JPH0263189B2 - - Google Patents

Description

[Detailed Description of the Invention] [Industrial Application Field] The present invention is applicable to biochemical analyzers, epidemiological testing equipment for cancer, etc., serum testing equipment, etc. by injecting a fixed amount of a specimen into a test tube or test dish. This invention relates to a device that fully automatically performs tip feeding/insertion work in a dispensing machine used for.

[Prior Art] This kind of conventional dispensing work was carried out by a female worker using a manual pipette. Even in today's most advanced automatic machines, the aspirating and dispensing of specimens and the movement of test tubes were done automatically, but none of them automatically inserted a new tip into the nozzle that aspirates and dispenses a fixed amount of specimen. It was hot.

In other words, in the dispensing process, the most important issue is dispensing different types of samples with the same nozzle, as well as strict quantitative dispensing of the sample, and when dispensing extremely dangerous factors such as hepatitis bacteria, etc. Contact with other specimens must be avoided at all costs. When using a manual pipette, a new tip was inserted in advance, and each time the sample was changed, the used tip was removed by hand and discarded. This had the disadvantage of contaminating and staining the newly inserted chip with a small amount of sample. In addition, in the case of automatic dispensing machines, the nozzle tip is fixed, so attempts have been made to prevent mixing by washing the inside and outside with water or air, or wiping with paper or a brush. It is impossible to eliminate residual bacteria with this level of cleaning treatment.
Mixing in the strict sense could not be prevented, and it was not as effective as exchanging chips.

Moreover, when replenishing the stock of chips in the magazine mechanism of the automatic dispensing machine, the chips are picked up one by one by hand and inserted in order to form a continuous insert consisting of a predetermined number of chips, and the continuous insert is inserted into the magazine mechanism. Insert into.

The above operations have to be repeated multiple times, which is troublesome and time-consuming.During this time, the feeding/insertion device cannot operate, which is extremely inconvenient, and also prevents chips that may come into contact with the hands during the operation. There is a risk that bacteria or dirt may adhere to the device, that similar chips of different types may be inserted during operation, or that foreign objects such as paper or vinyl may be mixed in with the continuous insert during operation.

[Problems to be Solved by the Invention] Therefore, in view of the seriousness of the mixing that must be avoided, the present invention provides a cassette containing a sufficient number of chips to accommodate the number of test tubes set on a dispensing work table. Easy to set up, effective for automatically and continuously feeding new tips one by one to the tip of the dispensing nozzle as the dispensing process progresses. It is intended to provide a feed insertion device.

[Means for Solving the Problems] A first embodiment of the present invention will be described with reference to FIGS. 1 to 3.

The device of the present invention is a dispensing tip cassette γ in which a plurality of tip connecting bodies β in which a predetermined number of tips α with a two-stage flange α ₁ are loosely inserted vertically are housed in a row in a line with equal intervals of tips P.
At least one extraction hole 1c (in this embodiment, two holes are shown) are inserted into the stock chamber 1a and are inserted through the bottom part 1b of the magazine case 1 at equal pitches p in the traveling direction. A magazine mechanism A that conveys the magazine box 1 in pitches along a guide plate 2 that supports and guides the lower end of the group of chip series β that has protruded from the group, and a magazine mechanism A that inserts between the central part of the guide plate 2 and advances and retreats intermittently. When the slide plate 6, which is provided to be able to slide back and forth, is in the most retracted position, the lower ends of the tip connecting inserts β, β which are positioned and stopped on the slide plate 3 are released, and the tip connecting members β, β are allowed to fall vertically under their own weight. A slide mechanism B having pit holes 3a and 3b with mutually spaced 2 pitches 2p extending through the slide plate 3;
7 are provided so that they can be opened and closed, respectively.
The lowest chips α, α of the chip series β, β falling from b are once caught and clamped by the pair of clamping pieces 6, 7 on the lower stage, and then by the pair of clamping pieces 4, 5 on the upper stage.
upper and lower stage and clamping separation mechanisms C and D that alternately open and close the chips α and α of the chip connecting bodies β and β to lower and stage and separate the chips one by one from the bottom; The chips α and α, which are vertically separated and falling, are stopped and waited directly under the mechanism D, and are separated into two pitches.
A transfer mechanism E that can freely move back and forth intermittently moves the holding plate 8 received and held by the receiving holes 8a and 8b at 2p intervals to the chip insertion work position and stops at the position, and the holding plate 8 is held and waited at the chip insertion work position. Chip α, α
Each nozzle 10, 10 of the dispensing pump 9, 9 from directly above
It consists of a dispensing pump elevating mechanism F that is inserted and raised by pushing in its tip, and is installed and installed at the positions shown in FIGS. 4 and 5 of the dispensing machine Y, respectively.

