method of blending surfactants, ethanol, etc. at high concentrations has been known. These high concentration formulations may cause irritation to the skin, eyes, mucous membranes, etc.

[Problems to be Solved by the Invention] In order to reduce these irritations, there is a method of using lecithin, which is derived from a natural product and is highly safe, instead of synthetic surfactants. Because lecithin has weak emulsifying and solubilizing power, high transparency of the system cannot be obtained, and it is also poor in stability.

Additionally, in order to reduce the particle size and increase transparency, a method of applying a powerful force such as a high-pressure emulsifier is also known.
This method also increases the transparency immediately after preparation, but the stability is poor and transparency cannot be maintained sufficiently, so it is often not suitable for practical use.

As mentioned above, sufficient stability cannot be obtained with lecithin alone, so there is a method of combining lecithin with some kind of nonionic surfactant or ethanol, but in order to obtain a completely transparent system, lecithin Requires a large amount of nonionic surfactant or ethanol. In order to further coexist other oily components, the amount of nonionic surfactant and ethanol added will inevitably increase, and as with the prior art, irritation will once again become a problem.

Although there are several methods for obtaining a stable transparent system containing an oily component, none of the methods has yet been suitable for practical use.

As a result of intensive research to solve these problems, the present invention was developed by uniformly dispersing an amphipathic substance such as lecithin and a small amount of surfactant in water, and then using a homomixer etc. By processing with an emulsifying machine having shearing force, we have obtained a new transparent composition in which an oily component is stably blended with a small amount of surfactant that does not cause irritation.

[Means for Solving the Problems] That is, the present invention provides: (1) A transparent composition containing an amphiphilic substance, a surfactant, an oily component, and water.

(2) The transparent composition according to claim 1, which is obtained by subjecting a mixture containing an amphiphilic substance, a surfactant, an oily component, and water to a strong shear force treatment.

(3) The transparent composition according to claim 1, which contains 10 parts by weight or less of a surfactant per 1 part by weight of the oily component.

(4) An external preparation comprising the transparent composition according to any one of claims 1 to 3.

It is.

These methods are applied using shearing force such as a homomixer, which is normally used to produce cosmetics, to prepare a mixed dispersion of a highly safe amphiphilic substance such as lecithin and a small amount of surfactant as a solubilization aid. The present invention aims to obtain a novel transparent composition that has excellent transparency, stability over time, and safety, and an external preparation containing the same, which can be obtained by processing with an emulsifying machine having the above-mentioned technology.

Hereinafter, the configuration of the present invention will be explained in detail.

In the present invention, an amphipathic substance is a substance that has the property of containing a hydrophobic group and a hydrophilic group in the same molecule, such as lecithin, quaternary ammonium salt type synthetic lipids such as dialkyldimethylammonium chloride, Ammonium salt and higher alcohol? Examples include kneaded foods. Among these, lecithin can be any phospholipid such as natural phospholipids such as soybean lecithin and egg yolk lecithin, synthetic phospholipids, or hydrogenated natural phospholipids. Since all natural phospholipids contain unsaturated fatty acids, it is more effective to use hydrogenated phospholipids in which the unsaturated fatty acids of the natural phospholipids are saturated with hydrogen. Synthetic phospholipids can also be used, although they are expensive.

Representative examples of phospholipids include lecithin, phosphatidylethanolamine, phosphatidic acid, phosphatidylinositol, phosphatidylserine, phosphatidylcholine, phosphatidylglycerol, sphingomyelin, calciolipin, and the like. Further examples include those obtained by hydrogenating these in accordance with conventional methods.

In particular, hydrogenated natural lecithin obtained by hydrogenating soybean lecithin, egg yolk lecithin, corn lecithin, cottonseed oil lecithin, rapeseed lecithin, etc. is preferably used.

In the present invention, the surfactant may be either a nonionic surfactant or an ionic surfactant (cationic, anionic, or amphoteric), but from the viewpoint of safety, nonionic surfactants commonly used in cosmetics are preferred. .

