JPH0241169A - Medicine for external application for preventing suppuration of skin - Google Patents

Abstract

PURPOSE:To prevent the suppuration obstructing the regeneration action of the cell of the skin/muscle by melting equine fat under heating to remove solid impurities and subsequently applying steaming or distillation thereto to remove an unsaponified substance and using' oils and fats having a specific acid value, a specific saponification value and a specific iodine value as an effective component. CONSTITUTION:Equine fat is melted under heating to remove solid impurities and subsequently subjected to steaming or distillation to remove an unsaponified substance to obtain oils and fats having an acid value of 0.9 or less, a saponification value of 195-201 and an iodine value of 70-72 as an effective component. The oils and fats being the effective component contain 56-62% of unsaturated fatty acid consisting of oleic acid, linolic acid, palmitoleic acid, lonoleic acid, eicosamonoenoic acid, eicosatrienoic acid and myristoleic acid and is a liquid wherein the m.p. of fatty acid is 35 deg.C or less. By this method, absorbability and compatibility are markedly enhanced and skin tissue can be activated.

Description

[Detailed description of the invention] [Industrial application field] The present invention relates to an external preparation for preventing suppuration of living skin.

[Conventional technology]

Conventionally, there have been three methods for preventing suppuration when the skin becomes inflamed: internal preparations and external preparations.

Among internal medicines, taking antibiotics is said to be the most effective, but it requires specialized knowledge regarding side effects, etc., and is limited to methods in which a doctor examines the patient and determines whether or not to use it. .

As for external preparations, there are liniments that contain deleterious substances such as iodine, and liniments that contain poisonous substances such as mercury, but their bactericidal action lasts only for a short time, so if the symptoms are severe, they may be administered at least once a day until the inflammation is cured. The application had to be repeated.

The daily application of conventional agents involves peeling off the gauze that is stuck to the skin and flesh of the affected area with plasma, etc., so the surface of the inflamed area is peeled off along with the gauze every day, significantly inhibiting skin regeneration activity. Not only did the treatment take a long time, but abnormal scars such as keloids often remained even after complete healing9.If suppuration occurred, recovery would be delayed and the scars would become even worse.

[Problem to be solved by the invention]

Inflamed skin regenerates and repairs skin and flesh cells using the body's natural healing powers such as immune and metabolic functions, but for 1 to 2 weeks while the skin regenerates, suppuration that inhibits this regenerative action is prevented. Prevention is the first priority.

Purulence occurs when bacteria invade the affected area, multiply, and release toxins, so after repeated tests in search of a method other than the conventional bactericidal properties, which have problems in preventing suppuration, unsaturated fatty acids The present invention, which is a purified oil with a high content, aims to prevent suppuration by a method that can be called a "new sterilization method" or "new bacteriostatic method" that blocks bacteria that try to invade the affected area. .

[Means to solve problems]

Horse tallow is heated and dissolved to remove solid impurities, and then unsaponifiables are removed by hot water washing or distillation to reduce the acid value to 0.9.
Below, the saponification value is 195 to 201. Iodine value 70-7
2. An external preparation for preventing skin suppuration characterized by containing the oil and fat as the active ingredient, and the oil and fat as the active ingredient are:
Unsaturated fatty acids consisting of oleic acid, linoleic acid, palmitoleic acid, linolenic acid, eicosamonenoic acid, eicosatrienoic acid, myristoleic acid, 56% to 6%
2% and is liquid at a melting point of the fatty acid of 35° C. or lower, as a means to solve the present invention.

