JPH0255050B2 - - Google Patents

Description

[Detailed description of the invention]

The present invention relates to drug-containing sterile bandages, and more particularly, to
The present invention relates to a sterile bandage for transdermal penetration of drugs as a surgical bandage. For this new bandage, its chemical composition and physical properties are of great importance. In the past, efforts have been made to develop sterile dressings that are both adhesive and absorbent. for example,
US Pat. No. 3,339,564 discloses an adhesive bandage made to adhere to moist surfaces, such as the moist mucous membranes of the oral cavity. However, one of the primary materials of this adhesive bandage is adhesive rubber, preferably polyisobutylene, which is hydrophobic. Similarly, U.S. Pat.
No. 3,598,123 discloses a bandage containing a drug that is continuously released from an adhesive layer. These bandages are
It is formed from a layered material that encapsulates the drug in an adhesive layer. The bandages disclosed in these prior patents are said to be adhesive and are satisfactory excipients for drugs, but even so, they are not effective as surgical bandages unless they are sterile. It is inconceivable that it would be possible to function. In this regard, it is pointed out that surgical dressings must not only be able to release drugs and absorb liquids at the site of attachment, but also be sterile. The only practical method of sterilization is by irradiation (particularly gamma irradiation), and it is unlikely that prior art dressings can be irradiated without affecting their adhesive properties and dimensional stability. Accordingly, it is a general object of the present invention to provide a new sterile and adhesive drug-containing dressing that readily absorbs liquid exudates such as sweat. The bandage has a flexible backing and a high degree of absorbency suitable for continuous absorption of sweat or liquid exudate from the wound as well as release of the drug to the site of application; In between is a tacky support material which maintains dimensional stability and gradually becomes tacky in the presence of moisture. Sterilization can be carried out by irradiation, with minimal impact on the dimensional stability of the support material and without affecting its adhesion. According to the invention, the following two components (a) and (b): (a) a flexible backing material selected from the group consisting of cotton fabrics, paper, synthetic fabrics and plastics; and (b) skin adhesion. a support material bonded to the backing material comprising a homogeneous, stable hydrophilic matrix having suitable tackiness and sufficient flexibility to deform to conform to the contours of the body. A flexible, liquid-absorbent adhesive gauze bandage, wherein the matrix comprises (i) a synthetic resin selected from the group consisting of polyacrylic acid, polyacrylamide, and analogs thereof; 50% solid phase and about 30 to 70% liquid phase by weight of said matrix consisting of a solution or emulsion of carbohydrates and/or proteins and containing the required drug; (ii) sterilized by irradiation; and (iii) an adhesive bandage is provided that is capable of effectively absorbing liquid exudate from a wound to which the adhesive gauze bandage is applied and retains dimensional stability and cohesion during such absorption. . As used herein, adhesive bandages (adhesive bandages)
Bandage), that is, a bandage, refers to a general covering material that is sterilized and can be used individually, such as a film or cloth coated with a pressure-adhesive material containing a drug. These and other objects and advantages of the present invention include:
It will be understood in more detail from the following description taken in conjunction with the accompanying drawings. In the drawings, the same reference symbols refer to the same or similar parts in all figures. In the accompanying drawings, FIG. 1 is a perspective view of the novel bandage according to the invention applied to a patient's arm, FIG. 2 is a perspective view of the bandage shown in FIG. 1, and FIG. 4 is a perspective view of a bandage according to the invention used as a surgical bandage, and FIG. 4 is a cross-sectional view taken generally along line 4-4 of FIG. 2, taken in the direction of the arrow. . The bandage of the present invention has suitable adhesion to maintain contact with the skin while having some elasticity against skin movement. This bandage is made to be easy to handle and is non-irritating to the patient in all respects. Referring now to the drawings, there is shown a bandage of the present invention. The bandage, designated generally by the reference numeral 10, includes a backing material 11 and an adhesive support material 12 secured to one side of the backing material. Backing material 1
1 and support material 12 are both shown as rectangular sheets of uniform thickness material. It is preferred that the bandage 10 is made to be of uniform thickness and can be of any shape, although a rectangular shape is preferred. In use, the bandage is applied with the support material 12 in direct contact with the skin to cover a non-surgical wound, a surgical wound, or burned tissue. The embodiment shown in Figure 3 is a surgical bandage that is applied to a patient to cover a surgical wound. The most important property for the unique structure of this bandage is the hydrophilic adhesive nature of the support, which increases adhesion to the skin. As the support absorbs moisture, it becomes increasingly sticky. The support material 12 is made of karaya gum, gwar gum, acacia gum, locust bean gum.
