JPH02246982A - Single needle type blood plasma separating circuit device - Google Patents

Abstract

PURPOSE:To allow the cleaning operation of a blood plasma separator and a blood taking operation and to allow the easy taking of blood plasma by consisting the device of a blood storage vessel having a blood taking needle, blood plasma separator, physiological salt soln. vessel and waste liquid vessel which respectively have connectable junctures. CONSTITUTION:The blood taking needle 10 of a blood taking instrument 2 is pierced to a vein to carry out the blood taking operation into the blood storage vessel 12. On the other hand, the juncture 22 of a blood feed tube 23 of the plasma separator 3 is connected to the juncture 27 of the waste liquid vessel 5 and the juncture 24 of a liquid feed tube 25 is connected to the juncture 28 and, therefore, the juncture 20 of a blood feed tube 18 is connected to the physiological salt soln. vessel 30 and the cleaning operation of the plasma separator 3 is carried out by the internal physiological salt soln. The juncture 19 of the tube 18 of the separator 3 is then connected to the juncture 11 of the vessel 12 and the vessel 5 and the separator 3 are removed, then the juncture 22 of a blood feed tube 23 and the juncture 13 of a blood feed tube 14 are connected and the juncture 24 of the tube 2 is connected to the juncture 26 of the plasma taking vessel 4 to admit the blood in the vessel 12 into a plasma separator 16. The separated plasma flows through the tube 25 into the vessel 4. The concd. red blood cell liquid flowing out of an outflow port 21 is returned into the vein.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Application Field 1] The present invention relates to a single-needle plasma separation circuit device for collecting plasma or plasma and concentrated red blood cell fluid from blood.

[Prior Art] Conventionally, a common method for obtaining plasma from healthy individuals has been to apply a blood bag from which blood has been collected from all sides to a centrifuge, centrifuge it, and separate it into concentrated red blood cells and plasma.

However, recently, plasma collection apparatuses have been developed that collect plasma from blood using a drop, and for example, there is one shown in Japanese Patent Application Laid-Open No. 63-226364.

As shown in FIG. 11, this plasma collection device 80 includes a blood collection bag 8 equipped with a blood collection needle 92 containing an anticoagulant in advance.
2, a detyped blood component separator 84, and a blood storage bag 86 for storing the concentrated blood from the detyped blood component separator 84;
A plasma bag 85 that stores the plasma separated by the blood component separator 84 and tubes 88 and 89 that connect each of the above members.
．． 90.91 are integrated. The blood component separator 84 is filled with a physiological isotonic solution.

[Problems to be Solved by the Invention] In the above-mentioned plasma collection device 80, since the whole is formed in one piece, the physiological isotonic liquid filled in the blood component separator 84 (plasma separator) is , a plasma bag 85 and a blood storage bag 8 along with plasma and concentrated red blood cell fluid to be collected.
6, and enters the human body along with blood transfusion.

A model is generally used as a plasma separator, and it is not preferable that liquid that has been in contact with the separation membrane for a long period of time flows into the human body.

Therefore, it is preferable to wash the liquid in the plasma separator before use, but the above-mentioned plasma collection device cannot perform this washing. Moreover, even if it were to be done, it would be necessary to remove the connected tube.

Therefore, in the present invention, it is possible to easily clean the plasma separator before use, and further, independently from the cleaning work,
The present invention provides a plasma separation device that can perform blood collection work and easily collect plasma.

[Means for Solving the Problems] A device that achieves the above object has a blood collection needle, a planning container having a first connection part, a second connection part, and communicating the planning container and the blood collection needle. a blood sampling device having a first blood supply tube, a plasma separator, and a second blood sampling device connected to the blood inlet of the plasma separator;
a feeding tube, the second feeding tube being provided with a first tube of the planning container;
a third connection part connectable to the connection part and a fourth connection part connectable to the saline container, or a third connection part connectable to both the first connection part of the planning container and the saline container;
a third blood supply tube connected to the blood outlet of the plasma separator and having a fifth connection part connectable to the second connection part of the first blood supply tube; a plasma separation device having a liquid feeding tube connected to a plasma outflow port; a plasma collection container having a seventh connecting portion connectable to a sixth connecting portion of the liquid feeding tube; and a fifth connecting portion of the third feeding tube. This is a single-needle plasma circuit separation device comprising a waste liquid container having an eighth connection part connectable to the connection part and a ninth connection part connectable to the sixth connection part of the liquid sending tube.

Further, a blood collection device that achieves the above object includes a blood collection needle, a planning container having a first connection part, and a first blood supply tube having a second connection part and communicating the planning container and the blood collection needle. a plasma separator, a second blood supply tube connected to the blood inlet of the plasma separator, a third connection portion provided on the second blood supply tube and connectable to the first connection portion of the planning container; a fourth connection connectable to a saline container or a first of said planning container;
a third connection part connectable to both the connection part and the physiological saline container; a fifth connection part connected to the blood outflow port of the plasma MaH and connectable to the second connection part of the first blood supply tube; a plasma separation device having a third feeding tube, a sixth connecting portion, and a liquid feeding tube connected to the plasma outflow port of the plasma separator; a plasma collection container having a seventh connection part; a first waste liquid container having an eighth connection part connectable to the fifth connection part of the third fluid supply pipe; This is a single-needle plasma separation circuit device consisting of a second waste liquid container having nine connections.

