JPH0236119Y2 - - Google Patents

Description

[Detailed Description of the Invention] Industrial Application Field The present invention relates to an improved test strip used for testing body fluids such as urine testing.

BACKGROUND ART As a test piece used for tests such as urinalysis, there are known test pieces in which a test reagent portion containing one or more different test target substances is formed on a support, and these test pieces The test method using this method is easy to perform and is suitable for mass screening and preliminary testing.

Problems that the invention aims to solve Test pieces such as those described above are usually stored stacked in the same direction, and when used, they are immersed one by one in a test liquid (e.g. urine) and pulled out, and after a certain period of time, the test reagent part is removed. Judgments are made by observing the color development, but the surface of the support is charged due to friction during handling, which causes the test pieces to stick together due to electrostatic force while stacked on top of each other. In addition to making it difficult to separate the pieces one by one, they also caused contamination and discharges that were unpleasant for the person handling them.

Therefore, what the present invention seeks to solve is to solve the various drawbacks associated with charging by conventional test pieces.

Means for Solving the Problems The present invention will be explained below using drawings.
The figure shows the most typical example of the test piece of the present invention, and the test piece 1 has test reagent parts 3, 4 and 5 on one side of the support 2, and these test reagent parts are shown in Fig. 1. The antistatic layer is concentrated on the left side of one side of the support 2 as shown in FIG.

The antistatic layer 6, which is a characteristic part of the present invention, is made of a synthetic resin that contains an antistatic agent and serves as a binder that can form a film.

Examples of synthetic resins that are a component of the antistatic layer 6 include the following: Cellulose derivatives such as ethyl cellulose, ethyl hydroxyethyl cellulose, cellulose acetate propionate, nitrocellulose, and cellulose acetate, polystyrene, and polyα-methylstyrene. Styrene resins and styrene copolymer resins such as polymethyl methacrylate, polyethyl methacrylate, polyethyl acrylate, polybutyl acrylate and other acrylic or methacrylic resins alone or copolymer resins, rosin, rosin-modified maleic acid resins, Rosin modified phenolic resin, rosin ester resin such as polymerized rosin, polyvinyl acetate resin,
Coumaron resin, vinyl toluene resin, vinyl chloride resin, polyester resin, polyurethane resin, butyral resin, polyamide resin, vinyl chloride-vinyl acetate copolymer resin, polyvinylidene chloride resin,
Melamine resin, silicone resin.

As the antistatic agent, which is another component of the antistatic layer 6, known antistatic agents can be used, such as the following types: quaternary ammonium compounds, amines and amine derivatives, phosphoric acid esters. , fatty acid polyglycol esters, polyhydrogen derivatives such as glycerin and sorbitol.

Among the above synthetic resins, it is preferable to select adhesive properties according to the material of the support 2, and to use the antistatic agent, select the antistatic agent based on its miscibility with the synthetic resin, non-migration property, etc.

The proportion of antistatic agent in the antistatic layer is synthetic resin.
The amount is preferably about 0.1 to 50 parts by weight per 100 parts by weight. If it is less than 0.1 part by weight, the effect of the addition is poor, and if it exceeds 50 parts by weight, the antistatic agent bleeds out from within the antistatic layer, and when test pieces are stacked, phenomena such as blocking occur, which is unfavorable for handling.

As the support 2 in the present invention, a sheet of plastic such as polyethylene terephthalate, polystyrene, or polyvinyl chloride, a nonwoven fabric of synthetic fiber such as polyester, polypropylene, or nylon, paper such as filter paper, art paper, or coated paper is used. can.

As the test reagent parts 3, 4 and 5, for example, 3 is a glucose test reagent part, 4 is a protein test reagent part, and 5 is a glucose test reagent part.
If this is used as the PH test reagent section, these three types of test targets can be tested. Note that the number of test reagent parts may be increased or decreased depending on the application, and one or more types of test reagent parts may be included.

For example, the test reagent part is made by pasting filter paper impregnated with test reagents selected according to various components in urine to a support using adhesive means such as double-sided tape, or by printing using ink containing test reagents. Alternatively, it can be formed by coating.

For the test piece having the structure described above, a sheet-like support is supplied in a roll, and the test reagent parts 3, 4 and 5 and the antistatic layer 6 are sequentially coated in stripes parallel to the flow direction of the sheet, or After printing, it is suitable for cutting the sheet in a direction perpendicular to the flow direction to obtain strip-shaped test pieces.

FIGS. 2 to 4 show test pieces of other embodiments of the present invention, and each test reagent portion, antistatic layer, and support itself are the same as those shown in FIG. 1.

Compared to the test piece 1 shown in FIG. 1, the test piece 1 shown in FIG. 2 has an antistatic layer 6 on the opposite side of the support sheet 2, that is, on the back side. When the antistatic layer 6 is provided on the back surface in this way, the antistatic layer 6 may cover the entire back surface of the support 2, but if the antistatic layer 6 covers the entire back surface, the test piece 1 Antistatic layer 6 when stacked in the same direction
and the test reagent part of another test piece, and the antistatic agent in layer 6 may affect the coloring reactivity of the test reagent in the test reagent part. It is preferable to use the structure shown in FIG. 2, and when it does not affect the coloring reactivity, it is preferable to use a structure in which the antistatic layer 6 is provided on the entire back surface.

The test piece 1 shown in FIG. 3 has a structure that is a combination of the one shown in FIG. 1 and the one shown in FIG. 2, and has an antistatic layer 6 on both the front and back surfaces of the support 2. Here, the antistatic layer 6 on the back surface may cover the entire back surface in some cases, as in the case shown in FIG.

