JPH02243158A - Doubly nucleated tablet and its preparation - Google Patents

Abstract

PURPOSE:To obtain a nucleated tablet, which has no defectives such as cracks without reducing a weight of nucleus tablet, by applying a construction of holding two nucleus tablets formed beforehand within that tablet formed by compressing a powder. CONSTITUTION:A nucleated tablet 1, which is oblate spheroidal and almost barrel- shaped, holds two nucleus tablets 3, which have been formed into a small oblate barrel- shape beforehand. That tablet 1 is prepared as follows. A powder 7, which is supplied from a powder inlet nozzle 18 into a pit of a large number of mortars 5 arranged on a circumference of a rotating disk 4, is filled in a fixed quantity by the first feed shoe 6, two nucleus tablets 3 are supplied on the powder by a nucleus supply instrument 8, and the second powder 7 is further filled into that mortar pit in a fixed quantity by the second feed shoe 9 after the supply of the nucleus tablets 3 is detected, memorized, etc. by an identification sensor 19. Then, the powder is compressed and formed by making an upper and a lower stamps pass through compression rolls 10, and a non-defective article is taken out and stored through a chute 20 into a receiver can 22 by a take-out damper 17. It is possible, therefore, not only to form a wall thickness of cover large but also to make a rate of wall thickness change small, resulting in a prevention of occurrences of defectives due to cracks.

Description

[Detailed Description of the Invention] [Industrial Application Field] The present invention relates to a double-coated tablet used as a pharmaceutical, which has a core tablet containing another drug inside, and a method for producing the same. be.

C. Conventional technology] In general, when taken, two types of medicinal effects act at different times and at different locations in the body, such as in the stomach or intestines, to create complex effects. Therefore, conventionally, a first powder is placed in the mortar hole of a mortar installed on a rotary disk, a pre-formed core tablet is supplied on top of the first powder, and the second powder is filled. However, there are dry-coated tablets that are compression-molded using an upper frame and a lower frame (for example, Japanese Patent Application No. 1987-
177146) This is because, as shown in FIGS. 8 and 9, the core tablet 31 is covered with an outer cover 3.
This is covered by 2.

[Problem to be solved by the invention] In the case of dry-coated tablets, the amount of powder in the core tablet and the amount of powder in the outer coating are determined depending on the intended use (a weight ratio of 1:1 is also required), and However, as shown in FIG. 9, there is a problem in that defects may occur due to misalignment or inclination of the core lock. If the core tablet 33 is tilted even if the center is not shifted, the wall thickness X of the outer cover 32 that covers the core tablet 33 will become thinner, which will of course impede the effect when taken, etc. Cracks occur in the parts, resulting in defective products.

In order to mass-produce dry-coated tablets efficiently, they are manufactured using a rotary powder compression molding machine, but even though this molding machine is capable of producing more than 1,100 tablets per minute, its ability is not fully demonstrated. There is a problem in that the manufacturing efficiency is low because the manufacturing efficiency is poor.

In other words, a parts feeder (vibrating parts feeder) is used to feed the core lock into the mortar hole of the molding machine, but in order to ensure the desired weight, if the core lock is long or large, The supply speed is slow, and manufacturing must be done to match this slow supply speed, resulting in poor production efficiency. For example, in the case of a deformed core lock such as a cylindrical one as shown in Fig. 9, it is necessary to take out the core lock in the longitudinal direction and flattened in order to take out the single alignment in the parts feeder. Since the axotiment of is arranged in one direction,
The larger the number of axotiments, the more the feed stops at that position, inhibiting the progress and slowing down the removal.
There is a problem that it cannot be supplied in small quantities.

The purpose of the present invention is to provide a core tablet without reducing the weight (volume) of the core tablet and without defects such as cracks, and also to efficiently utilize the capacity of a rotary powder compression molding machine to produce a large quantity of core tablets. The purpose of the present invention is to provide a method for manufacturing dry-coated tablets that can be produced.

[Means for Solving the Problems] In order to achieve the above object, the double-coated tablet of the present invention is a powder compression molded product, which includes supplying a pre-molded core tablet and covering the core tablet. In the dry-coated tablet manufactured by a rotary powder compression molding machine that supplies a core tablet as described above, fills the second powder so as to cover the core tablet, and then compresses it using an upper frame and a lower frame, It has two locks.

Then, the first powder is put into the mortar hole of the mortar arranged on the rotary disk, the pre-formed core tablet is supplied on top of the powder, and the second powder is filled so as to cover the core tablet. In the method for producing dry-coated tablets that are compressed after drying, the core tablet is divided into two parts to form two core tablets, and each core tablet, which is a supply unit, is divided into two core tablets without reducing the total weight of the core tablet. There is a manufacturing method in which the product is miniaturized and supplied.

[Function] By dividing the core tablet into two parts, one core tablet serving as a supply unit can be made smaller, so the best shape suitable for transporting the parts feeder can be selected, and the shape of the core tablet to the molding machine can be reduced. Improved feeding capacity (when round or spherical, 2,400 tablets can be fed in two rows per minute, making it possible to feed 1,200 dry-coated tablets per minute)
The capacity of rotary powder compression molding can be utilized to the maximum since individual core tablets can be supplied.

