JPH0269159A - Nutrition enriching agent - Google Patents
Nutrition enriching agentInfo
- Publication number
- JPH0269159A JPH0269159A JP63219928A JP21992888A JPH0269159A JP H0269159 A JPH0269159 A JP H0269159A JP 63219928 A JP63219928 A JP 63219928A JP 21992888 A JP21992888 A JP 21992888A JP H0269159 A JPH0269159 A JP H0269159A
- Authority
- JP
- Japan
- Prior art keywords
- phytic acid
- iodochlorella
- nutritional
- present
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 235000016709 nutrition Nutrition 0.000 title claims description 18
- 230000035764 nutrition Effects 0.000 title description 2
- IMQLKJBTEOYOSI-GPIVLXJGSA-N Inositol-hexakisphosphate Chemical compound OP(O)(=O)O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O IMQLKJBTEOYOSI-GPIVLXJGSA-N 0.000 claims abstract description 23
- IMQLKJBTEOYOSI-UHFFFAOYSA-N Phytic acid Natural products OP(O)(=O)OC1C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C1OP(O)(O)=O IMQLKJBTEOYOSI-UHFFFAOYSA-N 0.000 claims abstract description 22
- 235000002949 phytic acid Nutrition 0.000 claims abstract description 22
- 229940068041 phytic acid Drugs 0.000 claims abstract description 22
- 239000000467 phytic acid Substances 0.000 claims abstract description 22
- 150000003839 salts Chemical class 0.000 claims abstract description 10
- 230000029087 digestion Effects 0.000 abstract description 3
- 239000007864 aqueous solution Substances 0.000 abstract description 2
- 239000000546 pharmaceutical excipient Substances 0.000 abstract description 2
- 239000000203 mixture Substances 0.000 description 13
- 238000004519 manufacturing process Methods 0.000 description 10
- 230000000694 effects Effects 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- 238000010521 absorption reaction Methods 0.000 description 4
- 235000013305 food Nutrition 0.000 description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- 241000195649 Chlorella <Chlorellales> Species 0.000 description 3
- 229920002261 Corn starch Polymers 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- 239000008120 corn starch Substances 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 239000003623 enhancer Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 210000000936 intestine Anatomy 0.000 description 2
- 239000004310 lactic acid Substances 0.000 description 2
- 235000014655 lactic acid Nutrition 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 235000010755 mineral Nutrition 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 230000003285 pharmacodynamic effect Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 210000000813 small intestine Anatomy 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- JMGZEFIQIZZSBH-UHFFFAOYSA-N Bioquercetin Natural products CC1OC(OCC(O)C2OC(OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5)C(O)C2O)C(O)C(O)C1O JMGZEFIQIZZSBH-UHFFFAOYSA-N 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- -1 Sucrose fatty acid ester Chemical class 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000004534 cecum Anatomy 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000001784 detoxification Methods 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000002183 duodenal effect Effects 0.000 description 1
- IVTMALDHFAHOGL-UHFFFAOYSA-N eriodictyol 7-O-rutinoside Natural products OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OC=2C=C3C(C(C(O)=C(O3)C=3C=C(O)C(O)=CC=3)=O)=C(O)C=2)O1 IVTMALDHFAHOGL-UHFFFAOYSA-N 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 235000002864 food coloring agent Nutrition 0.000 description 1
- 239000000576 food coloring agent Substances 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
- 230000003308 immunostimulating effect Effects 0.000 description 1
- 230000031891 intestinal absorption Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 159000000014 iron salts Chemical class 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- FDRQPMVGJOQVTL-UHFFFAOYSA-N quercetin rutinoside Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 FDRQPMVGJOQVTL-UHFFFAOYSA-N 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 235000005493 rutin Nutrition 0.000 description 1
- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 description 1
- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 description 1
- 229960004555 rutoside Drugs 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- UJMBCXLDXJUMFB-UHFFFAOYSA-K trisodium;5-oxo-1-(4-sulfonatophenyl)-4-[(4-sulfonatophenyl)diazenyl]-4h-pyrazole-3-carboxylate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C1=NN(C=2C=CC(=CC=2)S([O-])(=O)=O)C(=O)C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 UJMBCXLDXJUMFB-UHFFFAOYSA-K 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Abstract
Description
【発明の詳細な説明】
(産業上の利用分野)
本発明は薬剤としての単独使用も可能であるが、通常は
食品、し好品に添加し、各種の栄養強化、例えは便秘、
下痢の改善整腸作用、ビタミン等栄養物質群の吸収促進
剤を有する栄養強化剤に係る。Detailed Description of the Invention (Industrial Field of Application) Although the present invention can be used alone as a drug, it is usually added to foods and favorites to provide various nutritional enrichments, such as constipation,
The present invention relates to a nutritional fortifier that has an intestinal regulating effect for improving diarrhea and an absorption enhancer for nutritional substances such as vitamins.