The test piece 1 shown in FIG. 4 has an antistatic layer 6 in a portion other than the test reagent portion and also in a portion surrounding the test reagent portion. The boundary between the test reagent part and the antistatic layer may be spaced or close to each other, but if the antistatic agent in the antistatic layer affects the coloring reactivity of the test reagent part, It is preferable to leave a gap in this way, and the same applies to the space between the test reagent portion 5 and the antistatic layer 6 (on the front side in FIG. 3) in FIGS. 1 and 3.

The antistatic layer 6 of the test piece 1 described above can be formed by dissolving the above-mentioned synthetic resin and antistatic agent in a solvent to form a composition and printing or coating it. Others can be printed using the above composition to also serve as a display function.

Function The test piece of the present invention has an antistatic layer, so even if the test pieces are stacked and handled, they will not become charged due to friction or the like.

Effects of the invention Therefore, the test pieces of the present invention have the advantage that even if they are stacked, it is easy to separate them one by one, and that they are resistant to staining and are resistant to electrical discharge.

Example 1 Using biaxially oriented polystyrene as a support, a striped test reagent portion and an antistatic layer were formed by silk screen printing using ink having the following composition, and then cut as shown in Figure 1. A test piece with the structure shown in was obtained.

Ink for forming an antistatic layer [Polyvinyl butyral resin 5 parts by weight (Sekisui Chemical Co., Ltd., BX-1) Alkylbenzyldimethylammonium chloride 1.5 (Kao Soap Co., Ltd., Sanizol) Isophorone 53.5 Cyclohexanol 40 [Glucose] Ink for glucose detection [Glucose] Oxidase 0.50 parts by weight (Toyobo: Grade) Peroxidase 0.10 (Toyobo: Grade) o-tolidine 2.0 Isobutylene/maleic anhydride 2.5 parts by weight Butanol ester of copolymer (Clare Isoprene Chemical, Isoban #10) DL-α-tocopherol 0.1 〃 Polyoxyethylene sorbitan mono 1.2 〃 Oleate (Kao Soap, Tween 20) Microcrystalline cellulose 30 〃 (Asahi Kasei, Avicel SF) n-Butanol 47 〃 Solvent Yellow 6 (dye) 0.05 〃 Citric acid 3.2 Sodium citrate 12.0 Protein detection ink [Tetrabromophenol blue 0.05 parts by weight Citric acid 8.6 Sodium citrate 3.7 Carboxymethyl ion exchanger 13.5 (Watmann, CM-32) Isobutylene/maleic anhydride 2.0 〃 Resin alcohol esterized solbitan mono -leate 1.1 〃 (made in Kao soap, Leodor SP -L10) Financial crystal cellulose 25 -layer part (Asahi Kasei, Avicel SF) Butyl Cello Solve 46 〃] PH measurement Ink [Methyl Rettrium Salt 0.01 Parts by weight Bromothymol blue 0.13 Hydroxyethyl cellulose 4 (GAF, K-90) Polyvinyl butyral resin 0.5 (Sekisui Chemical, BX-1) Alkylbenzyldimethylammonium chloride 0.14 (Kao Soap, Sanizol) 0.14 Microcrystalline cellulose 36 〃 (Asahi Kasei, Avicel SF) Ethyl cellosolve 60 〃 〃 For the above glucose detection, protein detection, and
The ink for PH measurement was prepared by micronizing and dispersing it using a homomixer.

100 of the obtained test pieces were stacked one on top of the other and used one by one in the test, and it was possible to easily pull them apart one by one without requiring any force.

For comparison, I made 100 test pieces similar to the above except that no antistatic layer was formed, and when I pulled them apart one by one, 2 to 3 other test pieces stuck to them, or Even when it was possible to pull the pieces apart one by one, it took a lot of force.

Example 2 Ink for forming an antistatic layer [Cationic antistatic agent 0.5 parts by weight (Analytical Chemical Laboratories, FG Statyside) Acrylic resin 5 (Mitsubishi Rayon, BR-50) Isophorone 54.5 Cyclohexanol 40 A test piece was prepared in the same manner as in Example 1 except that the above ink was used as the antistatic layer forming ink.

The obtained test piece, like the test piece obtained in Example 1, had sufficient antistatic effect. In addition, since the test piece obtained in Example 2 contained less antistatic agent (1/3) than that obtained in Example 1,
Drying during formation of the antistatic layer was faster, and bleeding of the antistatic agent was also better.

[Brief explanation of drawings]

Figures 1 to 4 are diagrams showing the test piece of the present invention; Figures 1 to 3 are cross-sectional views;
The figure is a plan view. 1... Test piece, 2... Support, 3, 4, 5...
Test reagent part, 6...Antistatic layer.

Claims (1)

[Claims for Utility Model Registration] (1) A support having a test reagent portion on one side, and at least a portion of the support other than the test reagent portion being made of a synthetic resin containing an antistatic agent. A test piece characterized by having an antistatic layer. (2) The test piece according to claim 1 of the utility model registration claim, which has an antistatic layer on the side of the support that has the test reagent portion. (3) The test piece according to claim 1 of the utility model registration claim, which has an antistatic layer on one side of the support that does not have the test reagent portion. (4) Scope of a claim for utility model registration characterized by having an antistatic layer on one side of the support that does not have the test reagent portion and at a location other than the back side of the portion corresponding to the test reagent portion The test piece described in item 3. (5) The test piece according to claim 1 of the utility model registration claim, which has an antistatic layer on both sides of the support. (6) The test piece according to any one of claims 1 to 5 of the utility model registration claim, wherein the support is a plastic sheet.