JPH02268767A - Preparation of blood treating device - Google Patents
Preparation of blood treating deviceInfo
- Publication number
- JPH02268767A JPH02268767A JP8809989A JP8809989A JPH02268767A JP H02268767 A JPH02268767 A JP H02268767A JP 8809989 A JP8809989 A JP 8809989A JP 8809989 A JP8809989 A JP 8809989A JP H02268767 A JPH02268767 A JP H02268767A
- Authority
- JP
- Japan
- Prior art keywords
- blood
- manufacturing
- hollow
- processing device
- hollow fiber
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008280 blood Substances 0.000 title claims abstract description 53
- 210000004369 blood Anatomy 0.000 title claims abstract description 53
- 239000012528 membrane Substances 0.000 claims abstract description 35
- 239000012510 hollow fiber Substances 0.000 claims abstract description 34
- 238000000034 method Methods 0.000 claims abstract description 28
- 239000004014 plasticizer Substances 0.000 claims abstract description 20
- 229920005989 resin Polymers 0.000 claims abstract description 7
- 239000011347 resin Substances 0.000 claims abstract description 7
- 238000005520 cutting process Methods 0.000 claims abstract description 5
- 238000007789 sealing Methods 0.000 claims abstract description 3
- 238000004519 manufacturing process Methods 0.000 claims description 24
- 238000009826 distribution Methods 0.000 claims description 12
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 6
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 claims description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
- 229920003174 cellulose-based polymer Polymers 0.000 claims description 4
- 235000011187 glycerol Nutrition 0.000 claims description 3
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- 229920002678 cellulose Polymers 0.000 claims description 2
- 239000001913 cellulose Substances 0.000 claims description 2
- 239000000470 constituent Substances 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 239000004627 regenerated cellulose Substances 0.000 claims description 2
- 239000002504 physiological saline solution Substances 0.000 abstract description 10
- 229920001747 Cellulose diacetate Polymers 0.000 abstract description 5
- 238000001035 drying Methods 0.000 abstract description 4
- 229920002803 thermoplastic polyurethane Polymers 0.000 abstract description 3
- 239000003822 epoxy resin Substances 0.000 abstract description 2
- 229920000647 polyepoxide Polymers 0.000 abstract description 2
- 238000000502 dialysis Methods 0.000 abstract 1
- 238000002074 melt spinning Methods 0.000 abstract 1
- 238000012856 packing Methods 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 230000037452 priming Effects 0.000 description 3
- 238000001631 haemodialysis Methods 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 230000000322 hemodialysis Effects 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 238000002615 hemofiltration Methods 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
Landscapes
- Separation Using Semi-Permeable Membranes (AREA)
- External Artificial Organs (AREA)
Abstract
Description
【発明の詳細な説明】
〈産業上の利用分野〉
本発明は、血液透析、血液７濾過、血漿分離などの中空
繊維半透膜を用いる血液処理器の製造方法に関する。DETAILED DESCRIPTION OF THE INVENTION <Industrial Application Field> The present invention relates to a method for manufacturing a blood processing device using a hollow fiber semipermeable membrane for hemodialysis, hemofiltration, plasma separation, etc.
〈従来技術〉
血液処理器は、血液を血液処理器に流す前処理として、
生理食塩水を血液処理器にプライミングが行なわれ、血
液処理器に完全に生理食塩水に置換し、その際充分に生
理食塩水を流して血液処理器内の洗浄も同時に行なわれ
る。これらの血液処理器のプライミングにおいて、血液
処理器の中空繊維半透明への生理食塩水が問題となる。<Prior art> A blood processor performs pre-treatment of blood before flowing into the blood processor.
The blood processing device is primed with physiological saline, and the blood processing device is completely replaced with physiological saline, at which time the inside of the blood processing device is simultaneously washed by sufficiently flushing the physiological saline. In priming these blood processors, saline solution into the hollow fiber translucency of the blood processor is problematic.
