JPH02264651A - Cancer treating device - Google Patents
Cancer treating deviceInfo
- Publication number
- JPH02264651A JPH02264651A JP1086520A JP8652089A JPH02264651A JP H02264651 A JPH02264651 A JP H02264651A JP 1086520 A JP1086520 A JP 1086520A JP 8652089 A JP8652089 A JP 8652089A JP H02264651 A JPH02264651 A JP H02264651A
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- gamma ray
- ultrasonic
- ultrasonic wave
- detecting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010028980 Neoplasm Diseases 0.000 title claims abstract description 78
- 201000011510 cancer Diseases 0.000 title claims abstract description 76
- 230000005251 gamma ray Effects 0.000 claims abstract description 40
- 238000001514 detection method Methods 0.000 claims description 18
- 239000003504 photosensitizing agent Substances 0.000 claims description 11
- 239000000126 substance Substances 0.000 claims description 3
- 230000002165 photosensitisation Effects 0.000 claims description 2
- 230000001678 irradiating effect Effects 0.000 abstract description 4
- 238000003745 diagnosis Methods 0.000 abstract description 2
- 238000002604 ultrasonography Methods 0.000 description 16
- 238000002428 photodynamic therapy Methods 0.000 description 7
- 230000000694 effects Effects 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 230000005540 biological transmission Effects 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 239000002033 PVDF binder Substances 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 230000022534 cell killing Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229920002981 polyvinylidene fluoride Polymers 0.000 description 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- UJKPHYRXOLRVJJ-MLSVHJFASA-N CC(O)C1=C(C)/C2=C/C3=N/C(=C\C4=C(CCC(O)=O)C(C)=C(N4)/C=C4\N=C(\C=C\1/N\2)C(C)=C4C(C)O)/C(CCC(O)=O)=C3C Chemical class CC(O)C1=C(C)/C2=C/C3=N/C(=C\C4=C(CCC(O)=O)C(C)=C(N4)/C=C4\N=C(\C=C\1/N\2)C(C)=C4C(C)O)/C(CCC(O)=O)=C3C UJKPHYRXOLRVJJ-MLSVHJFASA-N 0.000 description 1
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 1
- 206010020843 Hyperthermia Diseases 0.000 description 1
- 230000000235 effect on cancer Effects 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 230000036031 hyperthermia Effects 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 238000005192 partition Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Landscapes
- Thermotherapy And Cooling Therapy Devices (AREA)
- Surgical Instruments (AREA)
- Nuclear Medicine (AREA)
Abstract
Description
【発明の詳細な説明】
［産業上の利用分野］
本発明は癌治療装置、更に詳しくは、生体内の光感受性
物質を取り込んた癌細胞に超音波を照射することによっ
て癌を治療する癌治療装置に関する。Detailed Description of the Invention [Industrial Field of Application] The present invention relates to a cancer treatment device, and more specifically, to a cancer treatment device for treating cancer by irradiating ultrasound to cancer cells that have incorporated a photosensitizer in a living body. Regarding equipment.
［従来の技術］
従来、癌の診断と治療を行なう一つの手段としては光力
学的治療法（以下、ＰＤＴと称す）か知られている。こ
のＰＤＴは、光感受性物質、例えばヘマトポルフィリン
誘導体を生体に投与し、定時間経過後、波長４３０ｎｍ
のレーザー光を照射すると癌細胞が蛍光を発するので、
これによって癌細胞の位置と拡がりを検出し、この検出
された癌細胞に向けて６３０ｎｍのレーザー光を照射す
るようにした手段であって、レーザー光が照射されると
、同病細胞に一重項酸素か生成され、この−重項酸素に
よって癌細胞が破壊され、死滅するという治療方法であ
る。[Prior Art] Conventionally, photodynamic therapy (hereinafter referred to as PDT) has been known as one means for diagnosing and treating cancer. This PDT involves administering a photosensitizer such as a hematoporphyrin derivative to a living body, and after a certain period of time elapses, a photosensitive substance with a wavelength of 430 nm is detected.
