JPH0242505B2 - - Google Patents

Description

[Detailed description of the invention]

(Industrial Application Field) The present invention relates to a medical hard resin composition and a medical device. Specifically, the present invention relates to medical hard resin compositions and medical devices that have extremely high stability and do not cause hemolysis when they come into contact with blood. (Prior art) Currently, hard resin compositions are often used in place of glass, metal, etc. for various hard medical devices because they are lightweight, hard to break, inexpensive, and disposable. It is being By the way, it is very important for such medical devices to be inert to blood components. However, for example, if blood is collected into a conventionally used blood collection tube made of glass or hard resin and then stored in the blood collection tube for a long time, red blood cells become hemolyzed. Hemoglobin released due to hemolysis adversely affects various measurement results for clinical tests. Generally, a blood bag containing donated blood is attached with a blood collection tube containing the same blood as the blood in the blood bag to check compatibility with the patient's blood before transfusion. However, as the red blood cell concentrate approaches its expiry date of 21 days (in Japan), the blood in the blood collection tube becomes hemolyzed, which interferes with the test. This was a problem because it was stored away. Therefore, it is desired to develop a hard resin that does not cause hemolysis even when it comes into contact with blood for a long time. (Problems to be Solved by the Invention) Therefore, an object of the present invention is to provide a novel medical hard resin composition and a medical device.
Another object of the present invention is to provide a medical hard resin composition and a medical device that have excellent preservability for red blood cells. (Means for Solving the Problems) The above objects are such that each monovalent hydrocarbon group having at least one ether bond and bonded to ether oxygen has 3 to 3 carbon atoms in a hard resin composition.
This is achieved by a medical hard resin composition characterized by blending an ether compound with a molecular weight of 1,000 or less, which has 20 chain hydrocarbon groups. The present invention also provides a medical hard resin composition containing 0.5 to 5% by weight of the above ether compound. The present invention also provides a medical hard resin composition in which at least one of the monovalent hydrocarbon groups bonded to the ether oxygen of the ether compound has a branched structure. The present invention also provides a medical hard resin composition in which the ether compound has two or more ether bonds. The present invention further provides a medical hard resin composition in which at least two of the monovalent hydrocarbon groups bonded to ether oxygen have different chain lengths. The present invention also provides that the ether compound has the general formula (') (However, in the formula, R ¹ and R ² each have 3 to 20 carbon atoms.
is a chain hydrocarbon group. ) is a medical hard resin composition which is a glycerin diether. The present invention further provides a medical hard resin composition in which the glycerin diether represented by the general formula (') is glycerin-1-butyl-3-isostearyl ether or glycerin-1,3-bis(2-ethylhexyl) ether. This shows that. The present invention also provides a medical hard resin composition in which the hard resin is selected from the group consisting of hard vinyl chloride resin, acrylic resin, styrene resin, olefin resin, thermoplastic polyester resin, and polycarbonate. It shows. The present invention further provides a medical hard resin composition in which the acrylic resin is a homopolymer or copolymer of methyl methacrylate, methyl acrylate, ethyl methacrylate, ethyl acrylate, acrylonitrile, or methacrylonitrile. The present invention also provides a medical hard resin composition in which the styrenic resin is polystyrene, an acrylonitrile-styrene copolymer, or an acrylonitrile-butadiene-styrene copolymer. The present invention also provides a medical hard resin composition in which the olefinic resin is polyethylene, polypropylene, or an ethylene-propylene copolymer. The present invention also provides a medical hard resin composition in which the thermoplastic polyester resin is polyethylene terephthalate or polybutylene terephthalate. The above objects also provide a cured resin composition having a molecular weight in which each monovalent hydrocarbon group having at least one ether bond and bonded to an ether oxygen is a chain hydrocarbon group having 3 to 20 carbon atoms. This is achieved by a medical device characterized in that it is substantially composed of a hard resin composition containing 1000 or less ether compounds. The present invention also provides a medical device characterized in that it is substantially composed of a hard resin composition containing 0.5 to 5% by weight of the above-mentioned ether compound. The present invention also provides a medical device in which at least one of the monovalent hydrocarbon groups bonded to the ether oxygen of the ether compound has a branched structure. The present invention also provides a medical device in which the ether compound has two or more ether bonds. The present invention further provides a medical device in which at least two of the monovalent hydrocarbon groups bonded to ether oxygen have different chain lengths. The present invention also provides that the ether compound has the general formula (') (However, in the formula, R ¹ and R ² each have 3 to 20 carbon atoms.