In the figure, ε is a test tube set up on a dispensing work rack δ.

As shown in FIGS. 1 and 6, the magazine mechanism A includes a feeding means A ₁ for horizontally reciprocating transport along the guide plate 2, a locking means A 2 for immovably fixing the positioning stop, and a horizontal transporting means A ₂ for immovably fixing the positioning stop. A first support and guide means A ₃ and a second support and guide means A ₄ are installed on the back side of the magazine box 1 for smoothly supporting and guiding the magazine box 1 by regulating vertical, horizontal, and longitudinal vibrations.

The feeding means A ₁ has a belt clamp 1 stuck to the center of the back side of the magazine box 1, and both ends of the feeding means A 1 are passed over the upper ends of a pair of left and right spacers 12 and 13 planted at the rear of both left and right ends on the guide plate 2. A protruding shaft 15 protruding toward the left end in the sideways forward channel 14
A driven timing pulley 16 that protrudes so that it can freely rotate
and a driving timing pulley 18 fixed to the front end of a pulley shaft 17 which is rotatably supported through the right end.
The timing belt 19 is stretched horizontally endlessly, and the timing belt 24 is stretched between the large timing pulley 20 fixed to the rear end of the pulley shaft 17 and the small timing pulley 23 fixed to the outer end of the motor shaft 22 of the pulse motor 21. The rotational torque of the pulse motor 21 is transferred to the timing belt 2 by fixing the other belt clamp 11 at one point in the upper direction of the timing belt 19.
4. Large timing pulley 20, pulley shaft 1
7. The magazine box 1 is horizontally moved from side to side via a driving timing pulley 18 and a timing belt 19.

The first support guide means _A3 has an abacus bead-shaped guide roller 27 and a back-up roller 28 attached to the tips of roller shafts 25 and 26 that protrude relative to each other diagonally up and down to the left and right at the upper part of the back side of the magazine box 1, respectively, so as to be freely rotatable. On the other hand, a V-groove guide rail 30 horizontally extended on the front upper end of the stand frame 29 is sandwiched between a guide roller 27 and a back-up roller 28 from above and below so as to be freely movable.

The second support guide means A ₄ has a slide block 32 with a slide groove 31 horizontally extending at a predetermined location on the lower side of the back side of the magazine case 1, and a hook portion of a "shaped guide rail 33" which extends cantileverly over the entire length of the lower side of the channel 14. 3
3a is engaged with the upward slide groove 1.

The locking means A ₂ is attached with a gauge 34 in which a group of positioning grooves 34 a are carved across the back area of the magazine box 1 in the lateral direction directly above the belt clamp 11;
The outer end of the movable core 37 of the solenoid 36 installed laterally near the rear end of the rack plate 35 that is shelved over the channel 14 and inside the stand frame 29 is attached to the rack plate 35 with the center portion of the solenoid 36 using a fulcrum step screw 38. One end of the pivotally fixed L-shaped lever 39 is pivotally connected, and the other end of an intermediate link 41 is pivotally connected with a connecting screw pin 40 to form a center-folding toggle mechanism near the other end. Attach the fulcrum step screw 4 near the front end of the rack plate 35.
2, the lock lever 43 is pivotally fixed by a connecting screw pin 44 near the tip bending claw 43a, so that the tip bending claw 43a faces the positioning groove 34a that brings it freely, and the other L-shaped. A return repellent strip 46 is stretched across the other end of the lever 39 and a repellent retaining pin 45 set on the frame plate 39 to prevent the movable iron core 37 from moving out at all times and to the positioning groove 34a of the bending claw 43a at the tip of the lock lever 43. By energizing the solenoid 36, the tip bending claw 43a is pulled out of the positioning groove 34a against the elastic tensile force of the return repellent strip 46, as shown in FIG. , the group of positioning grooves 34a is arranged at the pitch p of the magazine case 1 and the group of chip connecting inserts β built in a line in a line with a pitch p interval in the cassettes γ, γ fitted into the stock chamber 1a of the magazine case 1. They are provided at positions corresponding to the extraction holes 1c group and having a repeating relationship of 1:3:1:3 pitch p.

FIG. 9 shows a magazine mechanism A' into which one cassette γ can be inserted and accommodated, and the same parts as those of the magazine mechanism A are given the same reference numerals.