Cancer cells emit fluorescence when irradiated with laser light, so
This method detects the location and spread of cancer cells, and irradiates the detected cancer cells with a 630 nm laser beam. This is a treatment method in which oxygen is generated and cancer cells are destroyed and killed by this heavyt oxygen.
一方、光感受性物質を集積させた癌細胞にｊｊｉ音波を
照射すると癌細胞に対する殺細胞効果が芹しく増大する
という報告（１９８８年癌学０総会）があり、新たな癌
治療法が示唆されている。On the other hand, there was a report (1988 Oncology Conference) that irradiating cancer cells with accumulated photosensitizers with sound waves significantly increased the cell-killing effect on cancer cells, suggesting a new cancer treatment method. There is.
［発明が解決しようとする課題］
ところで、上述した従来のＰＤＴにおいては、癌か生体
の深部に発生しているような場合には、照射したレーザ
ー光が中間の組織に吸収されて生体の深部まで到達せず
、診断も治療もてきないという欠点があった。[Problems to be Solved by the Invention] By the way, in the conventional PDT described above, when cancer occurs deep within the living body, the irradiated laser light is absorbed by the intermediate tissue and is transmitted to the deep part of the living body. The disadvantage was that it was not possible to diagnose or treat the disease.
また、上述した光感受性物質を取り込んだ癌細胞に超音
波を照射する治療法では、超音波は生体深部まで到達す
ることができるので、深部症の治療も可能となるが、癌
の位置や大きさを検知する手段を有していないため、正
確に癌細胞に超音波を照射することが困難であり、治療
も充分に行なうことはできなかった。In addition, in the treatment method described above in which cancer cells that have incorporated photosensitizers are irradiated with ultrasound, the ultrasound can reach deep into the body, making it possible to treat deep-seated diseases, but the location and size of the cancer Since there is no means to detect cancer cells, it is difficult to accurately irradiate cancer cells with ultrasound, and treatment cannot be performed satisfactorily.
本発明は、上述した従来の癌治療装置が有していた欠点
を解消して、生体の深部迄適確に癌の診断および治療を
行なうことがてきる癌治療装置を提供することを目的と
するものである。SUMMARY OF THE INVENTION An object of the present invention is to provide a cancer treatment device that can accurately diagnose and treat cancer deep within the body by eliminating the drawbacks of the conventional cancer treatment devices described above. It is something to do.
［課題を解決するための手段］
本発明による癌治療装置は、上記目的を達成するために
、光感受性物質の生体への投与により、生体内の癌細胞
から放射されるγ線を検出して癌細胞の位置を検出する
手段と、癌細胞に向けて集束するように照射され、同細
胞を破懐して死滅させる超音波を発生する超音波発生手
段と、この超音波発生手段と上記位置検出手段とを一体
化すると共に、γ線の検出方向と超音波の集束方向とを
同一方向に向ける手段と、を具備したことを特徴とする
ものである。[Means for Solving the Problems] In order to achieve the above object, the cancer treatment device according to the present invention detects γ-rays emitted from cancer cells in the living body by administering a photosensitizer to the living body. a means for detecting the position of cancer cells; an ultrasonic wave generating means for generating ultrasonic waves that are irradiated in a focused manner toward the cancer cells to destroy and kill the cells; and the ultrasonic wave generating means and the position detecting means. The present invention is characterized in that it has a means for directing the detection direction of gamma rays and the focusing direction of ultrasonic waves in the same direction.