(従来の技術)
栄養強化剤としては、アミノ酸、無機質、ルチン、ビタ
ミン系薬剤のように直接生体に投与して作用するものと
、乳酸菌のように生体内での有害細菌の増殖を防ぎ、結
果アミノ酸、無機質等の栄養物の腸管吸収を促進し、整
腸作用を有する間接的に生体に作用するものが存在する
。(Prior art) Nutritional fortifiers include those such as amino acids, minerals, rutin, and vitamins that are administered directly to the living body, and those that prevent the growth of harmful bacteria in the living body such as lactic acid bacteria. There are some substances that act indirectly on the living body by promoting the intestinal absorption of nutrients such as amino acids and minerals, and having an intestinal regulation effect.
ヨードクロレラは、本出願人らにより発見された新種ク
ロレラであり、海産クロレラに類した栄養分を多量に含
み、免疫賦活作用、抗老化作用等興味ある薬効か発見さ
れている。Iodochlorella is a new species of chlorella discovered by the present applicants, which contains a large amount of nutrients similar to marine chlorella, and has been found to have interesting medicinal effects such as immunostimulatory and anti-aging effects.
一方、フィチン酸は古くからしられた1ヒ合1勿であり
、乳酸菌の培養促進作用(特公昭39−72686号公
報)、ビタミンCの安定化作用等が報告されている。ま
た、最近解毒作用かあることが本発明者等により発見さ
れている。(特願昭63−140385号)
(発明が解決しようとする課題)
しかし、生体に経口的に投与した場合、ヨードクロレラ
は消化されに<<、従って栄養成分の完全な吸収のため
促進剤を選択開発する必要があった。On the other hand, phytic acid has been known for a long time to have 1-1-1 effect, and its effects on promoting the culture of lactic acid bacteria (Japanese Patent Publication No. 72,686/1986), stabilizing effect on vitamin C, etc. have been reported. Additionally, the present inventors have recently discovered that it has a detoxifying effect. (Patent Application No. 63-140385) (Problem to be Solved by the Invention) However, when administered orally to a living body, iodochlorella is not easily digested. It was necessary to develop a selection.
また、栄養強化剤としてヨードクロレラの消化吸収促進
剤としてフィチン酸またはその塩が利用できるとの報告
例はない。Furthermore, there is no report that phytic acid or its salts can be used as a digestive absorption enhancer for iodochlorella as a nutritional fortifier.
ところが本発明者らは、フィチン酸栄養実験の過程でフ
ィチン酸を経口的に投与したところ、解毒作用等新規な
薬理作用かあることを発見し、さらに追及したところ、
本発明に到達したものである。However, during the course of phytic acid nutrition experiments, the present inventors discovered that phytic acid had novel pharmacological effects such as detoxification when administered orally, and upon further investigation, found that
This has led to the present invention.
(課題を解決するための手段)
この外明は上記知見に基ついてヨードクロレラ及びフィ
チン酸またはその塩からなる栄養強化剤を提1共するも
のである。(Means for Solving the Problems) Based on the above findings, this invention proposes a nutritional fortifier comprising iodochlorella and phytic acid or a salt thereof.