is a chain hydrocarbon group. ) indicates a medical device that is a glycerin diether. The present invention further provides a medical device in which the glycerin diether represented by the general formula (') is glycerin-1-butyl-3-isostearyl ether or glycerin-1,3-bis(2-ethylhexyl) ether. . The present invention also provides a medical device in which the hard resin is selected from the group consisting of hard vinyl chloride resins, acrylic resins, styrenic resins, olefin resins, thermoplastic polyester resins, and polycarbonates. . The invention further provides a medical device in which the acrylic resin is a homopolymer or copolymer of methyl methacrylate, methyl acrylate, ethyl methacrylate, ethyl acrylate, acrylonitrile or methacrylonitrile. The present invention also provides a medical device in which the styrenic resin is polystyrene, acrylonitrile-styrene copolymer, or acrylonitrile-butadiene-styrene copolymer. The present invention also provides a medical device in which the olefinic resin is polyethylene, polypropylene or ethylene-propylene copolymer. The present invention also provides a medical device in which the thermoplastic polyester resin is polyethylene terephthalate or polybutylene terephthalate. The present invention further provides a medical device characterized in that it is a blood collection tube. The present invention also provides medical devices that are capable of withstanding autoclave sterilization. (Function) Therefore, the medical hard resin composition of the present invention:
In the hard resin composition, an ether compound having a molecular weight of 1000 or less, which has at least one ether bond and in which each monovalent hydrocarbon group bonded to ether oxygen is a chain hydrocarbon group having 3 to 20 carbon atoms. The biggest feature is that it is blended with Surprisingly, it has been found that the above ether compounds have an effect of preventing red blood cell hemolysis. Furthermore, since the ether compounds mentioned above have sufficient compatibility with various hard resins, by blending the ether compounds, a hard resin composition with good preservability for red blood cells when in contact with blood can be obtained. You will be able to do that. That is, when the hard resin composition comes into contact with blood, the action of the ether compound eluted from the resin composition prevents hemolysis of red blood cells, resulting in an excellent protective effect on red blood cells. . Therefore, the medical hard resin composition of the present invention is suitable as a material for medical devices, and molded products made using the material have excellent safety, processability, transparency, and heat resistance. Because of its properties, it can be very effective when used as a medical device, and its effects are particularly remarkable in the case of medical devices that come into contact with body fluids such as blood, such as blood collection tubes. Hereinafter, the present invention will be explained in more detail based on embodiments. The hard resin used in the medical hard resin composition according to the present invention is not particularly limited as long as it is physiologically safe and has appropriate compatibility with the ether compounds described below.
Examples include hard vinyl chloride resin, acrylic resin, styrene resin, olefin resin, thermoplastic polyester resin, and polycarbonate. In addition, in these hard resins,
Regardless of the type of hard resin, its melt flow index is 0.5g/10min, especially 5 to 12g/10min.