More specifically, sugar or sugar alcohol fatty acid esters such as sucrose fatty acid esters, multi-yl fatty acid esters, sorbitan fatty acid esters, glycerin fatty acid esters, polyglycerin fatty acid esters, propylene glycol fatty acid esters, polyoxyethylene sorbitan fatty acid esters, polyoxy Ethylene sorbitan fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyethylene glycol fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene phytosterol ether, polyoxyethylene polyoxypropylene alkyl ether, polyoxyethylene alkylphenyl ether, polyoxyethylene cholestanol Examples include ether, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil, polyoxyethylene beeswax derivatives, polyoxyethylene lanolin derivatives, polyoxyethylene alkylamine, polyoxyethylene alkylamide, and the like.

In the present invention, the oily components blended into the system are liquid oil,
It may be a solid oil, a semi-solid oil, or a substance that is poorly soluble in water, such as avocado oil, thorn oil, turd oil,
Macadamia oil, corn oil, mink oil, olive oil, rapeseed oil, feral oil, sesame oil, persic oil, wheat germ oil, sasanquat oil, castor oil, linseed oil, safflower oil, cottonseed oil, evening primrose oil, eno oil, soybean oil , peanut oil,
Tea seed oil, Kaya oil, Rice bran oil, Shinagiri oil, Japan; 1-
Liquid fats and oils such as lily oil, jojoba oil, germ oil, triglycerin, glycerin trioctanoate, glycerin triisopalmitate, cacao butter, coconut oil, horse tallow, hydrogenated coconut oil, palm oil, beef tallow, mutton tallow, hydrogenated beef tallow, Solid oils and fats such as palm kernel oil, liver fat, beef bone fat, Japanese oak kernel oil, hydrogenated oil, beef leg fat, Japanese oak, hydrogenated castor oil, beeswax, candelilla wax, cotton wax, Chikara Av-J-Hallow, Hayberry wax, Ibokuro , spermaceti wax, monokunwa, bran [2 pieces, lanolin, kapok wax, acetic acid lanolin, liquid lanolin, sugar cane wax, lanolin fatty acid isopropyl, hexyl laurate, reduced lanolin, jojoba wax, hard lanolin, shellac [1 piece, POE lanolin alni 1 piece] -Luether, P
OE lanolin alcohol acetate, lanolin fatty acid polyethylene glycol, POIE water $) Jl Waxes such as lanolin alcohol ether, hydrocarbons such as liquid paraffin, osikelite, squalene, pristane, paraffin, ceresin, squalane, vaseline, microcrystalline wax, Isopropyl myristate, cetyl octoate, octyldodecyl myristate,
Isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, decyl oleate, hexyldecyl dimethyloctoate, cetyl lactate, myristyl lactate, lanolin acetate, isocetyl stearate, isocetyl isostearate, colsteryl 12-hydroxystearate, Ethylene glycol di-2-ethylhexylate, dipentaerythritol fatty acid ester, N-alkyl glycol monoisostearate, neopentyl glycol capriate, diisastearyl malate, glycerin di-2-heptylundecanoate, trimethylolpropane tri-2-ethylhexylate. , trimethylolpropane triisostearate,
pentaerythritol tetra-2-ethylhexylate,
Tri-2-ethylhexylic acid glycerin, triisostearate trimethylolpropane, cetyl-2-ethylhexanoate, 2-ethylhexyl palmitate, trimyristate glycerin, tri-2-heptyl undecanoic acid glyceride, castor oil fatty acid methyl ester,
Oleic acid oil, cetostearyl alcohol, acetoglyceride, 2-heptylundecyl palmitate, diisopropyl adipate, N-lauroyl-glutamic acid-2-octyldodecyl ester, di-2-hebutylundecyl adipate, ethyllau rate, di-2-ethylhexyl cehatate, myristic acid-2-
hexyldecyl, 2-hexyldecyl palmitate,
2-hexyldecyl adipate, diisopropyl cehatylate, 2-ethylhexyl succinate, ethyl acetate,
Synthetic esters such as butyl acetate, amyl acetate, triethyl citrate, lauric acid, myristic acid, palmitic acid,
stearic acid, hehenic acid (behenyl) acid, oleic acid,
12-hydroxystearic acid, undecanoic acid, tolic acid, lanolin fatty acid, isostearic acid, linoleic acid,
Higher fatty acids such as riluic acid and eicosapene citric acid, lauric alcohol, cetyl alcohol, stearyl alcohol, hehenyl alcohol, myristyl alcohol,
Oleyl alcohol, cetostearyl alcohol, monostearylglycerenether (hatyl alcohol),
Linear and branched higher alcohols such as 2-denlutetradecinol, lanolin alcohol, cholesterol, phytosterols, hexyldodecanol, isostearyl alcohol, and octyldodecanol, vitamin A and its derivatives, vitamin D and its derivatives, vitamin E and Derivatives thereof, vitamins such as vitamin K and its derivatives, sterols, natural and synthetic fragrances, etc. Of these, those with melting points below room temperature are liquid oils, and those with melting points above room temperature are solids.
Distinguished from semi-solid oils.

