JPH02180275A - Medicine injection tool having ultrasonic wave oscillation element - Google Patents

Abstract

PURPOSE:To permit the superior diffusion and permeation into the organ at an aimed part by joining a conduit having a ultrasonic wave oscillation element at the top edge of a basic part equipped with a feeding part for medicine, etc., ultrasonic wave oscillator, or a connector connected with the ultrasonic wave oscillator, and electrically joining the ultrasonic wave oscillation element and the ultrasonic wave oscillator, thus carrying out the injection of medicine, etc., applying vibration. CONSTITUTION:A connector 7 connected with a ultrasonic wave oscillator 8 is installed onto an injector basic part 1, and at the top edge on the opposite side of a body liquid discharge port 14 and a feeding port 6 for medicine, etc., a conduit is divided into a center passage and an outer peripheral passage by a partitioning wall 16 similarly at the basic part. In the conduit 2 having a center passage as body liquid flow passage 15 and the outer peripheral passage as flow passage 4 for medicine, etc., a body liquid flow passage 13 and a flow passage 5 for medicine, etc., at the basic part 1 and body liquid flow passage 15 and the flow passage 4 for medicine, etc., of the conduit 2 are joined so as to communicate each other. Therefore, the injection of medicine, etc., into organs is carried out, applying the ultrasonic wave vibration, and the dispersion and permeation of medicine, etc., can be improved.

Description

Detailed Description of the Invention [Industrial Application Field] The present invention is a method of injecting a drug into the body from outside the human body through a catheter or a drug injection conduit, applying ultrasonic vibration directly to the injection site, and injecting drugs, etc. This invention relates to a drug injection device that improves the diffusion and penetration of drugs.

[Conventional technology]

Methods for externally administering drugs for the treatment and prevention of human diseases include oral and parenteral administration using injections, oral preparations, suppositories, transdermal preparations, and the like. In particular, methods for directly injecting drugs and the like into the body include methods of injecting drugs into a target site within the body via local injection, arteriovenous injection, intravascular catheter, and the like.

When drugs are directly injected into the body by these means, it may be difficult for the injected drugs to diffuse into tissues within the body, and in order to improve this, chemical methods have traditionally been used. Ta.

The present inventor first focused on the use of ultrasound to improve the diffusion and penetration of drugs when administering drugs through catheters, and invented a blood vessel cleaning machine that applies ultrasonic vibrations from the base connected to the catheter. (Unexamined Japanese Patent Publication No. 56-5207)
(Publication No. 1) [Problems to be Solved by the Invention] The present invention solves the above-mentioned conventional technology by improving sales expansion and penetration of the drug injected into the blood vessel by the catheter into the intravascular indwelling device in the case of drug injection using a catheter. In the method of using ultrasound to transmit ultrasound to the tip of the catheter, the ultrasound oscillator is located outside the body and is located far from the tip of the catheter, so there is no need for ultrasound processing during the process. It was difficult to achieve a sufficient effect due to the attenuation of 100 lbs.

[Means to solve the problem]

The present inventor conducted further research on a method of using ultrasound to improve the diffusion and penetration of drugs, etc. injected into blood vessels into intravascular indwelling objects when injecting drugs, etc. using a catheter. By attaching a sound wave oscillation element to the tip of the catheter's body-inserted section, attaching the oscillator to the base located outside the body, and electrically connecting the oscillator and oscillation element, it is possible to increase sales and penetration of drugs at the injection site. The present invention has been completed, which provides a drug injection device with a wide range of uses by applying this to not only catheters but also devices inserted into the body.

The present invention connects a conduit equipped with an ultrasonic oscillation element to the tip of a base equipped with a supply part for drugs, an ultrasonic oscillator, or a connector connected to an ultrasonic oscillator, and connects this ultrasonic oscillation element to an ultrasonic This is a drug injection device with an ultrasonic oscillation element that is electrically connected to an oscillator.