［作 用］
本発明の癌治療装置では、超音波照射部とγ線検出器と
を同一装置に組み込んでいるので、予じめ腫瘍に集積さ
せておいたγ線源を標識する光感受性物質から放射され
るγ線を、上記γ線検出器で検知して癌の位置を検出・
診断すると共に、その位置に超音波を直ちに照射して、
光感受性物質との併用により体外から癌の治療を行なう
。[Function] In the cancer treatment device of the present invention, since the ultrasound irradiation unit and the γ-ray detector are incorporated into the same device, a photosensitizing substance that labels the γ-ray source that has been accumulated in the tumor in advance is used. The γ-ray detector described above detects the γ-rays emitted from the cancer and detects the location of the cancer.
In addition to diagnosing the problem, we immediately irradiate the area with ultrasound.
Cancer is treated from outside the body by using it in combination with a photosensitizer.
［実 施 例］ 以下、本発明を図示の実施例に基づいて説明する。[Example] Hereinafter, the present invention will be explained based on illustrated embodiments.
第１図は、本発明の第１実施例を示す癌治療装置全体の
構成ブロック図である。この癌治療装置１は、第１図に
示すように、生体２を載せたベツド３の周りに円形状（
第２図り照）にγ線検出部４か配置され、同γ線検出部
４には超音波照射部５が一体的に配設されると共に、電
気的に制御部６に接続されている。そして、上記γ線検
出部４はγ線を検出してγ線が発生した位置、即ち癌の
位置を検知すると共に、画像表示部８によって生体の断
層像が得られるようになっている。また、上記γ線検出
部４で得られた癌７の位置に、上記超音波照射部５から
照射された超音波が集束できるように、ベツド３は制御
部６からの指令に基づいて駆動部９により３次元的に移
動できるようになっている。FIG. 1 is a block diagram of the overall configuration of a cancer treatment apparatus showing a first embodiment of the present invention. As shown in FIG. 1, this cancer treatment device 1 has a circular shape (
A gamma ray detection section 4 is disposed in the gamma ray detection section 4, and an ultrasonic irradiation section 5 is integrally disposed in the gamma ray detection section 4, and is electrically connected to a control section 6. The gamma ray detection section 4 detects gamma rays and detects the position where the gamma rays are generated, that is, the position of the cancer, and the image display section 8 is configured to obtain a tomographic image of the living body. In addition, the bed 3 is operated by a drive unit based on a command from the control unit 6 so that the ultrasound irradiated from the ultrasound irradiation unit 5 can be focused on the position of the cancer 7 obtained by the γ-ray detection unit 4. 9 allows for three-dimensional movement.
第２図は、γｉ検出器１０を示したものであって、この
検出器１０は上述のようにγ線検出部４を同心円上に複
数個配列すると共に、その一部には、超音波照射部５が
固定されている。また同超音波照射部５の内方側のベツ
ド３上の生体２に近接する部分には、生体２によく密着
するゴム製のポーラス１１が締付部材１２によって取り
付けられて、同ポーラス１１が生体２の表面に接触する
ようになっている。このポーラス１〕には、送水孔１３
と空気抜き孔１４か設けられており、これにより例えば
水等の超音波伝達液を内部に１１ｊＩ−たし、超音波の
生体内への伝達を良好にしている。FIG. 2 shows the γi detector 10, which has a plurality of γ-ray detection units 4 arranged concentrically as described above, and a part of which is irradiated with ultrasonic waves. Part 5 is fixed. Furthermore, a rubber porous 11 that is in close contact with the living body 2 is attached to a portion of the bed 3 on the inner side of the ultrasonic irradiation unit 5 that is close to the living body 2 using a tightening member 12. It is designed to come into contact with the surface of the living body 2. This porous 1] has a water supply hole 13
An air vent hole 14 is provided, which allows an ultrasonic transmission liquid such as water to enter the inside, thereby improving the transmission of ultrasonic waves into the living body.