As shown in FIGS. 10 and 11, the slide mechanism B includes a slide hole 3c in the front center protrusion on the slide 47, a pair of left and right slide holes 3d on the rear side,
3e is attached with guide step screws 48, 49, and 50 so that it can slide forward and backward, and there are 2 pitches on the front half side.
A connecting screw pin 51 is attached to the center of the rear end of the slide plate which has a pair of left and right drop holes 3a, b spaced apart from each other.
The other end of the short link 52 is pivotally connected to one end of the short link 52 by a connecting screw pin 55, and the other end of the short link 52 is pivotally connected to one end of a lever 54 whose center is movable by a fulcrum screw 53.
The other end of the lever 54 was pivotally connected to the outer end of a movable core 58 inserted into a solenoid 57 placed on a pedestal 56 with a connecting pin 59, and one end of the other lever 54 was planted on the pedestal 56. A return plucking strip 61 is stretched over the plucking strip retaining pin 60 to always urge the movable iron core 58 to move out and the slide plate 3 to move backward, and when the slide plate 3 is at the most retracted position, the drop hole 3a is , 3b and the extraction hole 1c in the bottom part 1b of the magazine box 1 waiting to be stopped.
1c, and by driving the solenoid 57, the slide plate 3 resists the tensile elastic force of the return repellent strip 61.
is configured to operate forward.

As shown in FIG. 12, the upper and lower stage clamping separation mechanisms C and D are composed of a pair of front and rear upper and lower stage clamping pieces 4, 5, 6, and 7, which are movably held so that they can be freely opened and closed back and forth. There are two pitches on the edge that can freely hold the upper flange α ₁ ″ of the second chip α from the bottom, and the lower side of the lower flange ₁ ′ of the lowest chip α on the relative edges of the lower clamping pieces 6 and 7. 2p A pair of left and right semicircular holes 4a, 4b, 5a, 5b, 6a, 6b, 7 spaced apart from each other
Upper and lower stage left and right operating means C ₁ , C ₂ , D 1 , and D _{2 are provided with the upper and lower stage front and rear holding pieces 4 , 5 , 6 , and 7 at both left and right ends of the upper and lower stage front and rear gripping pieces 4 , 5 , 6 , and 7} to operate the front and back, separation, and _opening /closing movements. Install the upper and lower front and rear clamping pieces 4, 5, 6, respectively.
7 can alternately open and close the upper and lower stages left and right operating means C ₁ ,
C ₂ , D ₁ , and D ₂ are constructed by a single disc grooved cam 62 that can be freely controlled.

As shown in FIGS. 13 to 14, the lower left and right actuating means D ₁ and D ₂ are disk groove cams 62 fixed to a cam shaft 65 between the upper deck 63 and the lower deck 64 that pass through the lower deck so as to be rotatable. A cam follower 66 that engages with the cam groove 62a is attached to the first corner so that it can freely rotate, and the second corner is attached to the lower floor board 64 via the pillow member 67' with the fulcrum step screw 6.
One end of the link 69 is pivotally connected to the third corner of the triangular lever 68 which can be freely levered at 7 with a pin 70, and the other end is connected to the first corner of the triangular interlocking lever 71 with a screw pin 72. Projecting pieces 71a, 71 on both sides of the second corner of the triangular interlocking lever 71 are pivotally connected and pivotably fixed to the lower staircase 64 with a fulcrum step screw 73.
A relay pin 74 and a freely rotatable right rear trochanter 75 are protruded from each of b, and the center is pivotally fixed to the lower deck board 64 with a fulcrum step screw 76, and one end of the bifurcated jaw portion 77a is secured to the jaw with the relay pin 74. A right front trochanter 78 that can freely rotate is protruded from the other end of the connected L-shaped lever 77, and the upper end is attached to the third corner of the triangular continuous lever 71 by a pivoting screw 7.
9, and one end of the first intermediate link 82 is pivotally connected to the lower end of a short shaft 80 passing through the elongated hole 64a of the lower floor board 64 with a pivot screw 81, and the center portion is attached to the lower floor board. 64 A connecting pin 8 is attached to one end of an intermediate lever 85 which is pivotally fixed by a fulcrum step screw 84 via a pillow member 83 on the lower side.
6, and the other end of the second intermediate link 88, which has one end pivotally connected to the other end of the intermediate lever 85 with a pin 87, is pivotally connected to the lower end with a pivot screw 89, and the lower floor board 64
One end of a T-shaped lever 92, whose center portion is pivotally fixed to the lower floor board 64 with a fulcrum step screw 91, is pivotally attached to the upper end of a short shaft 90 passing through the elongated hole 64b with a pivot screw 93,
In addition, a relay pin 94 and a freely rotatable left front trochanter 95 are protruded from the other end and the center protrusion, respectively, and a fulcrum step screw 96 is pivotally fixed to the lower floor board 64 at the center part, and one end of the two-stage jaw part 97a is attached to the pin 94. Connected L-shaped lever 97
A freely rotatable left rear trochanter 98 protrudes from the other end, and the left and right front and rear trochanters 75, 78, 95, and 98 groups face each other in a symmetrical manner, and guide the lower floor board 64 so that it can be opened and closed forward and backward. Slide hole 6 in protrusion 99, 100
Left and right mouth grooves 6d, 6e, respectively, are provided at both left and right ends of the pair of front and rear gripping pieces 6, 7 into which the grippers 6d, 7c are loosely fitted.
Left and right anteroposterior trochanter 7 corresponding to 7d and 7e respectively
5, 78, 95, 98 are connected, and the disc groove cam 6 is installed.
The front and rear clamping pieces 6 and 7 are rotated in accordance with one rotation of 2.
It is configured to open and close, and the lower floor board 64 has half circular holes 6a, 7a, 6b, with front and rear clamping pieces 6, 7 closed.
Holes 64c and 64d are provided at positions corresponding to holes 7b, respectively.
It is made by penetrating it.