The drug injection device with a conduit connected to the tip used in the present invention is as follows:
A base having a distribution channel for drugs, etc. in the center and an opening thereof as a supply port for drugs, etc.; a metal having a distribution channel corresponding to the distribution channel for drugs, etc. in the center at the tip opposite to the supply port of the base; It is a conduit made of hollow thin tubes such as rubber or plastic, and is generally used for the stomach, intestines, esophagus, trachea, blood vessels, etc., and can also be used as a drug injection device to directly inject drugs into the body's tissues. can.

The oscillation element used in the present invention has approximately the same diameter as the conduit, approximately 1
A cylindrical ceramic oscillation element having a diameter of ~1Q mm or a cylindrical ceramic oscillation element having a through hole in the center, or a soft type film oscillation element molded into the same shape can be suitably used.

Note that when an oscillation element having a through hole in the center of the oscillation element is used, this through hole may be used as an inlet for injected drugs or the like, or as an outlet for body fluids. In addition, when using it as a discharge port, install a cylindrical partition inside the base and the conduit, divide it into two chambers, a central passage and an outer circumferential passage, connect the central passage and the outer circumferential passage of the base and the conduit in a corresponding manner, and connect the central passage and outer circumferential passage of the base and the conduit. The channel is used as a flow path for body fluids, and the outer circumferential path is used as a flow path for drugs and the like. Then, the through hole of the oscillation element is connected to the body fluid flow path of the conduit.

The conduit is provided with an outflow hole for drugs, etc. in a region close to the oscillation element.

When using a cylindrical oscillation element that does not have a through hole in the center, it is necessary to provide an outflow hole for drugs, etc. in the conduit body at a portion adjacent to the oscillation element.

The ultrasonic oscillation element provided at the tip of the conduit is the ultrasonic oscillator provided at the base of the injection device of the present invention or the ultrasonic oscillation element provided at the tip of the conduit.
It is connected by a conductor to the connector connected to the i-machine. The conductor may be embedded and retained within the conduit member;
It may also be retained by adhering to its internal surface.

[Effect]

Although the present invention is configured as described above, the drug or the like is injected while the ultrasonic oscillating element always vibrates at a position closest to the target site of the drug or the like. Therefore, the diffusion penetration into the tissue of the target site is extremely good.

Further, the intensity of the ultrasonic waves of the oscillation element and the ultrasonic frequency can be adjusted as appropriate using an ultrasonic oscillator installed or connected to the injection tool of the present invention. Therefore, the size of the restricted region can be controlled by selection.

〔Example〕

Next, an example of the drug injection device of the present invention will be explained with reference to the accompanying drawings.

Example 1 As shown in Fig. 1, a base 1 of an injector has a distribution passage 5 for drugs, etc. passed through the central part, and the open part thereof is a supply port 6 for drugs, etc.
is equipped with a connector 7 to be connected to an ultrasonic oscillator 8, and a connector 7 with a diameter of 1 to 10 mm is provided at the tip opposite to the supply port 6 of the base 1.
A hollow plastic conduit 2 having a flow path 4 for a drug or the like is joined to the tip of the conduit 2, and a cylindrical ceramic oscillation element 3 having a diameter and a height of 1 to 10 mm that matches the conduit is joined to the tip of the conduit 2. This cylindrical ceramic oscillation element 3 is provided with a through hole 9 having a diameter of 0.5 to 9 ml Tl in the center thereof.

The ceramic oscillation element 3 and the connector 7 are connected by a conductive wire 10. This conducting wire 10 is held on the inner wall surface or within the wall of the conduit 2.

On the other hand, the connector 7 is connected to an ultrasonic oscillator 8.

Example 2 This example is a case where the oscillation element 3 does not have a through hole in the drug injection device of Example 1.

Therefore, the components other than the oscillation element 3 and the tip of the conduit 2 are the same as in Example 1.

FIG. 2 shows the oscillation element 3 and the tip of the conductor 92.

As shown in FIG. 2, the ceramic oscillation element 3 does not have a through hole, but a through hole 11 is provided slightly above the portion of the lower part of the conduit where it is joined to the ceramic oscillation element 3.