Further, the apparatus for achieving the above object includes a blood collection device having a blood collection needle, a planning container having a first connection part, a first blood supply tube communicating the planning container and the blood collection needle, a plasma separator, and the plasma separator. a second blood supply tube connected to the blood inlet of the separator; a third connection part provided on the second blood supply tube and connectable to the first connection part of the planning container; and a third connection part connectable to the saline container. 4 connection or a third connection connectable to both the first connection of the planning container and the saline container; a third connection connected to the blood outlet of the plasma separator and having a fifth connection;
a plasma separation device having a liquid feeding tube, a sixth connection, and a liquid feeding tube connected to a plasma outflow port of the plasma separator; and a seventh connection connectable to the sixth connection of the liquid feeding tube. a waste liquid container having an eighth connection part connectable to the fifth connection part of the third blood supply tube and a ninth connection part connectable to the sixth connection part of the liquid supply tube; , a single-needle plasma bone decircuit device comprising a concentrated red blood cell collection container having a second connection part connectable to a fifth connection part of the third blood supply tube.

Further, the apparatus for achieving the above object includes a blood collection device having a blood collection needle, a planning container having a first connection part, a first blood supply tube communicating the planning container and the blood collection needle, a plasma separator, and the plasma separator. a second blood supply tube connected to the blood inlet of the separator; a third connection part provided on the second blood supply tube and connectable to the first connection part of the planning container; and a third connection part connectable to the saline container. 4 connection or a third connection connectable to both the first connection of the planning container and the saline container; a third blood supply tube connected to the blood outlet of the plasma separator and having a fifth connection; , a plasma separation device having a sixth connection part and a liquid feeding pipe connected to a plasma outlet of the plasma separator, and a seventh connecting part connectable to the sixth connection part of the liquid feeding pipe. a first waste liquid container having an eighth connection part connectable to the fifth connection part of the third liquid supply pipe;
Single-needle plasma separation comprising a second waste liquid container having a ninth connection part connectable to the connection part, and a concentrated red blood cell collection container having a second connection part connectable to the fifth connection part of the third blood supply tube. It is a circuit device.

Furthermore, it is preferable that the first blood supply tube is configured such that the height positional relationship of the planning container can be arbitrarily changed. Furthermore, it is preferable that at least a portion of the first blood vessel is made of a flexible material.

Further, it is preferable that the plasma separator is filled with liquid. Furthermore, the fifth connection part and the eighth connection part and the sixth connection part and the ninth connection part may be in a connected state in advance. Further, it is preferable that the single-needle plasma separation circuit device includes a storage section for the planning container and a planning container storage device having functions of depressurizing and pressurizing the inside of the storage section. Moreover, the planning container may have a tenth connection part connectable to an anticoagulant container.

Therefore, the single-needle type plasma separation circuit device of the present invention will be explained using an embodiment shown in the drawings.

The single-needle plasma separator 1 of the present invention has a blood collection needle 10, a planning container 12 having a first connection part 11, and a second connection part 13, and has a first feeder that communicates the planning container 12 and the blood collection needle 1G. blood vessel 1
4, a plasma separator 16, a second blood supply tube 18 connected to the blood inlet 17 of the plasma separator 16,
A third connection 19 provided on the second blood supply tube 18 and connectable to the first connection 11 of the planning container 12 and a fourth connection 20 connectable to the saline container 30 or the first connection of the planning container 12 11 and the saline container 30, the third connecting portion 19, the plasma bone 111! is connected to the blood outlet 21 of the vessel 16, and the second connection part 1 of the first blood supply tube 14 is connected to the blood outlet 21 of the vessel 16.
A third blood supply tube 23 having a fifth connecting portion 22 connectable to the third blood vessel 23
, a sixth connection part 24, and a liquid feed pipe 25 connected to a plasma outlet 29 of a plasma separator 16.
, a plasma collection container 4 having a seventh connecting portion 26 connectable to the sixth connecting portion 24 of the liquid feeding tube 25, an eighth connecting portion 27 connectable to the fifth connecting portion 22 of the third feeding tube 23, and The waste liquid container 5 has a ninth connection part 28 connectable to the sixth connection part 24 of the liquid sending pipe 25.

An embodiment of the single-needle type plasma separation circuit device of the present invention shown in FIGS. 1 to 1θ will now be described with reference to the drawings.

FIG. 1 shows a schematic diagram of an embodiment of the single-needle plasma separation circuit device of the present invention.

This single-needle plasma separator 1 includes a blood collection device 2, a plasma separation device 3, a plasma collection container 4, and a waste liquid container 5.

The blood collection device 2 is for collecting blood from a blood donor, and has a blood collection needle 10, a planning container 12 having a first connection part 11, and a second connection part 13. and a first blood supply tube 14 that communicates with the blood collection needle 10. As the blood collection needle 10, a known metal blood collection needle having a puncture needle at its tip capable of puncturing a blood donor's vein, or a resin blood collection needle is suitably used. Also,
As the planning container 12, a blood bag made of soft synthetic resin (for example, soft vinyl chloride resin) is preferably used. Then, inside the planning container 12, an ACDi
, CPDd, sodium citrate, and anticoagulant fluids such as heparin. Preferably, the anticoagulant solution is a physiologically isotonic solution. The first connecting portion It provided in the planning container 12 is configured of, for example, something into which a bottle needle, a hollow needle, etc. can be inserted, or a connector. As the first blood supply tube 14, a transparent flexible synthetic resin tube made of soft vinyl chloride resin, silicone rubber, etc. is preferably used. The second connection part 13 provided on the first blood supply tube I4 is also constructed of a connector, or something into which a bottle needle, hollow needle, etc. can be inserted, like the first connection part.