It is preferable that the time is about 10 min. As the hard vinyl chloride resin, in addition to vinyl chloride homopolymers, other copolymerizable resins containing vinyl chloride at 40% by weight or more, preferably 65% by weight or more, most preferably 75% by weight or more, such as: Examples include copolymers with monomers such as vinylidene chloride, ethylene, propylene, styrene, methyl methacrylate, and acrylonitrile. Examples of acrylic resins include homopolymers and copolymers of alkyl (meth)acrylates such as methyl methacrylate, methyl acrylate, ethyl methacrylate, and ethyl acrylate, acrylonitrile, and methacrylonitrile; examples of polystyrene resins include There are polystyrene, acrylonitrile-styrene copolymer, acrylonitrile-butadiene-styrene copolymer (ABS resin), etc.Olefin resins include medium to high density polyethylene, polypropylene, or ethylene-propylene copolymer, etc. There are copolymers made of combinations of ethylene, propylene, and other α-olefins, and thermoplastic polyester resins include polyethylene terephthalate, polybutylene terephthalate, and the like. Furthermore, the polycarbonate includes, in addition to bisphenol A type polycarbonate, those having various carbonate type structures. The hard resin used in the medical hard resin composition of the present invention is of course not limited to those exemplified above, but further hard resins include polymer blends of various resins. It is included. Therefore, in the medical hard resin composition of the present invention, each monovalent hydrocarbon group having at least one ether bond and bonded to ether oxygen has 3 to 20 carbon atoms, more preferably 4 carbon atoms. An ether compound having a molecular weight of 1000 or less and having ~18 chain hydrocarbon groups is blended. This ether compound acts as a hemolysis inhibitor in the medical hard resin composition of the present invention. That is, when blood comes into contact with a product made of the medical hard resin composition of the present invention, the ether compound eluted from the composition exerts a protective effect on red blood cells. In this ether compound, each monovalent hydrocarbon group bonded to ether oxygen has 3 to 3 carbon atoms.
20 chain hydrocarbon groups are used because chain hydrocarbon groups with less than 3 carbon atoms do not have a hemolytic inhibitory effect, and one chain hydrocarbon group with more than 20 carbon atoms This is because if it has, it becomes solid and loses compatibility with the hard resin, making it difficult to uniformly disperse it in the resin composition. Furthermore, the molecular weight of this ether compound is 1000 or less because
This is because if the molecular weight exceeds 1,000, the polymer becomes solid and has no compatibility with the hard resin, making it difficult to uniformly disperse it in the resin composition. Further, in this ether compound, it is more preferable that at least one of the monovalent hydrocarbon groups bonded to the ether oxygen has a branched structure in order to improve the compatibility with the hard resin and the effect of suppressing hemolysis. In addition, this ether compound may have two or more ether bonds, and furthermore, in the case where it has two or more ether bonds, at least two of the monovalent hydrocarbon groups bonded to the ether oxygen are mutually It is desirable that the chain lengths are different from the viewpoint of better inhibition of hemolysis. In this ether compound, each of the monovalent hydrocarbon groups bonded to the ether oxygen may be a saturated chain hydrocarbon group or an unsaturated chain hydrocarbon group.
Such an ether compound compounded in the medical hard resin of the present invention has, for example, the general formula () R ¹ -O-R ² () (wherein R ¹ and R ² each have 3 to 3 carbon atoms).
It is a 20-chain hydrocarbon group. ), General formula () R ¹ -O (-R ⁴ O) - _o R ² () (However, in the formula, R ¹ and R ² are chain hydrocarbon groups having 3 to 20 carbon atoms, and R ⁴ is a carbon number 1 to 3 linear or branched saturated hydrocarbon groups, n is an integer of 1 to 5.), and a single carrier () (However, in the formula, R ¹ to ^{R 3} are each a chain hydrocarbon group having 3 to 20 carbon atoms or hydrogen, and R ⁵ to ^{R 9}
are each a methyl group or hydrogen, but R ¹ ~
Two or more of R ³ cannot become hydrogen at the same time. ) are listed as representative examples, but of course they are not limited to these. More specifically, the compounds represented by the general formula () include, for example, 2-ethylhexyl isopropyl ether, di-2-ethylhexyl ether, diisopentyl ether, diisolauryl ether, diisomyristyl ether, diisopalmityl Examples include ether, diisostearyl ether, and compounds represented by the general formula () include ethylene glycol di(2-ethylhexyl) ether, ethylene glycol 2-ethylhexyl isopropyl ether, and ethylene glycol isopentyl.