この発明に係わる栄養強化剤は、ヒト及び動物を灯′東
とするものである。The nutritional fortifier according to the present invention is beneficial to humans and animals.
フィチン酸の塩としては、鉄塩の利用がヨードクロレラ
の消化吸収を向上させる意味で最も好ましい。As the phytic acid salt, iron salts are most preferable in terms of improving the digestion and absorption of iodochlorella.
本発明による栄養強化剤は、医薬品、食品、飼ね等とし
て直接あるいは添加され各種の形態で使用される。The nutritional fortifier according to the present invention can be used in various forms as medicines, foods, feed, etc., either directly or as additives.
本発明による栄養強化剤の製造において、フィチン酸ま
たはその塩を水に溶解してそのまま利用することらでき
るが、賦形剤を添加して粉末化したり、更には造粒して
顆粒剤の形に製剤化したものか食品等の添加前として利
用される。In the production of the nutritional fortifier according to the present invention, phytic acid or its salt can be dissolved in water and used as it is, but it can also be powdered by adding excipients or further granulated to form granules. It is used either in formulations or before addition to foods, etc.
また、フィチン酸は強酸であり、かつ、本発明による栄
え強化剤を直接経口投与を主眼としだ場合は、味覚等の
問題から、p[」6〜8程度の各種の塩となしておき、
これらの塩を単独でまたは混合して有効成分となし、経
口投与に適当な製剤となすことかできる。In addition, phytic acid is a strong acid, and when the main purpose of direct oral administration of the phytic acid enhancer of the present invention is to prepare it as various salts with p['6 to 8] due to taste issues, etc.
These salts can be used alone or in combination as active ingredients to form preparations suitable for oral administration.
(発明の効果)
本発明の栄養強(ヒ則は、後記の薬効薬理試験の結果か
ら明らかにヨードクロレラの消化促進を速め、フィチン
酸またはその塩の特性を競合的に向上させ得るものであ
る。(Effects of the Invention) The nutritional strength of the present invention is clearly capable of accelerating the digestion of iodochlorella and competitively improving the properties of phytic acid or its salts from the results of the medicinal efficacy and pharmacology tests described below. .
(実施例等)
次に試1倹例、製剤例に関連して本発明を更に詳細に説
明する。(Examples, etc.) Next, the present invention will be described in further detail with reference to Test 1 and Formulation Examples.
実施例1
薬効薬理試験
薬効薬理試験1(消化管内クロレラ流通時間に対する作
用)
一群8匹の体重200g前後のラントを使用し24時間
飢餓状態にする。試験群には食紅で着色した製造例2の
製剤50%混合飼料を与え、対象群にはヨードクロレラ
のみ50?6混合飼料を与えた。Example 1 Pharmacodynamics Test Pharmacodynamics Test 1 (Effect on Chlorella Distribution Time in the Gastrointestinal Tract) A group of 8 runts weighing around 200g were starved for 24 hours. The test group was given a 50% mixed feed of the preparation of Production Example 2 colored with food coloring, and the control group was given a 50-6 mixed feed containing only iodochlorella.
食後3()分、60分、120分、180分に2匹つつ
殺して、腸を取出し切開し、着色飼料の位置を確認した
。The mice were killed in pairs at 3 () minutes, 60 minutes, 120 minutes, and 180 minutes after eating, and the intestines were removed and incised, and the position of the colored feed was confirmed.
その結果は食後30分では、食物先端部は両群とも胃上
半部に位iff L、60分では胃下部から十二士旨腸
に位置していた。120分後では試験群が小腸内に位置
するに対して、対象群では盲腸部分に達しており、投与
180分では試験群では大腸に全部移転していた。この
結果から、本発明製剤は小腸内での滞留時間を延長する
効果があり、従って吸収時間の延長効果かあるものと判
断した。The results showed that at 30 minutes after eating, the food tip was located in the upper half of the stomach in both groups, and at 60 minutes, it was located from the lower part of the stomach to the duodenal intestine. At 120 minutes after administration, the test group was located in the small intestine, while in the control group it had reached the cecum, and at 180 minutes after administration, it had completely moved to the large intestine in the test group. From this result, it was determined that the preparation of the present invention has the effect of prolonging the residence time in the small intestine, and therefore has the effect of prolonging the absorption time.