In the figure, reference numeral 101 denotes an upper restraining member for the front and rear holding pieces 6, 7.

In addition, a driven gear 102 fixed to the lower end of the camshaft 65
A pinion 103 externally engaged with the table frame 104 is fixed to the upper end of a motor shaft 106 of a motor 105 fixed to the table frame 104.

As shown in FIGS. 13 to 15, the upper left and right actuating means C ₁ and C ₂ include a disc groove cam 62 and a cam groove 6.
A triangular lever 109 has a cam follower 107 that engages at a position 180 degrees opposite to the cam follower 66 of 2a, and is freely rotatable at the first corner, and the second corner is movable from the lower floor board 64 with a fulcrum step screw 108. One end of the link 110 is fixed to the third corner of the link 110, and the lower end of the link 110 is pivotally connected to the other end of the link 110, and the third corner of the triangular interlocking lever 111 is attached to the upper end of the short shaft (not shown) passing through the notch 63a of the upper staircase 63. One corner is pivoted with a pivot screw 112, and a fulcrum step screw 1 is attached to the upper floor board 63.
Projecting pieces 111a and 111b on both sides of the second corner of the triangular interlocking lever 111, which is pivotably fixed at 13.
A relay pin 114 and a freely rotatable left rear trochanter 115 are protruded from each side, and the center is pivotally fixed to the upper floor board 63 with a fulcrum step screw 116, and one end is a two-step jaw portion 117a.
The L-shaped lever 1 is connected with the relay pin 114.
A freely rotatable left front trochanter 118 protrudes from the other end of the lever 17, while its upper end is pivotally connected to the third corner of the triangular interlocking lever 111 with a pivot screw 119, and passes through the elongated hole 63b of the upper floor plate 63. A first intermediate link 121 whose one end is pivotally connected to the lower end of the short shaft 120 by a pivot screw (not shown).
Attach the other end to the pillow member 122 and the center part to the lower floor board 63 side.
In addition to a second intermediate link 127, which is pivotally connected to one end of an intermediate lever 124 which is pivotably fixed by a fulcrum step screw 123, by a connecting pin 125, and whose other end is pivotally connected to one end by a connecting pin 126. A short shaft 12 whose end is pivoted to the lower end and passes through the long hole 63c of the upper floor board 63
8 At the top end, connect the center part to the upper floor board 63 with a fulcrum step screw 129
One end of the T-shaped lever 130, which is pivotally fixed in a freely movable manner at The part is pivotally fixed to the upper floor board 63 with a fulcrum step screw 134, and one end is connected to the bifurcated jaw part 1.
L-shaped lever 135 with 35a tied to pin 132
A right rear trochanter 136 that can freely rotate freely protrudes from the other end, and left and right front and rear trochanters 115, 118, 133, and 136 groups face each other in a symmetrical manner, and guide the upper floor board 63 so that they can be opened and closed forward and backward. Left and right mouth grooves 4 are provided at both left and right ends of a pair of front and rear gripping pieces 4 and 5 in which slide holes 4c and 5c are loosely fitted into protrusions 137 and 138, respectively.
The left and right front and rear rotors 115, 118, 133, and 136 corresponding to d, 4e, 5d, and 5e, respectively, are tied together to follow and interlock with one rotation of the disc grooved cam 62, and the lower front and rear clamping pieces 6, 7 The opening/closing movement is configured to open/close by 180 degrees rotationally, and the upper floor plate 63 has half circular holes 4a and 5 when the front and rear clamping pieces 4 and 5 are closed.
Holes 63 are provided at positions corresponding to a, 4b and 5b, respectively.
d and 63e are installed through the hole.