The plasma separator 3 is for separating the blood collected in the planning container into plasma components and blood cell components, and includes a plasma separator 16 and a blood inlet 17 of the plasma separator 16.
a second blood supply tube 18 connected to a second blood supply tube 18, a third connection part 19 connectable to the first connection part II of the planning container 12 and a fourth connection part 20 connectable to the saline container 3o. A fifth blood vessel connected to the blood vessel 18 and the blood outflow port 21 of the plasma separation W16 and connectable to the second connection portion 13 of the first blood supply tube I4.
A third blood vessel 23 having a connecting portion 22 and a sixth connecting portion 24
and a liquid feed pipe 25 connected to a plasma outflow port 29 for the plasma component 111516. The plasma separator 3 (particularly the plasma separator 16) is preferably autoclaved or radiation sterilized while being filled with liquid. This is because the brimming operation during use becomes easier. The plasma separator 16 has a blood inlet 17, a blood outlet 21 through which concentrated red blood cell fluid flows out, a blood separation function to separate blood into plasma components and blood cell components, and an outlet 29 for the separated plasma components. are doing.

As the structure of the plasma separator, a hollow fiber membrane type, a flat membrane type, etc. are used. As the second blood supply tube 18 connected to the blood inlet 17 of the plasma separator 16, a transparent flexible synthetic resin tube made of soft vinyl chloride resin, silicone rubber, etc. is preferably used. The second blood supply tube 18 has a distal end branched into two, and a third connecting portion 19 and a fourth connecting portion 20 are provided at each distal end. The third connecting portion I9 is connectable to the first connecting portion 11, and is configured by, for example, a bottle needle, a hollow needle, a connector, or the like. Similarly, the fourth connecting portion 20 can also be connected to the physiological saline container 30, and is configured by, for example, a bottle needle, a hollow needle, a connector, or the like. Also, the second
As shown in FIG. 5, the blood supply tube 18 does not have a distal end that is bifurcated into two, and only has a third connecting portion 19 that can be connected to both the first connecting portion 11 and the saline container 3o. It may also be provided with

Further, it is preferable that the second blood supply tube 18 has a sufficient head height with respect to the plasma separator 16, and has a height of 50cx.
It is preferable that the length is longer than that.

In addition, a liquid feeding tube 25 is connected to the plasma outflow port 19 for the plasma fraction 111 ita, and the tip of this feeding tube 25 has a
A sixth connection portion 24 is provided. It is preferable that a certain amount of head can be secured between the liquid sending pipe 25 and the plasma separator I6, and it is preferable that the liquid sending pipe 25 has a length of 1 occi or more. Preferably, this liquid feeding pipe 25 is also formed from a flexible synthetic resin pipe.

Further, the sixth connecting portion 24 is configured by, for example, a connector, a bottle needle, a hollow needle, or the like. A third blood supply tube 23 is connected to the blood outlet 21 of the plasma separator 16, and a fifth connection portion 22 is connected to the tip of the third blood supply tube 23.
The fifth connecting portion 22 is connectable to the second connecting portion 13 of the first blood vessel 14 .

It is preferable that this third feeding tube 23 is also formed from a flexible synthetic resin tube. Further, the fifth connecting portion 22 is configured by, for example, a connector, a bottle needle, a hollow needle, or the like. And, as the fifth connection part 22 and the second connection part 13,
It is preferable to use a connector that can easily connect the two in a liquid-tight state. When the inside of the plasma separator 3 is filled with liquid, caps (not shown) are attached to the third, fourth, fifth and sixth connection parts, and the liquid is filled inside the plasma separator 3. Prevents liquid from flowing out.

Further, the fifth connecting portion may be connected to the eighth connecting portion and the sixth connecting portion may be connected to the ninth connecting portion in advance. If this is done, caps are provided on the fifth connecting portion and the sixth connecting portion. This is not necessary, and furthermore, it becomes possible to buffer the expansion of the liquid when the plasma separator 3 is sterilized in an autoclave with the liquid filled inside. moreover,
If the third connection part and the fourth connection part are constituted by a bottle needle, a hollow needle, etc., and it is difficult to reliably seal them liquid-tight with a cap, the third connection part and the fourth connection part Preferably, each of the connections or the second blood vessel to which they are attached is provided with a breakable communication member to ensure a fluid-tight state. When a breakable communication member is provided in the second blood supply tube, it is preferably provided near the third connection portion and the fourth connection portion, respectively.

A breakable communication member has a breakable member attached therein, is in a closed state in a normal state, and becomes in a communicating state by breaking the breakable member from the outside.

The plasma collection container 4 is for storing plasma flowing out from the plasma outlet 29 of the plasma separator 16 and flowing out through the liquid feeding pipe 25, and is a bag-shaped container made of soft synthetic resin. It can be used suitably. The plasma collection container 4 is provided with a seventh connecting portion 26, which can be connected to the sixth connecting portion 24 of the liquid feeding tube 25. As the sixth connecting portion 24 and the seventh connecting portion 26, it is preferable to use connectors that can easily connect the both in a liquid-tight state.

