JPH0245461A - Feeding-stimulating substance for fish and feed - Google Patents
Feeding-stimulating substance for fish and feedInfo
- Publication number
- JPH0245461A JPH0245461A JP63194217A JP19421788A JPH0245461A JP H0245461 A JPH0245461 A JP H0245461A JP 63194217 A JP63194217 A JP 63194217A JP 19421788 A JP19421788 A JP 19421788A JP H0245461 A JPH0245461 A JP H0245461A
- Authority
- JP
- Japan
- Prior art keywords
- group
- fish
- feed
- feeding
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000251468 Actinopterygii Species 0.000 title claims abstract description 32
- 239000000126 substance Substances 0.000 title claims abstract description 18
- 150000001875 compounds Chemical class 0.000 claims abstract description 13
- 230000004936 stimulating effect Effects 0.000 claims abstract description 10
- 150000003839 salts Chemical class 0.000 claims abstract description 8
- CWERGRDVMFNCDR-UHFFFAOYSA-N thioglycolic acid Chemical compound OC(=O)CS CWERGRDVMFNCDR-UHFFFAOYSA-N 0.000 claims abstract description 6
- HTIRHQRTDBPHNZ-UHFFFAOYSA-N Dibutyl sulfide Chemical compound CCCCSCCCC HTIRHQRTDBPHNZ-UHFFFAOYSA-N 0.000 claims abstract description 4
- 229910052736 halogen Inorganic materials 0.000 claims abstract description 4
- 150000002367 halogens Chemical class 0.000 claims abstract description 4
- ZERULLAPCVRMCO-UHFFFAOYSA-N Dipropyl sulfide Chemical compound CCCSCCC ZERULLAPCVRMCO-UHFFFAOYSA-N 0.000 claims abstract description 3
- 150000001450 anions Chemical class 0.000 claims abstract description 3
- -1 dithiocarboxy group Chemical group 0.000 claims description 15
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 5
- 125000000623 heterocyclic group Chemical group 0.000 claims description 4
- 125000001183 hydrocarbyl group Chemical group 0.000 claims description 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 3
- PSBDWGZCVUAZQS-UHFFFAOYSA-N (dimethylsulfonio)acetate Chemical compound C[S+](C)CC([O-])=O PSBDWGZCVUAZQS-UHFFFAOYSA-N 0.000 claims description 2
- KYLIZBIRMBGUOP-UHFFFAOYSA-N Anetholtrithion Chemical group C1=CC(OC)=CC=C1C1=CC(=S)SS1 KYLIZBIRMBGUOP-UHFFFAOYSA-N 0.000 claims description 2
- 125000003545 alkoxy group Chemical group 0.000 claims description 2
- 125000004414 alkyl thio group Chemical group 0.000 claims description 2
- 125000003277 amino group Chemical group 0.000 claims description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 2
- 125000002648 azanetriyl group Chemical group *N(*)* 0.000 claims description 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 2
- 239000002131 composite material Substances 0.000 claims description 2
- 125000001651 cyanato group Chemical group [*]OC#N 0.000 claims description 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 2
- 125000000664 diazo group Chemical group [N-]=[N+]=[*] 0.000 claims description 2
- 125000004119 disulfanediyl group Chemical group *SS* 0.000 claims description 2
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims description 2
- 125000005067 haloformyl group Chemical group 0.000 claims description 2
- 125000000717 hydrazino group Chemical group [H]N([*])N([H])[H] 0.000 claims description 2
- 125000001867 hydroperoxy group Chemical group [*]OO[H] 0.000 claims description 2
- 125000001841 imino group Chemical group [H]N=* 0.000 claims description 2
- 125000002462 isocyano group Chemical group *[N+]#[C-] 0.000 claims description 2
- 125000001810 isothiocyanato group Chemical group *N=C=S 0.000 claims description 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 2
- 125000000018 nitroso group Chemical group N(=O)* 0.000 claims description 2
- 125000004043 oxo group Chemical group O=* 0.000 claims description 2
- 239000001301 oxygen Chemical group 0.000 claims description 2
- 229910052760 oxygen Inorganic materials 0.000 claims description 2
- 229930195734 saturated hydrocarbon Chemical group 0.000 claims description 2
- 125000000213 sulfino group Chemical group [H]OS(*)=O 0.000 claims description 2
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 claims description 2
- 125000005300 thiocarboxy group Chemical group C(=S)(O)* 0.000 claims description 2
- 125000000858 thiocyanato group Chemical group *SC#N 0.000 claims description 2
- 125000005323 thioketone group Chemical group 0.000 claims description 2
- 125000003396 thiol group Chemical group [H]S* 0.000 claims description 2
- 125000000464 thioxo group Chemical group S=* 0.000 claims description 2
- 229930195735 unsaturated hydrocarbon Chemical group 0.000 claims description 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- HHVIBTZHLRERCL-UHFFFAOYSA-N sulfonyldimethane Chemical compound CS(C)(=O)=O HHVIBTZHLRERCL-UHFFFAOYSA-N 0.000 claims 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 claims 1