Saturated fat 1 Capric acid Lauric acid Myristic acid Palmitic acid Stearic acid Melting point °C 53.9 Unsaturated fatty acids Melting point °C Oleic acid 12-16 Linoleic acid - 5.2 years - 5.0 Lilunic acid - 10 Sea 113 Lumitoleic acid -〇, 5〆05 Eifsatrienoic acid Eifsamonoenoic acid 23-24 Myristoleic acid 4.5-4 Table 1 Fatty acid composition +72.27 200.32 229, 38 256, 43 284.45 Molecular weight Number of carbons 282.43 18 280.45 18 278.43 18 254.41 306, 49 310, 54 226.26 Number Fatty acid composition Mol% Sample 1 Sample 2 Sample 3 0 0.16 0.15 0.150 0
．． 47 0.39 0.450 6.25
6,91 6.170 28i8 32.04
27.910 3.34 3,92 3.61
Subtotal 38.40 43.41 38.29 Number fatty acid composition Mol% Sample 1 Sample 2 Sample 3 31.07 29.18 31.92 15.90 +4.49 15.31349 3.
02 132 9.31 8,35 8.53 0.46 0,49 0.44 1 0.79 0.59 0.70 Subtotal 6+
, 60 56.59 61.71 Total 100.00 100.00 100.00 Note Number of double bonds [Function] a) As is clear from Table 1, the composition ratio of saturated fatty acids to unsaturated fatty acids is 3829% : 61.71%, and is characterized by a high content of unsaturated fatty acids. Therefore, due to its permeability, it adheres closely to the skin tissue and forms an oil film, acting to have an affinity with the unsaturated fatty acids in the fingers.90) As shown in Table 1, linole is an essential fatty acid among unsaturated fatty acids. It contains acid and phosphoric acid at a high concentration (around 20%).

Linoleic acid has already become a component of cell membranes for 197 years.
``Linoleic acid rapidly passes through the skin barrier and reaches the skin capillaries''1.
He has published over 10,000 clinical cases. In other words, it has proven to have excellent penetrating power. Therefore, topical administration of linoleic acid has a significant effect on the proliferation of dermal cells.

In detail, due to its strong penetrating power, it rapidly seeps into the microscopic pores of cells, becomes compatible with the finger, expels air (oxygen) inside the skin tissue, and adheres closely to the skin tissue, creating an oil film. act. This action produces secondary antioxidant and sterilizing properties. Therefore, by forming an oil film and making the affected tissue anoxic, it is widely distributed in the natural world, and is a typical pyogenic bacterium that invades the skin and mucous membranes of living organisms through damaged areas, proliferates, and releases enterotoxins to cause inflammation. Invasion of aerobic Staphylococcus genus is blocked and suppuration is prevented.

c) As is clear from Table 2, the properties of the external preparation of the present invention are particularly:
Through repeated trial and trial, we achieved properties that are very similar to human fingers in terms of specific gravity, iodine value, and saponification value.

This is something that was later realized. The saponification value is related to the molecular weight or chain length of fatty acids and is one of the factors for identifying fats and oils, and the iodine value is an index showing the degree of unsaturated bonds in fatty acids.

By approximating this external preparation to the human finger, the absorbability and affinity of the present invention are inevitably improved significantly, and therefore, it has the basic characteristics of activating skin tissue.

2) Next, as shown in Table 2, the external preparation of the present invention has a 35%
Since fats and oils with a high melting point that do not dissolve at °C are separated and removed, and the melting point is set to 265 °C to 35 °C, it acts so that it liquefies directly at the body temperature (36 °C to 37 °C).

Therefore, the above-mentioned permeation power peculiar to unsaturated fatty acids acts to be 100% exhibited.

〔Example〕

Examples of the present invention will be described below.

B) A woman forgot to turn off the fire and slipped in the boiling bathroom, causing her arm to fall into the water up to her shoulder. Because it was winter and he was wearing a long-sleeved jacket, the boiling water seeped into his clothing, causing severe burn symptoms, and when he took off his clothing, the epithelium of his skin sore, torn, and fell off.

The condition in which the epithelium erodes and peels off is called a "third-degree burn," and it is common knowledge in the dermatology community that the prognosis is keloid scars.

The treatment she received was to thoroughly apply the present invention, cover it with gauze, and protect it with a bandage. She applied the present invention over the gauze once or twice a day, and about 10 days later, blood and fluids appeared. leather·
The gauze that was stuck to the meat loosened and came off, and I replaced it with new gauze for the first time.