In the figure, reference numeral 139 indicates an upper restraining member for the front and rear holding pieces 4 and 5.

As shown in FIGS. 1 to 3, the transfer mechanism E
is detected by the sensor S ₀ at the most retracted position, and the receiving hole 8a receives and inserts and holds the lower flange α ₁ ′ of the chips α, α that are separated and dropped by the clamping and separating mechanism D. _{. _} It consists of a feeding means _E2 for conveying. The holding plate 8 has a planar shape, and has its base end fixed in a cantilever manner to the upper end of the transfer body 140, and has a light emitter _L1 and a light receiver _L2 on opposite sides in the diametrical direction of the inner peripheral surfaces of the receiving holes 8a and 8b, respectively. The guide means _E1 extends in the front and back direction within the table frame 104 and is embedded in the front and back slide blocks 14 of the transfer body 140.
A guide rod 143 that passes through the 1,142 smooth holes 141a and 142a in an axially slidable manner, and a bit-fitting slide piece 144 that extends parallel to the guide rod 143 and is fixed to the lower end of the retaining plate 8, The table frame 104 is made up of a guide beam 145 that is slidably inserted into the table frame 104, and a chip insertion work column 146 that supports the lower side of the holding plate 8 between the receiving holes 8a and 8b at its upper end is placed at the most advanced position of the holding plate 8. ,1
It is installed upright on the front base frames B and F.

The feeding means _E2 extends between a driven timing pulley 147 which is freely rotatable at the front end between the guide rod 143 and the guide beam 145, and a driving timing pulley 150 which is fixed to the outer end of the shaft 149 of the pulse motor 148 at the rear end. Guide rod 1
43 and the guide beam 145, a timing belt 151 is stretched endlessly in parallel with the guide beam 145, and the lower plate 15 of the transport body 140 is placed above the timing belt 151.
It is formed by locking a belt clamp 153 attached to 2.

As shown in FIGS. 3 to 5, the dispensing pump elevating mechanism F includes a guide beam that is fixed at one end to a wall frame 154 erected toward the front of the table frame 104 and horizontally cantilevered forward. Each reversible motor 15 along the frame 155
A pair of left and right hanging shafts 15 are movable together with 6, 157 and have dispensing pumps 9, 9 attached to them, respectively.
8 and 159 are suspended parallel to each other at a predetermined interval, and pinions 160 and 161 are connected to the reversible motor 15 and are engaged with racks 158a and 159a, respectively, which are carved and extended in the axial direction on the outer circumferential surface 1 of the hanging shafts 158 and 159.
6,157 Hanging shaft 15 fixed to the outer ends of shafts 162, 163 and brought to the most advanced position above chip insertion work column 146 along guide beam frame 155
The reversible motors 156, 157 are driven in the forward direction to vertically lower the chip insertion work column 1.
Receiving holes 8a and 8b of the holding plate 8 placed on standby on 46
After inserting the tips α and α by pushing the tips of the nozzles 10 and 10 attached to the lower surface of the dispensing pumps 9 and 9 into the tips α and α held at the lowermost positions, respectively, the reversible motors 156 and 157 are inserted. It is configured to be driven in reverse and vertically raised to the upper limit position.

The interlocking operation timing and operation command signals of each mechanism A to F of the fully automatic tip feeding/inserting device of the present invention provided in the dispensing machine Y are determined by a computer or a sequencer.

[Function] Since the present invention is constructed as described above, the cassettes γ, γ are inserted into the insertion stock chamber 1a of the magazine box 1 in a manner that allows them to be withdrawn and replaced before starting the apparatus of the present invention, and are wound outwardly. Set aside the seal tape T.