- 229940081974 saccharin Drugs 0.000 claims 1
- 235000019204 saccharin Nutrition 0.000 claims 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 claims 1
- 239000000463 material Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- 229910001868 water Inorganic materials 0.000 description 10
- 230000000694 effects Effects 0.000 description 9
- 239000000021 stimulant Substances 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- ZDDDFDQTSXYYSE-UHFFFAOYSA-N 1-ethylsulfanylpropane Chemical compound CCCSCC ZDDDFDQTSXYYSE-UHFFFAOYSA-N 0.000 description 4
- NVLPQIPTCCLBEU-UHFFFAOYSA-N 3-(Methylthio)-1-propene Chemical compound CSCC=C NVLPQIPTCCLBEU-UHFFFAOYSA-N 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 235000019733 Fish meal Nutrition 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 239000004467 fishmeal Substances 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 239000012085 test solution Substances 0.000 description 3
- XJIRSLHMKBUGMR-UHFFFAOYSA-N 1-ethylsulfanylbutane Chemical compound CCCCSCC XJIRSLHMKBUGMR-UHFFFAOYSA-N 0.000 description 2
- QMMFVYPAHWMCMS-UHFFFAOYSA-N Dimethyl sulfide Chemical compound CSC QMMFVYPAHWMCMS-UHFFFAOYSA-N 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 235000014102 seafood Nutrition 0.000 description 2
- 230000008786 sensory perception of smell Effects 0.000 description 2
- 230000014860 sensory perception of taste Effects 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- WCXXISMIJBRDQK-UHFFFAOYSA-N 1-methylsulfanylbutane Chemical compound CCCCSC WCXXISMIJBRDQK-UHFFFAOYSA-N 0.000 description 1
- 241000473391 Archosargus rhomboidalis Species 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
- YKJJGFKHVXHWEM-UHFFFAOYSA-N CCCC[S+](CCCC)CC([O-])=O Chemical compound CCCC[S+](CCCC)CC([O-])=O YKJJGFKHVXHWEM-UHFFFAOYSA-N 0.000 description 1
- SRUUVQYETMAMAK-UHFFFAOYSA-N CCC[S+](CCC)CCC([O-])=O Chemical compound CCC[S+](CCC)CCC([O-])=O SRUUVQYETMAMAK-UHFFFAOYSA-N 0.000 description 1
- JFUBBUCDFVLJCA-UHFFFAOYSA-N C[S+](C)CN Chemical compound C[S+](C)CN JFUBBUCDFVLJCA-UHFFFAOYSA-N 0.000 description 1
- SJFXETLCKTUZNA-UHFFFAOYSA-N C[S+](CCCCCC(=O)[O-])C Chemical compound C[S+](CCCCCC(=O)[O-])C SJFXETLCKTUZNA-UHFFFAOYSA-N 0.000 description 1
- 241000252229 Carassius auratus Species 0.000 description 1
- 241001609213 Carassius carassius Species 0.000 description 1
- 241000252233 Cyprinus carpio Species 0.000 description 1
- GAZXPZNJTZIGBO-UHFFFAOYSA-N Dipropyl trisulfide Chemical compound CCCSSSCCC GAZXPZNJTZIGBO-UHFFFAOYSA-N 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- YNSNVPCUBZPECP-UHFFFAOYSA-N N[S+](CC([O-])=O)N Chemical compound N[S+](CC([O-])=O)N YNSNVPCUBZPECP-UHFFFAOYSA-N 0.000 description 1
- 241001327682 Oncorhynchus mykiss irideus Species 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 241000238037 Palinurus vulgaris Species 0.000 description 1
- 241000269908 Platichthys flesus Species 0.000 description 1
- 241001600434 Plectroglyphidodon lacrymatus Species 0.000 description 1
- UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical compound [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 238000009360 aquaculture Methods 0.000 description 1
- 244000144974 aquaculture Species 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- IVRMZWNICZWHMI-UHFFFAOYSA-N azide group Chemical group [N-]=[N+]=[N-] IVRMZWNICZWHMI-UHFFFAOYSA-N 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- XYWDPYKBIRQXQS-UHFFFAOYSA-N di-isopropyl sulphide Natural products CC(C)SC(C)C XYWDPYKBIRQXQS-UHFFFAOYSA-N 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- LJSQFQKUNVCTIA-UHFFFAOYSA-N diethyl sulfide Chemical compound CCSCC LJSQFQKUNVCTIA-UHFFFAOYSA-N 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 235000012631 food intake Nutrition 0.000 description 1
- 239000013505 freshwater Substances 0.000 description 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 238000004898 kneading Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- OAAIJTVKKHCOGM-UHFFFAOYSA-N methyl(dipropyl)sulfanium Chemical compound CCC[S+](C)CCC OAAIJTVKKHCOGM-UHFFFAOYSA-N 0.000 description 1
- WXEHBUMAEPOYKP-UHFFFAOYSA-N methylsulfanylethane Chemical compound CCSC WXEHBUMAEPOYKP-UHFFFAOYSA-N 0.000 description 1
- 125000005740 oxycarbonyl group Chemical group [*:1]OC([*:2])=O 0.000 description 1
- 238000009372 pisciculture Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Feed For Specific Animals (AREA)
- Fodder In General (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
【発明の詳細な説明】
「産業上の利用分野」
本発明は、魚類の摂餌量を増大させ、成長を促進させる
ようにしだ魚類の摂餌刺激物質および餌料に関する。DETAILED DESCRIPTION OF THE INVENTION "Industrial Application Field" The present invention relates to a feeding stimulant and a feed for fishes that increase their food intake and promote their growth.