gum), irradiated karaya (exposed to 2.5 Mrads of gamma radiation) as well as sorbitol and other polysaccharides. The support material is also
It can also be formed from synthetic polymers such as carboxymethyl cellulose, carboxypropyl cellulose, polyacrylic acid, polyacrylamide and analogs thereof. Examples of synthetic polymers include molecular weights of 250,000, 450,000, 1,000,000 and
4,000,000 polyacrylic acid and the trade name Reten from Hercules Co.
Examples include polyacrylamide sold in When polymerizing monomers such as acrylic acid or acrylamide, the use of activators is necessary. Activators used in the polymerization process include ferrous sulfate, sodium pyrosulfite and potassium persulfate. or,
The solid phase of the matrix may be an adhesive polymer or natural gum as disclosed in the applicant's US Pat. Polysaccharide or protein solutions or emulsions can be used to form the matrix. Alternatively, a combination of polysaccharide, saccharide or protein solutions or emulsions can be used in the liquid phase of the matrix. The support material 11, which is a stable matrix, can include a synthetic polymer matrix, a Karaya matrix or a solid phase comprising a matrix of Karaya and a synthetic polymer. The matrix solids constitute 30 to 50% by weight of matrix 11. The matrix continuous phase is then e.g. 2.5 Mrad
However, if the matrix is made of only Karaya and polyhydric alcohol, its dimensional stability will be impaired to the extent that it will deform even under slight pressure due to irradiation, and its water absorption will decrease. is also severely affected and becomes inoperable. However, as mentioned above
These damages are effectively suppressed by the addition of high molecular weight polyacrylamide such as Reten. In addition, the drugs to be contained in the support material (base material) include various bactericidal and antibacterial agents such as polyvinylpyrrolidone-dissolved iodine (povidone and iodine), anti-inflammatory and analgesic agents such as methyl salicylate and camphor, hormonal preparations such as hydrocortidone, vitamin A,
Nutrients such as B ₁ and B ₂ , antihistamines, and the like can be used as desired, but particularly useful in the present invention are those containing 0.1 to 15% by weight based on the matrix. I can give you nitroglycerin. Nitroglycerin is usually used in ointment form as a vasodilator;
For preventive use against acute heart failure and the like, stable sustained release and skin adhesion are required, and these ointments have not been able to achieve their objectives. On the other hand, when using the bandage of the present invention, which has self-adhesive properties, hygroscopic properties, and shape-retaining properties, a stable and favorable sustained release effect can be maintained for a long period of time without staining clothes. In particular, when karaya gum is included in the matrix, suitable compatibility with nitroglycerin is observed, and an innovative plaster for preventing myocardial infarction or heart failure can be provided. Incidentally, when adding the above-mentioned various drugs, cinnamon oil, lemon oil, olive oil, coconut oil, etc. may be used in combination as a vehicle. If karaya gum or other gums are used to form the matrix, it is necessary to use polyacrylic acid and/or polyacrylamide to protect the karaya during radiation exposure. However, instead of polyacrylamide and/or polyacrylic acid, predetermined concentrations of salts, such as aluminum sulfate or sodium chloride, may also be used in the matrix together with Karaya. For example, sodium chloride or aluminum sulfate at a concentration of about 6% can be used to form the solid phase of the matrix. It has also been found that vinyl acetate-dioctyl maleate copolymers can also be used advantageously to form the solid phase of the matrix. Vinyl acetate-dioctyl maleate copolymer (Air Products & Chemicals, Inc.)
and Chemicals, Inc. under the trade name "Flexbond 150" and the Bostik Co., Inc. under the trade name "Bostik 8761") is a bandage. Strengthen the adhesive strength of As the backing material, any desired material such as flexible cloth material, paper material, plastic sheet or film may be used. Here, a starch graft copolymer can be mentioned as an example of another gummy material useful as a matrix forming material. Namely, the starch graft copolymer, which is a copolymer of corn starch and acrylonitrile and is commercially available as "FVP502S Abprotect" (trade name) from Kötzchel, or the "starch graft copolymer" (trade name). Various starch derivatives are also useful as matrix-forming materials, such as the acrylamide-sodium acrylate-starch grafted polymer commercially available as the commercially available acrylamide-sodium acrylate-starch graft polymer. Furthermore, in the structure of the bandage of the present invention, it is also useful to use an adhesive tape as the backing member and to adhere the drug-containing support member only to the central portion of the adhesive tape. Hereinafter, the present invention will be explained in more detail with reference to Examples showing the composition of the support member. Note that all numerical values are parts by weight.