上記超音波照射部５は、第２図中のＡ−Ａ線に沿う断面
が第３図に示されるように、上記検出器１０の本体に対
して取付ねじ１５ａによってる脱自在に取り付けられる
支持板１５ｂてなる脱る′部１５と超音波発生部１６と
で構成されていて、装着時には仕切板１７によってγ線
検出部４と超音波発生部１６とは上下に分けられるよう
になっている。そして、超音波発生部１６は超音波発生
索子１８とそれを取り付ける固定板１９とで（１′１−
成されている。また上記超音波発生素子１８はγ線を透
過する、例えばポリ弗化ビニリデン等によって構成され
ていて、γ線検出時にはγ線を透過するようになってい
る。また、上記固定板］９の超音波発生索子１８の取付
面は、凹面状となっていて、取り付けられた超音波発生
索子１８から照射される超音波が癌位置に向けて集束さ
れるようになっており、同超音波発生素子１８に給電す
るための送電ケーブル２０は、発生部１６に設けられた
ケーブル孔および支持板１５ｂに穿設された貫通孔２１
を通して制御部６（第１図参照）に導かれるようになっ
ている。The ultrasonic irradiation unit 5 is supported by a support that is removably attached to the main body of the detector 10 using a mounting screw 15a, as shown in FIG. 3, a cross section taken along line A-A in FIG. It is composed of a removable section 15 consisting of a plate 15b and an ultrasonic generation section 16, and when installed, the gamma ray detection section 4 and the ultrasonic generation section 16 can be separated into upper and lower sections by a partition plate 17. . The ultrasonic generator 16 is constructed of an ultrasonic generator 18 and a fixing plate 19 to which it is attached (1'1-
has been completed. The ultrasonic generating element 18 is made of, for example, polyvinylidene fluoride, which transmits gamma rays, and transmits gamma rays when detecting gamma rays. Further, the attachment surface of the ultrasound generating cord 18 of the fixing plate [9] is concave, and the ultrasonic waves emitted from the attached ultrasound generating cord 18 are focused toward the cancer position. A power transmission cable 20 for feeding power to the ultrasonic generating element 18 is connected to a cable hole provided in the generating section 16 and a through hole 21 bored in the support plate 15b.
through which it is guided to the control section 6 (see FIG. 1).
このように構成された本実施例における癌治療装置１に
おいては、先ず、癌細胞に選択的に集積する光感受性物
質、例えばヘマトポルフィリン誘導体、プロトポルフィ
リン、フェオフォルバイトａなどにγ線放出核種（以下
、Ｒ１と称す）、例えば弗素１８Ｆ、ヨウ素１２３１な
どを標識した光感受性物質を生体２に投与する。すると
、上記光感受性物質は癌７に集積され、上記Ｒ１より発
生したγ線は、γ線検出器１０によって検出される。In the cancer treatment device 1 of this embodiment configured as described above, first, a γ-ray emitting nuclide ( A photosensitizer labeled with, for example, fluorine 18F or iodine 1231 (hereinafter referred to as R1) is administered to the living body 2. Then, the photosensitizer is accumulated in the cancer 7, and the gamma rays generated from the R1 are detected by the gamma ray detector 10.
そして、このγ線の検出によって発生する電気信号から
制御部６でγ線の生じた位置、即ち癌７の位置を算出し
、画像表示部８に癌７の像を再構成する。次いで上記制
御部６て算出された癌７の位置に超音波が集束するよう
に、上記ベツド３を駆動部９によって移動し、ポーラス
１１を生体２に密着させた後、超音波照射部５から超音
波を７７；ｚｉ ７に向けて照射・集束させる。すると
、この超音波照射によって癌７に集積した光感受性物質
か癌に対する殺細胞効果を発揮し、癌細胞を死滅させ、
癌を治療することができる。Then, the control unit 6 calculates the position where the γ-rays have occurred, that is, the position of the cancer 7, from the electric signal generated by the detection of the γ-rays, and reconstructs an image of the cancer 7 on the image display unit 8. Next, the bed 3 is moved by the drive unit 9 so that the ultrasonic waves are focused on the position of the cancer 7 calculated by the control unit 6, and after bringing the porous 11 into close contact with the living body 2, the ultrasonic waves are focused from the ultrasound irradiation unit 5. Ultrasonic waves are irradiated and focused toward 77; zi 7. Then, due to this ultrasonic irradiation, the photosensitizer accumulated in the cancer 7 exerts a cell-killing effect on the cancer, killing the cancer cells,
Can treat cancer.
