JPH02272084A - Aerosol product for application to human body - Google Patents

Abstract

PURPOSE:To obtain the subject aerosol product having excellent spraying characteristics, giving refreshing feeling and producible at a low cost by filling a specific amount of an aerosol composition containing an alcohol, CO2, etc., in a specific aerosol container. CONSTITUTION:The objective aerosol product is produced by filling 30-85vol.% of an aerosol composition containing (A) <=55wt.% of a 1-3C alcohol, (B) 45-95wt.% of liquefied gas having a vapor pressure of 0.8-5kg/cm<2>G at 20 deg.C and (C) 0.2-2.5wt.% of carbon dioxide gas in an aerosol container having a valve satisfying the following conditions. The diameter of the lower hole of a housing is 0.3-1.6mm; the diameter of the paper tap of the housing is 0.3-0.8mm; the number of stem holes is <=2; the diameter of stem hole is 0.2-0.6mm: and the diameter of the button nozzle is 0.3-0.6mm.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to an aerosol product for application to the human body using carbon dioxide gas as a propellant.

[Prior Art and Problems to be Solved by the Invention] Conventionally, liquefied gases such as fluorocarbons, liquefied petroleum gas, and dimethyl ether (DME) have been mainly used as propellants for aerosol compositions.

Aerosol products for application to the human body that use these liquefied gases as propellants can maintain a constant spray pressure, so that a constant spray state can be obtained from the beginning to the end of product use. In addition, the liquid to be injected can be atomized into fine, uniform particles by the rapid expansion of the liquefied gas at the same time as the liquid is crushed by the nozzle of the valve. Furthermore, a portion of the liquefied gas contained in the aerosol composition evaporates on the body surface, providing a refreshing feeling.

However, on the other hand, liquefied gas is expensive and
In order to obtain the desired injection pressure, it is necessary to blend a large amount, which causes dissatisfaction with the rising cost of materials for aerosol products.

Furthermore, since the injection pressure obtained with liquefied gas is highly temperature dependent, this aerosol product has the disadvantage that the injection pressure varies significantly depending on the temperature.

On the other hand, compressed gases obtained by compressing carbon dioxide gas, nitrogen gas, laughing gas, air, etc. are known as propellants with few such drawbacks. Aerosol products for human body application that use compressed gas as a propellant are inexpensive and have little temperature dependence on injection pressure.

However, conventional aerosol products for application to the human body that use compressed gas as a propellant have problems in that the aerosol composition is difficult to break up during injection, resulting in a wet or lackluster feel. There was also the problem of a lack of refreshing sensation.

The present invention was made in view of the above circumstances, and an object of the present invention is to provide an aerosol product for application to the human body that can be manufactured at low cost, has good spray characteristics (and has a refreshing feeling).

[Means to solve the problem]

The aerosol product for human body application of the present invention has: 1 to 3 carbon atoms;
Alcohol 55% by weight or less ■ Vapor pressure is 0 at 20°C
．． An aerosol composition that absorbs 8 to 5 kg/amNG of liquefied gas 45 to 95% by weight ■ Carbon dioxide gas 0.2 to 25% by weight (a) The diameter of the lower hole of the housing is 03 to 1.6 mm (b ) Vapor tap (ventilation hole) diameter of housing 0.3 to 0.8
+am (C) There are no more than 2 stem holes with a diameter of 02~06ta* (d) An aerosol container equipped with a valve that satisfies the condition of button nozzle hole diameter of 0.3~0.6mm. % filled by volume.

Specific examples of the alcohols having 1 to 3 carbon atoms (hereinafter abbreviated as alcohol) include methyl alcohol, ethyl alcohol, propyl alcohol, isopropyl alcohol, and denatured alcohol. Since alcohols having 4 or more carbon atoms have a high boiling point and low vaporizing power, the use of alcohols with 4 or more carbon atoms may cause the disadvantage that a refreshing sensation cannot be obtained.

The amount of alcohol blended varies depending on the use of the product, and increases or decreases with the amount of carbon dioxide gas blended in products for the same use, but it is usually desirably 55% by weight or less.

If the alcohol content exceeds 55% by weight, there will be an inconvenience that the product will feel sticky. Furthermore, if the alcohol content is less than 2% by weight, there will be an inconvenience that a refreshing feeling cannot be obtained.

