JPH0259804B2 - - Google Patents
Info
- Publication number
- JPH0259804B2 JPH0259804B2 JP57089419A JP8941982A JPH0259804B2 JP H0259804 B2 JPH0259804 B2 JP H0259804B2 JP 57089419 A JP57089419 A JP 57089419A JP 8941982 A JP8941982 A JP 8941982A JP H0259804 B2 JPH0259804 B2 JP H0259804B2
- Authority
- JP
- Japan
- Prior art keywords
- oral
- ointment base
- pectin
- oral ointment
- mesh
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003883 ointment base Substances 0.000 claims description 19
- 229940042125 oral ointment Drugs 0.000 claims description 18
- 239000001814 pectin Substances 0.000 claims description 13
- 235000010987 pectin Nutrition 0.000 claims description 13
- 229920001277 pectin Polymers 0.000 claims description 13
- 239000002245 particle Substances 0.000 claims description 5
- 239000000853 adhesive Substances 0.000 claims description 4
- 230000001070 adhesive effect Effects 0.000 claims description 4
- 239000003814 drug Substances 0.000 description 7
- 229940079593 drug Drugs 0.000 description 5
- 238000002156 mixing Methods 0.000 description 5
- 210000000214 mouth Anatomy 0.000 description 5
- 239000004372 Polyvinyl alcohol Substances 0.000 description 4
- 229920002451 polyvinyl alcohol Polymers 0.000 description 4
- 210000004872 soft tissue Anatomy 0.000 description 4
- 208000003265 stomatitis Diseases 0.000 description 4
- 229940099259 vaseline Drugs 0.000 description 3
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 description 2
- 230000008021 deposition Effects 0.000 description 2
- 208000007565 gingivitis Diseases 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 201000001245 periodontitis Diseases 0.000 description 2
- 239000002562 thickening agent Substances 0.000 description 2
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- WJLVQTJZDCGNJN-UHFFFAOYSA-N Chlorhexidine hydrochloride Chemical compound Cl.Cl.C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 WJLVQTJZDCGNJN-UHFFFAOYSA-N 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 208000005232 Glossitis Diseases 0.000 description 1
- MPDGHEJMBKOTSU-UHFFFAOYSA-N Glycyrrhetinsaeure Natural products C12C(=O)C=C3C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(C)C MPDGHEJMBKOTSU-UHFFFAOYSA-N 0.000 description 1
- 208000025157 Oral disease Diseases 0.000 description 1
- 239000004264 Petrolatum Substances 0.000 description 1
- 102000004139 alpha-Amylases Human genes 0.000 description 1
- 108090000637 alpha-Amylases Proteins 0.000 description 1
- 229940024171 alpha-amylase Drugs 0.000 description 1
- 229960004504 chlorhexidine hydrochloride Drugs 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 229960003720 enoxolone Drugs 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
- 208000030194 mouth disease Diseases 0.000 description 1
- 210000002200 mouth mucosa Anatomy 0.000 description 1
- 229940126701 oral medication Drugs 0.000 description 1
- 229940066842 petrolatum Drugs 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 229920013716 polyethylene resin Polymers 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 229940126585 therapeutic drug Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Dental Preparations (AREA)
- Medicinal Preparation (AREA)
Description
【発明の詳細な説明】
本発明は口腔薬基剤に関し、更に詳しくは微粒
ペクチンを配合した付着性口腔軟膏基剤に関す
る。DETAILED DESCRIPTION OF THE INVENTION The present invention relates to oral medicine bases, and more particularly to adhesive oral ointment bases containing finely divided pectin.
口内炎、舌炎、歯槽膿漏、歯肉炎などの口腔疾
患を治療するのに適用する口腔薬は、吸収性が強
く常に湿潤している口腔内粘膜に直接作用するも
のであるから、人体に対して無害であるとともに
患部に長く付着していることが必要である。 Oral medicines used to treat oral diseases such as stomatitis, glossitis, alveolar pyorrhea, and gingivitis are highly absorbable and act directly on the always moist oral mucosa, so they are not harmful to the human body. It must be harmless and remain attached to the affected area for a long time.
しかしながら、口腔内粘度、特にほほの内側な
どの口腔軟組織は、柔軟で弾力性に富んでいて常
に睡液で湿潤しており、しかも口腔の機能上そこ
にものを付着して長時間保持させておくには最も
不適当な個所であり、口腔軟組織に長時間付着、
保持させることができる口腔薬基剤が求められて
いた。 However, the viscosity of the oral cavity, especially the soft tissues of the oral cavity such as the inside of the cheeks, are flexible and elastic and are constantly moistened with sleeping liquid, and due to the functionality of the oral cavity, it is difficult for objects to stick there and retain them for long periods of time. This is the most unsuitable place to leave it, and it can stick to the soft tissues of the oral cavity for a long time.