Example 3 As shown in FIG. 3, the inside of the injection device base 1 is divided into a central passage and an outer peripheral passage by a partition wall 12, and the central passage is divided into a body fluid drainage passage 1.
3, and the outer circumferential path is used as a distribution path 5 for drugs, etc. The open portions of each of the flow passages were defined as a body fluid discharge port 14 and a drug supply port 6. A connector 7 connected to an ultrasonic oscillator 8 is provided at the base 1 of the injector, and a connector 7 connected to the ultrasonic oscillator 8 is provided at the tip opposite to the body fluid discharge port 14 and the supply port 6 for drugs, etc. The central passage is divided into a central passage and a peripheral passage, and the central passage is connected to the body fluid flow passage 15 of the conduit 2. The conduit 2 whose outer peripheral path is the distribution path 4 for drugs, etc. is connected to the body fluid distribution path 13 of the base 1, the distribution path 5 for drugs, etc., the body fluid distribution path 15 of the conduit 2, and the distribution path 4 for drugs, etc.
Connect each passage so that they are connected.

The inner circumference of the cylindrical ceramic oscillation element 3 with a through hole 9 provided at the other end of the conduit 2 is connected to the body fluid flow passage 15 of the conduit 2, and the outer circumference of the ceramic oscillation element 3 is connected to the outer circumference of the conduit 2, respectively. Then, a through hole 11 is bored in the wall of the conduit slightly above the joint between the conduit 2 and the ceramic oscillation element 3 to serve as an outlet for drugs and the like.

Note that the ceramic oscillation element 3 and the connector 7 are connected to a conductor 10.
Connect by. The conducting wire 10 is then adhered to and held on the inner wall surface of the conduit 2.

On the other hand, the connector 7 is connected to an ultrasonic oscillator 8.

Honjima is capable of injecting drugs, etc., and using ultrasonic waves to crush and dissolve any aggregates floating in the liquid in the organ and discharge them to the outside.

Effects of C-Facing] In the present invention, drugs, etc. are injected into tissues while applying ultrasonic vibrations, so the diffusion and penetration of drugs, etc. is significantly improved.
For example, in the treatment of thrombosis in the coronary arteries of the heart, if the drug injection device of the present invention is inserted close to the thrombus and a dissolving agent (urokinase, etc.) is injected, the dissolution rate of the thrombolytic agent will be significantly enhanced, and it will take time until blood flow resumes. The duration of treatment is also shortened, and clinical outcomes are improved.

In addition, when the drug injection device of the present invention, especially the structure of Example 3, is used in a hematoma in a cerebral hemorrhage site, the thrombolytic agent is injected, the hematoma is simultaneously dissolved by ultrasonic irradiation, and the hematoma is inhaled through a conduit and delivered to the outside. It has the effect of greatly expanding its therapeutic potential for cerebral hemorrhage.

[Brief explanation of the drawing]

FIG. 1 is a sectional view of a drug injection device according to Example 1 of the present invention, and FIG.
The figure is a perspective view showing the connecting portion of the conduit and the ultrasonic vibration element of Example 2, and FIG. 3 is a sectional view of the drug injection device of Example 3. l: Base of drug injector 2: Conduit 3; Ultrasonic oscillation element 4; 3m flow path for drugs, etc. in the conduit 5.
Blood flow path 6 for drugs, etc. at the base; Supply port for drugs, etc. 7: Connector 8; Ultrasonic oscillator 9: Through hole 10 of the ultrasonic oscillator element:
Conductor wire 11: Conduit through hole 12: Base partition
13: Body fluid flow path at the base 14: Body fluid outlet
15: Body fluid flow path of the conduit 16: Partition of the conduit

Claims (1)

[Claims] 1. A conduit equipped with an ultrasonic oscillation element is joined to the tip of the base that is equipped with a supply part for drugs, etc. and an ultrasonic oscillator or a connector for connecting to the ultrasonic oscillator, and the ultrasonic oscillator and the ultrasonic oscillator are connected to each other. 1. A drug injection device with an ultrasonic oscillation element, characterized in that the device is electrically coupled with the ultrasonic oscillation element.