すなわち、中空繊維半透膜への生理食塩水の充填が完全
に行なわれないとプライミング時の中空繊維の洗浄効果
が悪いのみならず血流を流した時に中空繊維部で血液の
クロットを誘発したり、使用後の返血過程で血液が処理
器に残血する等の問題が発生する４
従って、生理食塩水の充填性は、病院におけるプライミ
ング作業の効率、さらには、使用時の安全性に影響する
特性であり、充填性の優れた血液処理器が要筆されてい
る。In other words, if the hollow fiber semipermeable membrane is not completely filled with physiological saline, not only will the cleaning effect of the hollow fibers during priming be poor, but also blood clots will be induced in the hollow fibers when blood flows through the membrane. Problems may occur, such as blood remaining in the processing device during the blood return process after use.4 Therefore, the filling performance of physiological saline is critical to the efficiency of priming work in hospitals, as well as the safety during use. This is an influential characteristic, and a blood processing device with excellent filling properties is highlighted.
〈発明の目的〉
本発明者は、かかる従来の問題点を解消することを目的
として、鋭意研究した結果、中空繊維半透膜を血液処理
器に樹脂で固定し両端部を開口させた後、他方より圧空
を流すことが中空繊維半透膜への生理食塩水の充填性改
善に効率なことを見い出し、本発明に到達した。<Purpose of the Invention> As a result of intensive research aimed at solving such conventional problems, the present inventor fixed a hollow fiber semipermeable membrane to a blood processing device with resin, opened both ends, and then We have discovered that flowing compressed air from the other side is efficient in improving the filling properties of physiological saline into the hollow fiber semipermeable membrane, and have arrived at the present invention.
〈発明の構成〉
本発明は、以下に示す血液処理器の製造方法を提供する
ものである。<Structure of the Invention> The present invention provides the following method for manufacturing a blood processing device.
（１）中空繊維状半透１摸を構成部材とする血液処理器
の製造方法において、可塑剤を付着せしめた状態で実質
的に乾燥状態とした該中空繊維状半透膜の集束体を筒状
容器に装填せしめ、その両端を樹脂によりシール固定し
た後、両端を切断して該中空繊維の中空部を開口せしめ
、該開部の一方側から該中空繊維の中空部に気体を流通
せしめて該中空部に存在する過剰の可塑剤を除去するこ
とを特徴とする血液処理器の製造方法。(1) In a method for manufacturing a blood processing device having a hollow fibrous semipermeable membrane 1 as a constituent member, a bundle of hollow fibrous semipermeable membranes that is substantially dried with a plasticizer attached thereto is made into a cylinder. After loading it into a shaped container and sealing and fixing both ends with resin, both ends are cut to open the hollow part of the hollow fiber, and gas is allowed to flow into the hollow part of the hollow fiber from one side of the opening. A method for manufacturing a blood processing device, characterized in that excess plasticizer present in the hollow portion is removed.
該中空繊維状半透膜がセルロース系高分子重合体を主体
としたものである請求項１の血液処理器の製造方法。2. The method for manufacturing a blood processing device according to claim 1, wherein said hollow fibrous semipermeable membrane is mainly composed of a cellulose-based polymer.
（３１該セルロース系高分子重合体が、セルロースアジ
チーｉ・又は再生セルロースである請求項２の血液処理
器の゛製造方法。(31) The method for producing a blood treatment device according to claim 2, wherein the cellulose-based polymer is cellulose ajiti or regenerated cellulose.
（勾 該切断工程と該気体の流通工程の間に、又は該気
体の流通工程の後に、該筒状容器の一端に血液分配部材
を、他端に血液集収部材を具備せしめる請求項１〜３の
いずれかの血液処理器の製造方法。(Claims 1 to 3) wherein between the cutting step and the gas distribution step or after the gas distribution step, a blood distribution member is provided at one end of the cylindrical container and a blood collection member is provided at the other end. A method for manufacturing any of the blood processing devices.
（５）該実質的に乾燥状態とした中空繊維状半透膜が５
０〜１５０重量％の範囲で可塑剤を含有するものである
請求項１〜４のいずれかに記載の血液処理器の製造方法
。(5) The hollow fibrous semipermeable membrane in a substantially dry state is 5
The method for manufacturing a blood treatment device according to any one of claims 1 to 4, which contains a plasticizer in a range of 0 to 150% by weight.
（ａ 該可塑剤が、グリセリン、エチレングリコ−ル、
ジエチレングリコール及びポリエチレングリコールの群
から選ばれる少なくとも一種である請求項の５の血液処
理器の製造方法。(a) The plasticizer is glycerin, ethylene glycol,
6. The method for manufacturing a blood treatment device according to claim 5, wherein the blood treatment device is at least one selected from the group of diethylene glycol and polyethylene glycol.