There was a need for an oral drug base that could be retained.
本発明者はペクチンを配合した口腔薬基剤につ
いて鋭意研究の結果、従来のペクチン（50〜100
メツシユ）に替えて、高速粉砕によつてえられる
150メツシユより細かい粒度のペクチンを口腔軟
膏基剤に配合する場合には、その口腔軟膏基剤の
口腔軟組織への付着時間が飛躍的に増大し、その
使用感も著しく改善されることを見いだして本発
明を完成した。 As a result of intensive research into oral medicine bases containing pectin, the present inventors found that conventional pectin (50 to 100
obtained by high-speed grinding instead of
It has been found that when pectin with a particle size finer than 150 mesh is added to an oral ointment base, the adhesion time of the oral ointment base to the oral soft tissues is dramatically increased, and the feeling of use is also significantly improved. The invention has been completed.
すなわち、本発明の口腔軟膏基剤は、150メツ
シユより細かい粒度のペクチンを５〜60重量％配
合することを特徴とする付着性口腔軟膏基剤であ
る。 That is, the oral ointment base of the present invention is an adhesive oral ointment base characterized by containing 5 to 60% by weight of pectin having a particle size smaller than 150 mesh.
本発明の口腔軟膏基剤は、ワセリン、プラスチ
ベース〔商品名、ポリエチレン樹脂５％分散液流
動パラフイン、大正製薬(株)製〕などの軟膏基剤30
〜90重量％、ポリビニールアルコールなどの増粘
剤５〜10重量％、粘着剤として150メツシユより
細かい粒度のペクチン５〜60重量％からなる。 The oral ointment base of the present invention is an ointment base such as Vaseline or Plastibase [trade name, 5% polyethylene resin dispersion liquid paraffin, manufactured by Taisho Pharmaceutical Co., Ltd.].
-90% by weight, 5-10% by weight of a thickener such as polyvinyl alcohol, and 5-60% by weight of pectin with a particle size finer than 150 mesh as an adhesive.
ここにおいて、ペクチンは、高速粉砕によつて
得られる200メツシユ程度の微粒子を20重量％前
後用いることが特に好ましい。 Here, it is particularly preferable to use about 20% by weight of pectin in fine particles of about 200 mesh obtained by high-speed pulverization.
本発明の口腔軟膏基剤の製造は常法に従つて行
えばよく、たとえで次のようにして行うことがで
きる。 The oral ointment base of the present invention may be produced according to a conventional method, and can be carried out as follows.
すなわち、軟膏基剤の組成成分をよく混合し、
これにベクチンを加えて混合した後、更に増粘剤
を徐々に加えながら全体が均一になるまで十分に
混合する。 That is, the components of the ointment base are thoroughly mixed,
After adding and mixing the vectin, the thickener is gradually added and mixed thoroughly until the whole is homogeneous.
本発明の口腔軟膏基剤は口腔軟組織に対する付
着時間を大幅に延長することができるから、これ
に適宜の薬物を適当量溶解または分散させること
により治療効果の高い所望の口腔軟膏を提供する
ことができる。たとえば、本発明の口腔軟膏基剤
にシコンエキスを配合すれば口内炎治療薬を調製
することができるし、またタイラーゼ〔商品名、
Bacillus amylosolvensのの産出するα−アミラ
ーゼ、大正製薬(株)製〕を配合すれば歯槽膿漏、歯
肉炎などの疾患の治療薬を調製することができ
る。 Since the oral ointment base of the present invention can significantly extend the adhesion time to oral soft tissue, a desired oral ointment with high therapeutic effect can be provided by dissolving or dispersing an appropriate amount of an appropriate drug therein. can. For example, a drug for the treatment of stomatitis can be prepared by blending Shikone extract with the oral ointment base of the present invention, and it is also possible to prepare a drug for treating stomatitis.
By blending α-amylase produced by Bacillus amylosolvens, manufactured by Taisho Pharmaceutical Co., Ltd., a therapeutic drug for diseases such as alveolar pyorrhea and gingivitis can be prepared.
次に試験例と実施例を挙げて本発明を詳細に説
明する。 Next, the present invention will be explained in detail by giving test examples and examples.
試験例
50〜200メツシユの各粒度のペクチン20ｇ、ポ
リビニールアルコール10ｇ、ワセリン57ｇ、プラ
スチベース13ｇを用いて後記実施例１に準じて本
発明の口腔軟膏基剤を調製した。Test Example An oral ointment base of the present invention was prepared according to Example 1 below using 20 g of pectin of each particle size of 50 to 200 meshes, 10 g of polyvinyl alcohol, 57 g of petrolatum, and 13 g of Plastibase.