Substances that are poorly soluble in water include vitamins such as ubiquinone and vitamin P, disinfectants such as chlorhexidine hydrochloride, trichlorocarbanilide, and Imegassan DP300, drugs such as dexamethacin acetate, and para-aminobenzoic acid (
(hereinafter abbreviated as PABA), N.

The amounts of amphipathic substances, surfactants and oily components in the present invention, including ultraviolet absorbers such as N-dimethyl PABA octyl ester, preservatives such as parabens, etc., are as follows:
0.001 to 1 part of surfactant per 1 part by weight of amphiphile
100 parts by weight is desirable, more preferably 0.01 to 1
It is preferably 0 parts by weight, and most preferably 0.01 to 5 parts by weight. Further, the total amount of the amphiphilic substance and surfactant is desirably 50 parts by weight or less, more preferably 20 parts by weight or less, per 1 part by weight of the oily component. A feature is that a highly transparent composition can be obtained even with 10 parts by weight or less, especially 1 part by weight or less, of the surfactant.

The transparent composition of the present invention can be obtained by treating a mixed dispersion containing the following essential components with an emulsifying machine such as a homomixer that is commonly used in the production of cosmetics. The transparent composition of the present invention can be processed using an emulsifier that can apply a stronger shearing force than a homomixer, such as a Manton Bowlin, French press, colloid mill, microfluidizer, or ultrasonic emulsifier. , its transparency, safety and stability will further increase.

In the present invention, strong shearing force processing refers to processing using an emulsifying machine that can apply a stronger shear than mixers (homogen mixers, disper mixers, propeller agitators, etc.) used in the production of regular products. , Manton Bowlin, French press, microfluidizer, or other high-pressure homogenizer at 500 psi or more, preferably 2,000 psi or more, or a colloid mill at 1. O
OOrpm, more preferably 5.000 rpm or more, or processing using an ultrasonic emulsifier or the like.

The shearing force treatment according to the present invention may be performed on the entire system, or
Optionally, a portion may be treated and then diluted with water or other formulations such as polyhydric alcohols.

In the present invention, when performing preliminary emulsification before main emulsification,
When blending oil or poorly soluble substances, it is convenient to take the following steps. That is, first, part or all of the amphiphilic substance, surfactant, and oily substance are dispersed or dissolved in molecular form in an aqueous solvent. At this time, a small amount of water may be added depending on the case. At this time, it is preferable to perform treatment by heating and/or using a homomixer. At this time, during gradual addition and/
Alternatively, after removing scale, it is recommended to homogenize the system using a propeller type stirrer, homomixer, etc.

Examples of the aqueous solvent here include polyglycerols such as ethylene glycol, propylene glycol, 1,3-butylene glycol, dipropylene glycol, glycerin, diglycerin, triglycerin, and tetraglycerin, glucose, "fuldose, maltitol, and sucrose." , fructose, xylitol, inositol, pentaerythritol, sorbitol, maltotriose,
Examples include R-lees decomposition sugar and starch decomposition tank reduced alcohol.

The aqueous phase here includes, for example, water-soluble active substances such as B vitamins, vitamin C and its derivatives, pantothenic acid and its derivatives, vitamins such as biotin, monosodium glutamate, arginine, aspartic acid, citric acid, and tartaric acid. Examples include buffering agents such as , lactic acid, ultraviolet absorbers such as chelating agents such as EDTA, and water-soluble dyes containing one or more of various dyes.

The transparent composition of the present invention is obtained in the manner described above.

Note that the term "transparent" in the present invention refers to the spectrophotometer 700.
If the transmittance of distilled water is 100% when measured in nm, the transmittance is 80% or more.

The transparent composition described above can be used in any field where its properties are required, and its use is not limited, but it is most suitable for use as an external preparation according to claim 4.

Note that external preparations include cosmetics, pharmaceuticals, quasi-drugs, etc.