（７）該気体の流通工程において、気体の流速か０．２
〜１０ｍ ／ Ｓｅｃ 、流通時間か１〜１０分である
請求項１〜６のいずれかに記載の血液処理器の製造方法
。(7) In the gas distribution process, the gas flow rate is 0.2
7. The method for manufacturing a blood processing device according to any one of claims 1 to 6, wherein the flow time is 1 to 10 minutes.
（８） 該気体の流通工程における該気体が空気であ
る請求項１〜７のいずれかの血液処理器の製造方法。(8) The method for manufacturing a blood processing device according to any one of claims 1 to 7, wherein the gas in the gas distribution step is air.
（９）該血液処理器が血液透析器である請求項１〜８の
いずれかの血液処理器の製造方法。(9) The method for manufacturing a blood processing device according to any one of claims 1 to 8, wherein the blood processing device is a hemodialyzer.
以下本発明についてさらに詳細に説明する。The present invention will be explained in more detail below.
本発明において中空ａ維半透膜に可塑剤を付着せしめ、
且つ実質的に乾燥状態にする方法としては、特に限定さ
れるものでなく、例えば所定濃度に可塑剤を溶解した水
溶液を中空繊維半透膜に付着させ余分の水溶液をエアー
ナイフで取り除いた後、熱風中で十分乾燥する方法があ
げられる。In the present invention, a plasticizer is attached to the hollow A-fiber semipermeable membrane,
There are no particular limitations on the method for substantially drying the membrane, such as attaching an aqueous solution containing a plasticizer to a predetermined concentration to the hollow fiber semipermeable membrane and removing the excess aqueous solution with an air knife. One method is to thoroughly dry it in hot air.
例えばセルロースジアセテートの可塑化溶融紡糸性によ
る血液透析用の中空繊維半透膜の場合にには、セルロー
スジアセテートの重量に対して、可塑剤が５０〜１５０
重景％の範囲で付着された状態で実質上乾燥した後に、
血液処理器用の筒状容器内に、中空繊維半透膜の集束体
として装填し、通常の方法によって両端がウレタン樹脂
やエポキシ樹脂等の樹脂を用いて遠心成型等によりシー
ル固定された後、その両端を中空糸を固定した樹脂と共
に切断して、中空繊維の中空部を開口させ、方より気体
を中空繊維半透膜へ圧入して、中空繊維半透膜内に流す
ことにより中空繊維半透膜の内壁部に付着している過剰
の可塑剤を収り除くことにより血液処理器の生理食塩水
の充填性を改善する
この場合の中空繊維半透膜内を流す気体の流速は、０．
２ｍ ／ ｓｅｃ 〜１０ｍ ／ ｓｅｃ気体の流通時
間は′１分〜１０分が好ましい。For example, in the case of a hollow fiber semipermeable membrane for hemodialysis using plasticized melt-spun properties of cellulose diacetate, the amount of plasticizer is 50 to 150% by weight based on the weight of cellulose diacetate.
After drying substantially in a state where it is attached in a range of %
A bundle of hollow fiber semipermeable membranes is loaded into a cylindrical container for a blood processing device, and both ends are sealed and fixed by centrifugal molding using a resin such as urethane resin or epoxy resin in the usual manner. The hollow fibers are made semipermeable by cutting both ends together with the resin that fixed the hollow fibers to open the hollow portions of the hollow fibers, and then pressurizing gas into the hollow fiber semipermeable membranes to flow through the hollow fiber semipermeable membranes. The flow rate of the gas flowing through the hollow fiber semipermeable membrane in this case, which improves the filling performance of physiological saline in the blood treatment device by removing excess plasticizer adhering to the inner wall of the membrane, is 0.
The gas flow time of 2 m/sec to 10 m/sec is preferably 1 minute to 10 minutes.
かかる範囲であれば、中空繊維半透膜内壁の過剰に付着
している可塑剤を取除くことが出来る。Within this range, excess plasticizer adhering to the inner wall of the hollow fiber semipermeable membrane can be removed.
気体の流通速度が０．２ｍ／Ｓｅｃ未満であると、中空
繊維半透膜内壁部に付着した過剰の可塑剤を収り除く効
果が少なく、好ましくない、又、１０ｍ／ ＳｅＣを超
えると気体の使用量が多く経済的にも好ましくない、一
方、流通時間については、１分〜１０分が好ましい、１
分未満までは可塑剤の除去が十分に行なわれず好ましく
ない、 １０分を超えると気体の使用量が多く経済的に
も好ましくない。If the gas flow velocity is less than 0.2 m/Sec, the effect of removing excess plasticizer adhering to the inner wall of the hollow fiber semipermeable membrane is small, which is undesirable. The amount used is large and it is economically unfavorable. On the other hand, the distribution time is preferably 1 to 10 minutes.