After about a month, remove the bandage and gauze and continue to apply a thin layer of the present invention to the affected area, which is not keloid-like but has turned reddish-brown.
Two months after the accident, her skin completely returned to its normal state.

There were no scars at all, so even when I told the doctor about the situation after he was fully healed, he didn't believe me.

I heard about the invention from a friend who came to visit me, and at my own discretion, I left the hospital and used the invention at home.

Since it had been four days since the burn occurred, recovery was delayed, but after complete healing there was no keloid and only a slight whitening of the skin. It took about two months to fully heal.

While working while wearing men's rubber boots, hot water accidentally got into the boots, resulting in a 13th degree burn that caused the skin on the heel of one foot to swell and peel.

The present invention was applied immediately, but the burn area became normal with no scars in about two months (the progress is shown in the drawing). d) Woman: Overturned a pot of cooking oil heated to 180 degrees and applied it to one hand and one leg. "Second degree burns" caused by oil exposure, both of which result in blistered skin.
I suffered a loss.

The present invention was immediately applied, and the hand, which had relatively mild symptoms, was completely healed after one month, and the foot was completely healed after two months, leaving no scars at all.

C) A man suffered third-degree burns on both legs and was hospitalized for treatment, but the doctor who examined the whites of his eyes warned him that the prognosis would be a keloid, and coincidentally E) A woman's left hand was attacked by a sharp knife. He suffered a laceration that cut his middle finger lengthwise by about 4 centimeters.

Immediately, I came up with the idea of carrying out the present invention, applied the present invention, and held it down with my right hand until the bleeding stopped.After about 20 minutes, the bleeding stopped, so I fixed it with a bandage in the same way as when treating a burn.

Just apply the present invention on gauze once a day,
It took about two months for the wound to heal completely, and even though it was a deep laceration, no scar remained.

f) A woman became pregnant, but due to her age, she had a caesarean section to give birth.

From the day after the surgery, apply the present invention with your fingers once or twice a day to the surgically sutured scar.Even after you are discharged from the hospital 92 weeks later, continue to apply the invention to the surgical scar once or twice a day 2 months after the surgery. All traces of the disease disappeared and the patient was completely cured.

The above are some examples related to burns and wounds.

Other details are shown in Table 3.

[Effects of the Invention] As shown in the examples, the present invention has the following effects.

b) Not only for burns and wounds, but also for a wide variety of skin and mucous membrane inflammations, the effect of the external preparation of the present invention is particularly remarkable, with no cases of worsening of suppuration in the affected area.

Oral) By using the topical preparation of the present invention immediately after an injury, 100% recovery is possible unless special treatment by a doctor is required.
It can also have a healing effect.

c) The external preparation of the present invention can sufficiently exhibit its effects as a household medicine.

2) Due to the difficulty of producing a product containing unsaturated fatty acids as its main component, it has not been realized and has not been utilized to date, but a new use for it has been developed by the present invention.

Therefore, the effects of the present invention on the development of new fields are particularly remarkable.

[Brief explanation of the drawing]

It is a reference figure showing the treatment state of Example (b). Figure 1 Figure 2 Figure 3 Figure 4 Condition after 1 week Condition after 2 weeks Status after 3 weeks Status after 8 weeks

Claims (1)

[Claims] 1) Horse tallow is heated and dissolved to remove solid impurities, and unsaponifiables are removed by hot water washing or distillation to reduce the acid value to 0.
9 or less, saponification value 195-201, iodine value 70-
72. An external preparation for preventing skin suppuration, characterized by containing oils and fats as an active ingredient. 2) The active ingredients are oleic acid, linoleic acid,
Palmitoleic acid, linolenic acid, eicosamonenoic acid,
An unsaturated fatty acid consisting of eicosatrienoic acid and myristoleic acid, with a weight ratio of 43% to 62% (hereinafter % to %).
2. The external preparation for preventing skin suppuration according to claim 1, which contains a fatty acid having a melting point of 35° C. or less.