The liquefied gas acts as a propellant, and at 20°C
At vapor pressure 0, 8 kg/cm” G or more 5 kg/c
It is preferable to use less than m2G, especially about 1.0 to 3.5 kg/cm2G (7.0).If the gas pressure exceeds this range and a filtrated liquefied gas is used, the spray particles will not become too fine and may scatter. In addition, if the gas pressure is not within this range, there is a risk that the desired spray state may not be obtained when the remaining amount of the aerosol composition decreases.Specific examples of this liquefied gas include chloro Mention may be made of fluorocarbons (fluorocarbons), dimethyl ether, hydrocarbons, liquefied petroleum gas and mixtures thereof.

The amount of this liquefied gas is 45% of the total aerosol composition.
It is desirable that the weight be at least 95% by weight and not more than 95% by weight.

It is not preferable for the amount of liquefied gas to exceed this range in order to reduce the amount of this expensive liquefied gas to obtain an inexpensive product and to add some effective ingredients to characterize the product. In addition, if the blending amount does not reach this range, there will be problems such as not being able to always obtain constant spray properties, or the crushing force of the liquid becoming weak, making it impossible to make the spray particles fine and uniform.

The carbon dioxide gas acts as a propellant, and its amount is set at 0.2 to 4% by weight of the entire aerosol composition. If the carbon dioxide content is less than 0.2% by weight, the effect of increasing the internal pressure of the container is insufficient and it is difficult to reduce the amount of liquefied gas used. Moreover, if it exceeds 4% by weight, the internal pressure of the container becomes too high, which is not preferable.

The aerosol composition may contain water as part of the active ingredients, if necessary, in order to improve transdermal absorption of medicinal ingredients and suppress the flammability of the aerosol. in this case,
It is desirable that the amount incorporated is limited to 15% by weight or less based on the entire aerosol composition. If the water content exceeds 15%, the aerosol composition will feel sticky when applied, and the refreshing sensation will be impaired.

In addition to the above-mentioned components, this aerosol composition contains other active ingredients for achieving the purpose of the aerosol product.

For example, if the aerosol product is for antiperspirant purposes, the active ingredients may include antiperspirant ingredients containing powder, deodorizing ingredients,
Contains aromatic ingredients. Furthermore, if the aerosol product is intended for anti-inflammatory and analgesic treatment, anti-inflammatory ingredients, analgesic ingredients, etc. are added as active ingredients. In the case of aerosol products for human application, the active ingredient is usually present in the composition between 0.1 and 1
It is blended at about 0% by weight.

The aerosol composition further contains commonly used components such as a solvent, a spreading agent, an antioxidant, an emulsifier, a suspending agent, and a flavoring agent. Specific examples of the solvent include acetone,
Ketones such as methyl ethicatone, ethers such as ethyl ether, esters such as butyl acetate and amyl acetate, aromatic hydrocarbons such as benzene, toluene, xylene, polyhydric alcohols such as glycerin and propylene glycol, chlorocene, ethylene chloride, etc. Hydrocarbons such as chlorinated hydrocarbons, kerosene, etc. can be mentioned. In addition, isopropyl myristate is used as a spreading agent for spreading and dispersing the powder, polymeric compounds such as dibutylhydroxyanisole, dibutylhydroxytoluene, carboxymethylcellulose, and carbobol are used as antioxidants, and emulsifiers and static dispersants are used. can be exemplified by various surfactants.

Next, FIG. 1 shows the general structure of an aerosol container constituting the aerosol product of the present invention. This aerosol container is composed of a container body 1 and a pulp 2. In the figure, numeral 3 is a lower hole in the housing, numeral 4 is a vapor tap (through hole) of the housing, numeral 5 is a stem hole, and numerals are button nozzle holes.

Lower housing hole 3 of the aerosol container used in the present invention
The diameter of the vapor tap 4 of the housing is set to 0.31 or more and 0.8ml or less, and the diameter of the stem hole 5 is 2g or less and its diameter is 0. The diameter of the button nozzle hole 6 is set to 0.2 mm or more and 0.6 m Im or less, and the diameter of the button nozzle hole 6 is set to 0.3 mm or more and 0.6 m Im or less.

If the diameter of the hole deviates from the above range, the aerosol composition may be sprayed in the form of foam or liquid, or become too fine and disperse into the surrounding area.

In conventional aerosol products, the aerosol composition is filled to 85 to 90% of the internal volume of the container, but in the aerosol product of the present invention, the amount of the aerosol composition filled is 30% or more of the internal volume of the aerosol container, which is 85% by volume. % or less.