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[Table] Phate: Potassium = Persulfate =
0.1:0.2:0.6

[Brief explanation of the drawing]

FIG. 1 is a perspective view of the novel bandage according to the invention applied to a patient's arm, FIG. 2 is a perspective view of the bandage shown in FIG. 1, and FIG. 3 is a perspective view of the bandage as shown in FIG. 4 is a perspective view of a bandage according to the invention as used, and FIG. 4 is a cross-sectional view taken generally along line 4--4 of FIG. 2 in the direction of the arrow; A... Patient's arm, 10... Adhesive gauze bandage, 1
1...Backing material, 12...Supporting material.

Claims (1)

[Claims] 1. Two components (a) and (b): (a) a flexible backing material selected from the group consisting of cotton fabric, paper, synthetic fabric and plastic; and (b) to the skin. a support material bonded to the backing material comprising a homogeneous stable hydrophilic matrix having a tackiness suitable for adhesion to the body and sufficiently flexible to deform to conform to the contours of the body. (i) the matrix comprises (1) polyacrylic acid, polyacrylamide and analogs thereof, ethylene-vinyl acetate copolymer, dioctyl maleate; a solid phase of 30 to 50% of the total weight of said matrix comprising a substance selected from the group consisting of vinyl acetate copolymers, natural gums and starch derivatives; and (2) a solution or emulsion of carbohydrates and polyhydric alcohols. 30 to 70 of said matrix consisting of
% by weight of a liquid phase; (3) further comprising a drug required for penetration through the skin; (ii) sterilized by irradiation;
and (iii) a bandage capable of effectively absorbing liquid exudate from a wound to which the adhesive bandage is applied and retaining dimensional stability and tack during such absorption. 2. The adhesive bandage of claim 1, wherein the liquid phase comprises a polysaccharide solution. 3. The adhesive bandage of claim 1, wherein said solid phase of the matrix comprises a natural gum selected from the group consisting of karaya gum, acacia gum, locust bean gum, and guwar gum. 4. The adhesive bandage of claim 1, wherein said liquid phase comprises glycerol. 5. The adhesive bandage of claim 1, wherein said matrix comprises 5 to 45% by weight of Karaya, 2 to 40% by weight of polyacrylamide, and 30 to 70% by weight of glycerol. 6 The matrix is polyacrylamide 10 to
50% by weight of glycerol and 30-70% by weight of glycerol. 7 The matrix is polyacrylamide 2 or
40% by weight of polyacrylic acid, 2 to 40% by weight of polyacrylic acid, and 30 to 70% by weight of glycerol. 8. The adhesive bandage of claim 1, wherein said matrix is formed from 2 to 50% by weight polyacrylic acid and 30 to 70% by weight glycerol. 9. Adhesive bandage according to claim 1, characterized in that said matrix contains 0.1-15% by weight of povidone-iodeine. 10. The adhesive bandage of claim 1, wherein said matrix contains 0.1-15% by weight camphor. 11. The adhesive bandage of claim 1, wherein said matrix contains 0.1-15% by weight of methyl salicylate. 12. The adhesive bandage of claim 1, wherein said matrix contains 0.1-15% by weight nitroglycerin.