The waste liquid container 5 is used to store the liquid that has been filled inside the plasma separator 3 (inside the plasma separator 16, the second feeding tube 18, the third feeding tube 23, and the liquid feeding tube 25) before use. A bag-shaped material made of soft synthetic resin can be suitably used. This waste liquid container 5 is provided with an eighth connection portion 27, and this eighth connection portion 27 can be connected to the fifth connection portion 22 of the third liquid sending pipe 23. Further, the waste liquid container 5 is provided with a ninth connecting portion 28 , which can be connected to the sixth connecting portion 24 of the liquid sending pipe 25 . Ninth connection part 2
It is preferable to use connectors that can easily connect them in a liquid-tight manner as the 8th and 7th connecting portions 26, the 8th connecting portions 27, and the 5th connecting portions 22.

In addition, as the waste liquid container 5, as shown in FIG.
A first waste liquid container 5a having a connecting portion 27 and a ninth connecting portion 2
The second waste liquid container 5b may have two waste liquid containers.

Next, an embodiment of the single needle plasma separation circuit device of the present invention shown in FIG. 3 will be described.

The single-needle plasma separator 40 of this embodiment includes a blood collection device 2, a plasma separation device 3, a plasma collection container 4, a waste liquid container 5, and a concentrated red blood cell collection container 6.

As the blood sampling device 2, a device similar to that shown in FIG. 1 and described above can be suitably used, except that the second connecting portion is not provided. Furthermore, as the plasma separator 3, waste liquid container 5, and plasma collection container 4, those shown in FIG. 1 and described above can be suitably used.

The concentrated red blood cell collection container 6 is for storing the concentrated red blood cell fluid flowing out from the blood outlet 21 of the plasma separator 16 and flowing out from the third feeding tube 23, and is a bag made of soft synthetic resin. Those with a shape can be suitably used. This concentrated red blood cell collection container 6 is provided with a second connecting portion 31 , which can be connected to the fifth connecting portion 22 of the third liquid feeding tube 23 . and,
As the second connecting portion 31 and the fifth connecting portion 22, it is preferable to use connectors that can easily connect the two in a liquid-tight state.

In addition, as the waste liquid container 5, as shown in FIG.
A first waste liquid container 5a having a connecting portion 27 and a ninth connecting portion 2
The second waste liquid volume 1ff15b may have two waste liquid containers.

Next, an embodiment of the single needle plasma separation circuit device of the present invention shown in FIG. 6 will be described.

The single-needle plasma separator 50 of this embodiment includes a blood collection device 2, a plasma separation device 3, a plasma collection container 4, a waste liquid container 5, and a planning container container 7.

As the blood collection device 2, plasma separation device 3, waste liquid container 5, and plasma collection container 4, those shown in FIG. 1 and described above can be suitably used. Further, as the waste liquid container 5, as shown in FIG.
and a second waste liquid container 5b having the ninth connection part 28. Further, in the plasma separation apparatus 50 shown in FIG. 6, the first blood vessel 14, the second blood vessel 18, and the plasma collection container 4 are provided with circuit opening/closing means 43, 44, and 45.

The planning container storage device 7 has a storage section that accommodates the planning container 12, and a function of depressurizing and pressurizing the inside of this storage section. If the planning container 12 is a flexible container, the storage section has a capacity that can accommodate the maximum amount of blood in the planning container. The decompression function of the storage section reduces the pressure inside the stored blood storage container,
This is for collecting blood into a blood storage container via the first blood supply tube 14. The pressurizing function of the storage section pressurizes the blood stored in the blood storage container, sends the blood to the plasma separator 16, and transfers the concentrated red blood cell fluid flowing out from the plasma separator 16 to the third blood supply tube 23. , the first blood supply tube 14 and the blood collection needle 1
This is for returning blood through 0.

To be more specific, examples of the planning container storage device 7 include those disclosed in Japanese Patent Publication No. 51-3153 and Japanese Patent Application Laid-open No. 63-23644.
A device having a storage part that can be sealed in a state in which a blood storage container is stored, and a pump connected to this storage part for sucking and supplying air, as shown in the above publication, is preferably used. More preferably, the planning container storage device 7 is
The device has a stirring function (shaking function) for the blood contained in the planning container 12, like the devices shown in Japanese Patent Laid-Open No. 63-23644 and the like. The stirring function is to stir the anticoagulant solution stored inside the planning container 12 and the blood that has flowed in. Possible stirring functions include, for example, a function in which both the front and rear ends of the planning container storage section repeatedly move up and down, as in the device disclosed in Japanese Patent Publication No. 51-3153, or a function that vibrates the entire storage section. It will be done. By providing the planning container container 7 with the above-mentioned functions, there is no need to secure a head for perfusing blood to the plasma separator, it is possible to concentrate the operation area, and it is possible to easily collect plasma. Can be collected. Furthermore, it is preferable that the planning container storage device 7 has a weight detection section that detects the weight inside the planning container.

Next, an embodiment of the single needle plasma separation circuit device of the present invention shown in FIG. 7 will be described.

The single-needle plasma separator 5o of this embodiment is composed of a blood collection device 2, a plasma separation device 3, a plasma collection container 4, a waste liquid container 5, and a planning container storage device 7, as shown in FIG. The difference from the embodiment shown is that the third blood supply tube 23 is provided with a bubble detection device 49, and furthermore, this bubble detection device 49, the planning container storage device 7, and the circuit opening/closing means 43, 44.
．． 45 has a control device 42 electrically connected thereto.