「従来技術」
財界的な２００海’ｌ漁業権の設定以来、水産資源に多
いに恩恵を浴している我国は、他国２００海土内の操業
を余儀なくされ、当然のことながらそこで得られる水産
資源は、漁獲時期や漁獲量の規制、あるいは入漁料金の
支払いなどで年々コスト高となって米ている。``Prior art'' Since the establishment of fishing rights in the 200 sea area in the financial world, our country, which has benefited greatly from fisheries resources, has been forced to operate within the 200 sea area of other countries, and as a matter of course, it has lost the fisheries obtained there. Resources are becoming more expensive each year due to regulations on fishing seasons and amounts, as well as the payment of fishing fees.
この事実を鑑みて、近海表層魚や養殖魚の漁獲量は年々
増大傾向にある。このため、近海表層魚や養殖魚に用い
られる生餌や魚粉等が大量に投与され、摂取されなかっ
た餌が海底に沈殿し、大陸だなにおける汚染源としてそ
の対策が待たれている。さらに、餌の有効利用率の低下
は、養殖魚の成長率の低下につながり、コスト面の上昇
を招いている。In view of this fact, the catch of inshore surface fish and farmed fish is increasing year by year. For this reason, large amounts of raw bait and fishmeal used for inshore surface fish and farmed fish are administered, and the uningested bait settles on the sea floor, which is a source of contamination in continental seas and needs countermeasures. Furthermore, a decrease in the effective utilization rate of feed leads to a decrease in the growth rate of farmed fish, leading to an increase in costs.
このため、遠洋魚や近海魚の魚粉や生餌を使用している
現在の養殖業においては、より少ない餌！’ｌＩで正常
あるいはそれ以上の成育がなされる、いわゆる餌料効率
を高める餌料組成の改良や、生餌１ｇ１扮などを用いた
配合餌料と同等の餌料効率を維持する代替餌料の開発が
望まれている。For this reason, in the current aquaculture industry, which uses fishmeal and raw bait from pelagic and nearshore fish, less feed is needed! It is desired to improve the feed composition to increase the so-called feed efficiency, which allows normal or higher growth at 'lI, and to develop alternative feeds that maintain feed efficiency equivalent to mixed feeds using 1 g of live feed. There is.
このような研究の一つとして、魚の臭覚や味覚を刺部し
て餌を食べさせるようにする摂餌刺激物質についての報
告もなされている。その代表的なものとして、グルタミ
ンが知られているが、餌享：ｌに混合するいわゆる混合
餌料では顕著な効果が得られないのが現状である。As part of such research, there have been reports on feeding stimulants that stimulate fish's sense of smell and taste to induce them to eat food. Glutamine is known as a typical example of this, but at present, no significant effects can be obtained with so-called mixed feeds that are mixed with food.
［発明が解決しようとする課題」
本発明は、上記従来技術の問題点に鑑みてなされたもの
であり、その目的は、魚類の味覚や臭４覚を刺部して餌
料効率を高めるようにした魚類の摂餌刺激物質および餌
料を提供することにある。[Problems to be Solved by the Invention] The present invention has been made in view of the problems of the prior art described above, and its purpose is to increase feed efficiency by stimulating the four senses of taste and smell of fish. The object of the present invention is to provide feeding stimulants and feeds for fish.
［課題を解決するための手段Ｊ
本発明による魚類の摂餌刺激物質は、下記−形式（Ｊ）
、（ＩＩ ）または（Ｉｌｌ ）で示される化合物およ
びそれらの塩（ただし、β−ジメチルプロピオテチン、
２−メルカプトアセティックアシッド、ジプロピルスル
フィド、ジブチルスルフィド、ジメチルスル
サッカリン、カルボキシメチルジメチルスルフオニウム
棹または二種以上からなることを特徴とする。[Means for Solving the Problem J The feeding stimulant for fish according to the present invention has the following format (J):
, (II) or (Ill) and their salts (with the exception of β-dimethylpropiotetin,
It is characterized by consisting of 2-mercaptoacetic acid, dipropylsulfide, dibutylsulfide, dimethylsulsaccharin, carboxymethyldimethylsulfonium, or two or more thereof.
水，牲、酸素、ハロゲン、飽和炭化水素基、飽和複素環
基、不飽和炭化水素法、不飽和複素環基、カルボキシ基
、チオカルボキシ基、ジチオカルボキシ基、スルホ基、
スルフィノ基、スルフェノ基、ハロホルミル基，カルバ
モイル基、ヒドラジノカルボニル基、シアノ基，ニトリ
ロ基，イソシアノ基、シアナト基、チオシアナト基、イ
ソチオシアナト基、チオケトン基、ホルミル基、オキソ
基。water, oxygen, halogen, saturated hydrocarbon group, saturated heterocyclic group, unsaturated hydrocarbon method, unsaturated heterocyclic group, carboxyl group, thiocarboxy group, dithiocarboxy group, sulfo group,
Sulfino group, sulfeno group, haloformyl group, carbamoyl group, hydrazinocarbonyl group, cyano group, nitrilo group, isocyano group, cyanato group, thiocyanato group, isothiocyanato group, thioketone group, formyl group, oxo group.
