JPH02142720A - Perfume - Google Patents

Abstract

PURPOSE:To provide a perfume having an arousal effect or sedative effect by containing musk ketone, etc., and camphor, etc. CONSTITUTION:A perfume having an arousal effect contains 0.1-80.0wt.% of one or more of musk ketone, cyclopentadecanolide and 8-alpha, 12-oxide-13,14,15,16- tetranorbane and a perfume contains 0.1-80wt.% of one or more of yukariputol, camphor and borneol. The perfumes are effective for the enhancement of the adaptive ability of a man to the change of conditions and the improvement of the maintenance function of his physiological psychological homeostasis.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Application Field] The present invention relates to a fragrance having a wake-up effect or a soothing effect.

More specifically, it is related to the purpose of helping modern people respond quickly to the environment from a physiological and psychological standpoint.
Modern people, especially those working within organizations, are forced to respond to ever-changing situations. In order to take action to respond to these changes without delay, a tremendous amount of effort is required.

The present invention is used for the purpose of improving the physiological and psychological homeostasis maintenance function of modern humans.

For example, it may be necessary to be awake for the purpose of strengthening the ability to adapt to changes in circumstances or for auxiliary purposes, such as eliminating fatigue and emotional fatigue that occur while driving a car for long periods of time. . Furthermore, modern society is bringing about rapid changes in daily life due to the rapid development of science and technology.

According to Elye and H., stress, which is a non-specific reaction caused by stimulation, is an essential element not only for individuals but also for the progress of humanity, and that living is, in other words, stress. Therefore, in order to utilize stress as a stimulant necessary for life, it is essential to maintain physiological and psychological homeostasis. It is necessary to maintain this state and improve homeostasis.
The present invention is used for this purpose and is incorporated into cosmetics such as room air fresheners, perfumes, and soaps.

[Conventional technology]

Anti-inflammatory effects, antiseptic effects, and appetite suppressing and enhancing effects have been reported to be useful for aromatic agents.

Although there are some reports of effects on the central nervous system, some are based on merely subjective results of the SD method, and there is a lack of scientific basis due to the influence of subjective preference. Furthermore, Japanese Patent Application Laid-Open No. 61-267526 discloses a "method for reducing physiological and/or subjective reactions to stress." This invention measures blood pressure and mood changes,
It mentions the usefulness of natural essential oils. Additionally, there are products that use fragrances containing plant essential oils, mainly monoterpenes, to reduce fatigue and maintain visual function.

In conventional techniques, test results were largely influenced by subjective preference, and therefore had large individual differences and lacked scientific basis. In addition, the above-mentioned Japanese Patent Application Laid-Open No. 61267526 also contains subjective parts and measures secondary physiological responses to stress such as blood pressure, so there are large uncertainties and stable effects cannot be expected. I wasn't getting it.

Furthermore, since natural essential oils are used as samples, it is generally known that their properties differ slightly depending on the region of production, time of collection, and age. Therefore, their effects are also very unstable.

[Means for solving problems]

In order to solve the problems of the above-mentioned conventional techniques, we investigated a number of high-purity single fragrance raw materials with clear chemical structures. As a result of examining the awakening or soothing effects of fragrances containing raw materials with clear structures, we found musk ketone, cyclopentadecanolide (hereinafter referred to as CPD), 8-α512-oxide-13,14,15°16-tetranorban (hereinafter referred to as 0TN) has a remarkable awakening effect, eucalyptol,
A remarkable soothing effect was observed in camphor and borneol.

Although it was discovered that musk ambrette also has a wake-up effect, it was not used in the present invention because musk ambrette has photosensitizing properties and has safety issues.

As a method to objectively measure the awakening effect, analysis of brain wave waveforms, which vary extremely sensitively depending on the level of consciousness, is carried out. The so-called alpha and beta brain waves fluctuate depending on the level of consciousness, but in the process of investigating the effects of fragrances, the level of consciousness increases as mental activity increases due to interest in fragrances, and alpha waves change to beta waves. A phenomenon of transition to waves is observed.

Therefore, so-called brain wave measurements cannot measure the specific psychological effects of fragrances. However, the influence on the electrical signals of the brain that occurs when the level of consciousness is high is a reaction under certain conditions, and the above drawbacks can be eliminated, making it an effective means.

In this study, we investigated the qontient negative fluctuations in the frontal region caused by voice stimulation.
A slow negative potential change called vevariation (CNV) was used for the measurements.

Detailed experimental methods are described. Two seconds after the warning stimulus sound, a light signal indicating the start of movement follows, and a motor response of a button press is required to express recognition of the light. In this series of repetitions, a sample is given before the warning stimulus, and 2
After three commanded breaths, the scent was administered from a container near the subject's nostrils during the third and final inhalation. Electrodes for CNV measurement were attached to the forehead,
Electric potential was recorded between the earlobe and changes in skin potential level between electrodes attached to the palm and forearm.