When the filling amount of the aerosol composition exceeds the above range, the remaining space becomes too small, and when the remaining amount of the aerosol composition decreases, the pressure decreases significantly, and there is a possibility that the atomized deafness will change significantly. Furthermore, if the filling amount is lower than the above range, there is a risk that the number of uses per can of the product, which is assumed to be approximately constant, cannot be guaranteed, and the dispersibility and solubility of the active ingredient may be impaired.

The human body application aerosol product according to the present invention can be manufactured in the same manner as conventional aerosol products. That is, it can be produced by blending and preparing the active ingredient and alcohol, placing this in an aerosol container, and then filling it with liquefied gas and carbon dioxide gas as propellants. There are no particular limitations on the method of filling the liquefied gas and carbon dioxide gas as propellants. For example, methods for filling carbon dioxide gas include a shaking method, in which a mixture of active ingredients and alcohol is first filled with liquefied gas, carbon dioxide gas is introduced at a constant pressure, and the carbon dioxide is absorbed by shaking. There is a high-pressure type in which the pressure of the gas to be supplied is increased to speed up the process, a cooling type in which the process is carried out at a low temperature, and a saturation type in which carbon dioxide is mixed into the liquid mixture in advance to saturation.

The aerosol product for human body application of the present invention can be applied to various fields such as antiperspirants, external analgesic and antiinflammatory agents, pest repellents, disinfectants, and athlete's foot treatment agents.

[Effect]

Since the alcohol blended into the aerosol composition constituting the aerosol product of the present invention has volatility, part of the injection pressure is compensated for by its vapor pressure. Additionally, since alcohol evaporates on the body surface to which it is applied, it can provide a cooling sensation. Alcohol also acts as a solvent to dissolve the active ingredients.

Furthermore, since the aerosol composition contains carbon dioxide gas, part of the injection pressure is compensated for by the carbon dioxide gas, making it possible to reduce the amount of liquefied gas used.

In the aerosol product of the present invention, the aerosol composition having the above-mentioned composition is filled into an aerosol container equipped with a valve that satisfies the above-mentioned conditions, so it exhibits better aerosol spray performance and is suitable for use on the human body. be able to.

Furthermore, since the aerosol product according to claim 2 contains water, it has low flammability and excellent percutaneous absorption of the active ingredient.

〔Example〕

(Example I) Aerosol products having the compositions and container configurations shown in Table 1 were prepared, and the usability and spraying conditions were examined. In the container used in this example, ratio 6. Ratio 7. Fruit 6 and fruit 7 are
It has two stem holes. Note that Comparative Example 1 and Comparative Example 6 in Table 1 are conventional products.

Evaluation method ■) Feeling of use Each aerosol product was sprayed onto the forearms of 10 men and women for 3 seconds from a distance of 1 Oct 1, and they were asked to evaluate the coolness and stiffness.

2) Spraying condition Each aerosol product was sprayed for 5 seconds in the same manner as when examining the feeling of use, and the size and flying state of the spray particles during spraying were observed.

These results were evaluated as shown in Table 1. The results are shown in Table 2.

Margin below evaluation Table 2 From the results shown in Table 1, the following can be seen.

■ Comparing Examples 1, 2.3 and Comparative Example 1, Comparative Example 1, which is a conventional product, weighs 48g[・80gX(26,4+
264 + 7.2)%] The liquefied gas that needed to be blended was reduced to 37.44g (・64g It was found that even if the amount was reduced, a good feeling of use and a good spray condition could be obtained.

■ Compared to Comparative Example 6, which is a conventional product that does not contain alcohol, Comparative Example 7, which added carbon dioxide to reduce the amount of liquefied gas, maintains a good spray condition but has a dry feel. However, it was found that adding alcohol as in Example 6 improved the refreshing feeling.

■ Example 4 and Comparative Example 2 are the results of examining the blending amount of ethanol. Comparing these results, when the blending amount of the mixture of active ingredient and alcohol exceeds 55%, a slightly sticky feeling occurs and the feeling of use is poor. I know it's going to get worse.

(2) In Comparative Examples 3 and 4, the valve diameter of the aerosol container was changed and the feeling of use and spray condition were observed. If a container with a too small diameter is used, the mist becomes too fine.

Furthermore, if the diameter is too large, the mist will become coarse and the amount of application can be secured, but it will feel sticky.

(2) In Example 5 and Comparative Example 5, the amount of water added was investigated. Comparing these results, it can be seen that when the amount of water added exceeds about 15% by weight, stickiness is felt and the feeling of use deteriorates.

