JPH023945B2 - - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a blood test that is used in the medical field to test a patient's blood by washing a test tube containing reaction beads (beads) reacted with blood as a specimen. This invention relates to improvements to the cleaning device in the device.

Blood tests performed on patients in medical care are usually
As shown in Fig. 1, a predetermined amount of blood as a sample is titrated into a large number of test tubes a supported in parallel on a rack 3 (or into a large number of test holes arranged in a titration plate). React with the reagent on the surface of reaction sphere b (beads coated with a reagent that reacts with blood) that has been placed in the tube in advance (the reagent is coated on the inner wall of the test tube or the inner wall of the test hole). ), then wash the reaction bulb b in the test tube a with a washing solution, and remove the washed reaction bulb b.
This is done by inspecting the surface of the The cleaning of the reaction bulb b (or the inner surface of the test tube/test hole) in the test tube a (or test hole) in this test is as follows:
Usually, the rack 3 (or titration plate) for supporting the test tubes a in parallel is set on a base plate 4 provided in the machine frame K of the blood test apparatus M, as shown in FIG. , each test tube a... is on the base plate 4
Reassemble the upper dispensing head A so that it faces the dispensing needles 1 and suction needles 2 that are installed vertically, and from this state, the washing liquid is fed to the dispensing head A and each dispensing needle 1 A certain amount of washing liquid is injected into each test tube a from ..., and then the platform 4 is raised by the lifting device 40 (the dispensing head A may be lowered), and the washing liquid is poured into each test tube a. With the suction needles 2 in the state, the cleaning liquid in each test tube a is suctioned and removed by each suction needle 2 by the operation of the vacuum pump connected to the dispensing head A, and then the base plate 4 is lowered. Then, each suction needle 2 is pulled upward from inside each test tube a, and in this state, the washing liquid is again dispensed, and this process is repeated.

By the way, in the conventional washing device, in order to supply washing liquid to a large number of dispensing needles 1 provided in the dispensing head A, the base of each dispensing needle 1 is placed in the inner cavity of the dispensing head A. As shown in FIG.
A single pipe 12 is connected to a cleaning liquid tank 13 whose inside is pressurized by a pipe 5, and by controlling and operating a valve V provided on this pipe 12, cleaning liquid is supplied to each dispensing needle 1. I'm trying to distribute it.

In this conventional means, when the dispensing of the washing liquid is finished, the washing liquid drips from the tip of the dispensing needle 1 over time, and as a result of the dropping of the washing liquid, a large number of the dispensing needles 1... When the cleaning liquid in one dispensing needle 1 runs out and the inner cavity of that dispensing needle 1 becomes empty, the airtightness of the reservoir inside the dispensing head A is broken and the empty dispensing As air flows in from the lumen of needle 1,
There is a problem in that all of the washing liquid accumulated in the reservoir section flows down from all the dispensing needles 1.

The present invention has been made to solve the problems of the conventional means, and aims to provide a new means for configuring a washing device that can accurately and smoothly wash specimens. purpose.

In the present invention, as means for achieving this object, there is provided a head on which a dispensing needle and an aspiration needle are attached, a base plate on which a test tube is set below the head, and a combination of these heads and base plates. a lifting device that relatively changes the distance between the suction needles, a suction pipe and a recovery tank that connect the suction needles to the vacuum pump, a dispensing pipe that connects each of the dispensing needles, and connections with the dispensing pipes. a pressurizing pipe and a cleaning liquid tank that connect the distributor to a pressurizing pump, a first valve provided on the pressurizing pipe, and a connection between the first valve of the pressurizing pipe and the distributor. It consists of a bypass pipe that connects the intermediate portion to the suction pipe, and a second valve provided on the bypass pipe, and the second valve is normally closed and opens for a certain period of time when the first valve opens and closes. The present invention proposes a cleaning device for a blood test device, which is characterized in that it is configured to operate.

Next, embodiments will be described in detail with reference to the drawings. Note that the same reference numerals in the drawings are used for components having the same effect as those of the conventional device.