チオホルミル基、チオキソ基、ヒドロキシ基、メルカプ
ト基、ヒドロペルオキシ基、アミノ基、イミノ基，ヒド
ラジノ基、ニトロ基、ニトロソ基、ジアゾ基、アジド基
、アルキルオキシ基，アルキルチオ基、アルキルジオキ
シ基、アルキルオキシカルボニル括，ジチオ基、トリチ
オ基、ポリチオ基またはこれらの複合基を表わし、Ｒ１
、Ｒ２は同じでも異なっていてもよい。Ｘ−はハロゲン
、水酸基など一価の陰イオンを表わす．）
（式中、ｎは０≦ｎ≦２０の整数である。Ｒ１、Ｒ２は
（式中、Ｒ１、Ｒ２、Ｘ−は前記と同様な意味である。Thioformyl group, thioxo group, hydroxy group, mercapto group, hydroperoxy group, amino group, imino group, hydrazino group, nitro group, nitroso group, diazo group, azide group, alkyloxy group, alkylthio group, alkyldioxy group, alkyl represents an oxycarbonyl group, a dithio group, a trithio group, a polythio group, or a composite group thereof, and R1
, R2 may be the same or different. X- represents a monovalent anion such as halogen or hydroxyl group. ) (In the formula, n is an integer of 0≦n≦20. R1 and R2 are (In the formula, R1, R2, and X- have the same meanings as above.
Ｒ３は、１ｃ１１２１゜−を基本骨格とし、この中の１
または複数の炭素の側鎖にｎｌ、 １＋２と同様なもの
が結合されているか、あるいはこの中の１または複数の
炭素が脱水素されてｌまたは複数の二重結合もしくは三
重結合を有するものを表わす、）（カルボキシメチルジ
アミノスルフオニウム）（式中、ｎ、 Ｒ１，Ｒ２，Ｘ
−は前記と同様な意味であり、Ｒ４は前記Ｒ，，Ｒ２と
同様な意味である。）また、本発明による魚類の餌料は
、上記の摂餌刺激物質が添加されていることを特徴とす
る。R3 has a basic skeleton of 1c1121°-, and 1 of these
Or something similar to nl, 1+2 is bonded to the side chain of multiple carbons, or one or more of these carbons is dehydrogenated to have l or more double or triple bonds. , ) (carboxymethyldiaminosulfonium) (wherein, n, R1, R2, X
- has the same meaning as above, and R4 has the same meaning as R, , R2 above. ) Furthermore, the fish feed according to the present invention is characterized in that the above-mentioned feeding stimulant substance is added.
さらに、この餌料としては、上記摂餌刺激物質をＩＯ−
”〜１０−１Ｍ含有する溶液を添加して得られたものが
より好ましい。Furthermore, as this feed, the above-mentioned feeding stimulant substance is added to IO-
More preferably, a solution obtained by adding a solution containing ~10-1M is more preferable.
−ＪＱ式（Ｉ）で示される化合物の具体例としては、例
えば次のものが挙げられる。-JQ Specific examples of the compound represented by formula (I) include the following.
１１、
（カルボキシメチルメル力ブタンノ
この他に、構造式は省略するが、カルボキシメチルジブ
チルスルフォニウム、カルボキシメチルジベンチルスル
フォニウム、カルボキシペンチルジメチルスル
ヂルスルフォニウム，カルボキシエチルジプロピルスル
フオニウムおよびこれらの塩などが挙げられる。11. (Carboxymethylmelbutane) In addition, although the structural formula is omitted, carboxymethyldibutylsulfonium, carboxymethyldibentylsulfonium, carboxypentyldimethylsulfonium, carboxyethyldipropylsulfonium, and Examples include these salts.
ＩｉｌＱ弐（Ｊ）で示される化合物は．例えば次のよう
な反応式で合成することができる６般弐四■）で示され
る化合物の具体例としては、例えば次のものが挙げられ
る６
Ｃ１１。The compound represented by IilQ2 (J) is. For example, specific examples of the compound represented by 6C24) which can be synthesized using the following reaction formula include the following 6C11.
フオニウム）
チルエヂルジメチルスルフオニウム、カルボキシ４−メ
チルプロピルジメチルスルフオニウム、カルボキシ２−
エチルプロピルジメチルスルフオニウムおよびこれらの
塩などが挙げられる。phonium) methyl edyl dimethyl sulfonium, carboxy 4-methylpropyl dimethyl sulfonium, carboxy 2-
Examples include ethylpropyldimethylsulfonium and salts thereof.
一般式（１１）で示される化合物は、例えば次のような
反応式で合成することができる。The compound represented by general formula (11) can be synthesized, for example, using the following reaction formula.
フォニウム〕
Ｃ］１３
（３−カルボキシ２−メチルプロピルジメチルスルフオ
ニウム）
１１７才ニウム）
（式中、Ｒ５はＩＩ，、 Ｒ２と同様な意味である。）
なお、一般式（ １１ ）においてＲ３が二重結合もし
くは三重結合を有する場合でも上記と同様な方法で合成
することができる。(In the formula, R5 has the same meaning as II, R2.)
In addition, even when R3 in general formula (11) has a double bond or triple bond, it can be synthesized by the same method as above.
一般式（ ＩＩ＋ ）で示される化合物の具体例として
は，例えば次のものが挙げられる。Specific examples of the compound represented by the general formula (II+) include the following.
ラム）
ディウムソルト）
その他，構造式は省略するが，カルボキシ２−メ（２−
トリメチルエチルジメチＪレスルフオニウム）（アミノ
メチルジメチルスル
ウム）
ウム）
（メルカブトメチルジメチＪレスル）オニウム）この他
、構造式は省略するが，ジプロピルトリスルフィド、メ
チルエチルスルフィド、メチルプロとルスルフィド、メ
チルブチルスルフィド、メチルアリルスルフィド、エチ
ルプロピルスルフィド、エチルブチルスルフィドおよび
これらの塩などが挙げられる。Although the structural formula is omitted, carboxy 2-method (2-
(trimethylethyldimethyJresulfonium) (aminomethyldimethylsulfonium) (merkabutomethyldimethyJresulfonium) (merkabutomethyldimethyJresulfonium) In addition, although the structural formula is omitted, dipropyltrisulfide, methylethylsulfide, methylpro and rusulfide, Examples include methylbutyl sulfide, methylallyl sulfide, ethylpropyl sulfide, ethyl butyl sulfide and salts thereof.