このように、本実施例における癌治療装置］によれば、
従来のＰＤＴては診断および治療ができなかった生体深
部の癌まで診断および治療かできると共に、γ線検出に
よって癌の位置やその大きさ迄適確に知ることができる
ので、超音波の照射を正確に行なうことができ、史には
超音波によるハイパーサーミアも同時にできるので、治
療効果を一段と向上させることができる。Thus, according to the cancer treatment device in this embodiment,
In addition to being able to diagnose and treat cancers deep within the body that could not be diagnosed and treated using conventional PDT, it is also possible to accurately determine the location and size of cancer by detecting gamma rays, making it possible to use ultrasonic irradiation. It can be performed accurately and, in history, hyperthermia can be performed at the same time using ultrasonic waves, making it possible to further improve the therapeutic effect.
第４図は、本発明の第２実施例を示す８１ζパ１治療装
置におけるγ線検出器の正面図である。なお、本実施例
における癌治療装置の全体の構成は、上記第１図に示し
た第１実施例の癌治療装置１とほぼ同様にｈｓ’ｉ成さ
れているので、相違点のみについて説明し、同一（１１
１１成部材には同一符号をトｊして、その説明は省略す
る。以下の実施例についても同＋、ｆｆとする。FIG. 4 is a front view of a gamma ray detector in an 81ζ PA1 treatment apparatus showing a second embodiment of the present invention. The overall configuration of the cancer treatment device in this embodiment is almost the same as that of the cancer treatment device 1 in the first embodiment shown in FIG. 1 above, so only the differences will be explained. , same (11
Eleven components are designated by the same reference numerals and their explanations will be omitted. The same + and ff are also used in the following examples.
この第２実施例の癌治療装置におけるγ線検出器１０Ａ
は、対向する２つの超音波照射部５Ａ。γ-ray detector 10A in the cancer treatment device of this second embodiment
are two opposing ultrasonic irradiation units 5A.
５ＢをＨし、両者間の中心点を中心として回転してγ線
を検出するように（１゛４成されており、更に生体２の
体軸方向（紙面に垂直な方向）にも移動できるようにな
っている。またベツド３はγ線検出器１０Ａの中央に位
置し３次元的に移動できるようになっている。上記超音
波照射部５Ａ、５Ｂは、第５図に示すように、γ線検出
部４と超音波発生索子１８とが一体的に組込まれている
。即ち、上記超音波照射部５Ａ、５Ｂの筺体２２の内部
には、外面を凸面、内面を凹面として球殻体形状の固定
板１９が配設されており、この固定板１つの外面にγ線
検出部４を構成する複数個のγ線検出部祠４ａを配列す
ると共に、内面には超音波発生水ｒ１８か超音波が一点
に集束するように球面状に配列されている。なお、上記
固定板１つはγ線を透過し得る材質のもので形成されて
おり、更に上記超音波発生索子１８もγ線を透過するポ
リ弗化ビニリデン等で構成されている。また、上記超８
′波発生索子］８の内方側はホーラス１１て囲まれてお
り、同ポーラス１１は締付部材１２によって筺体２２の
外周壁に固定されている。そして、同ホーラス１１内に
は送水孔１３と空気抜き孔１４を介して水等の超音波伝
達液か満たされるようになっている。5B to H, and rotates around the center point between the two to detect gamma rays. The bed 3 is located at the center of the gamma ray detector 10A and can be moved three-dimensionally.The ultrasonic irradiation sections 5A and 5B are arranged as shown in FIG. The gamma ray detection section 4 and the ultrasonic generation probe 18 are integrated.In other words, the inside of the housing 22 of the ultrasonic irradiation sections 5A and 5B has a spherical shell with a convex outer surface and a concave inner surface. A body-shaped fixing plate 19 is disposed, and a plurality of gamma-ray detecting portions 4a constituting the gamma-ray detecting portion 4 are arranged on the outer surface of one fixing plate, and ultrasonic-generated water r18 is arranged on the inner surface. The ultrasonic waves are arranged in a spherical shape so that the ultrasonic waves are focused on one point.The fixing plate is made of a material that can transmit gamma rays, and the ultrasonic wave generating cord 18 is also made of a material that can transmit gamma rays. It is composed of polyvinylidene fluoride, etc., which transmits gamma rays.