FIG. 2 is a partially cutaway side view of a blood test apparatus in which the present invention can be carried out.
4 indicates the base plate.

The head A is a normal type in which a plurality of pairs of dispensing needles 1 and suction needles 2 are assembled on the lower side at predetermined intervals, and in this example, they are fixedly attached to the machine frame K. It's on a shelf.

The base plate 4 is for setting a large number of test tubes a, a... or a titration plate with a large number of holes.A lifting device 40 is installed on the upper surface side of the machine frame K located below the head A. It is attached so that it can be raised and lowered through the The lifting device 40 allows the distance between the head A and the base plate 4 to be relatively changed.

Inside the head A, as shown in FIG. 3, a common suction guiding chamber 20 is provided which communicates with a plurality of suction needles 2, 2, . . . provided on the lower surface of the head A. The suction guiding chamber 20 communicates with a recovery tank 22 via a single suction pipe 21, as shown in FIG. The recovery tank 22 further includes, via a suction pipe 23,
Connect to vacuum pump 24. The liquid used for cleaning is collected in the collection tank 22.

Also, as shown in FIG. 3, the plurality of dispensing needles 1, 1... attached to the head A are connected to separate dispensing pipes 11, 11..., respectively, and are connected to a common funnel. It communicates with the shape distributor 10. The distributor 10 communicates with a cleaning liquid tank 13 via a pressurizing pipe 12, and the cleaning liquid tank 13 further communicates with a pressurizing pump 15 via a pressurizing pipe 14. The cleaning liquid tank 13 stores cleaning liquid.

A flow rate adjustment device 16 is provided in the middle of the pipes 11, 11... for dispensing, and each pipe 11, 11...
The flow rate of... can be adjusted by tightening the screw 16a (Fig. 3).

Further, the pressurizing pipe 12 is provided with a first valve 17 (FIG. 3). The valve 17
is opened for a certain period of time to supply a certain amount of the cleaning liquid in the tank 13 to the distributor 10 side.

Furthermore, a third valve is provided at an intermediate portion of the pressurizing pipe 12 between the first valve 17 and the distributor 10.
As shown in the figure, a bypass pipe 5 communicating with the suction pipe 21 is connected. The bypass pipe 5 is provided with a second valve 51 . The second valve 51 is normally closed, and when the first valve 17 performs an opening operation and closes, it is opened for a certain period of time and the distributor 1 is opened.
It is configured to apply suction pressure to the 0 side. b is a bead (reaction sphere) that has undergone a reaction and is placed in advance in a test tube a.

Next, the main functions of the cleaning device configured as described above will be explained.

First, the rack 3 supporting the test tubes a, a, etc. in parallel is set on the base plate 4, and by operating the lifting device 40, the distance between the rack 3 and the dispensing head A is adjusted appropriately, and each test tube a is placed above the rack 3. The dispensing needle 1 and the suction needle 2 combined as a pair are in a state facing each other.

Subsequently, the first valve 17 is opened for a certain period of time while the pressurizing pump 15 is operated. Then, the calculated amount of the cleaning liquid in the tank 13 passes through the first valve 17 from the pressurizing pipe 12 and is fed to the funnel-shaped distributor 10 side. In the distributor 10, the cleaning liquid is distributed to each dispensing pipe 11, 1.
1... and is fed under pressure to each dispensing needle 1, 1.
A predetermined amount of washing liquid is injected into each test tube a, a, and so on.

Next, by operating the elevating device 40, the relative distance between the base plate 4 and the dispensing head A is reduced, so that the lower end of each suction needle 2 provided on the dispensing head A is connected to each test tube a...
Let the state reach the bottom of your inner self.

As a result, each suction needle 2... is operated by the vacuum pump 24 (the vacuum pump 24 is always operated).
The cleaning liquid in each test tube a is sucked by the negative pressure in the collection tank 22 and collected into the collection tank 22 via the suction pipe 21.

Next, the elevating device 40 is operated again to remove the suction needle 2.
With ... pulled upward from each test tube a, dispense the washing liquid from the dispensing needle 1 into each test tube a using the operation described above, and aspirate the washing liquid with the suction needle 2. Collect and repeat this as many times as necessary.