１４Ｂ式（ ＩＩＩ ）で示される化合物は、例えば次
のような反応式で合成することができる。The compound represented by Formula 14B (III) can be synthesized, for example, by the following reaction formula.
（アミノジメチルスルフオニウム）
（メトキシジメチルスル）オニウム）
「作用」
本発明者らは，各種物質について魚介類の摂餌刺激効果
を測定し、その結果、いくつかの物質が優れた摂餌刺激
効果を示すことを見出し、既に特許出願をしている（特
開昭６３−１４６７５８号、特願昭６２−２３２ １
０号，特願昭６３−２８５０３号、特願昭６３−９６４
９６号参照）。本発明は，上記研究をさらに継続し、摂
餌刺激効果を有する新たな化合物を見出した結果なされ
たものである。(aminodimethylsulfonium) (methoxydimethylsulfonium) "Effect" The present inventors measured the effect of various substances on stimulating the feeding intake of seafood, and found that some substances were excellent stimulants on the feeding intake of seafood. They found that it is effective and have already filed a patent application (Japanese Patent Laid-Open No. 146758/1982, Japanese Patent Application No. 232/1983
No. 0, patent application No. 1983-28503, patent application No. 1983-964
(See No. 96). The present invention was made as a result of further continuation of the above research and the discovery of a new compound that has a feeding stimulating effect.
本発明の摂餌※１１激物質は、後述する実験例に示され
るように，魚類の味覚や臭覚を刺激して、魚類の食欲を
増進する作用を有していることが確認された。したがっ
て、この摂餌刺激物質を添加することにより、魚類の養
殖などにおける餌料効率を高めることができる。また、
低コストで入手できる代替餌料であっても、生餌、魚粉
などを用いた配合餌料と同等の餌料効率を維持すること
が可能となる。As shown in the experimental examples described below, the feeding substance*11 of the present invention was confirmed to have the effect of stimulating the taste and smell of fish and increasing their appetite. Therefore, by adding this feeding stimulant, it is possible to increase the feed efficiency in fish farming and the like. Also,
Even with alternative feeds available at low cost, it is possible to maintain feed efficiency equivalent to mixed feeds using raw bait, fishmeal, etc.
本発明の摂餌刺激物質は、例えば合成餌料、半天然餌料
、完全天然餌料なと、各種の餌料に添加することにより
，魚類の摂餌量を増加させ、その成長を促進させる効果
がある．この効果は、例えばコイ、フナ、金魚、ウナギ
、ニジマス、ティラビアなどの淡水魚や、ハマチ、タイ
、イセエビ、ヒラメなどの海水魚など、あらゆる魚類に
認められる６
本発明の餌料は、上記の摂餌刺激物質を添加したことに
特徴があり、ベースとなる餌料としては．合成餌料、半
天然餌料，完全天然餌料など、いずれも採用することが
できる。The feeding stimulant of the present invention has the effect of increasing the amount of food consumed by fish and promoting their growth when added to various types of feed, such as synthetic feed, semi-natural feed, and completely natural feed. This effect is observed in all types of fish, including freshwater fish such as carp, crucian carp, goldfish, eel, rainbow trout, and tilavia, and saltwater fish such as yellowtail, sea bream, spiny lobster, and flounder. It is characterized by the addition of stimulants, and as a base feed. Synthetic feeds, semi-natural feeds, completely natural feeds, etc. can all be used.
摂餌刺激物質の添加方法は、特に限定されないが，例え
ば摂餌刺激物質をＩＱ− １ ０〜１０−１Ｍ金含有る
溶液を添加して調製することが好ましい。この場合，溶
液中の摂餌刺激物質の濃度が１０−” Ｍ未満では，魚
類に対する摂餌刺激効果が充分に得られず． １０−１
Ｍを超えると，臭気が発生し、効果が低下する傾向があ
る．より好ましくは、餌料原料に上記溶液を添加して練
り合せて調製する。The method of adding the feeding stimulant is not particularly limited, but for example, it is preferable to prepare the feeding stimulant by adding a solution containing IQ-10 to 10-1M gold. In this case, if the concentration of the feeding stimulating substance in the solution is less than 10-''M, a sufficient feeding stimulating effect on fish cannot be obtained. 10-1
If it exceeds M, odor will occur and the effectiveness will tend to decrease. More preferably, it is prepared by adding the above solution to feed raw materials and kneading them.
「発明の実施例Ｊ
（１）実験方法および装置
第１図には、摂餌刺激効果の実験に用いた装置が示され
ている，図において，ｌは水槽であり、台２の上に支持
されている．水槽ｌ内には魚３が入れられている．水ｆ
ｆｌｌの側方には支柱４が立設され、記録針５に連接さ
れたアーム６が支軸７を介して支柱４に回転自在に支持
されている。記録針５の後端には糸８が連結され、糸８
の下端には磁石９が固着されており、この磁石９が水槽
ｌの底部に密着することにより、糸が張られている。Embodiment J of the invention (1) Experimental method and apparatus Figure 1 shows the apparatus used in the experiment on the feeding stimulation effect. Fish 3 is placed in tank l.Water f
A support post 4 is erected on the side of the fll, and an arm 6 connected to a recording needle 5 is rotatably supported by the support post 4 via a support shaft 7. A thread 8 is connected to the rear end of the recording needle 5.