The bubble detection device 49 uses infrared rays, ultrasonic waves, etc.
It has a sensor that detects air bubbles in the tube constituting the blood supply tube 23, and in response to a signal from this sensor, the control device 42 issues a warning signal (a warning sound or a flashing warning lamp). Furthermore, the bubble detection device 49 may have a circuit opening/closing function that closes the third blood supply tube 23 when detecting bubbles. The control device 4z is configured to send a blood weight signal inside the planning container 12 from the planning container storage device 7. Then, based on this weight signal, an opening/closing signal is sent to the circuit opening/closing means 43, 44, 45,
control them.

To explain the operation specifically, first, after cleaning the plasma separator 3, the first connection part 11 and the third connection part 19 are connected, and the second connection part 13 and the fifth connection part 22 are connected. connection,
The sixth connecting portion 24 and the seventh connecting portion 26 are connected. In this state, the blood collection needle 10 is punctured into the blood donor's vein, the planning container storage device 7 is activated, the pressure inside the storage portion of the planning container is reduced, and blood is collected into the planning container 12. In this state, the circuit opening/closing means 43 is in an open state, and the circuit opening/closing means 44 and 45 are in a closed state. When the blood volume inside the planning container 12 reaches the set weight, a signal is sent from the weight detection section provided in the planning container container 7 to the control device 42 and the pressure inside the planning container container 7 is reduced. The operation that was in this state will stop. A signal is sent from the control device 42 to each circuit opening/closing means, causing the circuit opening/closing means 43 to be in a closed state and the circuit opening/closing means 44, 45 to be in an open state. Then, a pressurization activation signal is sent from the control device 42 to the planning container storage device 7, and the blood in the planning container 12 is sent to the plasma separator 16, and the separated plasma is collected into the plasma collection container 4 and concentrated. The red blood cell fluid is returned to the donor. Then, when the treatment of the blood in the planning container 12 is completed, the operation of the planning container storage device 7 is stopped.

Further, the circuit opening/closing means 44 is not the second blood supply tube 18,
It may be provided between the planning container 12 and the first connection part II,
Furthermore, in that case, the circuit opening/closing means 44 may be included in the planning container storage device 7.

Similarly, the circuit opening/closing means 43 may also be included in the planning container storage device 7.

Next, an embodiment of the single needle plasma separation circuit device of the present invention shown in FIG. 8 will be described.

The single-needle plasma separation device 60 of this embodiment includes a blood collection device 2, a plasma separation device 3, a plasma collection container 4, a waste liquid container 5, a concentrated red blood cell collection container 6, and a planning container storage device 7. The difference from the embodiment shown in FIG. 6 is that the blood collection instrument 2 does not have a first connection part and that a concentrated red blood cell collection container 6 is provided. This single-needle plasma separator 60 is similar to the one shown in FIG.
The device 60 is configured to be able to collect plasma and concentrated red blood cell fluid, and furthermore, this device 60 mechanically performs blood collection and blood feeding for plasma separation using the planning container storage device 7.

As the blood sampling device 2, a device similar to that shown in FIG. 1 and described above can be suitably used, except that it does not have the first connecting portion. Furthermore, as the plasma separation device 3, waste liquid container 5, and plasma collection container 4, those shown and explained in FIG. 1 can be suitably used. As the concentrated red blood cell collection container 6, the one shown and explained in FIG. 4 can be suitably used, and similarly, as the planning container container 7, the one shown and explained in FIG. 6 can be suitably used.

Next, an embodiment of the single needle plasma separation circuit device of the present invention shown in FIG. 9 will be described.

The single-needle plasma separator 70 of this embodiment is composed of a blood collection device 2, a plasma separator 3, a plasma collection container 4, a waste liquid container 5, and a planning container storage device 7, as shown in FIG. The difference from the embodiment shown in FIG.
It has a tenth connection part 15 that can be connected to.

This single-needle plasma separator 70 is configured to be able to send an anticoagulant to the planning container 12, and is capable of collecting blood multiple times. The blood sampling device 2 is provided with a circuit opening/closing means 46. The tenth connection part 15 is connectable to the anticoagulant container 8, and is constituted by, for example, a bottle needle, a hollow needle, a funecta, or the like. Furthermore, as the plasma separation device 3, waste liquid container 5, and plasma collection container 4, those shown and explained in FIG. 1 can be suitably used. As the concentrated red blood cell collection container 6, the one shown and explained in FIG. 4 can be suitably used, and similarly, as the planning container container 7, the one shown and explained in FIG. 6 can also be suitably used. Inside the anticoagulant container 8, an AC
Contains anticoagulant solutions such as D solution, CPD solution, sodium citrate, and heparin. Preferably, the anticoagulant solution is a physiologically isotonic solution. This anticoagulant container 8 is connectable to the tenth connection portion 15 .

Next, an embodiment of the single-needle type plasma separation circuit device of the present invention shown in FIG. 1θ will be described.

The single-needle plasma separation device 50 of this embodiment is composed of a blood collection device 2, a plasma separation device 3, a plasma collection container 4, a waste liquid container 5, and a planning container storage device 7, as shown in FIG. The difference from the illustrated embodiment is that the third blood supply tube 23 is provided with a bubble detection device 49;
Planning container storage 7 and circuit opening/closing means 43.44.45
．． 46 has a control device 42 electrically connected thereto.