If the heating time is less than 10 minutes, the plasticizer will not be removed sufficiently, which is undesirable. If the heating time exceeds 10 minutes, the amount of gas used will be large, which is also economically undesirable.
〈実施例〉
以下に本発明の実施例と比較例と共に示すが、本発明は
、それらによって何ら限定されるものでない、セルロー
スジアセテートをポリエチレングリコールと共に可塑化
溶融により紡糸して得られた血液透析用中空繊維半透膜
の集束体に、グリセリンを含有した水溶液を付着せしめ
た後エアーナイフにより過剰に付着した水溶液を除去し
熱風中で乾燥することによりセルロースジアセテート中
空繊維半透膜の集束体を得な。<Example> The present invention is shown below together with Examples and Comparative Examples of the present invention, but the present invention is not limited thereto. A bundle of cellulose diacetate hollow fiber semipermeable membranes is produced by attaching an aqueous solution containing glycerin to a bundle of hollow fiber semipermeable membranes, removing the excess aqueous solution with an air knife, and drying in hot air. Don't get it.
かかる集束体を常法に従って筒状容器に装填し両端をウ
レタン樹脂により遠心成型後に切断し、分配板等のヘッ
ダ一部材を固着させて、血液透析器を組み立てた、一方
のへラダーより、圧空をを吹込み、中空繊維半透膜内で
の圧空の流速を０〜１０ｍ／Ｓｅｃ圧空処理時間を０〜
１０分の条件で中空繊維半透膜に圧空を流した。The bundle was loaded into a cylindrical container according to a conventional method, both ends were centrifugally molded with urethane resin, cut off, and a header member such as a distribution plate was fixed to assemble the hemodialyzer. The flow rate of compressed air inside the hollow fiber semipermeable membrane was set at 0 to 10 m/Sec, and the compressed air treatment time was set at 0 to 10 m/Sec.
Pressure air was passed through the hollow fiber semipermeable membrane for 10 minutes.
圧空処理後に、血液処理器を立てた状態で固定し下側よ
り、生理食塩水１！をヘッド圧力５０ｇ／−・Ｇで導入
して血液透析器内に充填を行なった後、血液透析器の外
面より生理食塩水の充填されていない中空繊維半透膜の
本数を測定したところ、表Ｉのような結果が得られた。After compressed air treatment, fix the blood treatment device in an upright position and add 1 portion of physiological saline from the bottom! was introduced into the hemodialyzer at a head pressure of 50 g/-.G, and then the number of hollow fiber semipermeable membranes that were not filled with physiological saline was measured from the outside surface of the hemodialyzer. Results similar to I were obtained.
実施例
〈発明の効果〉
本発明の血液処理器の製造方法によれば、ブライミング
性のり良好な血液処理器を製造することが可能になり、
残血の少ないより安全な血液処理器を提供することがで
きる。Examples (Effects of the Invention) According to the method for manufacturing a blood processing device of the present invention, it is possible to manufacture a blood processing device with good briming properties,
A safer blood processing device with less residual blood can be provided.
Claims (9)
製造方法において、可塑剤を付着せしめた状態で実質的
に乾燥状態とした該中空繊維状半透膜の集束体を筒状容
器に装填せしめ、その両端を樹脂によりシール固定した
後、両端を切断して該中空繊維の中空部を開口せしめ、
該開部の一方側から該中空繊維の中空部に気体を流通せ
しめて該中空部に存在する過剰の可塑剤を除去すること
を特徴とする血液処理器の製造方法。(1) In a method for manufacturing a blood processing device having a hollow fibrous semipermeable membrane as a constituent member, a bundle of hollow fibrous semipermeable membranes that is substantially dried with a plasticizer attached thereto is shaped into a cylindrical shape. After loading the container into a container and sealing and fixing both ends with resin, cutting both ends to open the hollow part of the hollow fiber,
A method for manufacturing a blood processing device, characterized in that excess plasticizer present in the hollow portion is removed by flowing gas into the hollow portion of the hollow fiber from one side of the opening.