A magnet 9 is fixed to the lower end of the tank 1, and the thread is stretched by bringing the magnet 9 into close contact with the bottom of the tank 1.
糸８の途中で水槽ｌの水に浸漬した部分には、実験用の
餌ｌＯが取付けられている。一方、水槽ｌの側方には記
録計本体１１が設置されており、記録計本体１１には逆
り字状の支柱１２が立設されている。支柱Ｉ２と記録計
本体１１との間には、回転ドラム１３が回転自在に支持
されており、前述した記録計５の先端部がこの回転ドラ
ム１３に摺接している０回転ドラム１３は、記録゛針本
体１１内部に設けられた図示しない駆動機構により、２
分５０秒で１回転するようになっている。Experimental bait lO is attached to the part of the string 8 that is immersed in the water of the tank l. On the other hand, a recorder main body 11 is installed on the side of the water tank l, and an inverted-shaped support 12 is erected on the recorder main body 11. A rotary drum 13 is rotatably supported between the column I2 and the recorder main body 11.゛By a drive mechanism (not shown) provided inside the needle main body 11, the 2
It rotates once every minute and 50 seconds.
上記装置を用いた実験の方法を説明すると、まず、各種
の摂餌刺激物質を添加した実験用の餌ｌＯを調製し、こ
の餌１０を糸８に付着させて、水槽ｌの水の中間高さ位
置に沈める。そして１回転ドラム１３を回転させて魚３
によりｆ！］ＩＩＯのついばみ状態を記録する。すなわ
ち、魚３が餌１０をついばむと、６１１石９により張ら
れている糸８が引っ張られ、記録針５が揺動して、回転
ドラム１３に記録がなされる。こうして回転ドラム１３
が一回転する間に、魚３が餌ｌＯをついばんだ回数を測
定した。なお、試験毎に、試験水を交換すると同時に、
糸８、魚３、水槽１は、飼育用水でよく洗うようにした
。To explain the experimental method using the above-mentioned device, first, an experimental bait 10 containing various feeding stimulants is prepared, the bait 10 is attached to the thread 8, and the water in the aquarium 1 is placed at an intermediate height. Place it in the correct position. Then rotate the drum 13 once and fish 3.
By f! ]Record the IIO pecking status. That is, when the fish 3 pecks the bait 10, the string 8 stretched by the 611 stones 9 is pulled, the recording needle 5 swings, and a record is made on the rotating drum 13. In this way, the rotating drum 13
The number of times Fish 3 pecked at the bait 1O during one rotation of the fish was measured. In addition, at the same time as replacing the test water for each test,
Thread 8, fish 3, and tank 1 were thoroughly washed with breeding water.
１２）餌の調装
試験用の餌は、次のようにして調製した。すなわち、ベ
ース餌料として、セルロース粉末を用いた。一方、摂口
ｌ刺激効果を試験する物質を１０−”Ｍ溶解させた水（
８液を作成した。そして、前記のベース餌料を０．５ｇ
とり、これに上記の試験液０．８ ｍｌを添加してａ訪
中で練り合せて餌を調製した。12) Preparation of bait The bait for the test was prepared as follows. That is, cellulose powder was used as the base feed. On the other hand, in water (
Eight liquids were prepared. Then, add 0.5g of the above base feed.
0.8 ml of the above test solution was added to this, and the mixture was mixed to prepare bait.
試験は、摂餌刺激物質を添加しない水だけを用いてベー
ス餌料を練り合せたもの（対照）と、各種の↑ＨｆｆＩ
Ｉ刺徴物質を溶解した水溶液でベース餌料を練り合せた
ものについて行なった。The test consisted of a mixture of base feed using only water without any feeding stimulants added (control), and a mixture of various ↑HffI
The test was carried out on a base bait mixed with an aqueous solution containing a stinging substance.
また、各実験は、５回繰り返して行ない、ついばみ回数
の合計をとって評価した。Each experiment was repeated five times, and the total number of pecking was evaluated.
（３）実験結果
（試験液） （評価）
・対照（水だけ） １７４（試験１
ｆ）
（評価）
フオニウムブロマイド
ド
ジメチルスルフィド
ジブロビルト用スルフィ
メチルエチルスルフィド
メチルプロピルスルフィ
メチルブチルスルフィド
メチルアリルスルフィド
ド
ド
（試験液） （評価）
・エチルプロピルスルフィド ２６４・エチルブ
チルスルフィド ２６２上記の結果から、−数
式（り〜（ＩＩ＋ ）で示される化合物は、優れた摂餌
刺部効果を有することがわかる。(3) Experimental results (test solution) (evaluation) ・Control (water only) 174 (Test 1
f) (Evaluation) Phonium bromide dodimethyl sulfide Sulfymethyl ethyl sulfide for dibrobilt Methyl propyl sulfimethyl butyl sulfide Methyl allyl sulfide (Test solution) (Evaluation) ・Ethylpropyl sulfide 264・Ethyl butyl sulfide 262 Above The results show that the compound represented by the formula (II+) has an excellent bait-feeding sting effect.
「発明の効果ノ
以上説明したように、本発明によれば、優れた摂餌刺激
効果を有する物質を提供することができる。この摂餌刺
激物質を各種の餌料に添加することにより、魚類の臭覚
や味覚を刺激し、摂餌１を増加させて魚類の成長を促進
させ、餌料効率を高めることができる。``Effects of the Invention'' As explained above, according to the present invention, it is possible to provide a substance that has an excellent feeding stimulating effect. By adding this feeding stimulating substance to various feeds, fish It can stimulate the sense of smell and taste, increase feed intake1, promote growth of fish, and improve feed efficiency.