The bubble detection device 49 uses infrared rays, ultrasonic waves, etc.
It has a sensor that detects air bubbles in the chinibu constituting the blood supply tube 23, and in response to a signal from this sensor, the control device 42 issues a warning signal (a warning sound or a flashing warning lamp). Furthermore, the bubble detection device 49 may have a circuit opening/closing function that closes the third blood supply tube 23 when detecting bubbles. The control device 42 is configured to send a blood weight signal inside the planning container 12 from the planning container storage device 7. Then, based on this weight signal, an opening/closing signal is sent to the circuit opening/closing means 43, 44, 45, 46 to control them.

To explain the operation specifically, first, after cleaning the plasma separator 3, the first connection part 11 and the third connection part 19 are connected, and the second connection part 13 and the fifth connection part 22 are connected. connection,
The tenth connection part and the anticoagulant container 8 are connected, and the sixth connection part 24 and the seventh connection part 26 are connected. Then, the circuit opening/closing means 46 is brought into an open state, and the circuit opening/closing means 43.44.4
5 is closed, and the decompression mechanism of the planning container container 12 is activated. The operation of this pressure reduction mechanism causes the anticoagulant solution to flow into the planning container 12 . This depressurization operation is stopped when the weight of the anticoagulant inside the planning container reaches a predetermined weight by the weight detection section of the planning container storage device 7. Then, the blood collection needle IO is punctured into the blood donor's vein, the planning container storage device 7 is activated, the pressure inside the storage section of the planning container is reduced, and the planning container 1
2. Collect blood. In addition, in this state, the circuit opening/closing means 43 is in an open state, and the circuit opening/closing means 44.45.4
6 is in a closed state. When the blood volume inside the planning container 12 reaches the set weight, a signal is sent to the control device 42 from the weight detection section provided in the planning container storage device 7.
At the same time, the operation that had reduced the pressure inside the planning container container 7 is stopped. A signal is sent from the control device 42 to each circuit opening/closing means, causing the circuit opening/closing means 43 to be in a closed state and the circuit opening/closing means 44, 45 to be in an open state. Further, a pressurization activation signal is sent from the control device 42 to the planning container storage device 7, and the blood in the planning container 12 is sent to the plasma separator 16, and the separated plasma is collected into the plasma collection container 4 and concentrated. The red blood cell fluid is returned to the donor. Then, when the treatment of the blood in the planning container 12 is completed, the operation of the planning container storage device 7 is stopped.

When blood is to be sampled again, the circuit opening/closing means 46 is automatically opened by switching the switch provided in the control device 42 or by a signal output from the weight detection section of the planning container storage 512, and the circuit is closed. The opening/closing means 43 and 44 are closed, and the decompression mechanism of the planning container container 12 is activated. By operating this pressure reducing mechanism, the anticoagulant solution flows into the planning container 12, and blood can be collected again. The circuit opening/closing means 44 may be provided between the planning container 12 and the first connection part 11 instead of the second blood supply tube 18, and in that case, the circuit opening/closing means 44 may be provided between the planning container container 7 and the planning container storage device 7. You can also use it as Similarly, the circuit opening/closing means 43 and 46 may also be included in the planning container storage device 7.

[Function 1] The function of the single-needle plasma separation circuit device of the present invention will be explained using the embodiment shown in FIG.

First, the blood sampling needle 10 of the blood sampling device 2 is punctured into the donor's vein, and blood is drawn into the planning container 12. At the same time, the plasma separation device 3 is cleaned. The fifth connection portion 22 attached to the tip of the third feeding tube 23 of the plasma separation device 3 is connected in advance to the eighth connection portion 27 of the waste liquid container 5, and similarly, the fifth connection portion 22 attached to the tip of the third feeding tube 23 of the plasma separation device 3 is connected to the eighth connection portion 27 of the waste liquid container 5. Since the portion 24 is connected in advance to the ninth connection portion 28 of the waste liquid container 5, the fourth connection portion 2 attached to the tip of the second blood supply tube 18
Remove the cap (not shown) attached to 0 and connect it to the saline container 30. Furthermore, this fourth
If a breakable member is provided near the connecting portion 20, it is broken to create a communication state, and the physiological saline inside the physiological saline container flows into the plasma separation device 3. The liquid filled inside is made to flow into the waste liquid container 5, and the plasma separation device 3 is cleaned.

Therefore, with this single-needle plasma separation circuit device, cleaning work and blood collection work can be performed at the same time.

After the blood collection work and washing work are completed, the cap (not shown) attached to the third connection part 19 of the second blood supply tube 18 of the plasma separation device 3 is removed, and the second connection part H of the planning container is removed. Connect to.

Further, if a breakable member is provided near the third connecting portion 19, the breakable member is broken to establish communication. In addition, the connection between the waste liquid container 5 and the plasma separation device 3 is removed, and the fifth connection portion 22 of the third blood supply tube 23 of the plasma separation device 3 and the first connection portion 13 of the first blood supply tube I4 are connected, moreover,
The sixth connection part of the liquid sending pipe 25 is connected to the seventh connection part of the plasma collection capacity 4. The blood storage capacity 12 is positioned above the plasma separator 816, and the blood in the planning container 12 flows into the plasma separator 16 due to the head. The plasma separated by the plasma separator 16 flows into the plasma collection container 4 via the liquid feed pipe 25. Further, the concentrated red blood cell fluid flowing out from the blood outlet 21 of the plasma separator 16 passes through the third blood supply tube 23, the fifth connection part, the first connection part, and the first liquid supply pipe I4, and then passes through the blood collection needle 10.
The blood is then returned into the donor's veins.