[Examples] Next, in order to further understand the present invention, Examples will be given and explained in more detail, but it goes without saying that the present invention is not limited to these Examples.

Examples 1 to 3 and Comparative Example 1 After heating and dissolving components 1) to 5) shown in Table 1 and making the system homogeneous using a homomixer, 6] was gradually added and emulsified under pressure using a Manton Bowlin.

Examples 4 to 6 and Comparative Example 2 Trial production was carried out in the same manner as in Examples 1 to 3 and Comparative Example 1 except that the Manton-Bowlin treatment was changed to the homomixer treatment.

The evaluation results of safety, transparency, and stability of Examples 1 to 6 and Comparative Examples 1 to 2 are shown in Table 2, and the examples of the present invention have high transparency and are very safe and stable. It received good reviews.

The test methods and evaluation methods employed in each example and comparative example are as follows.

The compositions of Examples and Comparative Examples were applied to the forearms of 30 72 support panelists, and a day/night occlusion patch test was conducted and evaluated.

On L dish: Transmittance at 700 nm was measured. The transmittance of the compositions of Examples and Comparative Examples was evaluated when the transmittance of distilled water was set as 100%.

On the support foot: Stability was visually evaluated after 1 month.

Table 1 Table 2 Example 7.8 Ingredients 1) to 5) shown in Table 3 were melted by heating and the system was made homogeneous using a homomixer, then 6) was gradually added and processed using a Manton Bowlin. Compressed emulsified (hereinafter blank) Table 3 Safety of Example 7.8 1. Transparency and stability evaluation tests were conducted in the same manner as in Example 1, and the results are shown in Table 3. It can be seen that it has high transparency, safety, and stability.

Example 9 Parts by weight 1) 1.3-butylene glycol 10.0
2) Hydrogenated Uoki lecithin 1.83
) POE (60) Hydrogenated castor oil 0.2
4) Squalane 0.25) Vitamin E acetate) 0.056) Methylparaben 0.17) Ion-exchanged water 87.628) Ascorbic acid 0.031-6) After heating to 70°C, while stirring with a homomixer 7 to 8) were gradually added. After that, 6,0OO by Manton Bowlin.
The treatment was carried out 10 times at psi to obtain an aqueous transparent composition with a transmittance of 90% or more and stable at room temperature for 6 months or more.

Example 10 Part by weight 1) Glycerin 10.02)
Propylene glycol 5.03) Dipalmitoylphosphatidylcholine 2.04)
POE (20) Sorbitan monooleic acid 2.0
Ester 5) Cetyl isooctanoate 0.16
) Octyldimethyl PABA O,3
7) Butylparaben 0.18)
Ion exchange water 20.09) Ion exchange water 60.51-7)
After heating to 70°C, stir with a homomixer.
) was gradually added. After that, it is treated with an ultrasonic emulsifier until it becomes transparent, and 9) is added at room temperature to produce a water-based transparent cosmetic that has a transmittance of 90% or more and a stable UV absorption effect of 6 months or more at room temperature. Obtained.

Example 11 Part by weight 1) Propylene glycol 15.02
) Cetyltrimethyl 1.5 ammonium chloride 3) Hydrogenated soybean lecithin 3.04
) Liquid paraffin 2.05)
Ion exchange water 20.06) Ion exchange water 58.51-4)
After heating to 70°C, stir with a homomixer.
) was added. Later, by Manton Bowlin 8
, 0OOps i five times, and 6) was added at room temperature to obtain a transparent hair rinse agent with a transmittance of 90% or more and stable for 6 months or more at room temperature.

In addition, the rinse agent obtained by the same method except for 3) and changing 6) to 61°5 parts by weight had low transparency;
Stability was also low.

Example 12 Parts by weight 1) Glycerin 5.02) Hydrogenated soybean lecithin 1.03) PO
E(14)-2-octyldodecyl ether 2.04)
Dexamethacin acetate 0,0255)
Cetyl isooctanoate 0.56) Ion exchange water 91.4751-5)
After heating at 70°C and 710°C, 6) was added while stirring with a homomixer. Thereafter, it was treated with Manton-Bourin 10 times at 5,000 psi to obtain a transparent external preparation having a transmittance of 90% or more and an anti-inflammatory effect that was stable for 6 months or more at room temperature.