First, in the magazine mechanism A, the pulse motor 21 is driven to adjust the pitch of the timing belt 19 to p.
The first support guide means integrally feeds the magazine box 1.
_A3 and the second support guide means _A4 , on the guide plate 2, from the extraction hole 1c group in the bottom 1b of the magazine box 1 for the group of chip inserts β loaded and housed in the cassettes γ and γ. When the magazine box 1 reaches the rightmost position by supporting and sliding the protruding lower end, the solenoid 57 shown in FIG. Then, the slide plate 3 is brought to the most retracted position, and the left and right drop holes 3a and 3b match the lower ends of the first and third chip connecting bodies β and β from the right side, so that the chip connecting bodies β and β are Losing support, it fell vertically downward under its own weight from the left and right drop holes 3a and 3b, and as shown in FIG.
At this stage, the semicircular holes 4a, 5a, 4 of the front and rear clamping pieces 4, 5 of the front and rear clamping pieces 4, 5 are raised by the rotational position of the disc cam groove 62 shown in FIG.
The semicircular holes 6a, 7a, 6b of the front and rear clamping pieces 6, 7 pass between b and 5b and are closed by the clamping separation mechanism D.
and 7b receive and clamp the lower side of each lower flange α', and are moved upward by further rotational displacement of the disc cam 62, and close the front and rear clamping pieces 4 and 5 of the clamping separation mechanism C toward each other, thereby forming a semicircular hole. 4a and 5a, 4b and 5b are used to clamp and receive the lower side of each upper stage collar α'' of the second chip α, α from the bottom of the chip connecting bodies β, β, and then lower it to the front and rear clamping pieces of the clamping separation mechanism D. 6 and 7 The lowest chips α and α, which are released from each other and separated from each other, separate and fall under their own weight, and the chips α and α that have separated and fallen are finally retreated from the lower side of the lower flange α′. When the holding plate ₈ is inserted and held in the receiving holes 8a and 8b of the holding plate 8, which is on standby after being detected by the sensor S0, the pulse motor 148 is driven by the light-blocking detection signals from the emitter and receiver of the sensors _S1 and _S2 , and the timing is set. Transfer body 140 via belt 151
is moved forward along the guide rod 143 and guide beam 145, and at the most advanced position, the holding plate 8
The chips α and α held in the receiving holes 8a and 8b of the holding plate 8 are held on the chip insertion work pillar 146 and then held on the chip insertion work pillar 146 directly above the receiving holes 8a and 8b of the holding plate 8. The hanging shaft 1 has already moved and stopped along the guide beam frame 155 at the most retracted position.
58, 159, and the pinions 160, 161 and the rack 1 by driving the reversible motors 156, 157 in normal rotation.
58a and 159a, the tips of the nozzles 10 and 10 are inserted into the tips α and α, and then pushed firmly at the lowest position to remove the nozzle 1.
After inserting chips α and α into the tips of 0 and 10, the reversible motors 156 and 157 are driven in reverse to rotate the hanging shaft 15.
8, 159 and insert the tips α, α into the tips of the nozzles 10, 10 while inserting them into the receiving holes 8 of the holding plate 8.
At the same time, the transfer body 140 is moved back along the guide rod 143 to the most retracted position.

After the lowermost chips α and α are separated by the upper and lower stage clamping and separating mechanisms C and D, the front and rear clamping pieces 4 and 5 of the upper and lower stage clamping and separating mechanism D are approached and closed, and the upper and lower clamping and separating mechanisms are assembled. The aforementioned clamping pieces 4 and 5 of C are separated and covered, and the lower part of the lower flange _α1 ' of the chips α and α, which have become the new lowest position, is lowered, and the semicircular holes 6a and 7a of the clamping separation mechanism D are opened. 6b and 7b are respectively received and held, and the chips α and α of the chip connecting bodies β and β are lowered and separated one by one from the bottom by alternately opening and closing the clamping and separating mechanisms C and D. At the same time, in the magazine mechanism A, after the rightmost and third chip connecting bodies β, β and the uppermost chips α, α are completely submerged from the drop holes 3a, 3b, the left and right receiving holes 8a, When the emitter and receiver of the sensors S ₁ and S ₂ installed in the sensor 8b do not emit a light shielding detection signal even after a predetermined period of time has elapsed, the solenoid 36 shown in FIG. The bending claw 43a at the tip of the lock lever 43 is pulled out of the positioning groove 34a of the gauge 34 to release the magazine box 1, and at the same time, the solenoid 57 shown in FIG. The pulse motor 21 in Fig. 1 returns to
If you move the magazine box 1 forward one pitch p at a time, the second and fourth extraction holes 1c and 1c from the right will be reached.
The tip connecting bodies β, β whose lower ends are exposed are positioned and stopped on the slide plate 3, and the solenoid 36
is energized to engage the bending claw 43a at the tip of the lock lever 43 into the positioning groove 34a of the gauge 34 against the tensile elastic force of the return bar 46.
is fixed immovably, the solenoid 57 is demagnetized, and the slide plate 3 is brought to the most retracted position by the action of the return repellent 61 and falls from the drop holes 3a and 3b. In short, the solenoids 36 and 57 are activated only when the light shielding detection signals from the emitters and light receivers of the sensors S ₁ and S ₂ installed in the left and right receiving holes 8a and 8b are not emitted even after a predetermined period of time has elapsed. The pulse motor 21 is driven to move the magazine box 1 forward by the number of pitches (1 pitch and 3 pitches are repeated alternately) according to a predetermined program, and at the same time as the positioning is stopped, the solenoids 36 and 57 are demagnetized. Each time, the magazine box 1 is locked, the slide plate 3 is retracted completely, and the chip connecting bodies β, β are vertically dropped into the drop holes 3a, 3b.