IM造例1 フィチン酸組成物の製造法 (フィチン酸組成液の製法) 次の処方に従い、溶解し、フィチン酸組成液とする。IM example 1 Method for producing phytic acid composition (Production method of phytic acid composition liquid) Dissolve and prepare a phytic acid composition solution according to the following recipe.
処方
フィチン酸 365.3gアル
カリ/fl液 1284d(水酸化
カリウム: 3.675N
水酸化すトリウム: 1.25N )
塩1ヒカルシウム 3.368 gリ
ン酸水素二ナトリウム(12水塩) 139.5g精
製水 適量(フィチン酸組
成物の製法)
次の処方に従い、混合乾燥し、
1勿とする。Prescription Phytic acid 365.3g Alkali/fl liquid 1284d (Potassium hydroxide: 3.675N Sothorium hydroxide: 1.25N) Salt 1 Hycalcium 3.368g Disodium hydrogen phosphate (12 hydrate) 139.5g Purified Appropriate amount of water (Production method of phytic acid composition) Mix and dry according to the following recipe and make 1 ml.
処方
フィチン酸組成液
結晶セルロース
トウモロコシデンプン
乳糖
フィチン酸組成
548.6mR
259,0g
259、 Of
送呈
ム 計
500g
(乾燥物として)
製造例2
ヨードクロレラ500
g、乳1! 173
トウモロ
コシデンプン259.、結晶セルロース259g、軽質
無水ケイ酸91fを採取して混合し、この混合物につき
、フィチン酸組成M、549m1及び食用色素黄色5号
15gを溶解した液を噴霧し、乾燥させて細粒状の栄養
強化剤を得た。Prescription Phytic Acid Composition Liquid Crystalline Cellulose Corn Starch Lactose Phytic Acid Composition 548.6mR 259.0g 259, Of Shipping Total 500g (as dry matter) Production Example 2 Iodochlorella 500g, Milk 1! 173 Corn starch 259. , 259 g of crystalline cellulose, and 91 f of light anhydrous silicic acid were collected and mixed, and this mixture was sprayed with a solution containing 549 ml of phytic acid composition M and 15 g of food color yellow No. 5, and dried to form fine granular nutritional enrichment. obtained the drug.
製造例3
ヨードクロレラ700g、フィチン酸組成物80g、V
t、[150g、トウモロコシテンプン60gを採取し
て混合し、この混合物につき、アラヒアゴム10fを溶
解した水溶液を用いてかつ常法により湿式造粒し、乾燥
させて顆粒状の栄養強化剤を得た。Production Example 3 Iodochlorella 700g, phytic acid composition 80g, V
t, [150 g, 60 g of corn starch were collected and mixed, and this mixture was wet-granulated by a conventional method using an aqueous solution in which 10 f of gum arahia was dissolved, and dried to obtain a granular nutritional fortifier. .
製造例2〜4で得た栄養強化剤について、経時的な安定
性試@、f!:行った。Regarding the nutritional fortifiers obtained in Production Examples 2 to 4, stability test over time @, f! :went.
試験は苛酷条件下(50°C530日間及び40°C1
相対湿度75%、30日間)におけるヨード含量及びフ
ィチン酸含量を測定しな。The test was conducted under harsh conditions (50°C for 530 days and 40°C for 1
Measure the iodine content and phytic acid content at 75% relative humidity for 30 days.
結果は、下記の表1及び表2に示される通りであり、い
ずれの栄養強化剤も安定であり、外観においても変化は
認められなかった。The results are shown in Tables 1 and 2 below, and all nutritional fortifiers were stable, and no change was observed in appearance.
