JPH02264721A - Production of powdery vitamin e - Google Patents

Abstract

PURPOSE:To obtain a powdery vitamin E composition usable widely in the field of drugs, foods, cosmetics, etc., having excellent dispersibility to water and fluidity, comprising vitamin E, emulsifying agent, casein or a salt thereof, gum and dextrin as essential components. CONSTITUTION:An emulsifying agent (e.g. glycerin fatty acid ester) is dissolved in vitamin E at 60-70 deg.C to give an oil phase part and casein or a salt thereof (e.g. sodium caseinate), gum (e.g. gum arabic) and dextrin are dissolved in water at 60-70 deg.C to give a water phase part. Then the water phase part is blended with the oil phase part, emulsified and dried to give the aimed substance. The amount of the emulsifying agent is <=5wt.% based on vitamin E and total amounts of the casein or the salt thereof and the gum is <=200wt.%.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to a powdered vitamin E composition and a method for producing the same. More specifically, the present invention provides a method for producing a powdered vitamin E composition that has extremely good dispersibility in an aqueous system and fluidity of the powder itself when vitamin E is used in the fields of medicine, food, cosmetics, etc. be.

[Conventional technology]

Tocopherol is known as vitamin E and includes α-tocopherol, β-tocopherol, γ-tocopherol,
There are 44Iti homologues of δ-tocopherol.

Conventionally, vitamin E has been widely used as an antioxidant in the fields of medicine, food, cosmetics, etc. In recent years, the use of vitamin E not only for antioxidant purposes but also for its nutritional and physiological effects has become more prominent, and it is increasingly being added to various foods, mainly animal and vegetable oils and fats. It's here.

However, vitamin E is fat-soluble and is a viscous liquid, so if the food is oil-based, it is easy to mix and add vitamin E, but if the food is aqueous-based, vitamin E It is difficult to disperse them uniformly, and the objects to which they can be added are naturally limited.

Under these circumstances, in order to apply vitamin E to an aqueous system, the invention of powdering vitamin E as a prior art (Japanese Patent Application Laid-Open No. 57-181009, Japanese Patent Application Laid-Open No. 58-1871)
No. 74, JP-A-60-64919, JP-A-6
0=178882, JP-A-61-60619, and JP-A-63-2994760) have been published so far.

These conventional powdered vitamin E compositions are usually manufactured by adding milk, skim milk, skim milk powder, whole milk powder, whey, casein, sodium caseinate, gelatin, soy protein, etc. to the vitamin together with an emulsifier, emulsifying the mixture, and drying. It was called.

[Problems to be solved by the invention]

However, in all of the conventional techniques, the dispersibility in aqueous systems and the fluidity of the powder itself cannot be said to be sufficient. Therefore, the present invention solves the above-mentioned drawbacks of conventional powdered vitamin compositions, and provides a powdered vitamin E composition and a method for producing the same, which have significantly improved dispersibility of the powder in an aqueous system and fluidity of the powder itself. The purpose is to provide new information.

[Means to solve the problem]

In order to achieve the above object, the present invention provides a powdered vitamin E composition containing vitamin E, an emulsifier, casein or its salt, a gum substance, and dextrin as essential components. A powder obtained by adding casein or its salt, gummy substance and dextrin to water to form an aqueous phase, then mixing the aqueous phase with the oil phase, emulsifying it, and drying it. A new method for producing a vitamin E composition is provided.

The present invention is characterized by using an emulsifier in an amount of 5% by weight or less based on the amount of vitamins, and casein, or its salt and gum, in a total amount of 200% or more by weight based on the amount of F based on the vitamins.

In addition, the present invention uses one or more lubricants such as light silicic anhydride, talc, aluminum silicate, higher fatty acids and metal salts thereof in combination to further improve the fluidity of the powdered vitamin E composition. 0.1 to 3% to the powdered vitamin E composition obtained by the method described in claim (1).
It is also characterized by the addition of.

Vitamin E as used in the present invention refers to natural and synthetic vitamin E or derivatives thereof. Natural vitamin E includes α-tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol, α-tocotrienol, β-tocotrienol, and T. -tocotrienol, δ-tocotrienol, synthetic ones include quasi-α-tocopherol, derivatives include acetate ester, nicotinic acid ester 2
, succinic acid ester, etc.

As the emulsifier, oil-soluble emulsifiers such as glycerin fatty acid ester, propylene glycol fatty acid ester, sorbitan fatty acid ester, and cibosugar fatty acid ester can be used, but glycerin fatty acid ester is particularly preferred. These emulsifiers can also be used alone or in combination of two or more, and are used in an amount of 5% by weight or less relative to vitamin E. Even if the emulsifier is 5% by weight or more, it does not affect emulsification, but in that case, the content of vitamin E becomes relatively low, which is not preferable.

Examples of casein include casein and its salts such as sodium caseinate and carlasim caseinate, and sodium caseinate is particularly preferred.

As the gum, gum arabic, guar gum, xanthan gum, etc. can be used, but gum arabic is particularly preferred.