In addition, in the embodiment of the present invention, two chip connected bodies β, β and two chips α,
Although we have exclusively explained cases in which α is processed in parallel, the present invention is not limited to this, and when processing one chip concatenation β and one chip α separated from it,
Alternatively, a case where two or more are processed in parallel is also naturally included in the present invention.

In addition, since the cassette γ is used to replenish the chip stock in the magazine box 1, it can be completed quickly with just a few operations.This greatly simplifies the stock replenishment work, so one operator can handle several dispensing machines. operation becomes possible. In addition, there is no need for the operator to touch the chips at all during stock replenishment work, and there is no need to worry about the mixing of similar chips of different types, which can reduce mechanical failures and reduce the number of mechanical failures that have previously been associated with chip stock replenishment work. Eliminates various inconveniences, and also improves the transportation, storage and counting management of chips,
Inventory management can also be performed easily and reliably.

In this way, in the present invention, the operation of supplying and inserting chips into the dispensing pump nozzle after replenishing the tip stock is fully automatic and does not involve any operator's hands. Since a clean tip can be inserted into the tip of the dispensing pump nozzle, it is possible to avoid contamination, and the risk of worker infection due to frequent contact with specimens, which conventionally occurred, is eliminated.Moreover, with the present invention, multiple samples can be processed in parallel, making it possible to avoid contamination. It has excellent effects such as rationalization, efficiency, efficiency, safety, labor saving, mechanization, speeding up, and large-scale processing of note work.

[Brief explanation of the drawing]

Figure 1 is a partially omitted schematic perspective view of the magazine mechanism, slide mechanism, vertically arranged clamping/separating mechanism, and transfer mechanism, Figure 2 is a diagram of the same arrangement, and Figure 3 is the transfer mechanism and dispensing shaft pump. A front perspective view of the main parts of the lowering mechanism,
4 and 5 are side views and partially cutaway front views of a dispensing machine incorporating the device of the present invention, FIG. 6 is a side view of the magazine mechanism, and FIGS. 7 and 8 are locking means. FIG. 9 is a front perspective view showing another embodiment of the magazine mechanism, FIGS. 10 to 11 are plan and side views of the slide mechanism, and FIG. A schematic explanatory diagram of the upper and lower row left and right operating means, FIG. 13 is a plan view of the lower row and clamp separation mechanism, FIG. 14 is an assembled side view of the upper and lower row and clamp separation mechanism, and FIG. 15 is a plan view of the upper and lower row and clamp separation mechanism. It is a diagram. α……Chip, α ₁ ……Second tsuba, α ₁ ″……Upper tsuba,
α ₁ ′...Lower flange, β... Chip connecting body, γ... Cassette, p... Pitch, A, A'... Magazine mechanism, A ₁ , E ₂ ... Feeding means, A ₂ ... Lock means,
_A3 ...First support and guide means, _A4 ...Second support and guide means, B...Slide mechanism, C...Upper stage clamp separation mechanism, D...Lower stage clamp separation mechanism, _C1 ,
C ₂ ... Upper left and right operating means, D ₁ , D ₂ ... Lower left and right operating means, E ... Transfer mechanism, E ₁ ... Guide means, F
...dispensing pump lifting mechanism, S ₀ , S ₁ , S ₂ ... sensor, 1 ... magazine box, 1a ... fitted stock chamber, 1b ... bottom, 1c ... extraction hole, 2 ... guide Board, 3...slide board, 3a, 3b...pithole,
4-7...Holding piece, 8...Holding plate, 8a-8b...
... Receiving hole, 9 ... Dispensing pump, 10 ... Nozzle, 1
1,153...Belt clamp, 16,147...
... Driven timing pulley, 18,150 ... Driving timing pulley, 19,151 ... Timing belt, 27 ... Guide roller, 28 ...
Backup roller, 30, 33... Guide rail, 31... Slide groove, 52... Short link,
54...Lever, 57...Solenoid, 58...
Movable iron core, 61...Return strip, 140...Transfer body, 143...Guide rod, 145...Guide beam, 146...Chip insertion work column, 156,
157... Reversible motor, 158, 159... Hanging shaft, 158a, 159a... Rack, 160,1
61...pinion, 162,163...shaft.