The inner side of the wave generating cord 8 is surrounded by a hole 11, which is fixed to the outer circumferential wall of the housing 22 by a fastening member 12. The holus 11 is filled with an ultrasonic transmission liquid such as water via a water supply hole 13 and an air vent hole 14.
このように構成された癌治療装置においては、第４図に
示すように、γ線検出器１０Ａを矢印方向に回転させて
γ線検出を行ない、生体２内の癌７の位置や大きさを検
知する。このとき、上記ポーラス１１は生体２に触れな
いようにしほんた縮小状態にしておく。次いで、勧７の
位置を検知した後、ベツド３を移動して超音波収束点と
ｉｉ；ｊ ７の位置が一致するようにすると共に、ポー
ラス１］を膨張させて生体２と密若するようにする。次
いで対向する両方あるいは一方の超音波照射部５Ａ５Ｂ
から超音波を癌７に向けて照射集束させこれを治療する
。In the cancer treatment device configured in this way, as shown in FIG. 4, the gamma ray detector 10A is rotated in the direction of the arrow to detect gamma rays, thereby detecting the position and size of the cancer 7 within the living body 2. Detect. At this time, the porous 11 is kept in a reduced state so as not to touch the living body 2. Next, after detecting the position of the membrane 7, the bed 3 is moved so that the ultrasonic convergence point and the position of the membrane 7 coincide with each other, and the porous 1] is expanded so that it is closely connected to the living body 2. Make it. Next, both or one of the opposing ultrasonic irradiation units 5A5B
The ultrasonic waves are irradiated and focused toward the cancer 7 to treat it.
この第２実施例の癌治療装置によれば、２つの対向する
γ線検出部４によって癌７を正確に険知すると共に、２
つの対向する超音波照射部５Ａ。According to the cancer treatment device of the second embodiment, the cancer 7 can be accurately detected by the two opposing gamma ray detection units 4, and the two
Two opposing ultrasonic irradiation units 5A.
５Ｂから超音波を照射することかできるので、極めて効
率の良い癌治療が行なえるという効果が得られる。Since ultrasonic waves can be irradiated from 5B, the effect of extremely efficient cancer treatment can be obtained.
第６図は、本発明の第３実施例を示す癌治療装置のγ線
検出器における超音波照射部５Ｃの断面図である。この
癌治療装置も上記第２実施例における癌治療装置と同様
にγ線検出器（第４図参照）か回転するようになってい
る。この超音波照射部５Ｃは、その筐体２２Ａの内部に
、中央に貫通孔２３ａを有し、外面が平面で内面が部分
球面の凹面に形成されている固定板２３が、その内面の
凹面をγ線検出器の回転中心に向けて固定されている。FIG. 6 is a cross-sectional view of an ultrasound irradiation section 5C in a γ-ray detector of a cancer treatment device showing a third embodiment of the present invention. This cancer treatment device also has a gamma ray detector (see FIG. 4) that rotates, similar to the cancer treatment device in the second embodiment. This ultrasonic irradiation unit 5C has a through hole 23a in the center inside its casing 22A, and a fixing plate 23 whose outer surface is flat and whose inner surface is a concave partially spherical surface has a concave inner surface. It is fixed toward the rotation center of the gamma ray detector.