Isopropyl ether, ethylene glycol isopentyl butyl ether, ethylene glycol isolauryl isopropyl ether, ethylene glycol isolauryl butyl ether, ethylene glycol isomyristyl isopropyl ether, ethylene glycol isomyristyl butyl ether, ethylene glycol isopalmityl isopropyl ether, Ethylene glycol diethers such as ethylene glycol isopalmityl butyl ether, ethylene glycol isostearyl isobutyl ether, ethylene glycol isostearyl butyl ether, diethylene glycol di(2-
ethylhexyl) ether, diethylene glycol 2-ethylhexyl isopropyl ether, diethylene glycol isopentyl isopropyl ether, diethylene glycol isopentyl butyl ether, dielene glycol isolauryl isopropyl ether, diethylene glycol isolauryl butyl ether, diethylene glycol isomyristyl isopropyl ether, diethylene glycol Diethylene glycol diethers such as isomyristyl butyl ether, diethylene glycol isopalmityl isopropyl ether, diethylene glycol isopalmityl butyl ether, diethylene glycol isostearyl isopropyl ether, diethylene glycol isostearyl butyl ether, propylene glycol di(2-ethylhexyl) ether ,
Propylene glycol = 2-ethylhexyl = isopropyl ether, propylene glycol = isopentyl = isopropyl ether, propylene glycol = isopentyl = butyl ether, propylene glycol = isolauryl = isopropyl ether, propylene glycol = isolauryl = butyl ether, propylene glycol = isomyristyl = isopropyl ether, Propylene glycol diethers such as propylene glycol isomyristyl butyl ether, propylene glycol isopalmityl isopropyl ether, propylene glycol isopalmityl butyl ether, propylene glycol isostearyl isopropyl ether, propylene glycol isostearyl butyl ether, and similar triglycerides. There are ethylene glycol diethers, dipropylene glycol diethers, butylene glycol diethers, etc. Furthermore, compounds represented by the general formula () include glycerin-1,3-bis(2-ethylhexyl) ether, glycerin- 1-isopropyl-3-(2-ethylhexyl) ether, glycerin-1-isopropyl-3-isopentyl ether, glycerin-1-butyl-3-isopentyl ether, glycerin-1-isopropyl-
3-Isolauryl ether, glycerin-1-butyl-3-isolauryl ether, glycerin-
1-isopropyl-3-isomyristyl ether, glycerin-1-butyl-3-isomyristyl ether, glycerin-1-isopropyl-3
- Glycerin diethers such as isopalmityl ether, glycerin-1-butyl-3-isopalmityl ether, glycerin-1-isopropyl-3-isostearyl ether, glycerin-1-butyl-isostearyl ether, glycerin triisopropyl Ether, glycerin triisobutyl ether, glycerin triisopentyl ether, 1,3-diisopropoxy-2-(2
-ethylhexyloxy)propane, 1,3-bis(ethylhexyloxy)-2-isopropoxypropane, 1,3-dibutoxy-2-(2-ethylhexyloxy)propane, 1,3-bis(2-ethyl hexyloxy)-2-butoxypropane, 1,
Examples include glycerin triethers such as 3-diisopropoxy-2-isopentyloxypropane and 1,3-diisopentyloxy-2-butoxypropane. Among these ether compounds, particularly preferred are those represented by the general formula () (However, in the formula, R ¹ and R ² each have 3 carbon atoms.