健康な正常成人男女20名の被験者を一群とし、
微温湯でうがいさせて口腔内を洗浄後、先に調製
した口腔軟膏基剤を大豆大（約0.5ｇ）にまるめ
て清潔な綿棒の先に付着させ、被験者の右ほほの
内側に塗付した。試験中は、被験者に飲食物の摂
取を禁じ、５分毎に観察し、口腔軟膏基剤の付着
時間を測定した。 A group of 20 healthy normal adult male and female subjects were selected.
After gargling with lukewarm water to clean the inside of the mouth, the oral ointment base prepared earlier was rolled into a soybean-sized ball (approximately 0.5 g), attached to the tip of a clean cotton swab, and applied to the inside of the subject's right cheek. During the test, subjects were prohibited from eating or drinking, and observations were made every 5 minutes to measure the adhesion time of the oral ointment base.
その結果、50〜100メツシユのペクチンを配合
した口腔軟膏基剤の付着時間は10〜20分に過ぎな
いのに対して、150〜200メツシユのペクチンを配
合した口腔軟膏基剤の付着時間は65〜95分と飛躍
的に増大した。 As a result, the deposition time of an oral ointment base containing 50 to 100 meshes of pectin was only 10 to 20 minutes, whereas the deposition time of an oral ointment base containing 150 to 200 meshes of pectin was 65 minutes. It increased dramatically to ~95 minutes.
実施例 １
ワセリン57ｇとプラスチベース13ｇとをよく混
合した後、ペクチン（200メツシユ）20ｇをこれ
に加えて更に混合し、最後にポリビニールアルコ
ール10ｇを徐々に加えながら全体が均一になるま
で混合を続け、口腔軟膏基剤100ｇを得た。Example 1 After thoroughly mixing 57 g of Vaseline and 13 g of Plastibase, 20 g of pectin (200 mesh) was added and further mixed.Finally, 10 g of polyvinyl alcohol was gradually added and mixing was continued until the whole was homogeneous. , 100 g of oral ointment base was obtained.
実施例 ２
ワセリン56.3ｇ、プラスチベース13ｇ、ペクチ
ン（200メツシユ）20ｇ、ポリビニルアルコール
10ｇを用いて、実施例１に準じて口腔軟膏基剤を
調製した。これにシコンエキス0.2ｇ、塩酸クロ
ルヘキシジン0.2ｇ、グリチルレチン酸0.3ｇの混
合物と微量の香料とを加えて均一に分散させて口
内炎治療薬100ｇを調製した。Example 2 Vaseline 56.3g, Plastibase 13g, pectin (200 mesh) 20g, polyvinyl alcohol
An oral ointment base was prepared according to Example 1 using 10 g. To this was added a mixture of 0.2 g of Sicon extract, 0.2 g of chlorhexidine hydrochloride, 0.3 g of glycyrrhetinic acid, and a trace amount of fragrance, and the mixture was uniformly dispersed to prepare 100 g of a drug for treating stomatitis.
Claims (1)
〜60重量％配合することを特徴とする付着性口腔
軟膏基剤。1 5 pectin with a particle size finer than 150 mesh
An adhesive oral ointment base characterized by containing ~60% by weight.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57089419A JPS58206534A (en) | 1982-05-26 | 1982-05-26 | Base for oral cavity drug |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57089419A JPS58206534A (en) | 1982-05-26 | 1982-05-26 | Base for oral cavity drug |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS58206534A JPS58206534A (en) | 1983-12-01 |
| JPH0259804B2 true JPH0259804B2 (en) | 1990-12-13 |
Family
ID=13970128
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP57089419A Granted JPS58206534A (en) | 1982-05-26 | 1982-05-26 | Base for oral cavity drug |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS58206534A (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61212515A (en) * | 1985-03-16 | 1986-09-20 | Taisho Pharmaceut Co Ltd | Ointment for hemorrhoid |
| US4867970A (en) * | 1987-05-21 | 1989-09-19 | E. R. Squibb & Sons, Inc. | Moistureless oral drug delivery formulation and method for preparing same |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54119038A (en) * | 1978-03-07 | 1979-09-14 | Takeda Chemical Industries Ltd | Digestion difficult polysaccaride containing food |
-
1982
- 1982-05-26 JP JP57089419A patent/JPS58206534A/en active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54119038A (en) * | 1978-03-07 | 1979-09-14 | Takeda Chemical Industries Ltd | Digestion difficult polysaccaride containing food |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS58206534A (en) | 1983-12-01 |
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