Furthermore, when the core lock is made smaller, even if the core lock is slightly tilted, the variation in wall thickness X with the outer cover is reduced, thereby preventing the occurrence of cracks.

Furthermore, since the core tablet has a round or spherical shape with no directionality, it becomes easy to feed it to the core supply device and into the mortar hole.

If two core tablets reduced in size into two pieces are fed into the mortar hole, the weight of the core tablet in the core tablet will not be reduced.

[Example] An example will be explained with reference to the drawings. Figures 1 to 4 show one example, and Figure 1 is a plan view of the main parts of a molding machine, and Figure 2 is a molding machine with a core. A plan view of the tablet, FIG. 3 is a semi-vertical front view of FIG. 2, and FIG. 4 is a left side view of FIG. 3.

The dry-coated tablet 1, which is flat, elliptical, and approximately barrel-shaped, has two small-sized core tablets 3 formed into a round shape (flat and barrel-shaped) inside thereof.

The outer jacket 2 that covers the core tablet 3 and forms the core tablet 1 is formed by compressing the powder 7 filled into the mortar hole by a first feed roller and a second feed roller 9.

During manufacturing, a large number of holes 85 are arranged at equal intervals on the circumference of the rotary disk 4, and a powder drop port 1 is placed in the mortar hole of 5 on this day.
The powder 7 supplied from 8 is filled quantitatively by the first feed roller, and the core feeder 8 is placed on top of the first powder tube in the mortar hole.
Two core tablets 3 are fed, and after the supply of the core tablets 3 is detected and memorized by the color-specific sensor 19, the second powder 7 is further quantitatively filled into the mortar hole by the second feeder 9.

Then, the powder in the mortar hole is compressed and molded by the upper frame and lower frame (not shown) passing through a compression roll 10, and good products are taken out by a damper 17 and passed through a chute 20 to a receiving can 22.
It is taken out and stored.

Here, if the color-coded sensor 19 detects that the core lock is defective, such as when the predetermined core lock is not present, the solenoid 23 is operated to move the rejection damper 1G to take out the defective product from the rejection chute. The device 8 is provided with a holding hole 24 that synchronizes with the rotation of the mortar 5. The holding hole 24 temporarily holds the core lock 3 transported from the feeder 11 via the feeding vibrator 12, and sequentially holds the core lock 3. is supplied into the mortar 5.

In addition, 13 is a timing hole for synchronization, 14 is a timing phototube, and 15 is a nuclear detection phototube.

Figures 5 to 7 show other embodiments, in which an egg-shaped (rugby ball-shaped) core tablet 1 has two core tablets 3 formed into a spherical shape and reduced in size. be.

Note that the present invention is not limited to the above embodiments,
For example, two core tablets may be made by combining powder raw materials with different types and shapes.

[Effects of the Invention] As explained above, the present invention enables the rotary powder compression molding to be mass-produced at high speed because the size of the core tablet is reduced, the shape can be freely selected, and the feeding speed by the feeder can be increased. It is possible to maximize the capacity of the machine and improve production efficiency.

In addition, due to the miniaturization, it is possible to form a large wall thickness with the outer cover, and even when the core tablet is supplied at an angle,
The rate of change in wall thickness is small and can prevent defects due to cracks.

Furthermore, the range of options for the weight of the core tablet per unit increases; for example, a core tablet with a weight ratio of 1:1 to the outer shell or a hard core tablet that is heavier can be easily provided. It has the following effects.

[Brief explanation of drawings]

Fig. 1 is a plan view of the main parts of the entire molding machine, Figs. 2 and 5 are plan views of the dry-coated tablet, Figs. 3 and 6 are semi-longitudinal front views, and Fig. 4
7 is a left side view, FIG. 8 is a plan view showing a conventional dry-coated tablet, and FIG. 9 is a semi-vertical front view of FIG. 8. DESCRIPTION OF SYMBOLS 1...Coated tablet, 2...Coating, 3. Core tablet, 4... Rotating disc, 5... Mortar, 6. First feeder, 7. Powder, 8. Core feeding device. 9...Second feed system, lO...Compression roll, 11...Feeder, 12.Feeding pipe, 13...Timing hole, 14
...Timing phototube, 15...Nuclear detection phototube, 1
6... Exclusion damper, 17... Extraction damper, 1
8...Powder drop port, I9...Color-specific sensor, 20...
・Chute, 21...Exclusion chute, 22...Receiving can, 23...Solenoid, 24...Retaining hole Representative patent attorney Yuzuru Koki

Claims (1)

[Claims] 1. Putting a first powder into a mortar hole of a mortar disposed on a rotary disk,
Produced by a rotary powder compression molding machine that supplies a pre-formed core tablet on top of the powder, fills the second powder so as to cover the core tablet, and then compresses it using an upper frame and a lower frame. A double-coated tablet characterized in that it has two core tablets. 2 Put the first powder into the mortar hole of the mortar installed on the rotary disk,
A method for producing a core tablet in which a pre-formed core tablet is supplied on top of the powder, a second powder is filled to cover the core tablet, and then compression molded, the core tablet being divided into two parts. A method for manufacturing a double-core tablet, characterized in that the core tablets are made into two core tablets, and each core tablet, which is a supply unit, is miniaturized and supplied without reducing the total weight of the core tablets.