そして、上記貫通孔２３ａ内にはγ線検出部４を構成す
るγ線検出部材４ａを複数個挿入し、充填剤２４により
固定し、その検出方向をγ線検出器の回転中心として配
設しである。また、固定板２３の凹面からなる内面には
、上記中央の貫通孔２３ａを除いて超音波発生素子１８
がその発生超８波が一点に集束するように固定されてい
る。Then, a plurality of gamma ray detection members 4a constituting the gamma ray detection section 4 are inserted into the through hole 23a, fixed with a filler 24, and arranged with the detection direction set as the rotation center of the gamma ray detector. It is. Furthermore, on the concave inner surface of the fixing plate 23, an ultrasonic generating element 18 is provided except for the central through hole 23a.
is fixed so that the generated ultra-8 waves are focused on one point.
その他の構成は上記第２実施例における超き波照射部５
Ａ、５Ｂと変る所はない。The other configuration is the superwave irradiation section 5 in the second embodiment.
There is no difference between A and 5B.
なお、上記第２．第３実施例においては、何れも対向す
る２つの超音波照射部５Ａ〜５Ｃを生体２を中心として
回転させるようにしているが、これは一つの超音波照射
部だけが回転するようにしても良い。In addition, the above 2. In the third embodiment, the two opposing ultrasound irradiators 5A to 5C are rotated around the living body 2, but this also applies even if only one ultrasound irradiator is rotated. good.
このように構成された本実施例の癌治療装置の作用も、
上記第２実施例における癌治療装置と全く同様に作用す
るが、この癌治療装置においては、γ線検出部４を固定
板２３の中央貫通孔２３ａ内に挿入固定しであるので、
超音波照射部５Ｃをそれだけ小さくすることができ、そ
の結果γ線検出器の回転半径を小さくすることができる
。従って、γ線検出器の空間分解能が向上し、それたけ
精密な診断と治療ができるという効果が得られる。The operation of the cancer treatment device of this embodiment configured in this way is also as follows:
The cancer treatment device operates in exactly the same way as the cancer treatment device in the second embodiment, but in this cancer treatment device, the γ-ray detection section 4 is inserted and fixed into the central through hole 23a of the fixing plate 23.
The ultrasonic irradiation section 5C can be made that much smaller, and as a result, the radius of rotation of the γ-ray detector can be made smaller. Therefore, the spatial resolution of the gamma ray detector is improved, and the effect of enabling more precise diagnosis and treatment can be obtained.
［発明の効果コ
以上説明したように本発明によれば、超ぎ波発生器とγ
線検出器とを一体化して（１１１成しているので、従来
のＰＤＴの場合と同様に、癌の位置・大きさの検出と治
療かできるたけでなく超詮波を照射するようにしている
ので、レーサー光を用いた場合に比して逗かに生体の深
部迄癌の診断と治療かｉｌ能となり、従来はＰＤＴでは
治療が不−ＩＳ能たった肝臓などの臓器への癌治療にも
適用可能となる等、極めて顕嵐な効果か得られる癌治療
装置を提供することができる。[Effects of the Invention] As explained above, according to the present invention, the super wave generator and the γ
Since it is integrated with a radiation detector (111), it can not only detect and treat the location and size of cancer, but also irradiate ultrasonic waves, as in the case of conventional PDT. Therefore, compared to the case of using laser light, it is possible to diagnose and treat cancer much deeper in the body, and it is also possible to treat cancer in organs such as the liver, which conventionally could not be treated with PDT. It is possible to provide a cancer treatment device that can be applied with extremely significant effects.