As a result, the inner surface of each test tube a and the reaction bulb b are washed, but the device of the present invention further allows the following to be carried out when the washing liquid has been dispensed from each dispensing needle 1 into each test tube a. It works like this.

That is, by opening the first valve 17 for a certain period of time, a calculated amount of cleaning liquid is dispensed into each test tube a, and when the first valve 17 is closed, the amount of washing liquid from each dispensing needle 1, 1, etc. is dispensed into each test tube a. The injection of the cleaning liquid stops, but in conjunction with the closing operation of the first valve 17, the second valve 51 opens for a certain period of time, and the pipe 12, the distributor 10, the dispensing pipes 11, 11, . . . Suction pressure from the vacuum pump 24 acts on the needles 1, 1, . . . via the bypass pipe 5, and each dispensing needle 1
... A predetermined amount of the washing liquid filling the washing liquid supply path from the inside to the first valve 17 and remaining therein is collected in the collection tank 22 in reverse, and each dispensing needle 1...
It acts to draw out the cleaning liquid from inside. The reverse recovery amount of the washing liquid is determined by changing the liquid level of the washing liquid remaining in the washing liquid supply path from the lower end position of each dispensing needle 1 supported by the dispensing head A. This is to prevent the washing liquid from dripping from each dispensing needle 1 by returning it downward, and the second valve 5
The liquid level position W to be lowered is set by the opening time of 1, but the liquid level position W to be lowered is determined by placing the distributor 10 below the lower end of the dispensing needle 1 as shown in FIG. It is desirable to have it descend to the inside.

As explained above, the cleaning device in the blood test device according to the present invention cleans each test tube (or test hole).
When a fixed amount of washing liquid is dispensed, once the dispensing is finished and the pressure acting on each dispensing needle stops, each dispensing needle becomes a negative pressure. The cleaning liquid in each dispensing needle is drained by connecting it to the collection tank for a certain period of time, so when a predetermined amount of cleaning liquid is dispensed, the liquid drips from the dispensing needle and the cleaning process is completed. The problem of disrupting the amount of liquid and causing uneven washing is eliminated, and each test tube and reaction bulb can be washed accurately.

[Brief explanation of drawings]

FIG. 1 is a perspective view of the rack and test tube, FIG. 2 is a partially cutaway side view of the apparatus according to the present invention, and FIG.
The figure is an explanatory diagram of the same device as above, and FIG. 4 is a side view of the dispensing head of the conventional device. Explanation of drawing symbols, A...Dispensing head, K...Machine frame, M...Blood test device, V...Valve, W...
Liquid level position, a... test tube, b... reaction bulb, 1...
Dispensing needle, 10... Distributor, 11... Dispensing pipe, 12... Pressurizing pipe, 13... Washing liquid tank, 14... Pressurizing pipe, 15... Pressurizing pump, 16... Flow rate Adjustment device, 16a...screw, 1
7...First valve, 2...Suction needle, 20...Suction guiding chamber, 21...Suction pipe, 22...Recovery tank, 23...Suction pipe, 24...Vacuum pump, 3...Titration Plate (rack), 4... base plate,
40... Lifting device, 5... Bypass pipe, 51
...Second valve.

Claims (1)

[Claims] 1. A head for attaching a dispensing needle and an aspiration needle, a platform for setting a test tube below the head, an elevating device for relatively changing the distance between the head and the platform, and a device for moving the aspiration needle to a vacuum. A suction pipe and a recovery tank connected to the pump, a dispensing pipe connected to each of the dispensing needles, a distributor connected to these dispensing pipes, and a pressurizer connecting the distributor to the pressurizing pump. A pressure pipe and a cleaning liquid tank, a first valve provided on the pressure pipe, a bypass pipe connecting an intermediate portion of the pressure pipe between the first valve and the distributor to the suction pipe, and the bypass. a second valve provided on the pipe;
1. A cleaning device for a blood test apparatus, characterized in that the valve is normally closed, and when the first valve opens and closes, it opens for a certain period of time.