製造例4
製造例3で得た顆粒剤90gにショ糖脂肪酸エステル2
gを添加して混合し、回転型錠剤成形機により直径9m
m、重量200■の錠剤を製し、栄養節1ヒ斉1jを得
た。Production Example 4 Sucrose fatty acid ester 2 was added to 90g of the granules obtained in Production Example 3.
g, mixed, and made into a 9 m diameter tablet using a rotary tablet molding machine.
Tablets with a weight of 200 cm and a weight of 200 cm were prepared to obtain a nutritional value of 1 j.
実施例2 表1 表2Example 2 Table 1 Table 2
Claims (1)
養強化剤。A nutritional fortifier consisting of iodochlorella and phytic acid or its salt.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP63219928A JPH0269159A (en) | 1988-09-02 | 1988-09-02 | Nutrition enriching agent |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP63219928A JPH0269159A (en) | 1988-09-02 | 1988-09-02 | Nutrition enriching agent |
Publications (1)
Publication Number | Publication Date |
---|---|
JPH0269159A true JPH0269159A (en) | 1990-03-08 |
Family
ID=16743216
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP63219928A Pending JPH0269159A (en) | 1988-09-02 | 1988-09-02 | Nutrition enriching agent |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPH0269159A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006070912A (en) * | 2004-08-31 | 2006-03-16 | Jatco Ltd | Lubricating structure of transmission unit |
-
1988
- 1988-09-02 JP JP63219928A patent/JPH0269159A/en active Pending
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006070912A (en) * | 2004-08-31 | 2006-03-16 | Jatco Ltd | Lubricating structure of transmission unit |
JP4672312B2 (en) * | 2004-08-31 | 2011-04-20 | ジヤトコ株式会社 | Transmission unit lubrication structure |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU759388B2 (en) | Pharmaceutical compositions containing lipase inhibitors and chitosan | |
KR101361379B1 (en) | Nutrient composition | |
JPH04128223A (en) | L-carnitine-containing preparation | |
JPH06500552A (en) | Calcium and trace mineral supplements | |
EP0382355A2 (en) | Growth promoting agent for bacteria containing pullulan and/or dextran | |
WO1998019675A1 (en) | Use of conjugated linoleic acid to enhance natural killer lymphocyte function | |
PT1481676E (en) | Phytoestrogens and probiotic for women`s health | |
ES2242770T3 (en) | PROCEDURE FOR THE PRODUCTION OF A GRANULABLE MIXTURE AND CARNITINE AND MAGNESIUM HYDROXICITRATE. | |
JP2005119983A (en) | Nutritive composition | |
EP1393636A1 (en) | Biologically active food additive and biologically active forage additive for preventing iodine deficiency and optimising iodine metabolism, food and forage products containing said additives | |
JPH08503964A (en) | Dietary hypocholesterolemic composition | |
WO2003024438A1 (en) | Composition comprising cysteamine for improving lactation in dairy animals | |
AU2002333863A1 (en) | Composition comprising cysteamine for improving lactation in dairy animals | |
KR100927254B1 (en) | Liquid compositions comprising branched amino acids and preparation methods thereof | |
CN108740305B (en) | Special calcium tablet for perinatal dairy cows and preparation method thereof | |
CN110584120A (en) | Bone health composition | |
JPH1036256A (en) | Anti-osteoporosis composition | |
JPH0269159A (en) | Nutrition enriching agent | |
KR100424660B1 (en) | Vitamin-enriched nutritional food composition comprising Bacillus polyfermenticus KCCM 10104 effectively for prevention of intestinal disorders | |
JP3279694B2 (en) | Mineral absorption enhancer containing lactulose oligosaccharide as active ingredient | |
JPH09154535A (en) | Natto (fermented soybean)-containing composition | |
JP2009013143A (en) | Sleep-improving composition | |
JPS6114124B2 (en) | ||
KR100424661B1 (en) | The composition of supplementary health-food comprising Bacillus polyfermenticus KCCM 10104 effectively for prevention of intestinal disorders | |
JPH09121811A (en) | Easily absorbable calcium composition |