[Effects of the Invention] The single-needle plasma separation circuit device of the present invention has a blood collection needle, a planning container having a first connection part, a second connection part, and a first connection part that communicates the planning container and the blood collection needle. a blood sampling device having a blood supply tube; a plasma separator; a second blood supply tube connected to a blood inlet of the plasma separator; and a blood collection device provided on the second blood supply tube and connectable to a first connection portion of the planning container. a third connection of the planning container and a fourth connection connectable to the saline container; or a first connection of the planning container and a third connection connectable to the saline container;
a third blood supply tube having a connection part, a fifth connection part connected to the blood outlet of the plasma separator and connectable to a second connection part of the first blood supply tube; a sixth connection part; a plasma separation device having a liquid feeding tube connected to a plasma outflow port of a separator; a plasma collection container having a seventh connecting portion connectable to a sixth connecting portion of the liquid feeding tube; and the third feeding tube. or a waste liquid container having an eighth connection part connectable to the fifth connection part of the liquid sending pipe and a ninth connection part connectable to the sixth connection part of the liquid sending pipe;
Consisting of a first waste liquid container having an eighth connection part connectable to the fifth connection part of the liquid feeding tube, and a second waste liquid container having a ninth connection part connectable to the sixth connection part of the liquid feeding tube. and
Since the entire device is not constructed in one piece, the liquid filled in the plasma separator can be easily replaced with physiological saline, and the discharged filled liquid can be easily collected into a waste liquid container. The inside of the plasma separator can be easily cleaned. Therefore, it is possible to prevent the liquid that has come into contact with the separation membrane, which is the plasma separation means of the plasma separation device, from flowing into the human body together with plasma or blood cell components to be returned. Furthermore, since the blood collection work can be performed independently from the above-mentioned washing work, the plasma collection work can be performed in a short time.

Further, the single-needle plasma separation circuit device of the present invention includes a blood collection device having a blood collection needle, a planning container having a first connection part, a first blood supply tube communicating the planning container and the blood collection needle, and a plasma separation device. a second blood supply tube connected to the blood inlet of the plasma separator, a third connection part provided on the second blood supply tube and connectable to the first connection part of the planning container, and a saline container. a fourth connection connectable to the first connection of the planning container and a third connection connectable to the saline container; a third connection connectable to the blood outlet of the plasma separator and having a fifth connection;
The blood supply tube has a sixth connection, and the plasma bone 1! a plasma separation device having a liquid feeding tube connected to a plasma outflow port of an II device, a plasma collection container having a seventh connecting portion connectable to a sixth connecting portion of the liquid feeding tube, and the third feeding tube. or a waste liquid container having an eighth connection part connectable to the fifth connection part of the liquid sending pipe and a ninth connection part connectable to the sixth connection part of the liquid sending pipe;
a first waste liquid container having an eighth connecting part connectable to the fifth connecting part of the liquid feeding tube; a second waste liquid container having a ninth connecting part connectable to the sixth connecting part of the liquid feeding tube; 3.The device is comprised of a concentrated red blood cell collection container having a fifth connecting portion of the blood supply tube and a connectable second connecting portion, so the entire device is not constructed as one piece, so it is packed in a plasma separator. The liquid can be easily replaced with physiological saline, the discharged filling liquid can be easily collected into a waste liquid container, and the inside of the plasma separator can be easily cleaned.

Therefore, it is possible to prevent the liquid that has come into contact with the separation membrane, which is the plasma separation means of the plasma separation device, from flowing into the human body together with plasma or concentrated red blood cells over a long period of time. In addition, blood collection can be performed independently from the above-mentioned cleaning work, so
Plasma and concentrated red blood cell collection work can be done in a short time.

Furthermore, by providing a storage section for the planning container and a planning container storage device having depressurization and pressurization functions inside the storage section,
There is no need to secure a head for perfusing blood to the plasma separator, the operation site can be concentrated, and plasma or plasma and concentrated red blood cell fluid can be easily collected.

[Brief explanation of drawings]

FIG. 1 is a diagram showing an embodiment of the single-needle plasma separation circuit device of the present invention, FIG. 2, FIG. 3, FIG. 4, FIG. 5, FIG.
7, 8, 9 and 10 are views showing other embodiments of the single needle plasma separation circuit device of the present invention, and FIG. 11 is a conventional single needle plasma separation circuit device. FIG. ■, 40...Single needle plasma separation circuit device, 2...Blood collection device 3...Plasma separation device 4...Plasma collection container 5...Waste liquid container 6...Concentrated red blood cell collection container 710. Planning container storage container 8... Anticoagulant container IO.
...Blood collection needle II...First connection part 12...
Planned container 13.31...Second connection part 14...
-First blood supply tube 16...Plasma separator 18...Second blood supply tube 19...Third connection part 30...Physiological saline container 20...Fourth connection part 22...Fifth Connection part 23...Third blood supply tube 24...Sixth connection part
25...Liquid feeding pipe 26...7th connection part 27.
...Eighth connection section 28...Ninth connection section 42...Control device Fig. 4! Figure 6! Figure 8 Figure 9

Claims (10)