を主体としたものである請求項１の血液処理器の製造方
法。(2) The method for manufacturing a blood processing device according to claim 1, wherein the hollow fibrous semipermeable membrane is mainly composed of a cellulose-based polymer.
テート又は再生セルロースである請求項２の血液処理器
の製造方法。(3) The method for manufacturing a blood treatment device according to claim 2, wherein the cellulose-based polymer is cellulose agitate or regenerated cellulose.
体の流通工程の後に、該筒状容器の一端に血液分配部材
を、他端に血液集収部材を具備せしめる請求項１〜３の
いずれかの血液処理器の製造方法。(4) Between the cutting step and the gas distribution step or after the gas distribution step, one end of the cylindrical container is provided with a blood distribution member and the other end is provided with a blood collection member. 3. The method for manufacturing a blood processing device according to any one of 3.
０〜１５０重量％の範囲で可塑剤を含有するものである
請求項１〜４のいずれかに記載の血液処理器の製造方法
。(5) The hollow fibrous semipermeable membrane in a substantially dry state is 5
The method for manufacturing a blood treatment device according to any one of claims 1 to 4, which contains a plasticizer in a range of 0 to 150% by weight.
ジエチレングリコール及びポリエチレングリコールの群
から選ばれる少なくとも一種である請求項の５の血液処
理器の製造方法。(6) The plasticizer is glycerin, ethylene glycol,
6. The method for manufacturing a blood treatment device according to claim 5, wherein the blood treatment device is at least one selected from the group of diethylene glycol and polyethylene glycol.
〜１０ｍ／ｓｅｃ、流通時間が１〜１０分である請求項
１〜６のいずれかに記載の血液処理器の製造方法。(7) In the gas distribution process, the gas flow rate is 0.2
7. The method for manufacturing a blood processing device according to claim 1, wherein the flow rate is 10 m/sec and the flow time is 1 to 10 minutes.
求項１〜７のいずれかの血液処理器の製造方法。(8) The method for manufacturing a blood processing device according to any one of claims 1 to 7, wherein the gas in the gas distribution step is air.
いずれかの血液処理器の製造方法。(9) The method for manufacturing a blood processing device according to any one of claims 1 to 8, wherein the blood processing device is a hemodialyzer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1088099A JP2710663B2 (en) | 1989-04-10 | 1989-04-10 | Blood processing device manufacturing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1088099A JP2710663B2 (en) | 1989-04-10 | 1989-04-10 | Blood processing device manufacturing method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH02268767A true JPH02268767A (en) | 1990-11-02 |
| JP2710663B2 JP2710663B2 (en) | 1998-02-10 |
Family
ID=13933422
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1088099A Expired - Fee Related JP2710663B2 (en) | 1989-04-10 | 1989-04-10 | Blood processing device manufacturing method |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2710663B2 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995024262A1 (en) * | 1994-03-08 | 1995-09-14 | Teijin Limited | Hollow-fiber blood-purifying membrane and process for producing the same |
| JP2003053156A (en) * | 2001-08-17 | 2003-02-25 | Kawasumi Lab Inc | Dialysis module and manufacturing method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5438927A (en) * | 1977-08-31 | 1979-03-24 | Senko Med Instr Mfg | Treating of hollow yarn |
| JPS56136567A (en) * | 1980-03-28 | 1981-10-24 | Terumo Corp | Method and apparatus for washing hollow thread type blood dialyzer |
| JPS59225066A (en) * | 1983-06-03 | 1984-12-18 | テルモ株式会社 | Production of blood treating apparatus |
-
1989
- 1989-04-10 JP JP1088099A patent/JP2710663B2/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5438927A (en) * | 1977-08-31 | 1979-03-24 | Senko Med Instr Mfg | Treating of hollow yarn |
| JPS56136567A (en) * | 1980-03-28 | 1981-10-24 | Terumo Corp | Method and apparatus for washing hollow thread type blood dialyzer |
| JPS59225066A (en) * | 1983-06-03 | 1984-12-18 | テルモ株式会社 | Production of blood treating apparatus |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995024262A1 (en) * | 1994-03-08 | 1995-09-14 | Teijin Limited | Hollow-fiber blood-purifying membrane and process for producing the same |
| JP2003053156A (en) * | 2001-08-17 | 2003-02-25 | Kawasumi Lab Inc | Dialysis module and manufacturing method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2710663B2 (en) | 1998-02-10 |
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