~20 chain hydrocarbon groups. ), more preferably glycerin-1-butyl-3-isostearyl ether and glycerin-1,3-bis(2-ethylhexyl) ether. Such an ether compound is blended in the medical hard resin composition of the present invention in an amount of 0.5 to 5% by weight, more preferably 2 to 3% by weight. That is, if the amount of the ether compound is less than 0.5% by weight, the effect of suppressing hemolysis of red blood cells will not be sufficient, while if it exceeds 5% by weight, there is a risk of deteriorating the physical properties of the hard resin composition. be. Furthermore, additives such as various stabilizers, lubricants, and antioxidants may be added to the medical vinyl chloride resin composition of the present invention, if necessary. The medical hard resin composition of the present invention can be molded by any of the methods used for conventional hard resin compositions, such as injection molding and extrusion molding. The medical device of the present invention has a hard resin composition in which each monovalent hydrocarbon group having at least one ether bond as described above and bonded to ether oxygen has a chain structure of 3 to 20 carbon atoms. Molecular weight that is a hydrocarbon
It is essentially composed of a hard resin composition containing 1000 or less ether compounds, and has various physical properties such as excellent processability and heat resistance, and has an especially effective inhibitory effect on hemolysis of red blood cells. is excellent. Therefore, the medical devices of the present invention preferably include those that come into contact with body fluids such as blood, concentrated red blood cells, or body fluid component solutions, such as blood collection tubes, and particularly those that come in contact for a long time. Preferred examples include, but are not limited to, blood collection bottles, test tubes, shears, various artificial organs such as artificial lungs and artificial kidneys, and housings for heat exchangers and the like. Next, one embodiment of the medical device according to the present invention will be described with reference to the drawings, taking a blood collection tube as an example. That is, FIG. 1 shows a tubular member 2 made of the medical hard resin composition according to the present invention with one end closed and the other end open, and a punctureable butyl rubber member with the open end 3 of the tubular member 2 sealed. 1 shows a reduced pressure blood collection tube 1 which maintains an internal space 5 formed by a stopper member 4 in a reduced pressure state. The reduced pressure blood collection tube 1 having such a configuration is used in the following manner. That is, as shown in FIG. 2, one end is closed and the other end is open, and a blood collection needle 7 is screwed into the screw hole 6 of the closed end 10. Blood vessel holder 8
The reduced pressure blood collection tube 1 is inserted into the tube from the open end 3 side. This blood collection needle 7 has a blood vessel piercing part 7 and a plug puncturing part 7.
b and is packaged with a lure adapter 9 made of synthetic resin. Next, when the blood vessel piercing portion 7a of the blood sampling needle 7 is inserted under pressure into the closed end 10 of the blood sampling tube holder 8, the plug piercing portion 7 of the blood sampling needle 7 is inserted as shown in FIG.
b punctures the luer adapter 9 and the stopper member 4 and reaches the internal space 5 of the blood collection tube 1, so the blood vessel and the internal space 5 communicate with each other, and the negative pressure in the internal space 5 causes the blood in the blood vessel to be at a reduced pressure. Blood collection tube equivalent to 1
into the internal space 5 of. Next, blood collection is completed by removing the blood vessel piercing portion 7b of the blood collection needle 7 from the blood vessel, and the collected blood is stored in the blood collection tube 1 until it is subjected to a test. However, as mentioned above, the blood collection tube 1 is made of the medical hard resin composition according to the present invention, and the hemolysis of red blood cells is prevented by the action of the above-mentioned ether compound that is eluted and transferred from the composition into the blood. Therefore, even if the storage period is long,
Free hemoglobin does not adversely affect various measurements for clinical tests, and accurate test values can be obtained. The above explanation uses blood collection tubes as an example, but other blood collection bottles, test tubes, shears, artificial lungs,
Housings for various artificial organs such as artificial kidneys and heat exchangers are also suitably constructed from the above-mentioned hard resin composition. (Examples) Hereinafter, the present invention will be explained in more detail based on Examples. Example 1 Polyethylene terephthalate (UNIPET)
RT560, made by Nippon Unipet Co., Ltd.) and 3 parts by weight of glycerin-1-butyl-3-isostearyl ether were mixed into pellets in a vented container.
The pellets were prepared using a screw extruder, and 5 ml blood collection tubes were made by injection molding. Approximately 3 ml of human EDTA-added blood was dispensed into the blood collection tube and stored at 4°C for 3 weeks. Then, the plasma hemoglobin concentration was measured using the TMB method (Clinical Chemistry 23) .
749~ (1977) [Clin.Chem. 23 749~
(1977)]). The results are shown in Table 1. Example 2 Glycerin-1-octyl-3 instead of glycerin-1-butyl-3-isostearyl ether
- A blood collection tube was prepared in the same manner as in Example 1 except that isostearyl ether was used, and the same experiment was conducted on this blood collection tube. The results are shown in Table 1. Comparative Example 1 For comparison, a blood collection tube was prepared in the same manner as in Example 1 using pellets made only of polyethylene terephthalate (Unipet RT560, manufactured by Nippon Unipet Co., Ltd.), and the same experiment was conducted on this blood collection tube. Summer. The results are shown in Table 1. Example 3 Polystyrene (Estyrene G-12F, manufactured by Nippon Steel Chemical Co., Ltd.) was used instead of polyethylene terephthalate.