■ In addition, Examples 1 to 4 and Comparative Example 1, which is a conventional product,
Comparing Example 6 and Comparative Example 6, which is a conventional product,
In order to fill 0.064 g of disinfectant or 1.6 g of antiperspirant, the conventional product must be filled with 80 g of the composition, whereas in the example, 64 g of the composition is sufficient.
It was found that the weight of the product could be reduced. The reason why the filling amount was able to be reduced in the examples is that the blended alcohol also acts as a solvent.

Next, the examples were sprayed at low temperature (5° C.) and the spraying conditions were examined. As a result, it was found that the aerosol products of Examples could be sprayed in the form of fine mist even at low temperatures.

Next, when the aerosol container constituting the aerosol product of the example was sprayed in an inverted state, the spray state was the same as in the upright state, and no situation where only carbon dioxide gas was sprayed occurred. This is because the valve of the container is equipped with a vapor tap.

(Example ■) The aerosol product of Example 1 shown in Table 1 and an aerosol product (Comparative Example 8) that differs from Example 1 only in that nitrogen gas was used instead of carbon dioxide gas were prepared, and the number of injections was The relationship between this and the injection amount was investigated. Note that the amount of nitrogen filling in Comparative Example 8 was set so as to obtain almost the same initial pressure as that in Example 1. The results are shown in Figure 2.

As a result, it was found that the aerosol product of Example 1 using carbon dioxide gas had a stable injection amount by 1°.

〔Effect of the invention〕

As explained above, the aerosol product for human body application of the present invention comprises a liquid mixture of an active ingredient and an alcohol having 1 to 3 carbon atoms;
An aerosol composition containing liquefied gas with a vapor pressure of 0.8 to 5 kg/cts2G at 20°C and carbon dioxide gas in a predetermined ratio is placed in an aerosol container with a pulp diameter of 30 to 85 volumes in a predetermined range. % filling, it is possible to reduce the amount of expensive liquefied gas used (can be reduced to 80% or less compared to conventional products) without compromising the cooling sensation or spray quality.

Therefore, according to the present invention, it is possible to reduce the manufacturing cost of aerosol products.

Furthermore, in the aerosol product of the present invention, the blended alcohol also acts as a solvent for the active ingredient, so the active ingredient can be blended at a higher concentration. Therefore, in the aerosol product of the present invention, the weight can be reduced by reducing the amount of aerosol composition filled. This aerosol product also allows the required amount of active ingredient to be applied in a short period of time.

Further, according to the aerosol product of the present invention, it is possible to reduce the amount of substances that may damage the environment, such as fluorocarbons.

Compressed gases include nitrous oxide (laughing gas), nitrogen, air, helium, neon, argon, etc., but carbon dioxide gas is superior in terms of price, safety, solubility in stock solutions, etc.
This aerosol product using carbon dioxide gas is inexpensive, has excellent safety, and has the advantage that there is little change in injection amount between the first half and the second half of use. Since it contains water, it has excellent transdermal absorption and is resistant to combustion and highly safe.

[Brief explanation of drawings]

FIG. 1 is a sectional view showing an example of an aerosol container constituting the aerosol product of the present invention, and FIG. 2 is a graph showing the results of Example 2. l... Container body, 2... Valve, 3... Lower housing hole, 4... Vapor tap hole of housing, 5... Stem hole, 6... Button nozzle hole.

Claims (2)

[Claims] (1) An aerosol product for human body application comprising an aerosol composition and an aerosol container containing the aerosol composition, wherein the aerosol composition contains [1] 55% by weight or less of alcohol having 1 to 3 carbon atoms [2] 20°C The vapor pressure at is 0.8~5kg/cm^
2G liquefied gas 45 to 95% by weight; [3] carbon dioxide gas 0.2 to 2.5% by weight; (b) Vapor tap diameter of housing 0.3 to 0.8
mm (c) No more than 2 stem holes with a diameter of 0.2 to 0.6 m
(d) The aerosol container is equipped with a valve that satisfies the condition that the diameter of the button nozzle hole is 0.3 to 0.6 mm, and the aerosol container is filled with 30 to 85% by volume of the aerosol composition. An aerosol product for human body application featuring: (2) Water as an active ingredient in the aerosol composition is 15%
2. The aerosol product for application to the human body according to claim 1, wherein the aerosol product contains less than % by weight.