H, Ashton found that when caffeine, which has a stimulant effect, is administered, the CNV amplitude increases, and when nitrazepam, which has a sedative effect, is administered, the CNV amplitude decreases.
It has been reported by et al.

These fluctuations range from 500 to 1000 m5ec after the warning stimulus.
It appears prominently in the initial components of. Table 1 shows the CNV measurement results for single chemical substances and Examples. This effectiveness is expressed by the maximum amplitude value of the initial component.

As seen in the results in Table 1, musk fragrances have a remarkable awakening effect. In the test of the difference in mean value between musk ketone and the unscented control, a difference was observed at a significance level of 1%, and a significant difference was observed at 5% for CPD and OTN. These chemicals are structurally different and are unlikely to have stimulant effects due to direct pharmacological action on the central nervous system like caffeine. It is thought that subconscious recognition of the odor as a musk promotes the release of stimulant substances, resulting in the awakening effect.

On the other hand, camphor-like fragrances were found to have a soothing effect. The chemical substance with the highest soothing effect was eucalyptol, with a significance of 1%, and camphor and borneol, which had a significant sedative effect with a significance of 5%. Measurements of eucalyptol's skin potential level (hereinafter referred to as 5PL) conducted at the same time also showed a significant decrease in skin potential, supporting its sedative effect.

Table 2 shows the composition of a perfume (Example 1) using the above-mentioned single chemical substance that had a wake-up effect.

Furthermore, Table 3 shows a perfume (Example 2) using the above-mentioned single chemical substance having a soothing effect.

Example 1. Samples in which the active ingredient was removed from Example 2 and each Example and ethanol was added instead were used as Comparative Example 1 and Comparative Example 2, respectively, and CNV was measured. Table the results.
4.

T-undecalactone orange oil turpenless 0.1 0.2 linalyl acetate 4.0 jasmine base 2.0 benzyl acetate 2.0 α-isomethylionone n-hexyl salicylate musk ketone 12.0 IOoo 10.0 CPD OTN Lemon Oil Ylang Ylang Oil Extra Terpineol Linalool Phenylethyl Alcohol Lyral LD Benzyl Acetate Clove Oil Sandal Wood Oil Ionone Cedarwood Oil 20.0 Eucalyptol Patchouli Oil Methyl Ionone Eukenol Lyral Rui C) Acetyl Cedren Pine Oil 10.0 14.0 Citronellol Terpineol Linalool Camphor Borneol Allyl Caproate Resinoid Olivanom Absolute Fur Balsam Turvinyl Propionate Resinoid Styranx However, no significant difference was observed between the CNV values of Comparative Example 1 and Comparative Example 2.

Next, the physiological and psychological comprehensive evaluations of the examples were investigated.

The test method is shown below.

A skin potential level (5PL) device was attached to five male and female subjects in a constant temperature, constant humidity, and odorless room equipped with a soundproof device, and their reflex speed was measured after a period of rest in the room to investigate their wakefulness and restfulness. .

The reflex speed is determined by determining the moment when two arrows displayed on the computer screen join, and then pressing a button.

The deviation between the set junction point and the point at which the button is pressed is measured 10 times, and the average value is determined. Hereinafter, this method will be referred to as RNM. After entering the room, the error distance was measured as a control without fragrance, and then the Examples and Comparative Examples were investigated. To further investigate the order effect,
A resting period of one hour was given in the unscented state, and a control measurement was carried out, and the samples were given in a different order. The concentration of the sample was set to the highest concentration that did not cause discomfort, as determined in advance. Table 5 shows the results of RNM and SPL in 6.
The results were shown.

RNM result table In order to obtain the SPL results, the difference in the mean values was tested using the standardized value divided by each mean value, and the subjects with a 1% significance level were evaluated as significant, those with 5% significance as effective, and 10%. Tests were performed using the chi-square method, with subjects showing significant results as slightly valid and subjects with a value greater than 10% as invalid. The results are listed in Table-7.

The results of the reflex ability survey were evaluated using the following method. Considering individual differences, we calculated the differences between individual samples and found no differences due to sample order or gender. Table 5.
The number of samples was set to 10. As a result of performing a chi-square test between each example and comparative example, the significance level was 1%.
An awakening effect or a relaxing effect was observed.

In the SPL measurement results, in Example 1, a decrease that occurs under normal conditions was not observed, indicating an awakening effect, and in Example 2, a significant decrease was observed, indicating a relaxing effect.

As described above, according to the present invention, a fragrance having an awakening effect and a fragrance having a soothing effect can be obtained, which can be used to strengthen the ability to adapt to changes in circumstances and improve the function of maintaining physiological and psychological homeostasis.

Claims (2)

[Claims] (1) Musk ketone, cyclopentadecanolide, 8-α
, 12-oxide-13,14,15,16-tetranorban. (2) A fragrance having a soothing effect, containing 0.1 to 80.0% by weight of one or more of eucalyptol, camphor, and borneol.