Example 13 Parts by weight 1) 1.3-butylene glycol 10
．． 02) Dipalmitoylphosphatidylcholine 1. [
]3) POE (10) Cholestanol ether
1.04) 3,4.4' trichlorocarbanilide 0.015) Cetyl isooctanoate
0.26) Methylparaben
0.17] Ion exchange water 20
．． 08) Ion exchange water 67.6
After heating 91-6) to 70'C, 7) was added while stirring with a homomixer. Then by Manton Bowlin? , 000ρsi 10 times, and 8
) was added to obtain a transparent external preparation having a transmittance of 90% or more and an anti-acne effect that was stable for 6 months or more at room temperature.

Example 14 Part by weight 1) 1.3-butylene glycol 1
0.02) Hydrogenated soybean lecithin 2.
03) POE (60) hydrogenated castor oil
2.04) Olive oil 1
．． 05) Vitamin A palmitate 0.0
56) Methylparaben 0.17
) Ion exchange water 84.851~
After heating 6) to 70°C, 7) was gradually added while stirring with a homomixer. After that, use a French press for 20
.

Example 15 Part by weight l) Glycerin 10.02) 1
．． 3-Butylene glycol 10.03) Hydrogenated soybean lecithin 1.54) P
OE (60) hydrogenated castor oil 0.55)
Liquid paraffin 0.56) Vitamin E acetate 0.057) Methylparaben 0.18) Ion exchange water 77.351~7) at 70°
After heating C, 8) was gradually added while stirring with a homomixer, and then 15. was added with a colloid mill. OOOrp
A transparent aqueous composition having a transmittance of 90% or more and stable for 6 months or more at room temperature was obtained.

Example 16 Parts by weight 1) Glycerin 10.02) Dipalmitoylphosphatidylcholine 0.53) PO
E (10) Cholestanol ether 1.54) Chlorhexidine hydrochloride 0.055) Cetyl isooctanoate 0.56) Ion exchange water 87.451~5) at 70°
After heating to C, 6) was removed while stirring with a propeller stirrer.

Thereafter, it was treated with Homomixer 10, OOOrpm for 10 minutes to obtain a transparent external preparation having a transmittance of 80% or higher and an antibacterial effect that is stable at room temperature for 6 months or more.

Example 17 Parts by weight 1) Glycerin 5.02) Hydrogenated soybean lecithin 2.03) P
OE(16)-2-octyldodecyl ether 0.1
4) Vitamin E acetate 0.55)
Ion exchange water 92.41~4)
After heating to 70°C, stir with a homomixer.
) was added. Then 5,0 by Manton Bowlin
The treatment with OQpsi was performed 10 times to obtain an aqueous transparent composition with a transmittance of 90% or more and stable at room temperature for 6 months or more.

[Effects of the Invention] The transparent composition of the present invention according to claims 1 to 3 is preferably an aggregate dispersion of a highly safe amphiphilic substance such as lecithin and a small amount of a surfactant as a solubilization aid. is a novel transparent composition that can be obtained by treatment with strong shearing force and has excellent transparency, stability over time, and safety. In particular, the desired oily component can be stably and transparently blended with 10 parts by weight or less, particularly 1 part by weight or less, of the surfactant per 1 part by weight of the oily component, so it is possible to prevent irritation that may occur when a large amount of surfactant is blended. It is extremely safe as it can avoid the occurrence of the disease.

Furthermore, since the average particle size of the aggregate is as small as 0.1 micron or less, it is also expected to be applied as an injection.

In addition, since it is water-based, it is not sticky and has a light feel, and when lecithin is used as an amphipathic substance, it has a moisturizing effect as well as oils that have other moisturizing effects. By retaining it, a high moisturizing effect can be imparted, so that excellent external preparations such as cosmetics, quasi-drugs, and pharmaceuticals as described in claim 4 can be provided.

Patent applicant: Shiseido Co., Ltd.

Claims (4)

[Claims] (1) A transparent composition containing an amphipathic substance, a surfactant, an oily component, and water. (2) The transparent composition according to claim 1, which is obtained by subjecting a mixture of an amphiphilic substance, a surfactant, an oily component, and water to a strong shear force treatment. (3) The transparent composition according to claim 1, which contains 10 parts by weight or less of a surfactant per 1 part by weight of the oily component. (4) An external preparation comprising the transparent composition according to any one of claims 1 to 3.