[Claims] (1) A blood collection needle, a blood storage container having a first connection portion, and a first blood storage container having a second connection portion and communicating the blood storage container and the blood collection needle.
a blood sampling device having a blood supply tube; a plasma separator; a second blood supply tube connected to a blood inlet of the plasma separator; and a blood collection device provided on the second blood supply tube and connectable to a first connection portion of the blood storage container. a third connection part connectable to a saline container, or a third connection part connectable to both the first connection part of the blood storage container and the saline container, the blood flow of the plasma separator; a third blood supply tube connected to the outlet and having a fifth connection part connectable to the second connection part of the first blood supply tube; a third blood supply tube having a sixth connection part and connected to the plasma outlet of the plasma separator; a plasma separation device having a liquid feeding tube; a plasma collection container having a seventh connecting portion connectable to a sixth connecting portion of the liquid feeding tube;
A single-needle plasma plasma container comprising a waste liquid container having an eighth connection part connectable to the fifth connection part of the liquid delivery tube and a ninth connection part connectable to the sixth connection part of the liquid delivery tube. Circuit isolation device. (2) a blood collection needle, a blood storage container having a first connection part, a first blood storage container having a second connection part and communicating the blood storage container and the blood collection needle;
a blood sampling device having a blood supply tube; a plasma separator; a second blood supply tube connected to a blood inlet of the plasma separator; and a blood collection device provided on the second blood supply tube and connectable to a first connection portion of the blood storage container. a third connection connectable to a saline container or a third connection connectable to both the first connection of the planning container and the saline container; a third blood supply tube connected to the outlet and having a fifth connection part connectable to the second connection part of the first blood supply tube; a third blood supply tube having a sixth connection part and connected to the plasma outlet of the plasma separator; a plasma separation device having a liquid feeding tube; a plasma collection container having a seventh connecting portion connectable to a sixth connecting portion of the liquid feeding tube;
Consisting of a first waste liquid container having an eighth connecting part connectable to the fifth connecting part of the liquid feeding tube, and a second waste liquid container having a ninth connecting part connectable to the sixth connecting part of the liquid feeding tube. A single-needle plasma separation circuit device featuring: (3) A blood collection device including a blood collection needle, a blood storage container having a first connection part, a first blood supply tube communicating the blood storage container and the blood collection needle, a plasma separator, and a blood inflow port of the plasma separator. a connected second blood supply tube; a third connection portion provided on the second blood supply tube and connectable to the first connection portion of the blood storage container; and a fourth connection portion connectable to the physiological saline container; or the blood storage container. a third connection connectable to both the first connection and the saline container, connected to the blood outlet of the plasma separator;
A plasma separation device including a third feeding tube having a fifth connection portion, a liquid feeding tube having a sixth connecting portion and connected to a plasma outlet of the plasma separator, and a sixth connection of the liquid feeding tube. a plasma collection container having a seventh connection part connectable to the third connection part, an eighth connection part connectable to the fifth connection part of the third blood supply tube, and a ninth connection part connectable to the sixth connection part of the liquid supply tube. A single-needle plasma separation circuit device comprising: a waste liquid container having a connecting portion; and a concentrated red blood cell collection container having a second connecting portion connectable to the fifth connecting portion of the third blood supply tube. (4) A blood collection device including a blood collection needle, a blood storage container having a first connection part, a first blood supply tube communicating the blood storage container and the blood collection needle, a plasma separator, and a blood inlet of the plasma separator. a connected second blood supply tube; a third connection portion provided on the second blood supply tube and connectable to the first connection portion of the blood storage container; and a fourth connection portion connectable to the physiological saline container; or the blood storage container. a third connection connectable to both the first connection and the saline container, connected to the blood outlet of the plasma separator;
A plasma separation device including a third feeding tube having a fifth connection portion, a liquid feeding tube having a sixth connecting portion and connected to a plasma outlet of the plasma separator, and a sixth connection of the liquid feeding tube. a plasma collection container having a seventh connection part connectable to the third connection part; a first waste liquid container having an eighth connection part connectable to the fifth connection part of the third blood supply tube; and a sixth connection of the liquid supply tube. a second waste liquid container having a ninth connection part connectable to the fifth connection part of the third blood supply tube; and a concentrated red blood cell collection container having a second connection part connectable to the fifth connection part of the third blood supply tube. Needle type plasma separation circuit device. (5) The single-needle plasma separation circuit device according to any one of claims 1 to 4, wherein the first blood supply tube is configured so that the height positional relationship of the blood storage container can be arbitrarily changed. (6) The single-needle plasma separation circuit device according to claim 5, wherein at least a portion of the first blood supply tube is made of a flexible material. (7) The single-needle plasma separation circuit device according to any one of claims 1 to 6, further comprising a storage portion for the blood storage container and a blood storage container storage device having functions of depressurizing and pressurizing the inside of the storage portion. The single needle plasma separation circuit device described. (8) The blood storage container includes a first blood storage container that is connectable to an anticoagulant container.
The single-needle plasma separation circuit device according to any one of claims 1 to 4, having a zero connection. (9) The single needle plasma separation circuit device according to any one of claims 1 to 4, wherein the plasma separator is filled with liquid. (10) The single needle type according to any one of claims 1 to 4 or 9, wherein the fifth connecting part and the eighth connecting part and the sixth connecting part and the ninth connecting part are connected in advance. Plasma separation circuit device.