第１図は、本発明の第１実施例を示す癌治療装置全体の
構成ブロック図、
第２図は、上記第１図の癌治療装置におけるγ線検出器
と超音波照射部の構成を示す正面図、第３図は、上記第
２図中のＡ−Ａ線に沿う断面図、
第４図は、本発明の第２実施例を示す癌治療装置におけ
るγ線検出器と超音波照射部の構成を示す正面図、
第５図は、上記第４図中の超音波照射部の拡大断面図、
第６図は、本発明の第３実施例を示す癌治療装置におけ
る超音波照射部の断面図である。
１・・・・・・・・・・・・癌治療装置２・・・・・・
・・・・・・生体
４・・・・・・・・・・・・γ線検出部＜ ｉｉ’７細
胞位置検出手段）５．５Ａ〜５Ｃ・・・・・・超音波照
射部（超音波発生手段）
７・・・・・・・・・・・・癌
１０、ＩＯＡ・・・・・・γ線検出器FIG. 1 is a block diagram of the overall configuration of a cancer treatment device showing a first embodiment of the present invention, and FIG. 2 shows the configuration of a gamma ray detector and an ultrasound irradiation section in the cancer treatment device shown in FIG. 1 above. A front view, FIG. 3 is a sectional view taken along the line A-A in FIG. FIG. 5 is an enlarged cross-sectional view of the ultrasound irradiation unit in FIG. FIG. 1......Cancer treatment device 2...
・・・・・・Living body 4・・・・・・・・・γ-ray detection unit <ii'7 cell position detection means) 5.5A to 5C…… Sound wave generation means) 7... Cancer 10, IOA... γ-ray detector
Claims (1)
癌細胞から放射されるγ線を検出して癌細胞の位置を検
出する手段と、 癌細胞に向けて集束するように照射され、同細胞を破壊
して死滅させる超音波を発生する超音波発生手段と、 この超音波発生手段と上記位置検出手段とを一体化する
と共に、γ線の検出方向と超音波の集束方向とを同一方
向に向ける手段と、 を具備したことを特徴とする癌治療装置。(1) A means for detecting the position of cancer cells by detecting gamma rays emitted from cancer cells in the living body by administering a photosensitizing substance to the living body; An ultrasonic generating means for generating ultrasonic waves that destroy and kill the cells, and the ultrasonic generating means and the position detecting means are integrated, and the gamma ray detection direction and the ultrasonic focusing direction are made the same. A cancer treatment device characterized by comprising: a means for directing; and a device for directing the cancer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1086520A JP2793832B2 (en) | 1989-04-05 | 1989-04-05 | Cancer treatment equipment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1086520A JP2793832B2 (en) | 1989-04-05 | 1989-04-05 | Cancer treatment equipment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH02264651A true JPH02264651A (en) | 1990-10-29 |
| JP2793832B2 JP2793832B2 (en) | 1998-09-03 |
Family
ID=13889263
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1086520A Expired - Fee Related JP2793832B2 (en) | 1989-04-05 | 1989-04-05 | Cancer treatment equipment |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2793832B2 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH11504534A (en) * | 1995-03-08 | 1999-04-27 | イコス コーポレイション | Ultrasound therapy equipment |
| WO2012153493A1 (en) * | 2011-05-06 | 2012-11-15 | 国立大学法人東京工業大学 | Photodynamic therapy or diagnostic agent, using infrared-spectrum light |
-
1989
- 1989-04-05 JP JP1086520A patent/JP2793832B2/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH11504534A (en) * | 1995-03-08 | 1999-04-27 | イコス コーポレイション | Ultrasound therapy equipment |
| WO2012153493A1 (en) * | 2011-05-06 | 2012-11-15 | 国立大学法人東京工業大学 | Photodynamic therapy or diagnostic agent, using infrared-spectrum light |
| US9757357B2 (en) | 2011-05-06 | 2017-09-12 | Tokyo Institute Of Technology | Photodynamic therapy or diagnostic agent, using infrared-spectrum light |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2793832B2 (en) | 1998-09-03 |
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