A blood collection tube was prepared in the same manner as in Example 1, except that a sample was used, and the same experiment was conducted on this blood collection tube. The results are shown in Table 1. Example 4 Glycerin-1-octyl-3 instead of glycerin-1-butyl-3-isostearyl ether
- A blood collection tube was prepared in the same manner as in Example 3 except that isostearyl ether was used, and the same experiment was conducted on this blood collection tube. The results are shown in Table 1. Comparative Example 2 For comparison, polystyrene (Estyrene G
-12F, manufactured by Nippon Steel Chemical Co., Ltd.), a blood collection tube was prepared in the same manner as in Example 1,
A similar experiment was conducted using this blood collection tube. The results are shown in Table 1. Example 5 A blood collection tube was prepared in the same manner as in Example 1 except that polymethyl methacrylate (Parapet G, manufactured by Kyowa Gas Chemical Industry Co., Ltd.) was used in place of polyethylene terephthalate, and the same experiment was conducted on this blood collection tube. I did it. The results are shown in Table 1. Example 6 Glycerin-1-octyl-3 instead of glycerin-1-butyl-3-isostearyl ether
- A blood collection tube was prepared in the same manner as in Example 5 except that isostearyl ether was used, and the same experiment was conducted on this blood collection tube. The results are shown in Table 1. Comparative Example 3 For comparison, a blood collection tube was prepared in the same manner as in Example 1 using pellets made only of polyethyl methacrylate (Parapet G, manufactured by Kyowa Gas Chemical Industry Co., Ltd.). I conducted an experiment. The results are shown in Table 1. Example 7 Example 1 except that polyacrylonitrile (BAREX210, manufactured by Vestron Corp.) was used instead of polyethylene terephthalate.
A blood collection tube was prepared in the same manner as described above, and the same experiment was conducted using this blood collection tube. The results are shown in Table 1. Example 8 Glycerin-1-octyl-3 instead of glycerin-1-butyl-3-isostearyl ether
- A blood collection tube was prepared in the same manner as in Example 7 except that isostearyl ether was used, and the same experiment was conducted on this blood collection tube. The results are shown in Table 1. Comparative Example 4 For comparison, polyacrylonitrile (BAREX210, Vestron
A blood collection tube was prepared in the same manner as in Example 1 using pellets made only by J.D. Co., Ltd.), and the same experiment was conducted on this blood collection tube. The results are shown in Table 1.

[Table] Tearirue
-tel

[Table] Stearyl
ether
Comparative example 4 Polyacrylic - 120
Lonitrile
*Each plasma hemoglobin concentration value is expressed as the average of three data values.
As is clear from the results shown in Table 1, when the hard resin composition according to the present invention was used (Examples 1 to
In 8), the elution is suppressed to a low level compared to the case of using a hard resin composition that does not contain the ether compound according to the present invention and hardly elutes anything into the blood (Comparative Examples 1 to 4). I understood. (Effects of the Invention) As described above, the present invention provides a hard resin composition in which each monovalent hydrocarbon group having at least one ether bond and bonded to ether oxygen has 3 to 20 carbon atoms. The molecular weight of the chain hydrocarbon group
This medical hard resin composition is characterized by containing an ether compound of 1000 or less, so unlike conventional glass or hard resin compositions, it has the effect of suppressing hemolysis of red blood cells, and it also has the effect of suppressing hemolysis of red blood cells. It has physical properties such as moldability, transparency, and heat resistance that are comparable to other compositions, and can be molded by any conventional molding method, such as injection molding or extrusion molding. It is ideal as a material for medical equipment, especially medical equipment that comes into contact with blood, such as blood collection tubes. Furthermore, in the medical hard resin composition of the present invention, the above ether compound is contained in an amount of 0.5 to 5% by weight.