４、図面ノｎｔｉｉな説明
第１図は摂餌刺激効果の実験に用いた装置の概略説明図
である。4. Explanation without drawings Figure 1 is a schematic explanatory diagram of the apparatus used in the experiment on the feeding stimulation effect.
特許出願人 中 島 謙 二 同 ジブコム株式会社 同代理人 弁理士 松井 茂Patent applicant: Kenji Nakajima Same as Jibcom Co., Ltd. Agent: Patent Attorney Shigeru Matsui
Claims (3)
れる化合物およびそれらの塩（ただし、β−ジメチルプ
ロピオテチン、２−メルカプトアセティックアシッド、
ジプロピルスルフィド、ジブチルスルフィド、ジメチル
スルフォキシド、ジメチルスルフォン、サッカリン、カ
ルボキシメチルジメチルスルフォニウムおよびこれらの
塩を除く）から選ばれた一種または二種以上からなるこ
とを特徴とする魚類の摂餌刺激物質。 ▲数式、化学式、表等があります▼・・・（ I ） （式中、ｎは０≦ｎ≦２０の整数である。Ｒ＿１、Ｒ＿
２は水素、酸素、ハロゲン、飽和炭化水素基、飽和複素
環基、不飽和炭化水素基、不飽和複素環基、カルボキシ
基、チオカルボキシ基、ジチオカルボキシ基、スルホ基
、スルフィノ基、スルフェノ基、ハロホルミル基、カル
バモイル基、ヒドラジノカルボニル基、シアノ基、ニト
リロ基、イソシアノ基、シアナト基、チオシアナト基、
イソチオシアナト基、チオケトン基、ホルミル基、オキ
ソ基、チオホルミル基、チオキソ基、ヒドロキシ基、メ
ルカプト基、ヒドロペルオキシ基、アミノ基、イミノ基
、ヒドラジノ基、ニトロ基、ニトロソ基、ジアゾ基、ア
ジド基、アルキルオキシ基、アルキルチオ基、アルキル
ジオキシ基、アルキルオキシカルボニル基、ジチオ基、
トリチオ基、ポリチオ基またはこれらの複合基を表わし
、Ｒ＿１、Ｒ＿２は同じでも異なっていてもよい。Ｘ＾
−は一価の陰イオンを表わす。） ▲数式、化学式、表等があります▼・・・（II） （式中、Ｒ＿１、Ｒ＿２、Ｘ＾−は前記と同様な意味で
ある。 Ｒ＾３は、−（ＣＨ＿２）＿ｎ−を基本骨格とし、この
中の１または複数の炭素の側鎖にＲ＿１、Ｒ＿２と同様
なものが結合されているか、あるいはこの中の１または
複数の炭素が脱水素されて１または複数の二重結合もし
くは三重結合を有するものを表わす。） ▲数式、化学式、表等があります▼・・・（III） （式中、ｎ、Ｒ＿１、Ｒ＿２、Ｘ＾−は前記と同様な意
味であり、Ｒ＿４は前記Ｒ＿１、Ｒ＿２と同様な意味で
ある。）(1) Compounds represented by the following general formula (I), (II) or (III) and their salts (with the exception of β-dimethylpropiotetin, 2-mercaptoacetic acid,
(excluding dipropylsulfide, dibutylsulfide, dimethylsulfoxide, dimethylsulfone, saccharin, carboxymethyldimethylsulfonium, and salts thereof) for fish feeding. irritating substances. ▲There are mathematical formulas, chemical formulas, tables, etc.▼...(I) (In the formula, n is an integer of 0≦n≦20.R_1, R_
2 is hydrogen, oxygen, halogen, saturated hydrocarbon group, saturated heterocyclic group, unsaturated hydrocarbon group, unsaturated heterocyclic group, carboxyl group, thiocarboxy group, dithiocarboxy group, sulfo group, sulfino group, sulfeno group, Haloformyl group, carbamoyl group, hydrazinocarbonyl group, cyano group, nitrilo group, isocyano group, cyanato group, thiocyanato group,
isothiocyanato group, thioketone group, formyl group, oxo group, thioformyl group, thioxo group, hydroxy group, mercapto group, hydroperoxy group, amino group, imino group, hydrazino group, nitro group, nitroso group, diazo group, azido group, alkyl Oxy group, alkylthio group, alkyldioxy group, alkyloxycarbonyl group, dithio group,
It represents a trithio group, a polythio group, or a composite group thereof, and R_1 and R_2 may be the same or different. X^
- represents a monovalent anion. ) ▲There are mathematical formulas, chemical formulas, tables, etc.▼...(II) (In the formula, R_1, R_2, and X^- have the same meanings as above. R^3 is based on -(CH_2)_n- A skeleton, and one or more carbon atoms in the skeleton have something similar to R_1, R_2 bonded to the side chain, or one or more carbon atoms in the skeleton are dehydrogenated to form one or more double bonds or (Represents something with a triple bond.) ▲There are mathematical formulas, chemical formulas, tables, etc.▼...(III) (In the formula, n, R_1, R_2, and X^- have the same meanings as above, and R_4 has the same meaning as above. It has the same meaning as R_1 and R_2.)
とを特徴とする魚類の餌料。(2) A feed for fish, characterized in that the feeding stimulating substance according to claim 1 is added.