Claims (1)

[Scope of Claims] 1. Inserting and removing at least one dispensing tip cassette into the stock chamber, which contains a plurality of tip inserters in which the required number of tips with two-stage flanges are loosely inserted vertically, arranged in parallel at equal pitch intervals. Pitchly transporting the magazine box along guide plates that support and guide the lower ends of the chip series insert groups that protrude from the extraction holes that are inserted through the bottom of the freely inserted magazine box at equal pitch intervals in the direction of travel. a magazine mechanism that releases the support for the lower end of the chip connecting body and drops vertically by a slide plate inserted between a predetermined portion of the guide plate so as to be able to move back and forth intermittently; The lowermost tip of the falling chip series inserter is installed in two upper and lower levels so that they can be opened and closed, respectively, and is once caught and clamped by a pair of clamping pieces on the lower level, and then opened and closed alternately with a pair of clamping pieces on the upper level. The upper and lower stage clamping and separating mechanism lowers the chips of the chip connecting body one by one from the bottom and separates them, and the chips that stop and wait directly below the lower stage, clamping and separating mechanism are vertically separated and dropped. The nozzle tip of the dispensing pump is inserted into the tip of the dispensing pump from directly above the chip being held and waiting at the chip insertion work position. A fully automatic chip supply/insertion device for a dispensing machine, which is equipped with a dispensing pump elevating mechanism that pushes in, inserts, and raises a dispensing pump. 2. The slide mechanism, the vertically arranged clamping and separating mechanism, the transfer mechanism, and the dispensing pump elevating mechanism are configured to be able to freely process at least two or more chip connecting bodies and separating chips, respectively. Fully automatic tip feeding/insertion device for dispensing machines. 3. The magazine mechanism includes a feeding means for horizontally pitch-transporting the magazine along the guide plate, a locking means for immovably fixing the positioning stop, and a first support for smoothly supporting and guiding the magazine by regulating vertical and horizontal vibrations during horizontal transportation. 3. A fully automatic tip feeding/inserting device for a dispensing machine according to claim 1 or 2, wherein the guide means and the second support guide means are respectively attached to the back side of the magazine box. 4. The slide mechanism consists of a link whose one end is pivotally connected to the rear end of the slide plate with a hole in the front half, and the other end of the link is pivotally connected near one end of the lever, while the intermediate part is pivotally fixed. The outer end of the movable core of the solenoid is pivotally connected to the other end of the lever, and one end of the return repellent strip is attached to one end of the lever to constantly urge the outward movement of the movable core and the backward movement of the slide plate. Claims 1, 2, or 3 are formed such that the drop hole is formed so that the ejection hole penetrated through the bottom of the magazine box that is positioned and stopped when the slide plate is at the most retracted position is aligned with the drop hole. A fully automatic tip feeding/insertion device for the dispensing machine according to item 3. 5. The upper and lower stage clamping separation mechanism has upper and lower front and rear clamping pieces that are freely held so as to be freely opened and closed in the front and rear directions, and the lower front and rear clamping pieces of the two-stage flanged chip are attached to the opposite edges of the upper and rear front and rear clamping pieces. Opposing semicircular holes are formed in the relative edges to allow the lower side of the lower flange of the tip to be held, respectively, and the front and back opening/closing movements of the upper and lower front and rear clamping pieces are operated at both left and right ends of the upper and lower front and rear clamping pieces. Claim 1: The upper and lower stages of left and right operating means are respectively attached, and the upper and lower stages of the front and rear clamping pieces can be alternately opened and closed, and the upper and lower stages of left and right operating means can be centrally driven and controlled by a single cam. Section, 2nd
A fully automatic tip feeding/insertion device for a dispensing machine according to item 1, 3 or 4. 6. The transfer mechanism consists of a transfer body that fixes a holding plate that has a receiving hole through which the lower side of the lower flange of the chip that is separated and dropped by the clamping separation mechanism is inserted and held, and a transfer body that guides the transfer body. Dispensing according to claim 1, 2, 3, 4, or 5, comprising a regulating guide means and a feeding means for conveying the transfer body along the guide means. Fully automatic chip feeding and insertion device in the machine. 7. The dispensing pump lifting mechanism has a pinion that meshes with the rack teeth carved and extended in the axial direction on one side of the suspension shaft, which has the dispensing pump fixed to the lower end, and is fixed to the outer end of the reversible motor shaft to move the dispensing pump to the tip insertion work position. The nozzle tip of the dispensing pump is pushed into the chip held in the receiving hole of the holding plate which is waiting at the chip insertion work position, and the tip of the nozzle of the dispensing pump is moved upward while the chip is pushed down. Claims 1 and 2 consisting of
A fully automatic tip feeding/insertion device for a dispensing machine according to item 1, 3, 4, 5 or 6. 8. The chip insertion work position is provided with a chip insertion work column that is erected so as to freely support the holding plate which has been positioned at its most forward position and is stopped at its upper end.
A fully automatic tip feeding/insertion device in a dispensing machine according to item 1, 2, 3, 4, 5, 6 or 7.