or when at least one of the monovalent hydrocarbon groups bonded to the ether oxygen of the ether compound has a branched structure, and the ether compound has two or more ether bonds. , and more preferably, when at least two of the monovalent hydrocarbon groups bonded to the ether oxygen have different chain lengths, the ether compound is preferably a glycerin diether represented by the general formula ('), especially glycerin -1
-Butyl-3-isostearyl ether or glycerin-1,3-bis(2-ethylhexyl)
When the ether is an ether, the hard resin is selected from the group consisting of a hard vinyl chloride resin, an acrylic resin, a styrene resin, an olefin resin, a thermoplastic polyester resin, and a polycarbonate, and the acrylic resin is a methyl A homopolymer or copolymer of methacrylate, methyl acrylate, ethyl methacrylate, ethyl acrylate, acrylonitrile or methacrylonitrile, and the styrenic resin is polystyrene, an acrylonitrile-styrene copolymer or an acrylonitrile-butadiene-styrene copolymer. When the olefin resin is polyethylene, polypropylene, or ethylene-propylene copolymer, and the thermoplastic polyester resin is polyethylene terephthalate or polybutylene terephthalate, safety, hemolysis suppressive action, and other physical properties are even better. It becomes something. The present invention also provides a hard resin composition in which each monovalent hydrocarbon group having at least one ether bond and bonded to ether oxygen has 3 to 3 carbon atoms.
This medical device is characterized by being substantially composed of a hard resin composition containing an ether compound with a molecular weight of 1000 or less, which is a chain hydrocarbon group of 20. It is said that it is an extremely excellent medical device that has no risk of denaturing blood components, especially when the medical device is something that can come into contact with blood, such as a blood collection tube. It is possible,
Even when used as a blood collection tube, there is no need to worry about free hemoglobin interfering with various tests due to hemolysis even after blood is stored for a long time. Furthermore, in the medical device of the present invention, when the hard resin composition that substantially constitutes the medical device contains 0.5 to 5 parts by weight of the above-mentioned ether compound,
In addition, if at least one of the monovalent hydrocarbon groups bonded to the ether oxygen of the ether compound has a branched structure, and the ether compound has two or more ether bonds, and furthermore, the ether compound has a branched structure, and When at least two of the monovalent hydrocarbon groups bonded to have different chain lengths, more preferably the ether compound is a glycerin diether represented by the general formula ('), particularly glycerin-1-butyl -3-
isostearyl ether or glycerin-1,
When the hard resin is 3-bis(2-ethylhexyl) ether, in addition, the hard resin is a hard vinyl chloride resin,
selected from the group consisting of acrylic resins, styrenic resins, olefinic resins, thermoplastic polyester resins and polycarbonates, in which the acrylic resin is methyl methacrylate, methyl acrylate, ethyl methacrylate, ethyl acrylate, acrylonitrile or methacrylonitrile It is a homopolymer or copolymer of
The styrenic resin is polystyrene, acrylonitrile-styrene copolymer, or acrylonitrile-
Butadiene-styrene copolymer, olefin resin is polyethylene, polypropylene or ethylene-propylene copolymer, and thermoplastic polyester resin is polyethylene terephthalate or polybutylene terephthalate, safety and hemolysis inhibitory effects The result is a medical device that is superior in other respects, such as heat resistance and transparency.

[Brief explanation of the drawing]

FIG. 1 is a cross-sectional view showing an embodiment of the medical device of the present invention, and FIGS. 2 and 3 are cross-sectional views showing how the same embodiment is used. DESCRIPTION OF SYMBOLS 1... Decompression blood collection tube, 2... Tubular member, 4... Plug member, 5... Internal space, 6... Screw hole, 7... Blood collection needle, 8... Blood collection tube holder, 9... Luer adapter.