The total amount of casein or its salt and gum substance is used in an amount of 200% by weight or less based on the amount of vitamins. Even if the total amount of casein or its salt and gum substance is 200% or more based on vitamin E, there is no problem in powdering, but in that case, the content of vitamin E becomes relatively low, which is not preferable.

Dextrin is wheat starch, potato starch5.
The dextrin used in the present invention is obtained by hydrolyzing corn starch or the like as a raw material, and there are no restrictions on the raw material or processing method, but in consideration of the solubility and hygroscopicity of the dextrin powder, it is preferable that the DE value is 25 or less. .

There is no limit to the vitamin E content in the powdered vitamin E composition produced by the present invention, but if it is used in the form of a tablet in a pharmaceutical, taking into account the leaching of vitamin E, the powdered vitamin E composition should be The vitamin E content of is preferably 40 to 60% by weight.

The method for producing the powdered vitamin E composition of the present invention can be the same as the conventional method. That is, an oil-soluble emulsifier is added to vitamin E and dissolved by stirring at 60 to 70°C to form an oil phase. On the other hand, casein or its salt, gummy substance, and dextrin are added to water, and stirred and dissolved at 60 to 70°C to form an aqueous phase.

Then, the oil phase is added little by little to the water phase while stirring to pre-emulsify, and then homogenized using a homomixer. As a drying method, spray drying, vacuum drying, freeze drying, etc. can be used, but spray drying is preferable.

The powdered vitamin E composition prepared in this way has very good dispersibility in water, has a smooth feel, and has excellent fluidity, so it can be widely used in medicines, foods, cosmetics, etc. be.

(Action) In addition to vitamins, glycerin fatty acid ester, propylene glycol fatty acid ester, sorbitan fatty acid ester,
One or more emulsifiers such as sig sugar fatty acid ester are dissolved to form an oil phase, and an emulsifier called casein or its salt is dissolved in water together with gum and dextrin to form an aqueous phase. When the oil phase is added to the phase, each emulsifier has a hydrophilic group and a lipophilic group, so it acts as a surfactant and is resistant to physical operations such as stirring, high heat, and mixing. With this help, the mixture described above emulsifies almost completely. When this is dried, vitamin E is protected by the lipophilic groups of the emulsifier and remains stable in an anhydrous state, and when mixed into an aqueous system, it is emulsified again by the action of the hydrophilic groups.

Casein or its salt, and gums such as gum arabic, guar gum, and xanthan gum ultimately act as a coating agent for the powdered vitamin E composition, and the powdered vitamin E
Prevents oxidative decomposition of the composition. In addition, these coating agents have high water activity and are easily dissolved in an aqueous system, and serve as a preparation for emulsifying and dissolving the powdered vitamin E composition in an aqueous system, and also have a good flavor.

Dextrin improves the emulsification state and improves the fluidity of the powdered vitamin E composition, the vitamin content of the powdered vitamin E composition can be adjusted depending on the amount added, and it has high water dispersibility, so it does not dissolve in aqueous systems. The powdered vitamin E composition is easily emulsified and soluble in an aqueous system.

Powdered vitamin E obtained by the method described in claim (1) using one or a combination of two or more lubricants such as light silicic anhydride, talc, aluminum silicate, higher fatty acids, and metal salts thereof. If 0.1 to 3% of the lubricant is added to the composition, since the surface of the lubricant is smooth, the fluidity of the powdered vitamin E composition is further improved from the standpoint of friction.

〔Effect of the invention〕

As explained above, according to the present invention, when used in the fields of medicine, food, cosmetics, etc.
A method for producing a powdered vitamin E composition that has extremely good dispersibility in aqueous systems and fluidity of the powder itself has been established, and as a result, vitamin E's antioxidant effects, nutrition as a vitamin, and physiological effects It has become possible to produce powdered vitamin E compositions with extremely high activity, improving health,
We became GJ so that we can provide products that greatly contribute to beauty etc.

〔Example〕

EXAMPLES The present invention will be explained in more concrete detail with reference to Examples below. However, the present invention is not limited to these Examples.

<Example 1> Gum arabic io, og, sodium caseinate 10
．． 0g, 25.0g of dextrin (Amycol Nα5L manufactured by Nippon Deki Kagaku Co., Ltd.) were added to 100ml of water, and heated to 60-70°C.
Stir to completely dissolve and form an aqueous phase. Then d-α-
50.0 g of tocopherol and 1.5 g of glyceryl monostearate are stirred at 60 to 70°C to completely dissolve and form an oil phase. Then, the oil phase was added little by little to the water phase while stirring, pre-emulsified for 10 minutes, and then homogenized for another 10 minutes using a homomixer. This emulsion was spray-dried (inlet temperature: 140° C.; outlet temperature: 80° C.) to obtain 86.5 g of a vitamin E powder composition with a water content of 2.0%.

This vitamin E powder composition has very good dispersibility in water, has a smooth texture, and has excellent fluidity.

Further, 1.0 g of light anhydrous silicic acid was added to 50.0 g of this vitamin E powder composition and mixed to obtain 51.0 g of a vitamin E powder composition with extremely high fluidity.