〜１０＾−＾１Ｍ含有する溶液を添加して得られた請求
項２記載の魚類の餌料。(3) 10^-^1^0 of the feeding stimulant according to claim 1.
The fish feed according to claim 2, obtained by adding a solution containing ~10^-^1M.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63194217A JPH0645589B2 (en) | 1988-08-03 | 1988-08-03 | Fish feeding stimulants and foods |
| US07/271,236 US5139791A (en) | 1988-02-09 | 1988-11-14 | Feeding stimulators for fishes and shellfishes, and feed |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63194217A JPH0645589B2 (en) | 1988-08-03 | 1988-08-03 | Fish feeding stimulants and foods |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH0245461A true JPH0245461A (en) | 1990-02-15 |
| JPH0645589B2 JPH0645589B2 (en) | 1994-06-15 |
Family
ID=16320902
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP63194217A Expired - Fee Related JPH0645589B2 (en) | 1988-02-09 | 1988-08-03 | Fish feeding stimulants and foods |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0645589B2 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997007853A1 (en) | 1995-08-31 | 1997-03-06 | Hisamitsu Pharmaceutical Co., Inc. | Iontophoresis device and method of current control therefor |
| EP3192558A1 (en) | 2016-01-14 | 2017-07-19 | Insung Information Co., Ltd. | Sheet mask for iontophoresis and mask assembly using the same |
-
1988
- 1988-08-03 JP JP63194217A patent/JPH0645589B2/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997007853A1 (en) | 1995-08-31 | 1997-03-06 | Hisamitsu Pharmaceutical Co., Inc. | Iontophoresis device and method of current control therefor |
| US6141582A (en) * | 1995-08-31 | 2000-10-31 | Hisamitsu Pharmaceutical Co., Ltd. | Iontophoresis system and its control process of current |
| EP3192558A1 (en) | 2016-01-14 | 2017-07-19 | Insung Information Co., Ltd. | Sheet mask for iontophoresis and mask assembly using the same |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0645589B2 (en) | 1994-06-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Shukla et al. | Bioaccumulation of Zn, Cu and cd in Channa punctatus | |
| Mount et al. | Dietary and waterborne exposure of rainbow trout (Oncorhynchus mykiss) to copper, cadmium, lead and zinc using a live diet | |
| Merlini et al. | Lead and freshwater fishes: Part 1—Lead accumulation and water pH | |
| Klumpp | Nutritional ecology of the ascidian Pyura stolonifera: Influence of body size, food quantity and quality on filter-feeding, respiration, assimilation efficiency and energy balance. | |
| Manzi et al. | ALGAL SUPPLEMENT ENHANCEMENT OF Macrobrachium rosenbergii (DE MAN) LARVICULTURE 1, 2 | |
| US5139791A (en) | Feeding stimulators for fishes and shellfishes, and feed | |
| Eisler | Radiocadmium exchange with seawater by Fundulus heteroclitus (L.)(Pisces: Cyprinodontidae) | |
| JPH0245461A (en) | Feeding-stimulating substance for fish and feed | |
| CN104054597A (en) | Nibea albiflora fry artificial mixed feed domestication method | |
| Newsome et al. | Aetiology of skeletal deformities in the Zebra Danio fish (Bruchydanio rerio, Hamilton‐Buchanan) | |
| Torrissen et al. | Tissue distribution of 14C-astaxanthin in the Atlantic salmon (Salmo salar) | |
| JPH01202260A (en) | Bait intake-stimulant for seafoods and bait containing same | |
| Celada et al. | Effects of stocking density on survival and growth of juvenile tench (Tinca tinca L.) | |
| Perry | Notes on the spawning of blue and channel catfish in brackish water ponds | |
| JPH0645588B2 (en) | Feeding stimulants and diets for shellfish | |
| Tidwell et al. | The effect of photoperiod on growth and survival of juvenile freshwater prawn, Macrobrachium rosenbergii in nursery tanks | |
| Wahl et al. | Application of liquid oxytetracycline in formulated feeds to mark and treat tiger muskellunge (northern pike x muskellunge) | |
| Obradović | Effects of anaesthetics (halothane and MS-222) on crayfish, Astacus astacus | |
| Mason et al. | THE EFFECTS OF SUPPLEMENTING PURIFIED PROTEINS WITH LIMITING ESSENTIAL AMINO ACIDS ON GROWTH AND SURVIVAL OF JUVENILE LOBSTERS (Homarus americanus) 1 | |
| JPH036779B2 (en) | ||
| JP7305088B2 (en) | Application of γ-Quaternary Ammonium Butyrate Ester Compounds in the Preparation of Animal Feed Additives | |
| JPH04126041A (en) | Feeding stimulating substance of fishes and shellfishes and feed | |
| Bryant et al. | Food of bluegill and longear sunfish in DeGray Reservoir, Arkansas, 1976 | |
| JPH057463A (en) | Feed for aquatic animal and method for culturing aquatic animal | |
| McNevin et al. | Galkanda‐Arachchige, HS, Roy, LA & Davis, DA (2020b) Evaluation of an alternative salt mixture to culture Pacific white shrimp (Litopenaeus vannamei) in inland aquaculture. Aquaculture Research. Gao, W., Tian, L., Huang, T., Yao, M., Hu, W. & Xu, Q.(2016) Effect of salinity on the growth performance, osmolarity and metabolism-related gene expression in white shrimp Litopenaeus |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| LAPS | Cancellation because of no payment of annual fees |