Claims (1)

[Scope of Claims] 1. A molecular weight in which each of the monovalent hydrocarbon groups having at least one ether bond and bonded to ether oxygen in the hard resin composition is a chain hydrocarbon group having 3 to 20 carbon atoms. A medical hard resin composition characterized by containing 1000 or less ether compounds. 2. The medical hard resin composition according to claim 1, which contains 0.5 to 5% by weight of the ether compound. 3. The medical hard resin composition according to claim 1 or 2, wherein at least one of the monovalent hydrocarbon groups bonded to the ether oxygen of the ether compound has a branched structure. 4. The medical hard resin composition according to any one of claims 1 to 3, wherein the ether compound has two or more ether bonds. 5. The medical hard resin composition according to claim 4, wherein at least two of the monovalent hydrocarbon groups bonded to ether oxygen have different chain lengths. 6 The above ether compound has the general formula (') (However, in the formula, R ¹ and R ² each have 3 carbon atoms.
~20 chain hydrocarbon groups. ) The medical hard resin composition according to any one of claims 1 to 5, which is a glycerin diether represented by: 7. Claim 6, wherein the glycerin diether represented by the general formula (') is glycerin-1-butyl-3-isostearyl ether or glycerin-1,3-bis(2-ethylhexyl) ether. Medical hard resin composition. 8 The hard resin is hard vinyl chloride resin, acrylic resin, styrene resin, olefin resin,
The medical hard resin composition according to any one of claims 1 to 7, which is selected from the group consisting of thermoplastic polyester resins and polycarbonates. 9 Acrylic resin is methyl methacrylate,
The medical hard resin composition according to claim 8, which is a homopolymer or copolymer of methyl acrylate, ethyl methacrylate, ethyl acrylate, acrylonitrile, or methacrylonitrile. 10. The medical hard resin composition according to claim 8, wherein the styrene resin is polystyrene, an acrylonitrile-styrene copolymer, or an acrylonitrile-butadiene-styrene copolymer. 11. The medical hard resin composition according to claim 8, wherein the olefin resin is polyethylene, polypropylene, or an ethylene-propylene copolymer. 12. The medical hard resin composition according to claim 8, wherein the thermoplastic polyester resin is polyethylene terephthalate or polybutylene terephthalate. 13 In the hard resin composition, 1 having at least one ether bond and bonded to ether oxygen
1. A medical device comprising a hard resin composition containing an ether compound having a molecular weight of 1000 or less, each of which has a chain hydrocarbon group having 3 to 20 carbon atoms. . 14. The medical device according to claim 13, characterized in that it is substantially composed of a hard resin composition containing 0.5 to 5% by weight of the ether compound. 15. The medical device according to claim 13 or 14, wherein at least one of the monovalent hydrocarbon groups bonded to the ether oxygen of the ether compound has a branched structure. 16. The medical device according to any one of claims 13 to 15, wherein the ether compound has two or more ether bonds. 17. The medical device according to claim 16, wherein at least two of the monovalent hydrocarbon groups bonded to ether oxygen have different chain lengths. 18 The above ether compound has the general formula (') (However, in the formula, R ¹ and R ² each have 3 carbon atoms.
~20 chain hydrocarbon groups. ) Claim 13 is a glycerin diether represented by
The medical device according to any one of Items 1 to 17. 19. Claim 18, wherein the glycerin diether represented by the general formula (') is glycerin-1-butyl-3-isostearyl ether or glycerin-1,3-bis(2-ethylhexyl) ether. Medical equipment. 20. Claims 13 to 19, wherein the hard resin is selected from the group consisting of hard vinyl chloride resin, acrylic resin, styrene resin, olefin resin, thermoplastic polyester resin, and polycarbonate. Medical equipment described in any of the paragraphs. 21. The medical device according to claim 20, wherein the acrylic resin is a homopolymer or copolymer of methyl methacrylate, methyl acrylate, ethyl methacrylate, ethyl acrylate, acrylonitrile, or methacrylonitrile. 22. The medical device according to claim 20, wherein the styrene resin is polystyrene, an acrylonitrile-styrene copolymer, or an acrylonitrile-butadiene-styrene copolymer. 23. The medical device according to claim 20, wherein the olefin resin is polyethylene, polypropylene, or an ethylene-propylene copolymer. 24. The medical device according to claim 20, wherein the thermoplastic polyester resin is polyethylene terephthalate or polybutylene terephthalate. 25. The medical device according to any one of claims 13 to 24, which is a blood collection tube.