<Example 2> Gum arabic 20. Og, sodium caseinate 10, O
g, dextrin (Amycol Nα5L manufactured by Nippon Chemistry)
Add 25.0g to 100Inl of water and heat at 60-70°
Stir at C to completely dissolve and form an aqueous phase. Next, natural vitamin E homologue mixture (α-tocopherol 50.0%
, 31.0% of γ-tocopherol, 19.0% of δ-tocopherol) and 1.5 g of glyceryl monostearate were stirred at 60 to 70°C to completely dissolve and form an oil phase.

Thereafter, the same procedure as in Example 1 was carried out to obtain 97.2 g of a vitamin E powder composition with a water content of 2.2%.

Further, 1.0 g of aluminum silicate was added to 50.0 g of this vitamin E powder composition and mixed to obtain 51.0 g of a vitamin E powder composition with extremely high fluidity.

<Example 3> Gum arabic io, og, sodium caseinate 20
．． 0 g and 25.0 g of dextrin (Paindex #3 manufactured by Matsutani Kagaku Kogyo ■, DE25) were added to 100 g of water and stirred at 60 to 70° C. to completely dissolve and form an aqueous phase.

Next, 50.0 g of quasi-α-tocopherol and 1.5 g of glyceryl monostearate are stirred for 60 to 70 cT:i to completely dissolve and form an oil phase.

Thereafter, the same procedure as in Example I was carried out to obtain 95.7 g of a vitamin E powder composition with a water content of 1.8%.

<Example 4> Gum arabic 30. Og, sodium caseinate 30.0
g, dextrin (Pindex #3 Matsutani Chemical Industry ■
25.0g (manufactured by DE25) was added to 100IIdl of water and stirred at 60-70°C to completely dissolve and form an aqueous phase.

Next, 1-60.0 g of d-α-tocopheryl acetate and 1.5 g of glyceryl monostearate are stirred at 60 to 70° C. to completely dissolve them to form an oil phase.

Thereafter, the same operation as in Example 1 was carried out to obtain 136.0 g of a vitamin E powder composition with a water content of 2.0%.

<Example 5> Gum arabic 5. Og, Sodium caseinate5. Og
, 59.5 g of dextrin (Amicol No., manufactured by Nippon Kagaku ■) was added to 100 mR of water, and heated at 60 to 70°C.
Stir to completely dissolve and form an aqueous phase. Then d-α
- 45.0 g of tocopheryl acetate and sucrose fatty acid ester (Ryoto Sugar Ester S-570 San-I)
Stir 0.5 g (manufactured by E Chemical Food Crystals) at 80 to 90°C to completely dissolve and form an oil phase.

Thereafter, the same operation as in Example 1 was carried out to obtain 92.0 g of a vitamin E powder composition with a water content of 2.3%.

<Example 6> Gum arabic 10. Add 20°0 g of sodium caseinate and 4.0 g of dextrin (Amicol No., manufactured by Nippon Kagaku ■) to 100 d of water and heat at 60 to 70'C.
Stir to completely dissolve and form an aqueous phase. Then d-α
- 75.0 g of tocopheryl acetate and 1.0 g of glyceryl morstearate (BOEM S-101 (V) manufactured by Riken Vitamin ■) were stirred at 70 to 80°C to completely dissolve and form an oil phase. .

Thereafter, the same procedure as in Example 1 was carried out to obtain 96.0 g of a vitamin E powder composition with a water content of 1.3%.

Procedural Amendment September 1989 Mr. Fumiki Yoshida, Director-General of the Anti-Fraud Agency 1゜2゜3゜4゜ Display of the case 1999 Patent Application No. 84768 Name of the invention A case involving a person amending the manufacturing method of powdered vitamin E Relationship with Patent applicant Address: 2-7-1 Nishi-Shinjuku, Shinjuku-ku, Tokyo Name: Masahiro Atsumi, Representative of Tama Biochemical Co., Ltd.

Claims (1)

[Claims] 1. A powdered vitamin E composition containing vitamin E, an emulsifier, casein or its salt, gum, and dextrin as essential components. 2. Add an emulsifier to vitamin E to obtain an oil phase, add casein or its salt, gum, and dextrin to water to obtain an aqueous phase, then mix the aqueous phase and the oil phase, A method for producing a powdered vitamin E composition, which comprises emulsifying and drying the emulsified product to produce a powdered vitamin E composition. 3. The method for producing a powdered vitamin E composition according to claim 2, wherein the emulsifier is used in an amount of 5% by weight or less based on vitamin E. 4. The method for producing a powdered vitamin E composition according to claims 2 and 3, wherein the total amount of casein or its salt and gum substance is 200% by weight or less based on vitamin E. 5. One or more lubricants such as light anhydrous silicic acid, talc, aluminum silicate, higher fatty acids and metal salts thereof, or a combination of two or more thereof, are added to the powdered vitamin E composition according to claim 1 at a concentration of 0.1 5. The method for producing a powdered vitamin E composition according to claims 2 to 4, which comprises adding 3% to 3%.